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NDUFA4: Measurement, Structure & Interactions

NDUFA4, mitochondrial complex associated is a protein that in humans is encoded by the NDUFA4 gene. The NDUFA4 protein was first described to be a subunit of NADH dehydrogenase (ubiquinone), which is located in the mitochondrial inner membrane and is the largest of the five complexes of the electron transport chain. However, recent research has described…

Language: English [EN]
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NDUFA4 topic overview

The analysis highlights Measurement, Structure and Interactions as prominent areas in the source structure around NDUFA4.

Related topics
15
Source areas
3
Connected nodes
18
Extracted relationships
70
Concept neighborhoods
14
Bridge connections
18

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 7 topics
Interactions · 4 topics
Structure · 4 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
NDUFA4, CI-9k, CI-MLRQ, MLRQ, mitochondrial complex associated, COXFA4, NDUFA4 mitochondrial complex associated, MC4DN21, MRCAF1, MISTR1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1LEG, 1LEK, 1MWA, 2CKB
Band
7p21.3
Bgee
right ventricle · myocardium · cerebellar vermis · myocardium of left ventricle · pons
BioGPS
n/a
Chr.
Chromosome 7 (human)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How NDUFA4 connects Entity context

The extracted context around NDUFA4 shows recurring relationship patterns in the source. For example, NDUFA4 → cytochrome-c oxidase activity, membrane, mitochondrial electron transport, cytochrome c to oxygen, mitochondrial electron transport, NADH to ubiquinone, mitochondrial inner membrane, mitochondrial respiratory chain complex I, mitochondrial respiratory chain complex IV, mitochondrion, NADH dehydrogenase (ubiquinone) activity, protein binding, protein-containing complex binding, proton transmembrane transport, respirasome Another extracted example is NDUFA4 → biceps brachii, cardiac muscle tissue of right atrium, cerebellar vermis, lateral nuclear group of thalamus, myocardium, myocardium of left ventricle, pons, prefrontal cortex, right ventricle, Skeletal muscle tissue of biceps brachii. Use these groups to spot repeated connection types before inspecting the individual relationships.

NDUFA4

Top relations

Gene ontology · 13
NDUFA4 → cytochrome-c oxidase activity, membrane, mitochondrial electron transport, cytochrome c to oxygen, mitochondrial electron transport, NADH to ubiquinone, mitochondrial inner membrane, mitochondrial respiratory chain complex I, mitochondrial respiratory chain complex IV, mitochondrion, NADH dehydrogenase (ubiquinone) activity, protein binding, protein-containing complex binding, proton transmembrane transport, respirasome
Bgee · 10
NDUFA4 → biceps brachii, cardiac muscle tissue of right atrium, cerebellar vermis, lateral nuclear group of thalamus, myocardium, myocardium of left ventricle, pons, prefrontal cortex, right ventricle, Skeletal muscle tissue of biceps brachii
RNA expression pattern · 10
NDUFA4 → biceps brachii, cardiac muscle tissue of right atrium, cerebellar vermis, lateral nuclear group of thalamus, myocardium, myocardium of left ventricle, pons, prefrontal cortex, right ventricle, Skeletal muscle tissue of biceps brachii
related to Clinical significance · 8
NDUFA4 → Complex, Complex IV, COX, Disruption, Given, Leigh, Leigh's, Mutations
related to Interactions · 3
NDUFA4 → CUL3, PARK7, UBL4A
related to Structure · 3
NDUFA4 → Complex, NADH, The NDUFA4
Aliases · 1
NDUFA4 → NDUFA4, CI-9k, CI-MLRQ, MLRQ, mitochondrial complex associated, COXFA4, NDUFA4 mitochondrial complex associated, MC4DN21, MRCAF1, MISTR1
Available structures · 1
NDUFA4 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1LEG, 1LEK, 1MWA, 2CKB
Band · 1
NDUFA4 → 7p21.3
BioGPS · 1
NDUFA4 → n/a

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

gene complex protein mitochondrial subunit chromosome associated human bp iv nadh dehydrogenase ubiquinone cytochrome oxidase chr mutations syndrome described membrane

NDUFA4 relationships Subject–Predicate–Object triples

TTTA extracted 70 structured relationships around NDUFA4. Examples in this analysis include NDUFA4 → Aliases → NDUFA4, CI-9k, CI-MLRQ, MLRQ, mitochondrial complex associated, COXFA4, NDUFA4 mitochondrial complex associated, MC4DN21, MRCAF1, MISTR1 and NDUFA4 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1LEG, 1LEK, 1MWA, 2CKB. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
NDUFA4AliasesNDUFA4, CI-9k, CI-MLRQ, MLRQ, mitochondrial complex associated, COXFA4, NDUFA4 mitochondrial complex associated, MC4DN21, MRCAF1, MISTR11.00infobox
NDUFA4Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1LEG, 1LEK, 1MWA, 2CKB1.00infobox
NDUFA4Band7p21.31.00infobox
NDUFA4Bgeeright ventricle1.00infobox
NDUFA4Bgeemyocardium1.00infobox
NDUFA4Bgeecerebellar vermis1.00infobox
NDUFA4Bgeemyocardium of left ventricle1.00infobox
NDUFA4Bgeepons1.00infobox
NDUFA4Bgeecardiac muscle tissue of right atrium1.00infobox
NDUFA4Bgeeprefrontal cortex1.00infobox
NDUFA4Bgeebiceps brachii1.00infobox
NDUFA4BgeeSkeletal muscle tissue of biceps brachii1.00infobox
NDUFA4Bgeelateral nuclear group of thalamus1.00infobox
NDUFA4BioGPSn/a1.00infobox
NDUFA4Chr.Chromosome 7 (human)1.00infobox
NDUFA4DatabasesNCBI: entry; OMA: entry1.00infobox
NDUFA4End10,940,153 bp1.00infobox
NDUFA4EnsemblENSG000001890431.00infobox
NDUFA4Entrez46971.00infobox
NDUFA4External IDsOMIM: 603833; MGI: 107686; GeneCards: NDUFA41.00infobox
NDUFA4Gene location (Human)Gene location (Human)Chr.Chromosome 7 (human)Band7p21.3Start10,931,943 bpEnd10,940,153 bp1.00infobox
NDUFA4Gene ontologyNADH dehydrogenase (ubiquinone) activity1.00infobox
NDUFA4Gene ontologycytochrome-c oxidase activity1.00infobox
NDUFA4Gene ontologyprotein binding1.00infobox
NDUFA4Gene ontologyprotein-containing complex binding1.00infobox
NDUFA4Gene ontologymitochondrial inner membrane1.00infobox
NDUFA4Gene ontologymitochondrial respiratory chain complex I1.00infobox
NDUFA4Gene ontologyrespirasome1.00infobox
NDUFA4Gene ontologymembrane1.00infobox
NDUFA4Gene ontologymitochondrion1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around NDUFA4 bring nearby vocabulary together. In this analysis, examples include Gene, Protein and Subunit. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • NDUFA4
    • Gene
    • Protein
    • Subunit
    • Dehydrogenase
    • Mutations
    • Nadh
    • Ubiquinone
    • Iv
    • Chain
    • Complexes
    • Described
    • Electron
  • ndufa4
    • Gene
    • Protein
    • Subunit
    • Dehydrogenase
    • Mutations
    • Nadh
    • Ubiquinone
    • Iv
    • Chain
    • Complexes
    • Described
    • Electron
  • gene
    • Ndufa4
    • Mitochondrial
    • Protein
    • Leigh's
    • Location
    • Search
    • Structure
    • Bp
    • Chr
    • Chromosome
    • Human
    • Mutations
  • nadh dehydrogenase (ubiquinone)
    • Dehydrogenase
    • Nadh
    • Ubiquinone
    • Chain
    • Complexes
    • Electron
    • Inner
    • Largest
    • Located
    • Membrane
    • Transport
    • Mitochondrial
  • mitochondrial inner membrane
    • Chain
    • Electron
    • Located
    • Membrane
    • Transport
    • Nadh
    • Ubiquinone
    • Protein
    • Inner
    • Location
    • Mitochondrial
    • Search
  • electron transport chain
    • Chain
    • Electron
    • Inner
    • Located
    • Membrane
    • Transport
    • Dehydrogenase
    • Nadh
    • Ubiquinone
    • Mitochondrial
    • Protein
    • Band
  • cytochrome c oxidase
    • Oxidase
    • Iv
    • Band
    • Described
    • Electron
    • However
    • Inner
    • Located
    • Location
    • Membrane
    • Recent
    • Research
  • complex i
    • Iv
    • Ndufa4
    • Gene
    • Mitochondrial
    • Location
    • Search
    • Structure
    • Associated
    • Bp
    • Chr
    • Chromosome
    • Cytochrome

Connections between topic areas Semantic bridges

For NDUFA4, one of the stronger structural bridges in this analysis connects NDUFA4 with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
NDUFA4Overview · splits 11 ⟂ 8
NDUFA4Structure · splits 14 ⟂ 5
NDUFA4Interactions · splits 14 ⟂ 5

Map overview Semantic statistics

NDUFA4

Nodes19
Edges18
Triples70
Avg. degree1.89
Density0.105263
Components1

Source & methodology

TTTA analyzes the structure around NDUFA4 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Measurement, Structure & Interactions, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — NDUFA4 · EN edition · Analysis: TopicsToTalkAbout

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