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Serpin

Serpins are a superfamily of proteins with similar structures that were first identified for their protease inhibition activity and are found in all kingdoms of life. The acronym serpin was originally coined because the first serpins to be identified act on chymotrypsin-like serine proteases (serine protease inhibitors). They are notable for their…

History, Biological function and localization & Conformational change and inhibitory mechanism

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Key facts & relationships

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AlphaFold
IPR000215 · PF00079
Available protein structures:
IPR000215 · PF00079
CDD
cd00172
InterPro
IPR000215
PDB
1m37A:1-378 1hleB:349-379 1jrrA:1-415 1by7A:1-415 1ovaA:1-385 1uhgA:1-385 1jtiB:1-385 1attB:77-433 1nq9L:76-461 1oyhI:76-461 1e03L:76-461 1e05I:76-461 1br8L:76-461 1r1lL:76-461…
Pfam
PF00079

Topics to explore

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Overview

History

Activity

Biological function and localization

Structure

Conformational change and inhibitory mechanism

Degradation

Disease and serpinopathies

Evolution

Distribution

Advanced semantic analysis

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Map overview Semantic statistics

Serpin

Nodes203
Edges202
Triples245
Avg. degree1.99
Density0.009852
Components1

How this topic connects Entity context

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Serpin

Top relations

related to External links · 28
Serpin → Archived, CambridgeFrank Church, Chapel HillPaul Declerck, ChicagoOverview, December, Family I4, Human Alpha-1-antitrypsin, Illinois, James Whisstock, Katholieke Universiteit LeuvenTom Roberts, Medicine Medical Subject Headings, MeSH, Monash UniversityJim Huntington, Month SerpinMerops, National Library, North Carolina, October, P01009, PDB, PDB Molecule
related to Allosteric activation · 16
Serpin → After, Fondaparinux, For, Furthermore, Heparin, II, In, MENT, P1, RCL, The, The X-ray, This, Understanding, Upon, Xa
related to Insect · 16
Serpin → Accordingly, Amino, As, Drosophila, Easter, Gastrulation Defective, In Tenebrio, Nudel, Serpin-27A, Snake, SPN93, Spätzle, Studies, The, The Drosophila, Thirteen
related to Latent conformation · 15
Serpin → Although PAI-1, C-sheet, Certain, Disruption, Finally, Latent, N-terminal, N-terminus, PAI-1, RCL, Regulation, Similarly, Since, The, Thermoanaerobacter
related to Polymerisation and aggregation · 15
Serpin → A-sheet, C1-inhibitor, Each, FENIB, First, HAE, However, In, RCL, Second, Serpinopathies, Serpins, The, Well-characterised, Within
related to Conformational change and inhibitory mechanism · 12
Serpin → C-terminus, For, However, Inhibitory, Initially, Instead, Kunitz-type, N-terminus, RCL, Serine, The, This
related to Plant · 11
Serpin → Although, Arabidopsis, BSZx, CmPS-1, However, In, It, Plant, The, The RCL, Zx
related to Protease inhibition · 10
Serpin → Approximately, By, C1-inhibitor, For, Further, In, Nevertheless, PAI-1, Serpin B9, The
related to Activity · 9
Serpin → B4, Examples, MENT, Most, Nonetheless, SCCA-1, Serpins, Some, These
related to Degradation · 9
Serpin → Drosophila, For, LDL, Lipophorin Receptor-1, LRP, One, PAI-1, Similarly, When

Important terminology Word statistics

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Important terminology

serpins protease proteases inhibitors also conformational change mechanism antithrombin protein structure rcl inhibitory function proteins active human plant cysteine serine

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
SerpinAlphaFoldIPR0002151.00infobox
SerpinAlphaFoldPF000791.00infobox
SerpinAvailable protein structures:IPR0002151.00infobox
SerpinAvailable protein structures:PF000791.00infobox
SerpinCDDcd001721.00infobox
SerpinInterProIPR0002151.00infobox
SerpinPDB1m37A:1-378 1hleB:349-379 1jrrA:1-415 1by7A:1-415 1ovaA:1-385 1uhgA:1-385 1jtiB:1-385 1attB:77-433 1nq9L:76-461 1oyhI:76-461 1e03L:76-461 1e05I:76-461 1br8L:76-461 1r1lL:76-461…1.00infobox
SerpinPfamPF000791.00infobox
SerpinPROSITEPDOC002561.00infobox
SerpinSCOP21hle / SCOPe / SUPFAM1.00infobox
SerpinSymbolSerpin, SERPIN (root symbol of family)1.00infobox
protein misfoldinginstance ofserpins are vulnerable to mutations that can result in serpinopathies0.80text

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