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Chemically induced dimerization

Chemically induced dimerization (CID) is a biological mechanism in which two proteins bind only in the presence of a certain small molecule, enzyme or other dimerizing agent. Genetically engineered CID systems are used in biological research to control protein localization, to manipulate signalling pathways and to induce protein activation.

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ConstructsSignal transductionBiocomputersFusion proteinsAND gate
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FK1012TacrolimusFKBPIn vivo
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Signalling pathways
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Chemically induced dimerization

Nodes15
Edges14
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Avg. degree1.87
Density0.133333
Components1

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cid proteins used dimerizing induced systems induce biological applications chemically dimerization cell chemical two bind small molecule agent genetically research

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