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Vitronectin: Structure, Function & Overview

Vitronectin (VTN or VN) is a glycoprotein of the hemopexin family which is synthesized and excreted by the liver, and abundantly found in serum, the extracellular matrix and bone. In humans it is encoded by the VTN gene.

Language: English [EN]
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Vitronectin topic overview

The analysis highlights Structure, Function and Overview as prominent areas in the source structure around Vitronectin.

Related topics
32
Source areas
3
Connected nodes
35
Extracted relationships
125
Concept neighborhoods
21
Bridge connections
35

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Structure · 14 topics
Overview · 13 topics
Function · 5 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
VTN, V75, VN, VNT, vitronectin
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1OC0, 1S4G, 1SSU, 2JQ8, 3BT1, 3BT2, 4K24
Band
17q11.2 · 11 B5|11 46.74 cM
Bgee
right lobe of liver · right adrenal gland · right adrenal cortex · left adrenal gland · left adrenal cortex
BioGPS
More reference expression data
Chr.
Chromosome 17 (human) · Chromosome 11 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure

Function

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Vitronectin connects Entity context

The extracted context around Vitronectin shows recurring relationship patterns in the source. For example, Vitronectin → alphav-beta3 integrin-vitronectin complex, basement membrane, blood microparticle, cell adhesion, cell adhesion mediated by integrin, cell migration, cell population proliferation, cell-matrix adhesion, collagen binding, collagen-containing extracellular matrix, cytoplasm, endocytosis, endodermal cell differentiation, endoplasmic reticulum, extracellular exosome, extracellular matrix, extracellular matrix binding, extracellular matrix organization, extracellular matrix structural constituent, extracellular region Another extracted example is Vitronectin → apex of heart, dentate gyrus of hippocampal formation granule cell, epithelium of lens, fetal liver hematopoietic progenitor cell, gallbladder, left adrenal cortex, left adrenal gland, left lobe of liver, left ventricle, neural layer of retina, optic nerve, pia mater, placenta, retinal pigment epithelium, right adrenal cortex, right adrenal gland, right hemisphere of cerebellum, right lobe of liver, sexually immature organism. Use these groups to spot repeated connection types before inspecting the individual relationships.

Vitronectin

Top relations

Gene ontology · 47
Vitronectin → alphav-beta3 integrin-vitronectin complex, basement membrane, blood microparticle, cell adhesion, cell adhesion mediated by integrin, cell migration, cell population proliferation, cell-matrix adhesion, collagen binding, collagen-containing extracellular matrix, cytoplasm, endocytosis, endodermal cell differentiation, endoplasmic reticulum, extracellular exosome, extracellular matrix, extracellular matrix binding, extracellular matrix organization, extracellular matrix structural constituent, extracellular region
Bgee · 19
Vitronectin → apex of heart, dentate gyrus of hippocampal formation granule cell, epithelium of lens, fetal liver hematopoietic progenitor cell, gallbladder, left adrenal cortex, left adrenal gland, left lobe of liver, left ventricle, neural layer of retina, optic nerve, pia mater, placenta, retinal pigment epithelium, right adrenal cortex, right adrenal gland, right hemisphere of cerebellum, right lobe of liver, sexually immature organism
RNA expression pattern · 19
Vitronectin → apex of heart, dentate gyrus of hippocampal formation granule cell, epithelium of lens, fetal liver hematopoietic progenitor cell, gallbladder, left adrenal cortex, left adrenal gland, left lobe of liver, left ventricle, neural layer of retina, optic nerve, pia mater, placenta, retinal pigment epithelium, right adrenal cortex, right adrenal gland, right hemisphere of cerebellum, right lobe of liver, sexually immature organism
related to Function · 8
Vitronectin → Cell, High, In, PAI-1, RGD, The, The Somatomedin, Thus
related to Structure · 5
Vitronectin → About, N-terminal, No, On, The
related to External links · 3
Vitronectin → Medicine Medical Subject Headings, MeSH, National Library
Band · 2
Vitronectin → 11 B5|11 46.74 cM, 17q11.2
Chr. · 2
Vitronectin → Chromosome 11 (mouse), Chromosome 17 (human)
End · 2
Vitronectin → 28,373,091 bp, 78,393,150 bp
Aliases · 1
Vitronectin → VTN, V75, VN, VNT, vitronectin

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

bp domain vtn chr human band gene protein somatomedin chromosome 17 cell disulfide binds structure receptor extracellular matrix adhesion location

Vitronectin relationships Subject–Predicate–Object triples

TTTA extracted 125 structured relationships around Vitronectin. Examples in this analysis include Vitronectin → Aliases → VTN, V75, VN, VNT, vitronectin and Vitronectin → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1OC0, 1S4G, 1SSU, 2JQ8, 3BT1, 3BT2, 4K24. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
VitronectinAliasesVTN, V75, VN, VNT, vitronectin1.00infobox
VitronectinAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1OC0, 1S4G, 1SSU, 2JQ8, 3BT1, 3BT2, 4K241.00infobox
VitronectinBand17q11.21.00infobox
VitronectinBand11 B5|11 46.74 cM1.00infobox
VitronectinBgeeright lobe of liver1.00infobox
VitronectinBgeeright adrenal gland1.00infobox
VitronectinBgeeright adrenal cortex1.00infobox
VitronectinBgeeleft adrenal gland1.00infobox
VitronectinBgeeleft adrenal cortex1.00infobox
VitronectinBgeegallbladder1.00infobox
VitronectinBgeeleft ventricle1.00infobox
VitronectinBgeeapex of heart1.00infobox
VitronectinBgeeplacenta1.00infobox
VitronectinBgeeright hemisphere of cerebellum1.00infobox
VitronectinBgeeneural layer of retina1.00infobox
VitronectinBgeeleft lobe of liver1.00infobox
VitronectinBgeeoptic nerve1.00infobox
VitronectinBgeeretinal pigment epithelium1.00infobox
VitronectinBgeedentate gyrus of hippocampal formation granule cell1.00infobox
VitronectinBgeeepithelium of lens1.00infobox
VitronectinBgeesexually immature organism1.00infobox
VitronectinBgeefetal liver hematopoietic progenitor cell1.00infobox
VitronectinBgeepia mater1.00infobox
VitronectinBioGPSMore reference expression data1.00infobox
VitronectinChr.Chromosome 17 (human)1.00infobox
VitronectinChr.Chromosome 11 (mouse)1.00infobox
VitronectinDatabasesNCBI: entry; OMA: entry1.00infobox
VitronectinEnd28,373,091 bp1.00infobox
VitronectinEnd78,393,150 bp1.00infobox
VitronectinEnsemblENSG000001090721.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Vitronectin bring nearby vocabulary together. In this analysis, examples include Extracellular, Matrix and Thus. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Vitronectin
    • Extracellular
    • Matrix
    • Thus
    • Vtn
    • Function
    • Glycoprotein
    • Hemostasis
    • Integrin
    • Liver
    • Vn
    • Adhesion
    • Binding
  • vitronectin
    • Extracellular
    • Matrix
    • Thus
    • Vtn
    • Function
    • Glycoprotein
    • Hemostasis
    • Integrin
    • Liver
    • Vn
    • Adhesion
    • Binding
  • glycoprotein
    • Liver
    • Extracellular
    • Matrix
    • Vtn
    • Complement
    • Function
    • Hemopexin
    • Integrin
    • Mouse
    • Pathway
    • Vn
    • Adhesion
  • extracellular matrix
    • Matrix
    • Glycoprotein
    • Liver
    • Binding
    • Receptor
    • Vtn
    • Vitronectin
    • Complement
    • Function
    • Hemopexin
    • Integrin
    • Mouse
  • gene
    • Location
    • Chromosome
    • Human
    • Vtn
    • Bp
    • Chr
    • Function
    • Mouse
    • Band
    • External
    • Complement
    • Glycoprotein
  • cell adhesion
    • Adhesion
    • Cell
    • Migration
    • Integrin
    • Receptor
    • Complement
    • Function
    • Glycoprotein
    • Liver
    • Mouse
    • Pathway
    • Binding
  • vitronectin receptor
    • Extracellular
    • Matrix
    • Thus
    • Vtn
    • Function
    • Glycoprotein
    • Hemostasis
    • Integrin
    • Liver
    • Vn
    • Adhesion
    • Binding
  • function
    • Location
    • Chromosome
    • External
    • Gene
    • Human
    • Vtn
    • Bp
    • Chr
    • Glycoprotein
    • Integrin
    • Liver
    • Mouse

Connections between topic areas Semantic bridges

For Vitronectin, one of the stronger structural bridges in this analysis connects Vitronectin with Structure. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
VitronectinStructure · splits 21 ⟂ 15
VitronectinOverview · splits 22 ⟂ 14
VitronectinFunction · splits 30 ⟂ 6

Map overview Semantic statistics

Vitronectin

Nodes36
Edges35
Triples125
Avg. degree1.94
Density0.055556
Components1

Source & methodology

TTTA analyzes the structure around Vitronectin to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Structure, Function & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Vitronectin · EN edition · Analysis: TopicsToTalkAbout

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