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Antithrombin

Antithrombin (AT) is a small glycoprotein that inactivates several enzymes of the coagulation system. It is a 464-amino-acid protein produced by the liver. It contains three disulfide bonds and a total of four possible glycosylation sites. α-Antithrombin is the dominant form of antithrombin found in blood plasma and has an oligosaccharide occupying each…

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Aliases
SERPINC1, AT3, AT3D, ATIII, THPH7, serpin family C member 1, ATIII-R2, ATIII-T2, ATIII-T1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4EB1, 1ANT, 1ATH, 1AZX, 1BR8, 1DZG, 1DZH, 1E03, 1E04, 1E05, 1JVQ, 1LK6, 1NQ9, 1OYH, 1R1L, 1SR5, 1T1F, 1TB6,…
Band
1q25.1 · 1 H2.1|1 69.75 cM
Bgee
right lobe of liver · gonad · stromal cell of endometrium · human kidney · islet of Langerhans
BioGPS
More reference expression data
Chr.
Chromosome 1 (human) · Chromosome 1 (mouse)

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Overview

Structure

Function

Antithrombin and heparin

Effect of glycosylation on activity

Deficiencies

Medical uses

Cleaved and latent antithrombin

Antiangiogenic antithrombin

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Map overview Semantic statistics

Antithrombin

Nodes101
Edges100
Triples212
Avg. degree1.98
Density0.019802
Components1

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Antithrombin

Top relations

Gene ontology · 23
Antithrombin → acute inflammatory response to antigenic stimulus, blood coagulation, blood microparticle, collagen-containing extracellular matrix, endoplasmic reticulum lumen, extracellular exosome, extracellular region, extracellular space, hemostasis, heparin binding, identical protein binding, lactation, negative regulation of endopeptidase activity, negative regulation of peptidase activity, peptidase inhibitor activity, plasma membrane, post-translational protein modification, protease binding, protein binding, regulation of blood coagulation
Bgee · 20
Antithrombin → abdominal wall, blood, fetal liver hematopoietic progenitor cell, gallbladder, gastric mucosa, gastrocnemius muscle, gonad, human fetus, human kidney, islet of Langerhans, left lobe of liver, metanephros, primary oocyte, renal cortex, right lobe of liver, secondary oocyte, sexually immature organism, stromal cell of endometrium, yolk sac, zygote
RNA expression pattern · 20
Antithrombin → abdominal wall, blood, fetal liver hematopoietic progenitor cell, gallbladder, gastric mucosa, gastrocnemius muscle, gonad, human fetus, human kidney, islet of Langerhans, left lobe of liver, metanephros, primary oocyte, renal cortex, right lobe of liver, secondary oocyte, sexually immature organism, stromal cell of endometrium, yolk sac, zygote
related to Function · 18
Antithrombin → C1, C1s, Factor, Factor II, Factor IX, Factor VII, Factor XI, Factor XII, Heparin, However, II, IIa, IXa, The, VIIa, Xa, XIa, XIIa
related to Structure · 14
Antithrombin → Antithrombin II, Antithrombin III, Antithrombin IV, AT, AT II, AT III, AT IV, Fell, III, IV, Johnson, Only AT III, Seegers, The
related to Toponyms · 12
Antithrombin → Alger, Amien, Barcelona, However, Kumamoto, Modern, Padua-2, Paris-1, Paris-2, Presently, Tours, Toyama
related to External links · 11
Antithrombin → Archived, Human SERPINC1, I04, III, Medicine Medical Subject Headings, MeSH, National Library, SERPINC1, The MEROPS, UCSC Genome Browser, Wayback MachineAntithrombin
related to Allosteric activation · 10
Antithrombin → Figure, II, In, Increased Factor IXa, MENT, P14, P15, The, This, Xa
related to Cleaved and latent antithrombin · 10
Antithrombin → Cleavage, Figure, For, However, In, L-antithrombin, Native, PAI-1, The, This
related to Further reading · 9
Antithrombin → DIC, Establishing Pediatric Reference Values, III, Medizinische Fakultät Charité, Panzer-Heinig, Relevance, Sabine, Thesis, Universitätsmedizin Berlin

Important terminology Word statistics

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Important terminology

heparin thrombin deficiency site blood human normal reactive plasma form glycosylation activity inhibition type latent binding within factor xa protease

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
AntithrombinAliasesSERPINC1, AT3, AT3D, ATIII, THPH7, serpin family C member 1, ATIII-R2, ATIII-T2, ATIII-T11.00infobox
AntithrombinAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4EB1, 1ANT, 1ATH, 1AZX, 1BR8, 1DZG, 1DZH, 1E03, 1E04, 1E05, 1JVQ, 1LK6, 1NQ9, 1OYH, 1R1L, 1SR5, 1T1F, 1TB6,…1.00infobox
AntithrombinBand1q25.11.00infobox
AntithrombinBand1 H2.1|1 69.75 cM1.00infobox
AntithrombinBgeeright lobe of liver1.00infobox
AntithrombinBgeegonad1.00infobox
AntithrombinBgeestromal cell of endometrium1.00infobox
AntithrombinBgeehuman kidney1.00infobox
AntithrombinBgeeislet of Langerhans1.00infobox
AntithrombinBgeegastrocnemius muscle1.00infobox
AntithrombinBgeegastric mucosa1.00infobox
AntithrombinBgeemetanephros1.00infobox
AntithrombinBgeeblood1.00infobox
AntithrombinBgeerenal cortex1.00infobox
AntithrombinBgeeleft lobe of liver1.00infobox
AntithrombinBgeegallbladder1.00infobox
AntithrombinBgeeyolk sac1.00infobox
AntithrombinBgeehuman fetus1.00infobox
AntithrombinBgeeprimary oocyte1.00infobox
AntithrombinBgeefetal liver hematopoietic progenitor cell1.00infobox
AntithrombinBgeezygote1.00infobox
AntithrombinBgeesecondary oocyte1.00infobox
AntithrombinBgeesexually immature organism1.00infobox
AntithrombinBgeeabdominal wall1.00infobox
AntithrombinBioGPSMore reference expression data1.00infobox
AntithrombinChr.Chromosome 1 (human)1.00infobox
AntithrombinChr.Chromosome 1 (mouse)1.00infobox
AntithrombinDatabasesNCBI: entry; OMA: entry1.00infobox
AntithrombinEnd173,917,378 bp1.00infobox
AntithrombinEnd160,833,433 bp1.00infobox

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