Antithrombin

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Antithrombin topic overview

The analysis highlights Applications and Regions as prominent areas in the source structure around Antithrombin.

Related topics: 91
Source areas: 9
Connected nodes: 100
Extracted relationships: 212
Concept neighborhoods: 25
Bridge connections: 100

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 21 topics

Overview · 17 topics

Structure · 14 topics

Deficiencies · 13 topics

Antithrombin and heparin · 12 topics

Antiangiogenic antithrombin · 5 topics

Medical uses · 4 topics

Cleaved and latent antithrombin · 3 topics

Effect of glycosylation on activity · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases: SERPINC1, AT3, AT3D, ATIII, THPH7, serpin family C member 1, ATIII-R2, ATIII-T2, ATIII-T1
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4EB1, 1ANT, 1ATH, 1AZX, 1BR8, 1DZG, 1DZH, 1E03, 1E04, 1E05, 1JVQ, 1LK6, 1NQ9, 1OYH, 1R1L, 1SR5, 1T1F, 1TB6,…
Band: 1q25.1 · 1 H2.1|1 69.75 cM
Bgee: right lobe of liver · gonad · stromal cell of endometrium · human kidney · islet of Langerhans
BioGPS: More reference expression data
Chr.: Chromosome 1 (human) · Chromosome 1 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Glycoprotein
Coagulation
Liver
Disulfide bonds Disulfide bond
Glycosylation
Blood plasma
Anticoagulant
Heparin
Factor IIa Thrombin
Factor Xa Factor X
Point mutations Point mutation
Base pairs Base pair
Codons Codon
Frame shift
Stop codon
UGA Genetic code
Glycosylation defects Congenital disorder of glycosylation

Structure

Function

Antithrombin and heparin

Rate constants Rate constant
Calcium
Allosteric
Ternary complex
Beta sheet
Serpins Serpin
MENT Myeloid and erythroid nuclear termination stage specific protein
N-terminal N-terminus
C-terminal C-terminus
Hydrogen bonded Hydrogen bond
Β-turn Turn (biochemistry)
Equilibrium Chemical equilibrium

Effect of glycosylation on activity

Deficiencies

Medical uses

Protein therapeutic Biologic medical product
Genetically modified Genetic engineering
Sepsis
Diffuse intravascular coagulation

Cleaved and latent antithrombin

Antiangiogenic antithrombin

Angiogenic stimulators Angiogenesis
Blood vessels Blood vessel
Angiogenic inhibitors Angiogenesis inhibitor
Tumor
In-vitro

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Antithrombin connects Entity context

The extracted context around Antithrombin shows recurring relationship patterns in the source. For example, Antithrombin → acute inflammatory response to antigenic stimulus, blood coagulation, blood microparticle, collagen-containing extracellular matrix, endoplasmic reticulum lumen, extracellular exosome, extracellular region, extracellular space, hemostasis, heparin binding, identical protein binding, lactation, negative regulation of endopeptidase activity, negative regulation of peptidase activity, peptidase inhibitor activity, plasma membrane, post-translational protein modification, protease binding, protein binding, regulation of blood coagulation Another extracted example is Antithrombin → abdominal wall, blood, fetal liver hematopoietic progenitor cell, gallbladder, gastric mucosa, gastrocnemius muscle, gonad, human fetus, human kidney, islet of Langerhans, left lobe of liver, metanephros, primary oocyte, renal cortex, right lobe of liver, secondary oocyte, sexually immature organism, stromal cell of endometrium, yolk sac, zygote. Use these groups to spot repeated connection types before inspecting the individual relationships.

Top relations

Gene ontology · 23

Antithrombin → acute inflammatory response to antigenic stimulus, blood coagulation, blood microparticle, collagen-containing extracellular matrix, endoplasmic reticulum lumen, extracellular exosome, extracellular region, extracellular space, hemostasis, heparin binding, identical protein binding, lactation, negative regulation of endopeptidase activity, negative regulation of peptidase activity, peptidase inhibitor activity, plasma membrane, post-translational protein modification, protease binding, protein binding, regulation of blood coagulation

Bgee · 20

Antithrombin → abdominal wall, blood, fetal liver hematopoietic progenitor cell, gallbladder, gastric mucosa, gastrocnemius muscle, gonad, human fetus, human kidney, islet of Langerhans, left lobe of liver, metanephros, primary oocyte, renal cortex, right lobe of liver, secondary oocyte, sexually immature organism, stromal cell of endometrium, yolk sac, zygote

RNA expression pattern · 20

related to Function · 18

Antithrombin → C1, C1s, Factor, Factor II, Factor IX, Factor VII, Factor XI, Factor XII, Heparin, However, II, IIa, IXa, The, VIIa, Xa, XIa, XIIa

related to Structure · 14

Antithrombin → Antithrombin II, Antithrombin III, Antithrombin IV, AT, AT II, AT III, AT IV, Fell, III, IV, Johnson, Only AT III, Seegers, The

related to Toponyms · 12

Antithrombin → Alger, Amien, Barcelona, However, Kumamoto, Modern, Padua-2, Paris-1, Paris-2, Presently, Tours, Toyama

related to External links · 11

Antithrombin → Archived, Human SERPINC1, I04, III, Medicine Medical Subject Headings, MeSH, National Library, SERPINC1, The MEROPS, UCSC Genome Browser, Wayback MachineAntithrombin

related to Allosteric activation · 10

Antithrombin → Figure, II, In, Increased Factor IXa, MENT, P14, P15, The, This, Xa

related to Cleaved and latent antithrombin · 10

Antithrombin → Cleavage, Figure, For, However, In, L-antithrombin, Native, PAI-1, The, This

related to Further reading · 9

Antithrombin → DIC, Establishing Pediatric Reference Values, III, Medizinische Fakultät Charité, Panzer-Heinig, Relevance, Sabine, Thesis, Universitätsmedizin Berlin

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

heparin thrombin deficiency site blood human normal reactive plasma form glycosylation activity inhibition type latent binding within factor xa protease

Antithrombin relationships Subject–Predicate–Object triples

TTTA extracted 212 structured relationships around Antithrombin. Examples in this analysis include Antithrombin → Aliases → SERPINC1, AT3, AT3D, ATIII, THPH7, serpin family C member 1, ATIII-R2, ATIII-T2, ATIII-T1 and Antithrombin → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4EB1, 1ANT, 1ATH, 1AZX, 1BR8, 1DZG, 1DZH, 1E03, 1E04, 1E05, 1JVQ, 1LK6, 1NQ9, 1OYH, 1R1L, 1SR5, 1T1F, 1TB6,…. The table shows each extracted connection, where it came from and its confidence.

Subject	Predicate	Object	Confidence	Src
Antithrombin	Aliases	SERPINC1, AT3, AT3D, ATIII, THPH7, serpin family C member 1, ATIII-R2, ATIII-T2, ATIII-T1	1.00	infobox
Antithrombin	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4EB1, 1ANT, 1ATH, 1AZX, 1BR8, 1DZG, 1DZH, 1E03, 1E04, 1E05, 1JVQ, 1LK6, 1NQ9, 1OYH, 1R1L, 1SR5, 1T1F, 1TB6,…	1.00	infobox
Antithrombin	Band	1q25.1	1.00	infobox
Antithrombin	Band	1 H2.1\|1 69.75 cM	1.00	infobox
Antithrombin	Bgee	right lobe of liver	1.00	infobox
Antithrombin	Bgee	gonad	1.00	infobox
Antithrombin	Bgee	stromal cell of endometrium	1.00	infobox
Antithrombin	Bgee	human kidney	1.00	infobox
Antithrombin	Bgee	islet of Langerhans	1.00	infobox
Antithrombin	Bgee	gastrocnemius muscle	1.00	infobox
Antithrombin	Bgee	gastric mucosa	1.00	infobox
Antithrombin	Bgee	metanephros	1.00	infobox
Antithrombin	Bgee	blood	1.00	infobox
Antithrombin	Bgee	renal cortex	1.00	infobox
Antithrombin	Bgee	left lobe of liver	1.00	infobox
Antithrombin	Bgee	gallbladder	1.00	infobox
Antithrombin	Bgee	yolk sac	1.00	infobox
Antithrombin	Bgee	human fetus	1.00	infobox
Antithrombin	Bgee	primary oocyte	1.00	infobox
Antithrombin	Bgee	fetal liver hematopoietic progenitor cell	1.00	infobox
Antithrombin	Bgee	zygote	1.00	infobox
Antithrombin	Bgee	secondary oocyte	1.00	infobox
Antithrombin	Bgee	sexually immature organism	1.00	infobox
Antithrombin	Bgee	abdominal wall	1.00	infobox
Antithrombin	BioGPS	More reference expression data	1.00	infobox
Antithrombin	Chr.	Chromosome 1 (human)	1.00	infobox
Antithrombin	Chr.	Chromosome 1 (mouse)	1.00	infobox
Antithrombin	Databases	NCBI: entry; OMA: entry	1.00	infobox
Antithrombin	End	173,917,378 bp	1.00	infobox
Antithrombin	End	160,833,433 bp	1.00	infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Antithrombin bring nearby vocabulary together. In this analysis, examples include Deficiency, Blood and Normal. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

Antithrombin
- Deficiency
- Blood
- Normal
- Heparin
- Plasma
- Form
- Latent
- Site
- Ii
- Reactive
- Activity
- Human
antithrombin
- Deficiency
- Blood
- Normal
- Heparin
- Plasma
- Form
- Latent
- Site
- Ii
- Reactive
- Activity
- Human
blood plasma
- Coagulation
- Plasma
- Activity
- Normal
- Type
- Thrombin
- Protease
- Protein
- Deficiency
- Also
- Binding
- Human
heparin
- Affinity
- Binding
- Thrombin
- Inhibition
- Factor
- Xa
- Increased
- Ixa
- Β-antithrombin
- Ii
- Within
- Reactive
factor iia
- Xa
- Ixa
- Inhibition
- Thrombin
- Conformational
- Increased
- Heparin
- Region
- Loop
- Within
- Reactive
- Site
factor xa
- Factor
- Xa
- Ixa
- Inhibition
- Thrombin
- Conformational
- Increased
- Heparin
- Region
- Loop
- Within
- Reactive
antithrombin ii
- Type
- Deficiency
- Plasma
- Blood
- Normal
- Heparin
- Form
- Latent
- Site
- Ii
- Reactive
- Activity
blood coagulation
- Coagulation
- Plasma
- Activity
- Normal
- Type
- Deficiency
- Also
- Binding
- Human
- Serpinc1
- Gene
- Region

Connections between topic areas Semantic bridges

For Antithrombin, one of the stronger structural bridges in this analysis connects Antithrombin with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

Antithrombin — Function · splits 79 ⟂ 22

Antithrombin — Overview · splits 83 ⟂ 18

Antithrombin — Structure · splits 86 ⟂ 15

Antithrombin — Deficiencies · splits 87 ⟂ 14

Antithrombin — Antithrombin and heparin · splits 88 ⟂ 13

Antithrombin — Antiangiogenic antithrombin · splits 95 ⟂ 6

Antithrombin — Medical uses · splits 96 ⟂ 5

Antithrombin — Cleaved and latent antithrombin · splits 97 ⟂ 4

Antithrombin — Effect of glycosylation on activity · splits 98 ⟂ 3

Map overview Semantic statistics

Antithrombin

Nodes101

Edges100

Triples212

Avg. degree1.98

Density0.019802

Components1

Source & methodology

TTTA analyzes the structure around Antithrombin to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Applications & Regions, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Antithrombin · EN edition · Analysis: TopicsToTalkAbout