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Serotonin–norepinephrine reuptake inhibitor

Serotonin–norepinephrine reuptake inhibitors (SNRIs) are a class of antidepressant medications used to treat major depressive disorder (MDD), anxiety disorders, chronic neuropathic pain, fibromyalgia, and menopausal symptoms. Off-label uses include treatments for attention deficit hyperactivity disorder (ADHD) and obsessive–compulsive disorder (OCD).…

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Biological target
Serotonin transporter; Norepinephrine transporter
MeSH
D000068760
Synonyms
Selective serotonin–noradrenaline reuptake inhibitor; SNaRI
Use
Depression; anxiety; pain; obesity; menopausal symptoms

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Overview

Medications

History

Mechanism of action

Structure activity relationship

Indications

Pharmacology

Contraindications

Side effects

Precautions

Overdose

Comparison to SSRIs

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Map overview Semantic statistics

Serotonin–norepinephrine reuptake inhibitor

Nodes179
Edges178
Triples21
Avg. degree1.99
Density0.011173
Components1

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Serotonin–norepinephrine reuptake inhibitor

Top relations

Biological target · 1
Serotonin–norepinephrine reuptake inhibitor → Serotonin transporter; Norepinephrine transporter
MeSH · 1
Serotonin–norepinephrine reuptake inhibitor → D000068760
Synonyms · 1
Serotonin–norepinephrine reuptake inhibitor → Selective serotonin–noradrenaline reuptake inhibitor; SNaRI
Use · 1
Serotonin–norepinephrine reuptake inhibitor → Depression; anxiety; pain; obesity; menopausal symptoms

Important terminology Word statistics

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Important terminology

norepinephrine serotonin snris reuptake ssris effects symptoms antidepressants drugs venlafaxine increased tcas depression pain milnacipran antidepressant inhibitors treatment duloxetine inhibition

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Serotonin–norepinephrine reuptake inhibitorBiological targetSerotonin transporter; Norepinephrine transporter1.00infobox
Serotonin–norepinephrine reuptake inhibitorMeSHD0000687601.00infobox
Serotonin–norepinephrine reuptake inhibitorSynonymsSelective serotonin–noradrenaline reuptake inhibitor; SNaRI1.00infobox
Serotonin–norepinephrine reuptake inhibitorUseDepression; anxiety; pain; obesity; menopausal symptoms1.00infobox
neuropathic paininstance ofSNRIs are also widely used for chronic pain conditions0.80text
fibromyalgia.The human serotonin transporterinstance ofSNRIs are also widely used for chronic pain conditions0.80text
muscarinic cholinergicinstance ofAntidepressants affect variable neuronal receptors0.80text
α1-instance ofAntidepressants affect variable neuronal receptors0.80text
α2-adrenergicinstance ofAntidepressants affect variable neuronal receptors0.80text
H1-histaminergicinstance ofAntidepressants affect variable neuronal receptors0.80text
and sodium channels in the cardiac muscleinstance ofAntidepressants affect variable neuronal receptors0.80text
leading to decreased cardiac conductioninstance ofAntidepressants affect variable neuronal receptors0.80text

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