Research any topic before you write.

Find related topics. | Discover entities. | See connections. | Build a topical map.

Ibuprofen: History, Applications, Research & Art

Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that is used to relieve pain, fever, and inflammation. This includes painful menstrual periods, migraines, and rheumatoid arthritis. It can be taken orally (by mouth) or intravenously (injected into a vein). It typically begins working within an hour.

Language: English [EN]
Use the mouse wheel or two fingers (on touchscreens) to zoom in and out of the map.
100%
More settings
100% 100% 100% 100% 100%

Ibuprofen topic overview

The analysis highlights History, Applications, Research and Art as prominent areas in the source structure around Ibuprofen.

Related topics
187
Source areas
8
Connected nodes
195
Extracted relationships
188
Concept neighborhoods
38
Bridge connections
195

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Adverse effects · 47 topics
Chemistry · 40 topics
Overview · 38 topics
Research · 24 topics
Pharmacology · 18 topics
Medical uses · 12 topics
Availability and administration · 4 topics
History · 4 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
C01EB16 (WHO) G02CC01 (WHO) M01AE01 (WHO) M02AA13 (WHO) R02AX02 (WHO)
Bioavailability
80–100% (oral), 87% (rectal)
Boiling point
157 °C (315 °F) at 4 mmHg
CAS Number
15687-27-1 Y

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Medical uses

Adverse effects

Pharmacology

Chemistry

History

Availability and administration

Research

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Ibuprofen connects Entity context

The extracted context around Ibuprofen shows recurring relationship patterns in the source. For example, Ibuprofen → Anti-Inflammatory Agents, August, Boots Pure Drug Co, Evidence, GBpatent, John Stuart Nicholson, Lowe, Ltd, National Safety Council, NSC, PDF, Science, September, Stewart Sanders Adams, The Ibuprofen Revolution Another extracted example is Ibuprofen → Adams, Boots, Boots Group, Boots's, In, Its, Later, NSAID, OTC, Queen's Award, Stewart Adams, Technical Achievement, The, United Kingdom, United States. Use these groups to spot repeated connection types before inspecting the individual relationships.

Ibuprofen

Top relations

related to External links · 15
Ibuprofen → Anti-Inflammatory Agents, August, Boots Pure Drug Co, Evidence, GBpatent, John Stuart Nicholson, Lowe, Ltd, National Safety Council, NSC, PDF, Science, September, Stewart Sanders Adams, The Ibuprofen Revolution
related to history · 15
Ibuprofen → Adams, Boots, Boots Group, Boots's, In, Its, Later, NSAID, OTC, Queen's Award, Stewart Adams, Technical Achievement, The, United Kingdom, United States
related to Availability and administration · 12
Ibuprofen → AAN, Advil, Australian Approved Name, BAN, British Approved Name, In, INN, Motrin, United Kingdom, United States, United States Adopted Name, USAN
related to Pharmacology · 12
Ibuprofen → A2, Antipyretic, COX, COX-1, COX-2, H2, However, Inhibition, Like, NSAIDs, PGH2, The
related to Research · 10
Ibuprofen → Alzheimer's, As, Aspirin, Harvard Medical School, In March, Japan, NSAIDs, Parkinson's, People, Use
related to Cardiovascular risk · 8
Ibuprofen → Along, EMA, FDA, July, NSAID, NSAIDs, On, The European Medicines Agency
related to Chemistry · 8
Ibuprofen → Boots Group, Darzens, EtOH, Firstly, Friedel-Crafts, Later, The, Then
related to Overdose · 8
Ibuprofen → Generally, Human, Many, Most, NSAIDs, OTC, Rarely, The
related to Skin · 7
Ibuprofen → Along, As, Johnson, Like, NSAIDs, SJS, Stevens
related to Ibuprofen lysine · 6
Ibuprofen → Drug Administration, FDA, Food, However, In, United States

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

nsaids aspirin risk pain effects drug may anti-inflammatory used however united states treatment include paracetamol blood including heart overdose nsaid

Ibuprofen relationships Subject–Predicate–Object triples

TTTA extracted 188 structured relationships around Ibuprofen. Examples in this analysis include Ibuprofen → 3D model (JSmol) → Interactive image and Ibuprofen → AHFS/Drugs.com → Monograph. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Ibuprofen3D model (JSmol)Interactive image1.00infobox
IbuprofenAHFS/Drugs.comMonograph1.00infobox
IbuprofenATC codeC01EB16 (WHO) G02CC01 (WHO) M01AE01 (WHO) M02AA13 (WHO) R02AX02 (WHO)1.00infobox
IbuprofenBioavailability80–100% (oral), 87% (rectal)1.00infobox
IbuprofenBoiling point157 °C (315 °F) at 4 mmHg1.00infobox
IbuprofenCAS Number15687-27-1 Y1.00infobox
IbuprofenChEBICHEBI:5855 Y1.00infobox
IbuprofenChEMBLChEMBL521 Y1.00infobox
IbuprofenChemSpider3544 Y1.00infobox
IbuprofenChiralityRacemic mixture1.00infobox
IbuprofenCompTox Dashboard (EPA)DTXSID50207321.00infobox
IbuprofenDensity1.03 g/cm31.00infobox
IbuprofenDrug classNonsteroidal anti-inflammatory drug (NSAID)1.00infobox
IbuprofenDrugBankDB01050 Y1.00infobox
IbuprofenECHA InfoCard100.036.1521.00infobox
IbuprofenElimination half-life2–4 hours1.00infobox
IbuprofenExcretionUrine (95%)1.00infobox
IbuprofenFormulaC13H18O21.00infobox
IbuprofenIUPHAR/BPS27131.00infobox
IbuprofenKEGGD00126 Y1.00infobox
IbuprofenLegal statusAU: OTC1.00infobox
IbuprofenLegal statusCA: OTC1.00infobox
IbuprofenLegal statusUK: General sales list (GSL, OTC)1.00infobox
IbuprofenLegal statusUS: OTC / Rx-only1.00infobox
IbuprofenLegal statusEU: OTC1.00infobox
IbuprofenLicense dataUS DailyMed: Ibuprofen1.00infobox
IbuprofenMedlinePlusa6821591.00infobox
IbuprofenMelting point75 to 78 °C (167 to 172 °F)1.00infobox
IbuprofenMetabolismLiver (CYP2C9)1.00infobox
IbuprofenMetabolitesIbuprofen glucuronide, 2-hydroxyibuprofen, 3-hydroxyibuprofen, carboxy-ibuprofen, 1-hydroxyibuprofen1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Ibuprofen bring nearby vocabulary together. In this analysis, examples include Nsaids, Aspirin and Risk. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Ibuprofen
    • Nsaids
    • Aspirin
    • Risk
    • Overdose
    • Used
    • Use
    • States
    • United
    • Pain
    • May
    • Lysine
    • Medical
  • ibuprofen
    • Nsaids
    • Aspirin
    • Risk
    • Overdose
    • Used
    • Use
    • States
    • United
    • Pain
    • May
    • Lysine
    • Medical
  • nonsteroidal anti-inflammatory drug
    • Fever
    • Administration
    • Pain
    • Used
    • Nsaid
    • Drug
    • Lysine
    • Nsaids
    • Adams
    • Medical
    • Boots
    • Kidney
  • pain
    • Used
    • Adams
    • Medical
    • Research
    • Boots
    • Paracetamol
    • People
    • Include
    • Effects
    • Aspirin
    • Risk
    • Pregnancy
  • side effects
    • Include
    • Blood
    • Kidney
    • Overdose
    • However
    • Pain
    • Risk
    • Pregnancy
    • Administration
    • Fever
    • Lysine
    • Medical
  • abdominal pain
    • Used
    • Adams
    • Medical
    • Research
    • Boots
    • Paracetamol
    • People
    • Include
    • Effects
    • Aspirin
    • Risk
    • Pregnancy
  • aspirin
    • Taken
    • Nsaid
    • Paracetamol
    • Recommended
    • Risk
    • Ibuprofen
    • Research
    • Pain
    • Used
    • Nsaids
    • Pregnancy
    • Administration
  • pain from kidney stones
    • Heart
    • Administration
    • Low
    • Nsaid
    • Used
    • Blood
    • Adams
    • Medical
    • Research
    • Boots
    • Paracetamol
    • People

Connections between topic areas Semantic bridges

For Ibuprofen, one of the stronger structural bridges in this analysis connects Ibuprofen with Adverse effects. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
IbuprofenAdverse effects · splits 148 ⟂ 48
IbuprofenChemistry · splits 155 ⟂ 41
IbuprofenOverview · splits 157 ⟂ 39
IbuprofenResearch · splits 171 ⟂ 25
IbuprofenPharmacology · splits 177 ⟂ 19
IbuprofenMedical uses · splits 183 ⟂ 13
IbuprofenHistory · splits 191 ⟂ 5
IbuprofenAvailability and administration · splits 191 ⟂ 5

Map overview Semantic statistics

Ibuprofen

Nodes196
Edges195
Triples188
Avg. degree1.99
Density0.010204
Components1

Source & methodology

TTTA analyzes the structure around Ibuprofen to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Applications, Research & Art, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Ibuprofen · EN edition · Analysis: TopicsToTalkAbout

For writers, content strategists, SEOs, marketers and creators — from quick topic research to advanced semantic analysis.