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Macrolide: History, Applications & Products

Macrolides are a class of mostly natural products with a large macrocyclic lactone ring to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. Macrolides belong to the polyketide class of natural products. Some macrolides have antibiotic or antifungal activity and are used as pharmaceutical drugs. Rapamycin is also a…

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Macrolide topic overview

The analysis highlights History, Applications and Products as prominent areas in the source structure around Macrolide.

Related topics
110
Source areas
9
Connected nodes
119
Extracted relationships
35
Related term clusters
20
Bridge connections
119

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Examples · 25 topics
Overview · 24 topics
Uses · 15 topics
Mechanism of action · 13 topics
Definition · 10 topics
Resistance · 9 topics
Side-effects · 9 topics
History · 3 topics
Interactions · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

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Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Definition

History

Uses

Mechanism of action

Examples

Resistance

Side-effects

Interactions

For the semantics nerds

You can skip this section if you’re here for content ideas and keyword inspiration.

Advanced semantic analysis

How Macrolide connects Entity context

The extracted context around Macrolide shows recurring relationship patterns in the source. For example, Macrolide → Antibiotic, Beta-hemolytic, Bordetella, Chlamydia, Gram-negative, Gram-positive, Haemophilus, Legionella, Macrolides, Mycobacterium, Mycoplasma, Rickettsia, Streptococcus, Unlike Another extracted example is Macrolide → British Medical Journal, CYP3A4, IHPS, Infantile, Macrolides, P450, QT. Use these groups to spot repeated connection types before inspecting the individual relationships.

Macrolide

Top relations

related to Uses · 14
Macrolide → Antibiotic, Beta-hemolytic, Bordetella, Chlamydia, Gram-negative, Gram-positive, Haemophilus, Legionella, Macrolides, Mycobacterium, Mycoplasma, Rickettsia, Streptococcus, Unlike
has effect · 7
Macrolide → British Medical Journal, CYP3A4, IHPS, Infantile, Macrolides, P450, QT
related to Resistance · 4
Macrolide → ATP-dependent, MLS-resistant, RNA, Two
related to Interactions · 3
Macrolide → CYP3A4, Macrolides, MBI
related to Antibacterial · 2
Macrolide → Another, Macrolides
related to Antifungal drugs · 2
Macrolide → Cruentaren, Polyene
related to history · 2
Macrolide → Erythromycin, Later
related to Ketolides · 1
Macrolide → Ketolides

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

macrolides erythromycin used azithromycin clarithromycin cyp3a4 also antibiotics drugs class lactone antifungal ring rings bacterial lead activity drug bind antibiotic

Macrolide relationships Subject–Predicate–Object triples

TTTA extracted 35 structured relationships around Macrolide. Examples in this analysis include Macrolide → has effect → British Medical Journal and Macrolide → has effect → P450. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Macrolidehas effectBritish Medical Journal0.60section
Macrolidehas effectP4500.60section
Macrolidehas effectCYP3A40.60section
Macrolidehas effectMacrolides0.60section
Macrolidehas effectQT0.60section
Macrolidehas effectIHPS0.60section
Macrolidehas effectInfantile0.60section
Macroliderelated to AntibacterialMacrolides0.60section
Macroliderelated to AntibacterialAnother0.60section
Macroliderelated to Antifungal drugsPolyene0.60section
Macroliderelated to Antifungal drugsCruentaren0.60section
Macroliderelated to historyErythromycin0.60section

Related concept clusters Related term clusters

The concept neighborhoods around Macrolide bring nearby vocabulary together. In this analysis, examples include Antibiotics, Dpb and Used. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • pharmaceutical drugs
    • Cyp3a4
    • Increase
    • Azithromycin
    • Fluoroketolides
    • Macrolides
    • Clarithromycin
    • Macrolide
    • Used
    • Erythromycin
    • Include
    • Inhibition
    • Ketolides
  • azithromycin
    • Clarithromycin
    • Cyp3a4
    • Erythromycin
    • Increase
    • Drugs
    • Caused
    • Lead
    • Macrolide
    • Used
    • Macrolides
    • Ketolides
    • Statins
  • clarithromycin
    • Erythromycin
    • Cyp3a4
    • Increase
    • Use
    • Lead
    • Class
    • Drugs
    • Macrolide
    • Macrolides
    • Another
    • Caused
    • Ketolides
  • erythromycin
    • Clarithromycin
    • Azithromycin
    • Cyp3a4
    • Increase
    • Use
    • Macrolide
    • Used
    • Lead
    • Macrolides
    • Caused
    • Ketolides
    • Statins
  • Macrolide
    • Antibiotics
    • Dpb
    • Used
    • Increase
    • Erythromycin
    • Azithromycin
    • Clarithromycin
    • Cyp3a4
    • Rapamycin
    • One
    • Ribosome
    • Another
  • macrolide
    • Antibiotics
    • Dpb
    • Used
    • Increase
    • Erythromycin
    • Azithromycin
    • Clarithromycin
    • Cyp3a4
    • Rapamycin
    • One
    • Ribosome
    • Another
  • lactone
    • Ring
    • Attached
    • One
    • Antibiotic
    • Antifungal
    • Fluoroketolides
    • Ketolides
    • Mechanism
    • Resistance
    • Macrolides
    • Rings
    • Drugs
  • antifungal
    • Rapamycin
    • Drugs
    • Macrolide
    • Another
    • Fluoroketolides
    • Ketolides
    • Mechanism
    • Resistance
    • Used
    • Activity
    • Drug
    • Rings

Connections between topic areas Semantic bridges

For Macrolide, one of the stronger structural bridges in this analysis connects Macrolide with Examples. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Macrolide — Examples · splits 94 ⟂ 26
Macrolide — Overview · splits 95 ⟂ 25
Macrolide — Uses · splits 104 ⟂ 16
Macrolide — Mechanism of action · splits 106 ⟂ 14
Macrolide — Definition · splits 109 ⟂ 11
Macrolide — Resistance · splits 110 ⟂ 10
Macrolide — Side-effects · splits 110 ⟂ 10
Macrolide — History · splits 116 ⟂ 4
Macrolide — Interactions · splits 117 ⟂ 3

Map overview Semantic statistics

Macrolide

Nodes120
Edges119
Triples35
Avg. degree1.98
Density0.016667
Components1

Source & methodology

TTTA analyzes the structure around Macrolide to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Applications & Products, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Macrolide · EN edition · Analysis: TopicsToTalkAbout

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