Alpha-1 antitrypsin

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Clinical significance

Autosomal co-dominant Hereditary disorder Pulmonary emphysema Met Liver cirrhosis

16 related topics

Analysis

Reference range in blood Turbidimetry Phenotype Electrophoresis PH

14 related topics

Function

KDa Medicine Acute phase reaction Neutrophil granulocytes Elastase

12 related topics

Overview

Protein Serpin Gene An endogenous protease inhibitor Proteases

28 related topics

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases: SERPINA1, A1A, A1AT, AAT, PI, PI1, PRO2275, alpha1AT, serpin family A member 1, nNIF
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1ATU, 1D5S, 1EZX, 1HP7, 1IZ2, 1KCT, 1OO8, 1OPH, 1PSI, 1QLP, 1QMB, 2D26, 2QUG, 3CWL, 3CWM, 3DRM, 3DRU, 3NDD,…
Band: 14q32.13 · 12 E|12 52.98 cM
Bgee: right lobe of liver · blood · islet of Langerhans · monocyte · granulocyte
BioGPS: More reference expression data
Chr.: Chromosome 14 (human) · Chromosome 12 (mouse)

Topics to explore

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Overview

Protein
Serpin
Gene
An endogenous protease inhibitor Protease inhibitor (biology)
Proteases Protease
Trypsin
Enzyme inhibitor
Tissues Tissue (biology)
Enzymes Enzyme
Inflammatory Inflammation
Neutrophil elastase
Blood
Alpha-1 antitrypsin deficiency
Elastin
Elasticity Elasticity (physics)
Lungs Lung
Respiratory issues Pulmonology
Chronic obstructive pulmonary disease
Liver
Systemic circulation Circulatory system
Cirrhosis
Children Pediatrics
An exogenous one used as medication Protease inhibitor (pharmacology)
Pharmaceutical Pharmaceutical drug
Human donor blood Blood donation
Nonproprietary name Drug nomenclature
Recombinant Recombinant DNA
Medical research

Nomenclature

Genetics

Chromosome 14
Europeans Europe

Structure

Medical uses

History

Laurell Carl-Bertil Laurell

Advanced semantic analysis

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Map overview Semantic statistics

Nodes105

Edges104

Triples130

Avg. degree1.98

Density0.019048

Components1

How this topic connects Entity context

See the strongest relationship patterns around the current topic before diving into the raw triples.

Alpha-1 antitrypsin

Top relations

Gene ontology · 28

Alpha-1 antitrypsin → acute-phase response, blood coagulation, collagen-containing extracellular matrix, COPII vesicle coating, COPII-coated ER to Golgi transport vesicle, endoplasmic reticulum, endoplasmic reticulum lumen, endoplasmic reticulum to Golgi vesicle-mediated transport, endoplasmic reticulum-Golgi intermediate compartment membrane, extracellular exosome, extracellular region, extracellular space, ficolin-1-rich granule lumen, Golgi apparatus, Golgi membrane, hemostasis, identical protein binding, intracellular membrane-bounded organelle, negative regulation of endopeptidase activity, negative regulation of peptidase activity

related to Medical uses · 22

Alpha-1 antitrypsin → A1AT, Alpha-1, Alpha1-proteinase, Aralast, August, Drug Administration, European Union, FDA, FEV1, Glassia, It, People, Pi, PiSZ, PiZ, PiZZ, Prolastin, Respreeza, The US Food, These

Bgee · 18

Alpha-1 antitrypsin → appendix, blood, duodenum, gallbladder, granulocyte, hepatobiliary system, Hindgut, human kidney, islet of Langerhans, liver, lobe of liver, midgut, monocyte, proximal tubule, right kidney, right lobe of liver, upper lobe of left lung, yolk sac

RNA expression pattern · 18

related to Analysis · 10

Alpha-1 antitrypsin → A1AT, Bristow, Cynthia, Edited, Humana, Methods, Molecular Biology, New York, Updated, US

related to Clinical significance · 9

Alpha-1 antitrypsin → An, Because A1AT, Disorders, Evidence, Met358Arg, One, Pi, PiPittsburgh, This

Band · 2

Alpha-1 antitrypsin → 12 E|12 52.98 cM, 14q32.13

Chr. · 2

Alpha-1 antitrypsin → Chromosome 12 (mouse), Chromosome 14 (human)

End · 2

Alpha-1 antitrypsin → 103,739,851 bp, 94,390,693 bp

Aliases · 1

Alpha-1 antitrypsin → SERPINA1, A1A, A1AT, AAT, PI, PI1, PRO2275, alpha1AT, serpin family A member 1, nNIF

Important terminology Word statistics

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Important terminology

a1at inhibitor protein alpha-1 elastase antitrypsin liver human gene also blood band bp protease neutrophil used serpin chr enzymes deficiency

Entity relationships Subject–Predicate–Object triples

Subject	Predicate	Object	Confidence	Src
Alpha-1 antitrypsin	Aliases	SERPINA1, A1A, A1AT, AAT, PI, PI1, PRO2275, alpha1AT, serpin family A member 1, nNIF	1.00	infobox
Alpha-1 antitrypsin	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1ATU, 1D5S, 1EZX, 1HP7, 1IZ2, 1KCT, 1OO8, 1OPH, 1PSI, 1QLP, 1QMB, 2D26, 2QUG, 3CWL, 3CWM, 3DRM, 3DRU, 3NDD,…	1.00	infobox
Alpha-1 antitrypsin	Band	14q32.13	1.00	infobox
Alpha-1 antitrypsin	Band	12 E\|12 52.98 cM	1.00	infobox
Alpha-1 antitrypsin	Bgee	right lobe of liver	1.00	infobox
Alpha-1 antitrypsin	Bgee	blood	1.00	infobox
Alpha-1 antitrypsin	Bgee	islet of Langerhans	1.00	infobox
Alpha-1 antitrypsin	Bgee	monocyte	1.00	infobox
Alpha-1 antitrypsin	Bgee	granulocyte	1.00	infobox
Alpha-1 antitrypsin	Bgee	gallbladder	1.00	infobox
Alpha-1 antitrypsin	Bgee	duodenum	1.00	infobox
Alpha-1 antitrypsin	Bgee	human kidney	1.00	infobox
Alpha-1 antitrypsin	Bgee	upper lobe of left lung	1.00	infobox
Alpha-1 antitrypsin	Bgee	appendix	1.00	infobox
Alpha-1 antitrypsin	Bgee	proximal tubule	1.00	infobox
Alpha-1 antitrypsin	Bgee	hepatobiliary system	1.00	infobox
Alpha-1 antitrypsin	Bgee	liver	1.00	infobox
Alpha-1 antitrypsin	Bgee	right kidney	1.00	infobox
Alpha-1 antitrypsin	Bgee	Hindgut	1.00	infobox
Alpha-1 antitrypsin	Bgee	lobe of liver	1.00	infobox
Alpha-1 antitrypsin	Bgee	yolk sac	1.00	infobox
Alpha-1 antitrypsin	Bgee	midgut	1.00	infobox
Alpha-1 antitrypsin	BioGPS	More reference expression data	1.00	infobox
Alpha-1 antitrypsin	Chr.	Chromosome 14 (human)	1.00	infobox
Alpha-1 antitrypsin	Chr.	Chromosome 12 (mouse)	1.00	infobox
Alpha-1 antitrypsin	Databases	NCBI: entry; OMA: entry	1.00	infobox
Alpha-1 antitrypsin	End	94,390,693 bp	1.00	infobox
Alpha-1 antitrypsin	End	103,739,851 bp	1.00	infobox
Alpha-1 antitrypsin	Ensembl	ENSG00000197249 ENSG00000277377	1.00	infobox
Alpha-1 antitrypsin	Entrez	5265	1.00	infobox

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