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Neofunctionalization

Neofunctionalization, one of the possible outcomes of functional divergence, occurs when one gene copy, or paralog, takes on a totally new function after a gene duplication event. Neofunctionalization is an adaptive mutation process; meaning one of the gene copies must mutate to develop a function that was not present in the ancestral gene. In other…

Examples, Selective constraints & Classical model

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Examples

Antifreeze proteinZoarcidLycodichthysSialic acidLight-sensitive opsin proteins in vertebrate eyes
8 related topics

Selective constraints

Amino acidMutation rateEffective population size
3 related topics

Classical model

MullerOhnoOhta
3 related topics

The process

Coding region
1 related topics

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Overview

The process

Selective constraints

Classical model

Neosubfunctionalization

Examples

Model limitations

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Map overview Semantic statistics

Neofunctionalization

Nodes28
Edges27
Triples52
Avg. degree1.93
Density0.071429
Components1

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Neofunctionalization

Top relations

related to Examples · 19
Neofunctionalization → AFPIII, After, Another, Antarctic, Antarctic Seas, Extant, III, In, LWS, Lycodichthys, P12102, Rh1, Rh2, SAS, SWS1, SWS2, The, These, This
related to Neosubfunctionalization · 7
Neofunctionalization → For, In, Liberles, Neosubfunctionalization, Rastogi, Some, The
related to Selective constraints · 7
Neofunctionalization → Ne, Regardless, S-1, Secondly, The, This, Walsh
related to Classical model · 6
Neofunctionalization → He, In, Muller, Ohno, Ohta, Today
related to The process · 5
Neofunctionalization → Following, In, It, The, This
is a · 4
Neofunctionalization → adaptive mutation process, end stage for all subfunctionalized genes, result of subfunctionalization, terminal fate of all duplicate gene copies retained in the genome and subfunctionlization merely exist as a transient state to preserve the duplicate gene copy
related to Model limitations · 4
Neofunctionalization → After, Darwinian, In, Limitations

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Important terminology

gene function one new duplication event copy copies process population mutation changes pseudogenization mutations functional divergence ancestral selective advantageous selection

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Neofunctionalizationis aadaptive mutation process0.90text
Neofunctionalizationis aresult of subfunctionalization0.90text
Neofunctionalizationis aend stage for all subfunctionalized genes0.90text
Neofunctionalizationis aterminal fate of all duplicate gene copies retained in the genome and subfunctionlization merely exist as a transient state to preserve the duplicate gene copy0.90text
Neofunctionalizationrelated to Classical modelIn0.60section
Neofunctionalizationrelated to Classical modelMuller0.60section
Neofunctionalizationrelated to Classical modelOhno0.60section
Neofunctionalizationrelated to Classical modelHe0.60section
Neofunctionalizationrelated to Classical modelOhta0.60section
Neofunctionalizationrelated to Classical modelToday0.60section
Neofunctionalizationrelated to ExamplesThe0.60section
Neofunctionalizationrelated to ExamplesAntarctic0.60section

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