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MT-ND2: Measurement, Structure & Clinical significance

MT-ND2 is a gene of the mitochondrial genome coding for the NADH dehydrogenase 2 (ND2) protein. The ND2 protein is a subunit of NADH dehydrogenase (ubiquinone), which is located in the mitochondrial inner membrane and is the largest of the five complexes of the electron transport chain. Variants of human MT-ND2 are associated with mitochondrial…

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MT-ND2 topic overview

The analysis highlights Measurement, Structure and Clinical significance as prominent areas in the source structure around MT-ND2.

Related topics
34
Source areas
4
Connected nodes
38
Extracted relationships
126
Concept neighborhoods
19
Bridge connections
38

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Structure · 10 topics
Overview · 9 topics
Clinical significance · 8 topics
Function · 7 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

7.1.1.2
Aliases
ND2, complex I ND2 subunit, NAD2, NADH-ubiquinone oxidoreductase chain 2, MT-MTNADH dehydrogenase subunit 2
Band
n/a
Bgee
subcutaneous adipose tissue · caudate nucleus · putamen · lactiferous gland · right uterine tube
BioGPS
n/a
Chr.
Mitochondrial DNA (human) · Mitochondrial DNA (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure

Function

Clinical significance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How MT-ND2 connects Entity context

The extracted context around MT-ND2 shows recurring relationship patterns in the source. For example, MT-ND2 → Abnormalities, BMI, Leber's, Leigh, LHON, MELAS, Mitochondrial, MT-ATP6, MT-CO3, MT-ND1, MT-ND3, MT-ND4, MT-ND4L, MT-ND5, MT-ND6, MT-TK, MT-TL1, MT-TV, MT-TW, Pathogenic Another extracted example is MT-ND2 → adrenal gland, C1 segment, caudate nucleus, cerebellar cortex, dentate gyrus of hippocampal formation granule cell, esophagus, hippocampus proper, hypothalamus, lactiferous gland, left uterine tube, muscle layer of sigmoid colon, neural layer of retina, primary visual cortex, putamen, right hemisphere of cerebellum, right uterine tube, striatum of neuraxis, subcutaneous adipose tissue, substantia nigra, superior frontal gyrus. Use these groups to spot repeated connection types before inspecting the individual relationships.

MT-ND2

Top relations

related to Clinical significance · 23
MT-ND2 → Abnormalities, BMI, Leber's, Leigh, LHON, MELAS, Mitochondrial, MT-ATP6, MT-CO3, MT-ND1, MT-ND3, MT-ND4, MT-ND4L, MT-ND5, MT-ND6, MT-TK, MT-TL1, MT-TV, MT-TW, Pathogenic
Bgee · 20
MT-ND2 → adrenal gland, C1 segment, caudate nucleus, cerebellar cortex, dentate gyrus of hippocampal formation granule cell, esophagus, hippocampus proper, hypothalamus, lactiferous gland, left uterine tube, muscle layer of sigmoid colon, neural layer of retina, primary visual cortex, putamen, right hemisphere of cerebellum, right uterine tube, striatum of neuraxis, subcutaneous adipose tissue, substantia nigra, superior frontal gyrus
RNA expression pattern · 20
MT-ND2 → adrenal gland, C1 segment, caudate nucleus, cerebellar cortex, dentate gyrus of hippocampal formation granule cell, esophagus, hippocampus proper, hypothalamus, lactiferous gland, left uterine tube, muscle layer of sigmoid colon, neural layer of retina, primary visual cortex, putamen, right hemisphere of cerebellum, right uterine tube, striatum of neuraxis, subcutaneous adipose tissue, substantia nigra, superior frontal gyrus
Gene ontology · 14
MT-ND2 → integral component of membrane, ionotropic glutamate receptor binding, membrane, mitochondrial electron transport, NADH to ubiquinone, mitochondrial inner membrane, mitochondrial respiratory chain complex I, mitochondrial respiratory chain complex I assembly, mitochondrion, NADH dehydrogenase (ubiquinone) activity, oxidoreductase activity, postsynaptic density, protein kinase binding, reactive oxygen species metabolic process, respirasome
related to Structure · 13
MT-ND2 → Also, Complex, DNA, L-shaped, MT-ND1, MT-ND3, MT-ND4, MT-ND4L, MT-ND5, MT-ND6, NADH, The, The MT-ND2
related to Function · 11
MT-ND2 → Complex, CoQ, CoQH2, Fe-S, FMN, FMNH2, Initially, NADH, Q10, The, The MT-ND2
related to External links · 3
MT-ND2 → COPaKB Archived, Mass, Wayback Machine
Chr. · 2
MT-ND2 → Mitochondrial DNA (human), Mitochondrial DNA (mouse)
End · 2
MT-ND2 → 4,951 bp, 5,511 bp
7.1.1.2 · 1
MT-ND2 → ↗

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

mitochondrial nadh human bp gene protein complex dehydrogenase chr band chain dna ubiquinone syndrome nd2 respiratory subunit electron location leigh

MT-ND2 relationships Subject–Predicate–Object triples

TTTA extracted 126 structured relationships around MT-ND2. Examples in this analysis include MT-ND2 → 7.1.1.2 → ↗ and MT-ND2 → Aliases → ND2, complex I ND2 subunit, NAD2, NADH-ubiquinone oxidoreductase chain 2, MT-MTNADH dehydrogenase subunit 2. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
MT-ND27.1.1.21.00infobox
MT-ND2AliasesND2, complex I ND2 subunit, NAD2, NADH-ubiquinone oxidoreductase chain 2, MT-MTNADH dehydrogenase subunit 21.00infobox
MT-ND2Bandn/a1.00infobox
MT-ND2Bgeesubcutaneous adipose tissue1.00infobox
MT-ND2Bgeecaudate nucleus1.00infobox
MT-ND2Bgeeputamen1.00infobox
MT-ND2Bgeelactiferous gland1.00infobox
MT-ND2Bgeeright uterine tube1.00infobox
MT-ND2BgeeC1 segment1.00infobox
MT-ND2Bgeemuscle layer of sigmoid colon1.00infobox
MT-ND2Bgeeleft uterine tube1.00infobox
MT-ND2Bgeeright hemisphere of cerebellum1.00infobox
MT-ND2Bgeesubstantia nigra1.00infobox
MT-ND2Bgeedentate gyrus of hippocampal formation granule cell1.00infobox
MT-ND2Bgeehypothalamus1.00infobox
MT-ND2Bgeestriatum of neuraxis1.00infobox
MT-ND2Bgeeprimary visual cortex1.00infobox
MT-ND2Bgeesuperior frontal gyrus1.00infobox
MT-ND2Bgeecerebellar cortex1.00infobox
MT-ND2Bgeeadrenal gland1.00infobox
MT-ND2Bgeehippocampus proper1.00infobox
MT-ND2Bgeeneural layer of retina1.00infobox
MT-ND2Bgeeesophagus1.00infobox
MT-ND2BioGPSn/a1.00infobox
MT-ND2Chr.Mitochondrial DNA (human)1.00infobox
MT-ND2Chr.Mitochondrial DNA (mouse)1.00infobox
MT-ND2DatabasesNCBI: entry; OMA: entry1.00infobox
MT-ND2End5,511 bp1.00infobox
MT-ND2End4,951 bp1.00infobox
MT-ND2EnsemblENSG000001987631.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around MT-ND2 bring nearby vocabulary together. In this analysis, examples include Nadh, Mt-nd1 and Variants. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • MT-ND2
    • Nadh
    • Mt-nd1
    • Variants
    • Ubiquinone
    • Dehydrogenase
    • Protein
    • Syndrome
    • Complex
    • Electron
    • Genes
    • Including
    • Leigh
  • mt-nd2
    • Nadh
    • Mt-nd1
    • Variants
    • Ubiquinone
    • Dehydrogenase
    • Protein
    • Syndrome
    • Complex
    • Electron
    • Genes
    • Including
    • Leigh
  • gene
    • Location
    • Dna
    • Bp
    • Chr
    • Dehydrogenase
    • Human
    • Protein
    • Function
    • Mitochondrial
    • Mouse
    • Mt-nd2
    • Nd2
  • mitochondrial genome
    • Mt-nd2
    • Dehydrogenase
    • Human
    • Syndrome
    • Dna
    • Leigh
    • Bp
    • Chain
    • Chr
    • Protein
    • Nadh
    • Genes
  • nadh dehydrogenase (ubiquinone)
    • Electron
    • Nd2
    • Nadh
    • Ubiquinone
    • Chain
    • Dehydrogenase
    • Inner
    • Located
    • Membrane
    • Transport
    • Protein
    • Function
  • mitochondrial inner membrane
    • Located
    • Membrane
    • Transport
    • Electron
    • Ubiquinone
    • Chain
    • Protein
    • Mt-nd2
    • Dehydrogenase
    • Human
    • Syndrome
    • Function
  • electron transport chain
    • Ubiquinone
    • Inner
    • Located
    • Membrane
    • Transport
    • Chain
    • Electron
    • Subunit
    • Dehydrogenase
    • Nadh
    • Protein
    • Function
  • mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes
    • Mt-nd2
    • Dehydrogenase
    • Human
    • Syndrome
    • Dna
    • Leigh
    • Bp
    • Chain
    • Chr
    • Protein
    • Nadh
    • Genes

Connections between topic areas Semantic bridges

For MT-ND2, one of the stronger structural bridges in this analysis connects MT-ND2 with Structure. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
MT-ND2Structure · splits 28 ⟂ 11
MT-ND2Overview · splits 29 ⟂ 10
MT-ND2Clinical significance · splits 30 ⟂ 9
MT-ND2Function · splits 31 ⟂ 8

Map overview Semantic statistics

MT-ND2

Nodes39
Edges38
Triples126
Avg. degree1.95
Density0.051282
Components1

Source & methodology

TTTA analyzes the structure around MT-ND2 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Measurement, Structure & Clinical significance, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — MT-ND2 · EN edition · Analysis: TopicsToTalkAbout

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