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NDUFA5: Measurement, Structure & Function

NADH dehydrogenase 1 alpha subcomplex subunit 5 is an enzyme that in humans is encoded by the NDUFA5 gene. The NDUFA5 protein is a subunit of NADH dehydrogenase (ubiquinone), which is located in the mitochondrial inner membrane and is the largest of the five complexes of the electron transport chain.

Language: English [EN]
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NDUFA5 topic overview

The analysis highlights Measurement, Structure and Function as prominent areas in the source structure around NDUFA5.

Related topics
33
Source areas
5
Connected nodes
38
Extracted relationships
105
Concept neighborhoods
20
Bridge connections
38

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Structure · 14 topics
Function · 7 topics
Overview · 5 topics
Interactions · 4 topics
Clinical significance · 3 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
NDUFA5, B13, CI-13KD-B, CI-13kB, NUFM, UQOR13, NADH:ubiquinone oxidoreductase subunit A5
Band
7q31.32 · 6|6 A3.1
Bgee
endothelial cell · Skeletal muscle tissue of rectus abdominis · right ventricle · biceps brachii · Skeletal muscle tissue of biceps brachii
BioGPS
More reference expression data
Chr.
Chromosome 7 (human) · Chromosome 6 (mouse)
Databases
NCBI: entry; OMA: entry

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure

Function

Clinical significance

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How NDUFA5 connects Entity context

The extracted context around NDUFA5 shows recurring relationship patterns in the source. For example, NDUFA5 → Achilles tendon, aortic valve, ascending aorta, biceps brachii, Brodmann area 9, cardiac muscle tissue of left ventricle, dorsolateral prefrontal cortex, endothelial cell, extraocular muscle, facial motor nucleus, germinal epithelium, Ileal epithelium, intercostal muscle, interventricular septum, masseter muscle, plantaris muscle, right auricle of heart, right ventricle, Skeletal muscle tissue of biceps brachii, Skeletal muscle tissue of rectus abdominis Another extracted example is NDUFA5 → membrane, mitochondrial electron transport, NADH to ubiquinone, mitochondrial inner membrane, mitochondrial respiratory chain complex I, mitochondrial respiratory chain complex I assembly, mitochondrion, NADH dehydrogenase (ubiquinone) activity, oxidoreductase activity, acting on NAD(P)H, protein binding, protein-containing complex, respirasome, respiratory chain complex I, respiratory electron transport chain. Use these groups to spot repeated connection types before inspecting the individual relationships.

NDUFA5

Top relations

Bgee · 20
NDUFA5 → Achilles tendon, aortic valve, ascending aorta, biceps brachii, Brodmann area 9, cardiac muscle tissue of left ventricle, dorsolateral prefrontal cortex, endothelial cell, extraocular muscle, facial motor nucleus, germinal epithelium, Ileal epithelium, intercostal muscle, interventricular septum, masseter muscle, plantaris muscle, right auricle of heart, right ventricle, Skeletal muscle tissue of biceps brachii, Skeletal muscle tissue of rectus abdominis
RNA expression pattern · 20
NDUFA5 → Achilles tendon, aortic valve, ascending aorta, biceps brachii, Brodmann area 9, cardiac muscle tissue of left ventricle, dorsolateral prefrontal cortex, endothelial cell, extraocular muscle, facial motor nucleus, germinal epithelium, Ileal epithelium, intercostal muscle, interventricular septum, masseter muscle, plantaris muscle, right auricle of heart, right ventricle, Skeletal muscle tissue of biceps brachii, Skeletal muscle tissue of rectus abdominis
Gene ontology · 13
NDUFA5 → membrane, mitochondrial electron transport, NADH to ubiquinone, mitochondrial inner membrane, mitochondrial respiratory chain complex I, mitochondrial respiratory chain complex I assembly, mitochondrion, NADH dehydrogenase (ubiquinone) activity, oxidoreductase activity, acting on NAD(P)H, protein binding, protein-containing complex, respirasome, respiratory chain complex I, respiratory electron transport chain
related to Function · 12
NDUFA5 → B13, Complex, CoQ, CoQH2, Fe-S, FMN, FMNH2, Initially, NADH, Q10, The, The NDUFA5
related to Structure · 11
NDUFA5 → C-terminal, Complex, IP, It, L-shaped, N-acetylation, N-terminal, NADH, Related, The, The NDUFA5
related to Clinical significance · 4
NDUFA5 → ATP, ATP5F1A, ATP5MC3, Mitochondrial
related to Interactions · 4
NDUFA5 → NADH, NDUFB1, NDUFB10, NDUFB9
Band · 2
NDUFA5 → 6|6 A3.1, 7q31.32
Chr. · 2
NDUFA5 → Chromosome 6 (mouse), Chromosome 7 (human)
End · 2
NDUFA5 → 123,557,904 bp, 24,528,012 bp

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

nadh ubiquinone mitochondrial gene protein bp complex dehydrogenase human membrane inner subunit chr band chromosome hydrophobic chain electrons structure location

NDUFA5 relationships Subject–Predicate–Object triples

TTTA extracted 105 structured relationships around NDUFA5. Examples in this analysis include NDUFA5 → Aliases → NDUFA5, B13, CI-13KD-B, CI-13kB, NUFM, UQOR13, NADH:ubiquinone oxidoreductase subunit A5 and NDUFA5 → Band → 7q31.32. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
NDUFA5AliasesNDUFA5, B13, CI-13KD-B, CI-13kB, NUFM, UQOR13, NADH:ubiquinone oxidoreductase subunit A51.00infobox
NDUFA5Band7q31.321.00infobox
NDUFA5Band6|6 A3.11.00infobox
NDUFA5Bgeeendothelial cell1.00infobox
NDUFA5BgeeSkeletal muscle tissue of rectus abdominis1.00infobox
NDUFA5Bgeeright ventricle1.00infobox
NDUFA5Bgeebiceps brachii1.00infobox
NDUFA5BgeeSkeletal muscle tissue of biceps brachii1.00infobox
NDUFA5BgeeAchilles tendon1.00infobox
NDUFA5Bgeedorsolateral prefrontal cortex1.00infobox
NDUFA5Bgeegerminal epithelium1.00infobox
NDUFA5Bgeeright auricle of heart1.00infobox
NDUFA5BgeeBrodmann area 91.00infobox
NDUFA5Bgeeaortic valve1.00infobox
NDUFA5Bgeefacial motor nucleus1.00infobox
NDUFA5Bgeecardiac muscle tissue of left ventricle1.00infobox
NDUFA5Bgeeascending aorta1.00infobox
NDUFA5Bgeeinterventricular septum1.00infobox
NDUFA5Bgeeextraocular muscle1.00infobox
NDUFA5Bgeeintercostal muscle1.00infobox
NDUFA5Bgeemasseter muscle1.00infobox
NDUFA5BgeeIleal epithelium1.00infobox
NDUFA5Bgeeplantaris muscle1.00infobox
NDUFA5BioGPSMore reference expression data1.00infobox
NDUFA5Chr.Chromosome 7 (human)1.00infobox
NDUFA5Chr.Chromosome 6 (mouse)1.00infobox
NDUFA5DatabasesNCBI: entry; OMA: entry1.00infobox
NDUFA5End123,557,904 bp1.00infobox
NDUFA5End24,528,012 bp1.00infobox
NDUFA5EnsemblENSG000001286091.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around NDUFA5 bring nearby vocabulary together. In this analysis, examples include Ubiquinone, Subunit and Respiratory. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • NDUFA5
    • Ubiquinone
    • Subunit
    • Respiratory
    • Complex
    • Chain
    • Human
    • Inner
    • Membrane
    • Protein
    • Complexes
    • Electron
    • Largest
  • ndufa5
    • Ubiquinone
    • Subunit
    • Respiratory
    • Complex
    • Chain
    • Human
    • Inner
    • Membrane
    • Protein
    • Complexes
    • Electron
    • Largest
  • gene
    • Human
    • Location
    • Chromosome
    • Ubiquinone
    • Bp
    • Chr
    • Subunit
    • End
    • Mouse
    • Nadh
    • Oxidoreductase
    • Ndufa5
  • nadh dehydrogenase (ubiquinone)
    • Nadh
    • Ubiquinone
    • Dehydrogenase
    • Subunit
    • Ndufa5
    • Gene
    • Function
    • Respiratory
    • Chain
    • Complexes
    • Electron
    • Inner
  • mitochondrial inner membrane
    • Membrane
    • Inner
    • Mitochondrial
    • Protein
    • Complex
    • Electron
    • Located
    • Transport
    • Chain
    • Function
    • Hydrophobic
    • Ubiquinone
  • electron transport chain
    • Located
    • Transport
    • Chain
    • Electron
    • Respiratory
    • End
    • Inner
    • Largest
    • Membrane
    • Mouse
    • Oxidoreductase
    • Protein
  • chromosome 7
    • Bp
    • Human
    • Location
    • Band
    • End
    • Mouse
    • Oxidoreductase
    • Gene
    • Function
    • Electron
    • Located
    • Transport
  • mitochondrial membrane
    • Inner
    • Membrane
    • Mitochondrial
    • Protein
    • Complex
    • Electron
    • Transport
    • Chain
    • Function
    • Hydrophobic
    • Ubiquinone
    • Domain

Connections between topic areas Semantic bridges

For NDUFA5, one of the stronger structural bridges in this analysis connects NDUFA5 with Structure. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
NDUFA5 — Structure · splits 24 ⟂ 15
NDUFA5 — Function · splits 31 ⟂ 8
NDUFA5 — Overview · splits 33 ⟂ 6
NDUFA5 — Interactions · splits 34 ⟂ 5
NDUFA5 — Clinical significance · splits 35 ⟂ 4

Map overview Semantic statistics

NDUFA5

Nodes39
Edges38
Triples105
Avg. degree1.95
Density0.051282
Components1

Source & methodology

TTTA analyzes the structure around NDUFA5 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Measurement, Structure & Function, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — NDUFA5 · EN edition · Analysis: TopicsToTalkAbout

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