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Helicase

Helicases are a class of enzymes that are vital to all organisms. Their main function is to unpack an organism's genetic material. Helicases are motor proteins that move directionally along a nucleic double helix, separating the two hybridized nucleic acid strands (hence helic- + -ase), via the energy gained from ATP hydrolysis. There are many helicases…

Measurement, Helicase disorders and diseases & Function

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Overview

Function

Structural features

Superfamilies

Helicase disorders and diseases

RNA helicases

Diagnostic tools for helicase measurement

Advanced semantic analysis

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Map overview Semantic statistics

Helicase

Nodes95
Edges94
Triples241
Avg. degree1.98
Density0.021053
Components1

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Helicase

Top relations

see also · 47
Helicase → BLM, BRIP1, CHD1, CHD1L, CHD2, CHD3, CHD4, CHD5, CHD6, CHD7, CHD8, CHD9DEAD, Chromodomain, DDX10, DDX11, DDX12, DDX3X, DDX5, DDX58, DDX6
related to Superfamilies · 42
Helicase → AAA, All SF4, Dda, DEAD-box RNA, DNA, E1, Helicases, Ia, Ib, If, II, In, MCM, Most, PcrA, RecA, RecA-like-fold, RecD, RecQ-like, Rep
related to history · 20
Helicase → ATP-dependent, ATPaseIII, Below, DEAD, Designation, Discovery, DNA, First, Identification, Isolation, Plasmodium, Report, Since, Superfamily, Superfamily II1989, SV40, T4, The, This, To
related to ATRX helicase mutations · 18
Helicase → ATP-dependent, ATR-X, ATRX, Characteristics, DNA, It, Mutations, SNF2, Studies, The, The ATRX, These, This, Various, X-linked-alpha-thalassaemia-mental, XH2, XNP, Xq13
related to RecQ family mutations · 18
Helicase → BLM, Bloom, BS, Cells, Deficiencies, DNA, Mutations, RecQ, RECQL4, Rothmund, RTS, SCEs, Superfamily II, There, Thomson, Werner, WRN, WS
related to RNA helicases · 18
Helicase → About, All, Although, Alzheimer's, ATP, Defective RNA, DHX30, DNA, However, On, RNA, RNAs, SF1, SF2, SF6, Some, Swi/Snf, They
related to XPD helicase point mutations · 15
Helicase → As, ATP-dependent, Cockayne, CS, DNA, ERCC2, Inherited, Superfamily II, TFIIH, The XPD, TTD, UV, Xeroderma, XP, XPD
related to Function · 10
Helicase → ATP, ATPase, DNA, Helicases, In, Metabolic, RNA, Studies, They, Whereas DnaB-like
related to Measuring and monitoring helicase activity · 9
Helicase → DNA, Following, In, PAGE, Strand, The, These, This, Various
related to External links · 6
Helicase → DNA, Helicases, Medicine Medical Subject Headings, MeSH, National Library, RNA

Important terminology Word statistics

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Important terminology

helicases dna rna unwinding also mutations nucleic syndrome xpd recombination family strand repair atp activity protein acid active recq function

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Helicaseis apapilloma virus E1 helicase.Superfamily 40.90text
translationinstance ofMetabolic processes of RNA0.80text
transcriptioninstance ofMetabolic processes of RNA0.80text
ribosome biogenesisinstance ofMetabolic processes of RNA0.80text
RNA splicinginstance ofMetabolic processes of RNA0.80text
RNA transportinstance ofMetabolic processes of RNA0.80text
RNA editinginstance ofMetabolic processes of RNA0.80text
and RNA degradation are all facilitated by helicasesinstance ofMetabolic processes of RNA0.80text
the XPD familyinstance ofMost of the SF2 helicases are type A with a few exceptions0.80text
chromatin remodelinginstance ofthat is thought to be responsible for functions0.80text
gene regulationinstance ofthat is thought to be responsible for functions0.80text
and DNA methylationinstance ofthat is thought to be responsible for functions0.80text

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