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Helicase: Measurement, Helicase disorders and diseases & Function

Helicases are a class of enzymes that are vital to all organisms. Their main function is to unpack an organism's genetic material. Helicases are motor proteins that move directionally along a nucleic double helix, separating the two hybridized nucleic acid strands (hence helic- + -ase), via the energy gained from ATP hydrolysis. There are many helicases…

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Helicase topic overview

The analysis highlights Measurement, Helicase disorders and diseases and Function as prominent areas in the source structure around Helicase.

Related topics
87
Source areas
7
Connected nodes
94
Extracted relationships
241
Concept neighborhoods
37
Bridge connections
94

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Helicase disorders and diseases · 28 topics
Function · 18 topics
Overview · 17 topics
RNA helicases · 8 topics
Superfamilies · 6 topics
Diagnostic tools for helicase measurement · 5 topics
Structural features · 5 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Structural features

Superfamilies

Helicase disorders and diseases

RNA helicases

Diagnostic tools for helicase measurement

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Helicase connects Entity context

The extracted context around Helicase shows recurring relationship patterns in the source. For example, Helicase → BLM, BRIP1, CHD1, CHD1L, CHD2, CHD3, CHD4, CHD5, CHD6, CHD7, CHD8, CHD9DEAD, Chromodomain, DDX10, DDX11, DDX12, DDX3X, DDX5, DDX58, DDX6 Another extracted example is Helicase → AAA, All SF4, Dda, DEAD-box RNA, DNA, E1, Helicases, Ia, Ib, If, II, In, MCM, Most, PcrA, RecA, RecA-like-fold, RecD, RecQ-like, Rep. Use these groups to spot repeated connection types before inspecting the individual relationships.

Helicase

Top relations

see also · 47
Helicase → BLM, BRIP1, CHD1, CHD1L, CHD2, CHD3, CHD4, CHD5, CHD6, CHD7, CHD8, CHD9DEAD, Chromodomain, DDX10, DDX11, DDX12, DDX3X, DDX5, DDX58, DDX6
related to Superfamilies · 42
Helicase → AAA, All SF4, Dda, DEAD-box RNA, DNA, E1, Helicases, Ia, Ib, If, II, In, MCM, Most, PcrA, RecA, RecA-like-fold, RecD, RecQ-like, Rep
related to history · 20
Helicase → ATP-dependent, ATPaseIII, Below, DEAD, Designation, Discovery, DNA, First, Identification, Isolation, Plasmodium, Report, Since, Superfamily, Superfamily II1989, SV40, T4, The, This, To
related to ATRX helicase mutations · 18
Helicase → ATP-dependent, ATR-X, ATRX, Characteristics, DNA, It, Mutations, SNF2, Studies, The, The ATRX, These, This, Various, X-linked-alpha-thalassaemia-mental, XH2, XNP, Xq13
related to RecQ family mutations · 18
Helicase → BLM, Bloom, BS, Cells, Deficiencies, DNA, Mutations, RecQ, RECQL4, Rothmund, RTS, SCEs, Superfamily II, There, Thomson, Werner, WRN, WS
related to RNA helicases · 18
Helicase → About, All, Although, Alzheimer's, ATP, Defective RNA, DHX30, DNA, However, On, RNA, RNAs, SF1, SF2, SF6, Some, Swi/Snf, They
related to XPD helicase point mutations · 15
Helicase → As, ATP-dependent, Cockayne, CS, DNA, ERCC2, Inherited, Superfamily II, TFIIH, The XPD, TTD, UV, Xeroderma, XP, XPD
related to Function · 10
Helicase → ATP, ATPase, DNA, Helicases, In, Metabolic, RNA, Studies, They, Whereas DnaB-like
related to Measuring and monitoring helicase activity · 9
Helicase → DNA, Following, In, PAGE, Strand, The, These, This, Various
related to External links · 6
Helicase → DNA, Helicases, Medicine Medical Subject Headings, MeSH, National Library, RNA

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

helicases dna rna unwinding also mutations nucleic syndrome xpd recombination family strand repair atp activity protein acid active recq function

Helicase relationships Subject–Predicate–Object triples

TTTA extracted 241 structured relationships around Helicase. Examples in this analysis include Helicase → is a → papilloma virus E1 helicase.Superfamily 4 and translation → instance of → Metabolic processes of RNA. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Helicaseis apapilloma virus E1 helicase.Superfamily 40.90text
translationinstance ofMetabolic processes of RNA0.80text
transcriptioninstance ofMetabolic processes of RNA0.80text
ribosome biogenesisinstance ofMetabolic processes of RNA0.80text
RNA splicinginstance ofMetabolic processes of RNA0.80text
RNA transportinstance ofMetabolic processes of RNA0.80text
RNA editinginstance ofMetabolic processes of RNA0.80text
and RNA degradation are all facilitated by helicasesinstance ofMetabolic processes of RNA0.80text
the XPD familyinstance ofMost of the SF2 helicases are type A with a few exceptions0.80text
chromatin remodelinginstance ofthat is thought to be responsible for functions0.80text
gene regulationinstance ofthat is thought to be responsible for functions0.80text
and DNA methylationinstance ofthat is thought to be responsible for functions0.80text

Related concept clusters Concept neighborhoods

The concept neighborhoods around Helicase bring nearby vocabulary together. In this analysis, examples include Xpd, Protein and Unwinding. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Helicase
    • Xpd
    • Protein
    • Unwinding
    • Recq
    • Rna
    • Found
    • Known
    • Single-strand
    • Helicases
    • Mutations
    • Transcription
    • Strand
  • helicase
    • Xpd
    • Protein
    • Unwinding
    • Recq
    • Rna
    • Found
    • Known
    • Single-strand
    • Helicases
    • Mutations
    • Transcription
    • Strand
  • dna replication
    • Recombination
    • Helicase
    • Repair
    • Due
    • Transcription
    • Helicases
    • Single-strand
    • Barrier
    • Replication
    • Unwinding
    • Family
    • Recq
  • dna repair
    • Transcription
    • Helicase
    • Replication
    • Recombination
    • Helicases
    • Repair
    • Single-strand
    • Family
    • Unwinding
    • Xpd
    • Also
    • Rna
  • nucleic acid
    • Nucleic
    • Unwinding
    • Barrier
    • Replication
    • Translocation
    • Proteins
    • Hydrolysis
    • Atp
    • Active
    • Due
    • Helicases
    • Recombination
  • amino acid
    • Nucleic
    • Replication
    • Hydrolysis
    • Barrier
    • Translocation
    • Unwinding
    • Atp
    • Active
    • Helicases
    • Separation
    • Due
    • Duplex
  • xpd
    • Protein
    • Syndrome
    • Mutations
    • Helicase
    • Also
    • Atp
    • Characterized
    • Function
    • Transcription
    • Cancer
    • Repair
    • Family
  • recq-type helicase
    • Xpd
    • Protein
    • Unwinding
    • Recq
    • Rna
    • Found
    • Known
    • Single-strand
    • Helicases
    • Mutations
    • Transcription
    • Strand

Connections between topic areas Semantic bridges

For Helicase, one of the stronger structural bridges in this analysis connects Helicase with Helicase disorders and diseases. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
HelicaseHelicase disorders and diseases · splits 66 ⟂ 29
HelicaseFunction · splits 76 ⟂ 19
HelicaseOverview · splits 77 ⟂ 18
HelicaseRNA helicases · splits 86 ⟂ 9
HelicaseSuperfamilies · splits 88 ⟂ 7
HelicaseStructural features · splits 89 ⟂ 6
HelicaseDiagnostic tools for helicase measurement · splits 89 ⟂ 6

Map overview Semantic statistics

Helicase

Nodes95
Edges94
Triples241
Avg. degree1.98
Density0.021053
Components1

Source & methodology

TTTA analyzes the structure around Helicase to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Measurement, Helicase disorders and diseases & Function, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Helicase · EN edition · Analysis: TopicsToTalkAbout

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