Alpha-1 antitrypsin

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Alpha-1 antitrypsin topic overview

The analysis highlights History and Applications as prominent areas in the source structure around Alpha-1 antitrypsin.

Related topics: 95
Source areas: 9
Connected nodes: 104
Extracted relationships: 130
Concept neighborhoods: 29
Bridge connections: 104

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 28 topics

Clinical significance · 16 topics

Analysis · 14 topics

Function · 12 topics

Nomenclature · 10 topics

Structure · 10 topics

Genetics · 2 topics

Medical uses · 2 topics

History · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases: SERPINA1, A1A, A1AT, AAT, PI, PI1, PRO2275, alpha1AT, serpin family A member 1, nNIF
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1ATU, 1D5S, 1EZX, 1HP7, 1IZ2, 1KCT, 1OO8, 1OPH, 1PSI, 1QLP, 1QMB, 2D26, 2QUG, 3CWL, 3CWM, 3DRM, 3DRU, 3NDD,…
Band: 14q32.13 · 12 E|12 52.98 cM
Bgee: right lobe of liver · blood · islet of Langerhans · monocyte · granulocyte
BioGPS: More reference expression data
Chr.: Chromosome 14 (human) · Chromosome 12 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Protein
Serpin
Gene
An endogenous protease inhibitor Protease inhibitor (biology)
Proteases Protease
Trypsin
Enzyme inhibitor
Tissues Tissue (biology)
Enzymes Enzyme
Inflammatory Inflammation
Neutrophil elastase
Blood
Alpha-1 antitrypsin deficiency
Elastin
Elasticity Elasticity (physics)
Lungs Lung
Respiratory issues Pulmonology
Chronic obstructive pulmonary disease
Liver
Systemic circulation Circulatory system
Cirrhosis
Children Pediatrics
An exogenous one used as medication Protease inhibitor (pharmacology)
Pharmaceutical Pharmaceutical drug
Human donor blood Blood donation
Nonproprietary name Drug nomenclature
Recombinant Recombinant DNA
Medical research

Nomenclature

Genetics

Chromosome 14
Europeans Europe

Structure

Medical uses

History

Laurell Carl-Bertil Laurell

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Alpha-1 antitrypsin connects Entity context

The extracted context around Alpha-1 antitrypsin shows recurring relationship patterns in the source. For example, Alpha-1 antitrypsin → acute-phase response, blood coagulation, collagen-containing extracellular matrix, COPII vesicle coating, COPII-coated ER to Golgi transport vesicle, endoplasmic reticulum, endoplasmic reticulum lumen, endoplasmic reticulum to Golgi vesicle-mediated transport, endoplasmic reticulum-Golgi intermediate compartment membrane, extracellular exosome, extracellular region, extracellular space, ficolin-1-rich granule lumen, Golgi apparatus, Golgi membrane, hemostasis, identical protein binding, intracellular membrane-bounded organelle, negative regulation of endopeptidase activity, negative regulation of peptidase activity Another extracted example is Alpha-1 antitrypsin → A1AT, Alpha-1, Alpha1-proteinase, Aralast, August, Drug Administration, European Union, FDA, FEV1, Glassia, It, People, Pi, PiSZ, PiZ, PiZZ, Prolastin, Respreeza, The US Food, These. Use these groups to spot repeated connection types before inspecting the individual relationships.

Top relations

Gene ontology · 28

Alpha-1 antitrypsin → acute-phase response, blood coagulation, collagen-containing extracellular matrix, COPII vesicle coating, COPII-coated ER to Golgi transport vesicle, endoplasmic reticulum, endoplasmic reticulum lumen, endoplasmic reticulum to Golgi vesicle-mediated transport, endoplasmic reticulum-Golgi intermediate compartment membrane, extracellular exosome, extracellular region, extracellular space, ficolin-1-rich granule lumen, Golgi apparatus, Golgi membrane, hemostasis, identical protein binding, intracellular membrane-bounded organelle, negative regulation of endopeptidase activity, negative regulation of peptidase activity

related to Medical uses · 22

Alpha-1 antitrypsin → A1AT, Alpha-1, Alpha1-proteinase, Aralast, August, Drug Administration, European Union, FDA, FEV1, Glassia, It, People, Pi, PiSZ, PiZ, PiZZ, Prolastin, Respreeza, The US Food, These

Bgee · 18

Alpha-1 antitrypsin → appendix, blood, duodenum, gallbladder, granulocyte, hepatobiliary system, Hindgut, human kidney, islet of Langerhans, liver, lobe of liver, midgut, monocyte, proximal tubule, right kidney, right lobe of liver, upper lobe of left lung, yolk sac

RNA expression pattern · 18

related to Analysis · 10

Alpha-1 antitrypsin → A1AT, Bristow, Cynthia, Edited, Humana, Methods, Molecular Biology, New York, Updated, US

related to Clinical significance · 9

Alpha-1 antitrypsin → An, Because A1AT, Disorders, Evidence, Met358Arg, One, Pi, PiPittsburgh, This

Band · 2

Alpha-1 antitrypsin → 12 E|12 52.98 cM, 14q32.13

Chr. · 2

Alpha-1 antitrypsin → Chromosome 12 (mouse), Chromosome 14 (human)

End · 2

Alpha-1 antitrypsin → 103,739,851 bp, 94,390,693 bp

Aliases · 1

Alpha-1 antitrypsin → SERPINA1, A1A, A1AT, AAT, PI, PI1, PRO2275, alpha1AT, serpin family A member 1, nNIF

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

a1at inhibitor protein alpha-1 elastase antitrypsin liver human gene also blood band bp protease neutrophil used serpin chr enzymes deficiency

Alpha-1 antitrypsin relationships Subject–Predicate–Object triples

TTTA extracted 130 structured relationships around Alpha-1 antitrypsin. Examples in this analysis include Alpha-1 antitrypsin → Aliases → SERPINA1, A1A, A1AT, AAT, PI, PI1, PRO2275, alpha1AT, serpin family A member 1, nNIF and Alpha-1 antitrypsin → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1ATU, 1D5S, 1EZX, 1HP7, 1IZ2, 1KCT, 1OO8, 1OPH, 1PSI, 1QLP, 1QMB, 2D26, 2QUG, 3CWL, 3CWM, 3DRM, 3DRU, 3NDD,…. The table shows each extracted connection, where it came from and its confidence.

Subject	Predicate	Object	Confidence	Src
Alpha-1 antitrypsin	Aliases	SERPINA1, A1A, A1AT, AAT, PI, PI1, PRO2275, alpha1AT, serpin family A member 1, nNIF	1.00	infobox
Alpha-1 antitrypsin	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1ATU, 1D5S, 1EZX, 1HP7, 1IZ2, 1KCT, 1OO8, 1OPH, 1PSI, 1QLP, 1QMB, 2D26, 2QUG, 3CWL, 3CWM, 3DRM, 3DRU, 3NDD,…	1.00	infobox
Alpha-1 antitrypsin	Band	14q32.13	1.00	infobox
Alpha-1 antitrypsin	Band	12 E\|12 52.98 cM	1.00	infobox
Alpha-1 antitrypsin	Bgee	right lobe of liver	1.00	infobox
Alpha-1 antitrypsin	Bgee	blood	1.00	infobox
Alpha-1 antitrypsin	Bgee	islet of Langerhans	1.00	infobox
Alpha-1 antitrypsin	Bgee	monocyte	1.00	infobox
Alpha-1 antitrypsin	Bgee	granulocyte	1.00	infobox
Alpha-1 antitrypsin	Bgee	gallbladder	1.00	infobox
Alpha-1 antitrypsin	Bgee	duodenum	1.00	infobox
Alpha-1 antitrypsin	Bgee	human kidney	1.00	infobox
Alpha-1 antitrypsin	Bgee	upper lobe of left lung	1.00	infobox
Alpha-1 antitrypsin	Bgee	appendix	1.00	infobox
Alpha-1 antitrypsin	Bgee	proximal tubule	1.00	infobox
Alpha-1 antitrypsin	Bgee	hepatobiliary system	1.00	infobox
Alpha-1 antitrypsin	Bgee	liver	1.00	infobox
Alpha-1 antitrypsin	Bgee	right kidney	1.00	infobox
Alpha-1 antitrypsin	Bgee	Hindgut	1.00	infobox
Alpha-1 antitrypsin	Bgee	lobe of liver	1.00	infobox
Alpha-1 antitrypsin	Bgee	yolk sac	1.00	infobox
Alpha-1 antitrypsin	Bgee	midgut	1.00	infobox
Alpha-1 antitrypsin	BioGPS	More reference expression data	1.00	infobox
Alpha-1 antitrypsin	Chr.	Chromosome 14 (human)	1.00	infobox
Alpha-1 antitrypsin	Chr.	Chromosome 12 (mouse)	1.00	infobox
Alpha-1 antitrypsin	Databases	NCBI: entry; OMA: entry	1.00	infobox
Alpha-1 antitrypsin	End	94,390,693 bp	1.00	infobox
Alpha-1 antitrypsin	End	103,739,851 bp	1.00	infobox
Alpha-1 antitrypsin	Ensembl	ENSG00000197249 ENSG00000277377	1.00	infobox
Alpha-1 antitrypsin	Entrez	5265	1.00	infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Alpha-1 antitrypsin bring nearby vocabulary together. In this analysis, examples include Antitrypsin, Deficiency and Protein. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

Alpha-1 antitrypsin
- Antitrypsin
- Deficiency
- Protein
- Blood
- A1at
- Location
- Proteinase
- Serpina1
- Trypsin
- Alpha
- Bp
- Chr
alpha-1 antitrypsin
- Antitrypsin
- Deficiency
- Blood
- Protein
- Neutrophil
- Human
- A1at
- Location
- Proteinase
- Serpina1
- Trypsin
- Α1-antitrypsin
an endogenous protease inhibitor
- Protease
- Proteinase
- Trypsin
- Alpha
- Pi
- Used
- Blood
- Enzyme
- Neutrophil
- A1pi
- Deficiency
- Human
enzyme inhibitor
- Neutrophil
- Protease
- Elastase
- Trypsin
- Proteinase
- Pi
- Used
- Blood
- Cell
- Inflammatory
- Enzyme
- Inhibitor
alpha-1 antitrypsin deficiency
- Antitrypsin
- Deficiency
- Blood
- Protein
- Neutrophil
- Inhibitor
- Disease
- Human
- A1at
- Mutation
- Pi
- Tissue
trypsin inhibitor
- Protease
- Enzyme
- Proteinase
- Inhibitor
- Trypsin
- Pi
- Used
- Blood
- A1pi
- Location
- Serpina1
- Neutrophil
human donor blood
- Location
- Bp
- Chr
- Chromosome
- Serpina1
- Band
- Alpha
- Neutrophil
- Serpin
- Inhibitor
- Protease
- Human
protein
- Gene
- Location
- Serpina1
- Alpha
- Serpin
- Liver
- Blood
- Human
- Inflammatory
- Trypsin
- Α1-antitrypsin
- Bp

Connections between topic areas Semantic bridges

For Alpha-1 antitrypsin, one of the stronger structural bridges in this analysis connects Alpha-1 antitrypsin with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

Alpha-1 antitrypsin — Overview · splits 76 ⟂ 29

Alpha-1 antitrypsin — Clinical significance · splits 88 ⟂ 17

Alpha-1 antitrypsin — Analysis · splits 90 ⟂ 15

Alpha-1 antitrypsin — Function · splits 92 ⟂ 13

Alpha-1 antitrypsin — Nomenclature · splits 94 ⟂ 11

Alpha-1 antitrypsin — Structure · splits 94 ⟂ 11

Alpha-1 antitrypsin — Genetics · splits 102 ⟂ 3

Alpha-1 antitrypsin — Medical uses · splits 102 ⟂ 3

Map overview Semantic statistics

Alpha-1 antitrypsin

Nodes105

Edges104

Triples130

Avg. degree1.98

Density0.019048

Components1

Source & methodology

TTTA analyzes the structure around Alpha-1 antitrypsin to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History & Applications, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Alpha-1 antitrypsin · EN edition · Analysis: TopicsToTalkAbout