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Respiratory complex I: Inhibitors, Genes & Function

Respiratory complex I, EC 7.1.1.2 (also known as NADH:ubiquinone oxidoreductase, Type I NADH dehydrogenase and mitochondrial complex I) is the first large protein complex of the respiratory chains of many organisms from bacteria to humans. It catalyzes the transfer of electrons from NADH to coenzyme Q10 (CoQ10) and translocates protons across the inner…

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Respiratory complex I topic overview

The analysis highlights Inhibitors, Genes and Function as prominent areas in the source structure around Respiratory complex I.

Related topics
141
Source areas
10
Connected nodes
151
Extracted relationships
9
Concept neighborhoods
31
Bridge connections
151

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Genes · 49 topics
Inhibitors · 23 topics
Function · 13 topics
Overview · 10 topics
Production of superoxide · 10 topics
Mechanism · 9 topics
Pathology · 9 topics
Active/inactive transition · 7 topics
Composition and structure · 7 topics
In chloroplasts · 4 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Membranome
255
OPM protein
6g72
OPM superfamily
246
Symbol
Respiratory complex I

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Mechanism

Composition and structure

Inhibitors

Active/inactive transition

Production of superoxide

Pathology

In chloroplasts

Genes

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Respiratory complex I connects Entity context

The extracted context around Respiratory complex I shows recurring relationship patterns in the source. For example, Respiratory complex I → 255 Another extracted example is Respiratory complex I → 6g72. Use these groups to spot repeated connection types before inspecting the individual relationships.

Respiratory complex I

Top relations

Membranome · 1
Respiratory complex I → 255
OPM protein · 1
Respiratory complex I → 6g72
OPM superfamily · 1
Respiratory complex I → 246
Symbol · 1
Respiratory complex I → Respiratory complex I

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

complex nadh electron ubiquinone enzyme transfer mitochondrial membrane subunits found dehydrogenase superoxide proton protons na two reduction electrons fmn iron-sulfur

Respiratory complex I relationships Subject–Predicate–Object triples

TTTA extracted 9 structured relationships around Respiratory complex I. Examples in this analysis include Respiratory complex I → Membranome → 255 and Respiratory complex I → OPM protein → 6g72. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Respiratory complex IMembranome2551.00infobox
Respiratory complex IOPM protein6g721.00infobox
Respiratory complex IOPM superfamily2461.00infobox
Respiratory complex ISymbolRespiratory complex I1.00infobox
ischemia/reperfusion damageinstance ofDefects in this enzyme are responsible for the development of several pathological processes0.80text
Schizosaccharomyces pombed Recent research has described NDUFA4 to be a subunit of complex IVinstance ofa Found in all species except fungib May or may not be present in any speciesc Found in fungal species0.80text
and not of complex I InhibitorsInhibition of complex I is the mode of action of the METI acaricidesinstance ofa Found in all species except fungib May or may not be present in any speciesc Found in fungal species0.80text
insecticidesinstance ofa Found in all species except fungib May or may not be present in any speciesc Found in fungal species0.80text
Antoniainstance ofRotenone and rotenoids are isoflavonoids occurring in several genera of tropical plants0.80text

Related concept clusters Concept neighborhoods

The concept neighborhoods around Respiratory complex I bring nearby vocabulary together. In this analysis, examples include Chain, Disease and Mechanism. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Respiratory complex I
    • Chain
    • Disease
    • Mechanism
    • Mitochondrial
    • Protein
    • Nadh
    • Ubiquinone
    • Proton
    • Enzyme
    • Iii
    • Fmn
    • Active
  • respiratory complex i
    • Chain
    • Disease
    • Mechanism
    • Mitochondrial
    • Protein
    • Electron
    • Nadh
    • Ubiquinone
    • Found
    • Enzyme
    • Proton
    • Inhibition
  • protein complex
    • Chain
    • Changes
    • N2
    • Respiratory
    • Electron
    • Transport
    • Nadh
    • Conformational
    • Found
    • Mitochondrial
    • Enzyme
    • Reduction
  • electrons
    • Transfer
    • Fmn
    • Iii
    • Mitochondrial
    • Ubiquinol
    • Nadh
    • Oxygen
    • Superoxide
    • Ubiquinone
    • Two
    • Membrane
    • Electron
  • nadh
    • Dehydrogenase
    • Ubiquinone
    • Electron
    • Respiratory
    • Chain
    • Electrons
    • Reduction
    • Membrane
    • Mitochondrial
    • Enzyme
    • Iv
    • Potential
  • mitochondrial
    • Subunits
    • Disease
    • Protein
    • Respiratory
    • Transfer
    • Chain
    • Electrons
    • Electron
    • Nadh
    • Mechanism
    • Inhibition
    • May
  • ubiquinone
    • Nadh
    • Reduction
    • Iv
    • Electron
    • N2
    • Respiratory
    • Rotenone
    • Transport
    • Electrons
    • Dehydrogenase
    • Iii
    • Protein
  • electron paramagnetic resonance
    • Transfer
    • Transport
    • Chain
    • Iron-sulfur
    • Reduction
    • N2
    • Protein
    • Superoxide
    • Ubiquinone
    • Fmn
    • Nadh
    • Mitochondrial

Connections between topic areas Semantic bridges

For Respiratory complex I, one of the stronger structural bridges in this analysis connects Respiratory complex I with Genes. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Respiratory complex IGenes · splits 102 ⟂ 50
Respiratory complex IInhibitors · splits 128 ⟂ 24
Respiratory complex IFunction · splits 138 ⟂ 14
Respiratory complex IOverview · splits 141 ⟂ 11
Respiratory complex IProduction of superoxide · splits 141 ⟂ 11
Respiratory complex IMechanism · splits 142 ⟂ 10
Respiratory complex IPathology · splits 142 ⟂ 10
Respiratory complex IComposition and structure · splits 144 ⟂ 8
Respiratory complex IActive/inactive transition · splits 144 ⟂ 8
Respiratory complex IIn chloroplasts · splits 147 ⟂ 5

Map overview Semantic statistics

Respiratory complex I

Nodes152
Edges151
Triples9
Avg. degree1.99
Density0.013158
Components1

Source & methodology

TTTA analyzes the structure around Respiratory complex I to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Inhibitors, Genes & Function, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Respiratory complex I · EN edition · Analysis: TopicsToTalkAbout

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