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Melanocortin 1 receptor: Functions, Pigmentation genetics & Evolution

The melanocortin 1 receptor (MC1R), also known as melanocyte-stimulating hormone receptor (MSHR), melanin-activating peptide receptor, or melanotropin receptor, is a G protein–coupled receptor that binds to a class of pituitary peptide hormones known as the melanocortins, which include adrenocorticotropic hormone (ACTH) and the different forms of…

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Melanocortin 1 receptor topic overview

The analysis highlights Functions, Pigmentation genetics and Evolution as prominent areas in the source structure around Melanocortin 1 receptor.

Related topics
126
Source areas
5
Connected nodes
131
Extracted relationships
92
Related term clusters
25
Bridge connections
131

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Functions · 42 topics
Overview · 29 topics
Pigmentation genetics · 27 topics
Evolution · 19 topics
Ligands · 9 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
MC1R, CMM5, MSH-R, SHEP2, Melanocortin 1 receptor
Band
16q24.3 · 8 E1|8 72.1 cM
Bgee
granulocyte · right uterine tube · left testis · right hemisphere of cerebellum · anterior pituitary
BioGPS
n/a
Chr.
Chromosome 16 (human) · Chromosome 8 (mouse)
Databases
NCBI: entry; OMA: entry

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Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Functions

Ligands

Pigmentation genetics

Evolution

For the semantics nerds

You can skip this section if you’re here for content ideas and keyword inspiration.

Advanced semantic analysis

How Melanocortin 1 receptor connects Entity context

The extracted context around Melanocortin 1 receptor shows recurring relationship patterns in the source. For example, Melanocortin 1 receptor → adenylate cyclase-activating G protein-coupled receptor signaling pathway, G protein-coupled peptide receptor activity, G protein-coupled receptor activity, G protein-coupled receptor signaling pathway, G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger, integral component of membrane, integral component of plasma membrane, intracellular anatomical structure, intracellular signal transduction, melanin biosynthetic process, melanocortin receptor activity, melanocyte-stimulating hormone receptor activity, membrane, multicellular organism development, negative regulation of tumor necrosis factor production, pigmentation, plasma membrane, positive regulation of protein kinase A signaling, positive regulation of protein kinase B signaling, positive regulation of protein kinase C signaling Another extracted example is Melanocortin 1 receptor → anterior pituitary, cornea, embryo, epithelium of lens, gastric mucosa, granulocyte, hair follicle, Ileal epithelium, iris, left lobe of thyroid gland, left ovary, left testis, neural layer of retina, right hemisphere of cerebellum, right lobe of thyroid gland, right testis, right uterine tube, skin of abdomen, yolk sac. Use these groups to spot repeated connection types before inspecting the individual relationships.

Melanocortin 1 receptor

Top relations

Gene ontology · 28
Melanocortin 1 receptor → adenylate cyclase-activating G protein-coupled receptor signaling pathway, G protein-coupled peptide receptor activity, G protein-coupled receptor activity, G protein-coupled receptor signaling pathway, G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger, integral component of membrane, integral component of plasma membrane, intracellular anatomical structure, intracellular signal transduction, melanin biosynthetic process, melanocortin receptor activity, melanocyte-stimulating hormone receptor activity, membrane, multicellular organism development, negative regulation of tumor necrosis factor production, pigmentation, plasma membrane, positive regulation of protein kinase A signaling, positive regulation of protein kinase B signaling, positive regulation of protein kinase C signaling
Bgee · 19
Melanocortin 1 receptor → anterior pituitary, cornea, embryo, epithelium of lens, gastric mucosa, granulocyte, hair follicle, Ileal epithelium, iris, left lobe of thyroid gland, left ovary, left testis, neural layer of retina, right hemisphere of cerebellum, right lobe of thyroid gland, right testis, right uterine tube, skin of abdomen, yolk sac
RNA expression pattern · 19
Melanocortin 1 receptor → anterior pituitary, cornea, embryo, epithelium of lens, gastric mucosa, granulocyte, hair follicle, Ileal epithelium, iris, left lobe of thyroid gland, left ovary, left testis, neural layer of retina, right hemisphere of cerebellum, right lobe of thyroid gland, right testis, right uterine tube, skin of abdomen, yolk sac
Band · 2
Melanocortin 1 receptor → 16q24.3, 8 E1|8 72.1 cM
Chr. · 2
Melanocortin 1 receptor → Chromosome 16 (human), Chromosome 8 (mouse)
End · 2
Melanocortin 1 receptor → 124,137,483 bp, 89,920,973 bp
Aliases · 1
Melanocortin 1 receptor → MC1R, CMM5, MSH-R, SHEP2, Melanocortin 1 receptor
BioGPS · 1
Melanocortin 1 receptor → n/a
Databases · 1
Melanocortin 1 receptor → NCBI: entry; OMA: entry
Ensembl · 1
Melanocortin 1 receptor → ENSG00000258839

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

mc1r skin receptor hair gene human red humans bp pigment also pain one reported melanocortin known chr melanin band cell

Melanocortin 1 receptor relationships Subject–Predicate–Object triples

TTTA extracted 92 structured relationships around Melanocortin 1 receptor. Examples in this analysis include Melanocortin 1 receptor → Aliases → MC1R, CMM5, MSH-R, SHEP2, Melanocortin 1 receptor and Melanocortin 1 receptor → Band → 16q24.3. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Melanocortin 1 receptorAliasesMC1R, CMM5, MSH-R, SHEP2, Melanocortin 1 receptor1.00infobox
Melanocortin 1 receptorBand16q24.31.00infobox
Melanocortin 1 receptorBand8 E1|8 72.1 cM1.00infobox
Melanocortin 1 receptorBgeegranulocyte1.00infobox
Melanocortin 1 receptorBgeeright uterine tube1.00infobox
Melanocortin 1 receptorBgeeleft testis1.00infobox
Melanocortin 1 receptorBgeeright hemisphere of cerebellum1.00infobox
Melanocortin 1 receptorBgeeanterior pituitary1.00infobox
Melanocortin 1 receptorBgeeright testis1.00infobox
Melanocortin 1 receptorBgeegastric mucosa1.00infobox
Melanocortin 1 receptorBgeeleft lobe of thyroid gland1.00infobox
Melanocortin 1 receptorBgeeright lobe of thyroid gland1.00infobox
Melanocortin 1 receptorBgeeleft ovary1.00infobox
Melanocortin 1 receptorBgeehair follicle1.00infobox
Melanocortin 1 receptorBgeeIleal epithelium1.00infobox
Melanocortin 1 receptorBgeeiris1.00infobox
Melanocortin 1 receptorBgeeembryo1.00infobox
Melanocortin 1 receptorBgeeneural layer of retina1.00infobox
Melanocortin 1 receptorBgeeepithelium of lens1.00infobox
Melanocortin 1 receptorBgeeskin of abdomen1.00infobox
Melanocortin 1 receptorBgeeyolk sac1.00infobox
Melanocortin 1 receptorBgeecornea1.00infobox
Melanocortin 1 receptorBioGPSn/a1.00infobox
Melanocortin 1 receptorChr.Chromosome 16 (human)1.00infobox
Melanocortin 1 receptorChr.Chromosome 8 (mouse)1.00infobox
Melanocortin 1 receptorDatabasesNCBI: entry; OMA: entry1.00infobox
Melanocortin 1 receptorEnd89,920,973 bp1.00infobox
Melanocortin 1 receptorEnd124,137,483 bp1.00infobox
Melanocortin 1 receptorEnsemblENSG000002588391.00infobox
Melanocortin 1 receptorEntrez41571.00infobox

Related concept clusters Related term clusters

The concept neighborhoods around Melanocortin 1 receptor bring nearby vocabulary together. In this analysis, examples include Receptor, Human and Pituitary. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Melanocortin 1 receptor
    • Receptor
    • Human
    • Pituitary
    • Hormone
    • Chromosome
    • Coupled
    • Development
    • Melanin
    • Peptide
    • Protein
    • Bp
    • Chr
  • melanocortin 1 receptor
    • Receptor
    • Human
    • Pituitary
    • Hormone
    • Chromosome
    • Coupled
    • Development
    • Melanin
    • Peptide
    • Protein
    • Bp
    • Chr
  • g protein–coupled receptor
    • Protein
    • Pituitary
    • Pain
    • Hormone
    • Cells
    • Development
    • Peptide
    • Known
    • Melanocortin
    • Receptor
    • Cell
    • Expressed
  • hair color
    • Red
    • Gene
    • Skin
    • Melanocortin
    • Mc1r
    • Human
    • Receptor
    • Chromosome
    • Development
    • Independent
    • Involved
    • Melanin
  • basal cell carcinoma
    • Pigment
    • Independent
    • Peptide
    • Protein
    • Role
    • Pain
    • Variants
    • Pituitary
    • Receptor
    • Expressed
    • Hormone
    • Chromosome
  • squamous cell carcinoma
    • Pigment
    • Independent
    • Peptide
    • Protein
    • Role
    • Pain
    • Variants
    • Pituitary
    • Receptor
    • Expressed
    • Hormone
    • Chromosome
  • agonist of mc1r
    • Skin
    • Gene
    • Hair
    • Reported
    • Pain
    • Variants
    • Humans
    • Red
    • Role
    • Known
    • Cell
    • One
  • gene
    • Red
    • Hair
    • Chromosome
    • Bp
    • Chr
    • Mc1r
    • Skin
    • Human
    • Band
    • Peptide
    • Receptor
    • Role

Connections between topic areas Semantic bridges

For Melanocortin 1 receptor, one of the stronger structural bridges in this analysis connects Melanocortin 1 receptor with Functions. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Melanocortin 1 receptor — Functions · splits 89 ⟂ 43
Melanocortin 1 receptor — Overview · splits 102 ⟂ 30
Melanocortin 1 receptor — Pigmentation genetics · splits 104 ⟂ 28
Melanocortin 1 receptor — Evolution · splits 112 ⟂ 20
Melanocortin 1 receptor — Ligands · splits 122 ⟂ 10

Map overview Semantic statistics

Melanocortin 1 receptor

Nodes132
Edges131
Triples92
Avg. degree1.98
Density0.015152
Components1

Source & methodology

TTTA analyzes the structure around Melanocortin 1 receptor to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Functions, Pigmentation genetics & Evolution, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Melanocortin 1 receptor · EN edition · Analysis: TopicsToTalkAbout

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