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Macrolide: History, Applications & Products

Macrolides are a class of mostly natural products with a large macrocyclic lactone ring to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. Macrolides belong to the polyketide class of natural products. Some macrolides have antibiotic or antifungal activity and are used as pharmaceutical drugs. Rapamycin is also a…

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Macrolide topic overview

The analysis highlights History, Applications and Products as prominent areas in the source structure around Macrolide.

Related topics
111
Source areas
9
Connected nodes
120
Extracted relationships
52
Concept neighborhoods
20
Bridge connections
120

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Examples · 26 topics
Overview · 24 topics
Uses · 15 topics
Mechanism of action · 13 topics
Definition · 10 topics
Resistance · 9 topics
Side-effects · 9 topics
History · 3 topics
Interactions · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Definition

History

Uses

Mechanism of action

Examples

Resistance

Side-effects

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Macrolide connects Entity context

The extracted context around Macrolide shows recurring relationship patterns in the source. For example, Macrolide → Antibiotic, Beta-hemolytic, Bordetella, Chlamydia, Gram-negative, Gram-positive, Haemophilus, It, Legionella, Macrolides, Mycobacterium, Mycoplasma, Rickettsia, Streptococcus, The, They, Unlike Another extracted example is Macrolide → British Medical Journal, CYP3A4, However, IHPS, In, Infantile, Macrolides, P450, QT, Some, This. Use these groups to spot repeated connection types before inspecting the individual relationships.

Macrolide

Top relations

related to Uses · 17
Macrolide → Antibiotic, Beta-hemolytic, Bordetella, Chlamydia, Gram-negative, Gram-positive, Haemophilus, It, Legionella, Macrolides, Mycobacterium, Mycoplasma, Rickettsia, Streptococcus, The, They, Unlike
has effect · 11
Macrolide → British Medical Journal, CYP3A4, However, IHPS, In, Infantile, Macrolides, P450, QT, Some, This
related to Resistance · 6
Macrolide → ATP-dependent, MLS-resistant, RNA, The, This, Two
related to Interactions · 5
Macrolide → CYP3A4, Macrolides, MBI, They, This
related to Antibacterial · 4
Macrolide → Another, Macrolides, The, This
related to history · 3
Macrolide → Erythromycin, Later, The
related to Antifungal drugs · 2
Macrolide → Cruentaren, Polyene
related to Ketolides · 2
Macrolide → Ketolides, They
related to Non-antibiotic macrolides · 2
Macrolide → The, They

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

macrolides erythromycin used azithromycin clarithromycin cyp3a4 also antibiotics drugs class lactone antifungal ring rings bacterial lead activity drug bind antibiotic

Macrolide relationships Subject–Predicate–Object triples

TTTA extracted 52 structured relationships around Macrolide. Examples in this analysis include Macrolide → has effect → British Medical Journal and Macrolide → has effect → This. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Macrolidehas effectBritish Medical Journal0.60section
Macrolidehas effectThis0.60section
Macrolidehas effectP4500.60section
Macrolidehas effectCYP3A40.60section
Macrolidehas effectMacrolides0.60section
Macrolidehas effectQT0.60section
Macrolidehas effectIn0.60section
Macrolidehas effectSome0.60section
Macrolidehas effectIHPS0.60section
Macrolidehas effectInfantile0.60section
Macrolidehas effectHowever0.60section
Macroliderelated to AntibacterialMacrolides0.60section

Related concept clusters Concept neighborhoods

The concept neighborhoods around Macrolide bring nearby vocabulary together. In this analysis, examples include Antibiotics, Dpb and Used. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • pharmaceutical drugs
    • Cyp3a4
    • Increase
    • Azithromycin
    • Fluoroketolides
    • Macrolides
    • Clarithromycin
    • Macrolide
    • Used
    • Erythromycin
    • Include
    • Inhibition
    • Ketolides
  • azithromycin
    • Clarithromycin
    • Cyp3a4
    • Erythromycin
    • Increase
    • Drugs
    • Caused
    • However
    • Lead
    • Macrolide
    • Used
    • Macrolides
    • Ketolides
  • clarithromycin
    • Erythromycin
    • Cyp3a4
    • Increase
    • Use
    • Lead
    • Class
    • Drugs
    • Macrolide
    • Macrolides
    • Another
    • Caused
    • Ketolides
  • erythromycin
    • Clarithromycin
    • Azithromycin
    • Cyp3a4
    • Increase
    • Use
    • Macrolide
    • Used
    • Lead
    • Macrolides
    • Caused
    • Ketolides
    • Statins
  • Macrolide
    • Antibiotics
    • Dpb
    • Used
    • Increase
    • Erythromycin
    • Azithromycin
    • Clarithromycin
    • Cyp3a4
    • Rapamycin
    • One
    • Ribosome
    • Another
  • macrolide
    • Antibiotics
    • Dpb
    • Used
    • Increase
    • Erythromycin
    • Azithromycin
    • Clarithromycin
    • Cyp3a4
    • Rapamycin
    • One
    • Ribosome
    • Another
  • lactone
    • Ring
    • Attached
    • One
    • Antibiotic
    • Antifungal
    • Fluoroketolides
    • Ketolides
    • Mechanism
    • Resistance
    • Macrolides
    • Rings
    • Drugs
  • antifungal
    • Rapamycin
    • Drugs
    • Macrolide
    • Another
    • Fluoroketolides
    • Ketolides
    • Mechanism
    • Resistance
    • Used
    • Activity
    • Drug
    • Rings

Connections between topic areas Semantic bridges

For Macrolide, one of the stronger structural bridges in this analysis connects Macrolide with Examples. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
MacrolideExamples · splits 94 ⟂ 27
MacrolideOverview · splits 96 ⟂ 25
MacrolideUses · splits 105 ⟂ 16
MacrolideMechanism of action · splits 107 ⟂ 14
MacrolideDefinition · splits 110 ⟂ 11
MacrolideResistance · splits 111 ⟂ 10
MacrolideSide-effects · splits 111 ⟂ 10
MacrolideHistory · splits 117 ⟂ 4
MacrolideInteractions · splits 118 ⟂ 3

Map overview Semantic statistics

Macrolide

Nodes121
Edges120
Triples52
Avg. degree1.98
Density0.016529
Components1

Source & methodology

TTTA analyzes the structure around Macrolide to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Applications & Products, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Macrolide · EN edition · Analysis: TopicsToTalkAbout

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