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EPS8: Interactions, Function & Clinical significance

Epidermal growth factor receptor kinase substrate 8 is an enzyme that in humans is encoded by the EPS8 gene.

Language: English [EN]
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EPS8 topic overview

The analysis highlights Interactions, Function and Clinical significance as prominent areas in the source structure around EPS8.

Related topics
15
Source areas
4
Connected nodes
19
Extracted relationships
122
Concept neighborhoods
8
Bridge connections
19

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Interactions · 8 topics
Function · 4 topics
Overview · 2 topics
Clinical significance · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
EPS8, DFNB102, epidermal growth factor receptor pathway substrate 8
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2E8M
Band
12p12.3 · 6 G1|6 66.78 cM
Bgee
jejunal mucosa · mucosa of sigmoid colon · Achilles tendon · cartilage tissue · corpus epididymis
BioGPS
More reference expression data
Chr.
Chromosome 12 (human) · Chromosome 6 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Clinical significance

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How EPS8 connects Entity context

The extracted context around EPS8 shows recurring relationship patterns in the source. For example, EPS8 → actin binding, actin crosslink formation, actin cytoskeleton reorganization, actin filament bundle assembly, actin polymerization-dependent cell motility, adult locomotory behavior, barbed-end actin filament capping, behavioral response to ethanol, brush border, cell cortex, cell junction, cell population proliferation, cell projection, cellular response to leukemia inhibitory factor, cytoplasm, dendritic cell migration, epidermal growth factor receptor signaling pathway, exit from mitosis, extracellular exosome, glutamatergic synapse Another extracted example is EPS8 → Achilles tendon, cartilage tissue, conjunctival fornix, corpus epididymis, ileum, jejunal mucosa, left colon, migratory enteric neural crest cell, mucosa of sigmoid colon, parotid gland, pericardium, popliteal artery, primary oocyte, right kidney, secondary oocyte, seminal vesicula, synovial joint, tail of epididymis, tibial arteries, zygote. Use these groups to spot repeated connection types before inspecting the individual relationships.

EPS8

Top relations

Gene ontology · 43
EPS8 → actin binding, actin crosslink formation, actin cytoskeleton reorganization, actin filament bundle assembly, actin polymerization-dependent cell motility, adult locomotory behavior, barbed-end actin filament capping, behavioral response to ethanol, brush border, cell cortex, cell junction, cell population proliferation, cell projection, cellular response to leukemia inhibitory factor, cytoplasm, dendritic cell migration, epidermal growth factor receptor signaling pathway, exit from mitosis, extracellular exosome, glutamatergic synapse
Bgee · 20
EPS8 → Achilles tendon, cartilage tissue, conjunctival fornix, corpus epididymis, ileum, jejunal mucosa, left colon, migratory enteric neural crest cell, mucosa of sigmoid colon, parotid gland, pericardium, popliteal artery, primary oocyte, right kidney, secondary oocyte, seminal vesicula, synovial joint, tail of epididymis, tibial arteries, zygote
RNA expression pattern · 20
EPS8 → Achilles tendon, cartilage tissue, conjunctival fornix, corpus epididymis, ileum, jejunal mucosa, left colon, migratory enteric neural crest cell, mucosa of sigmoid colon, parotid gland, pericardium, popliteal artery, primary oocyte, right kidney, secondary oocyte, seminal vesicula, synovial joint, tail of epididymis, tibial arteries, zygote
related to Function · 9
EPS8 → Alternate, EGFR, Highly, It, PH, Rac, Ras, SH3, This
related to Interactions · 5
EPS8 → ABI1, BAIAP2, DVL1, SHB, SHC1SOS1
Band · 2
EPS8 → 12p12.3, 6 G1|6 66.78 cM
Chr. · 2
EPS8 → Chromosome 12 (human), Chromosome 6 (mouse)
End · 2
EPS8 → 137,631,874 bp, 15,882,329 bp
Aliases · 1
EPS8 → EPS8, DFNB102, epidermal growth factor receptor pathway substrate 8
Available structures · 1
EPS8 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2E8M

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

bp gene chr human band growth chromosome 12 epidermal factor receptor location pathway mouse substrate function search 882 329 end

EPS8 relationships Subject–Predicate–Object triples

TTTA extracted 122 structured relationships around EPS8. Examples in this analysis include EPS8 → Aliases → EPS8, DFNB102, epidermal growth factor receptor pathway substrate 8 and EPS8 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2E8M. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
EPS8AliasesEPS8, DFNB102, epidermal growth factor receptor pathway substrate 81.00infobox
EPS8Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2E8M1.00infobox
EPS8Band12p12.31.00infobox
EPS8Band6 G1|6 66.78 cM1.00infobox
EPS8Bgeejejunal mucosa1.00infobox
EPS8Bgeemucosa of sigmoid colon1.00infobox
EPS8BgeeAchilles tendon1.00infobox
EPS8Bgeecartilage tissue1.00infobox
EPS8Bgeecorpus epididymis1.00infobox
EPS8Bgeepericardium1.00infobox
EPS8Bgeetail of epididymis1.00infobox
EPS8Bgeepopliteal artery1.00infobox
EPS8Bgeetibial arteries1.00infobox
EPS8Bgeesynovial joint1.00infobox
EPS8Bgeesecondary oocyte1.00infobox
EPS8Bgeeleft colon1.00infobox
EPS8Bgeezygote1.00infobox
EPS8Bgeeseminal vesicula1.00infobox
EPS8Bgeemigratory enteric neural crest cell1.00infobox
EPS8Bgeeprimary oocyte1.00infobox
EPS8Bgeeileum1.00infobox
EPS8Bgeeconjunctival fornix1.00infobox
EPS8Bgeeright kidney1.00infobox
EPS8Bgeeparotid gland1.00infobox
EPS8BioGPSMore reference expression data1.00infobox
EPS8Chr.Chromosome 12 (human)1.00infobox
EPS8Chr.Chromosome 6 (mouse)1.00infobox
EPS8DatabasesNCBI: entry; OMA: entry1.00infobox
EPS8End15,882,329 bp1.00infobox
EPS8End137,631,874 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around EPS8 bring nearby vocabulary together. In this analysis, examples include Factor, Receptor and Growth. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • EPS8
    • Factor
    • Receptor
    • Growth
    • Gene
    • Function
    • Search
    • Substrate
    • Location
    • Pathway
    • Chromosome
    • Human
    • Bp
  • eps8
    • Factor
    • Receptor
    • Growth
    • Gene
    • Function
    • Search
    • Substrate
    • Location
    • Pathway
    • Chromosome
    • Human
    • Bp
  • gene
    • Location
    • Receptor
    • Chromosome
    • Growth
    • Human
    • Bp
    • Chr
    • End
    • Function
    • G1
    • Mouse
    • Search
  • function
    • Search
    • Location
    • Pathway
    • Receptor
    • Chromosome
    • Growth
    • Human
    • Interactions
    • Reading
    • References
    • Significance
    • Bp
  • actin
    • Rac
    • Transduction
    • Growth
    • End
    • Function
    • G1
    • Mouse
    • Protein
    • Search
    • Epidermal
    • Factor
    • Location
  • clinical significance
    • Interactions
    • Reading
    • References
    • Significance
    • Function
    • Search
    • Substrate
    • Epidermal
    • Factor
    • Location
    • Pathway
    • Receptor
  • enzyme
    • Encoded
    • Humans
    • Kinase
    • Substrate
    • Epidermal
    • Factor
    • Receptor
    • Growth
    • Eps8
    • Gene
  • interactions
    • Reading
    • References
    • Significance
    • Search
    • Substrate
    • Location
    • Pathway
    • Receptor
    • Human

Connections between topic areas Semantic bridges

For EPS8, one of the stronger structural bridges in this analysis connects EPS8 with Interactions. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
EPS8Interactions · splits 11 ⟂ 9
EPS8Function · splits 15 ⟂ 5
EPS8Overview · splits 17 ⟂ 3

Map overview Semantic statistics

EPS8

Nodes20
Edges19
Triples122
Avg. degree1.9
Density0.1
Components1

Source & methodology

TTTA analyzes the structure around EPS8 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Interactions, Function & Clinical significance, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — EPS8 · EN edition · Analysis: TopicsToTalkAbout

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