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NDUFA2: Measurement, Structure & Function

NADH dehydrogenase 1 alpha subcomplex subunit 2 is a protein that in humans is encoded by the NDUFA2 gene. The NDUFA2 protein is a subunit of NADH dehydrogenase (ubiquinone), which is located in the mitochondrial inner membrane and is the largest of the five complexes of the electron transport chain. Mutations in the NDUFA2 gene are associated with…

Language: English [EN]
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NDUFA2 topic overview

The analysis highlights Measurement, Structure and Function as prominent areas in the source structure around NDUFA2.

Related topics
26
Source areas
4
Connected nodes
30
Extracted relationships
102
Concept neighborhoods
17
Bridge connections
30

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Structure · 11 topics
Function · 8 topics
Overview · 6 topics
Interactions · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
NDUFA2, B8, CD14, CIB8, NADH:ubiquinone oxidoreductase subunit A2, MC1DN13
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1S3A
Band
5q31.3 · 18|18 B2
Bgee
biceps brachii · right ventricle · Skeletal muscle tissue of biceps brachii · apex of heart · triceps brachii muscle
BioGPS
More reference expression data
Chr.
Chromosome 5 (human) · Chromosome 18 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure

Function

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How NDUFA2 connects Entity context

The extracted context around NDUFA2 shows recurring relationship patterns in the source. For example, NDUFA2 → aortic valve, apex of heart, ascending aorta, biceps brachii, body of tongue, condyle, facial motor nucleus, fossa, intercostal muscle, left ventricle, medullary collecting duct, mucosa of transverse colon, Paneth cell, renal corpuscle, right kidney, right ventricle, Skeletal muscle tissue of biceps brachii, thoracic diaphragm, triceps brachii muscle, vastus lateralis muscle Another extracted example is NDUFA2 → blastocyst hatching, membrane, mitochondrial electron transport, NADH to ubiquinone, mitochondrial inner membrane, mitochondrial membranes, mitochondrial respiratory chain complex I, mitochondrial respiratory chain complex I assembly, mitochondrion, NADH dehydrogenase (ubiquinone) activity, respirasome. Use these groups to spot repeated connection types before inspecting the individual relationships.

NDUFA2

Top relations

Bgee · 20
NDUFA2 → aortic valve, apex of heart, ascending aorta, biceps brachii, body of tongue, condyle, facial motor nucleus, fossa, intercostal muscle, left ventricle, medullary collecting duct, mucosa of transverse colon, Paneth cell, renal corpuscle, right kidney, right ventricle, Skeletal muscle tissue of biceps brachii, thoracic diaphragm, triceps brachii muscle, vastus lateralis muscle
RNA expression pattern · 20
NDUFA2 → aortic valve, apex of heart, ascending aorta, biceps brachii, body of tongue, condyle, facial motor nucleus, fossa, intercostal muscle, left ventricle, medullary collecting duct, mucosa of transverse colon, Paneth cell, renal corpuscle, right kidney, right ventricle, Skeletal muscle tissue of biceps brachii, thoracic diaphragm, triceps brachii muscle, vastus lateralis muscle
Gene ontology · 10
NDUFA2 → blastocyst hatching, membrane, mitochondrial electron transport, NADH to ubiquinone, mitochondrial inner membrane, mitochondrial membranes, mitochondrial respiratory chain complex I, mitochondrial respiratory chain complex I assembly, mitochondrion, NADH dehydrogenase (ubiquinone) activity, respirasome
related to Function · 10
NDUFA2 → Complex, CoQ, CoQH2, Fe-S, FMN, FMNH2, Initially, NADH, Q10, The
related to Structure · 8
NDUFA2 → C-terminal, Complex, It, L-shaped, N-terminal, NADH, The, The NDUFA2
related to Clinical significance · 6
NDUFA2 → Complex, Leigh's, Mutations, One, The NDUFA2, This
related to Interactions · 3
NDUFA2 → Complex, NADH, This
Band · 2
NDUFA2 → 18|18 B2, 5q31.3
Chr. · 2
NDUFA2 → Chromosome 18 (mouse), Chromosome 5 (human)
End · 2
NDUFA2 → 140,647,771 bp, 36,877,610 bp

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

nadh gene ubiquinone complex protein bp subunit human dehydrogenase chr band chromosome mitochondrial membrane inner chain hydrophobic redox assembly location

NDUFA2 relationships Subject–Predicate–Object triples

TTTA extracted 102 structured relationships around NDUFA2. Examples in this analysis include NDUFA2 → Aliases → NDUFA2, B8, CD14, CIB8, NADH:ubiquinone oxidoreductase subunit A2, MC1DN13 and NDUFA2 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1S3A. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
NDUFA2AliasesNDUFA2, B8, CD14, CIB8, NADH:ubiquinone oxidoreductase subunit A2, MC1DN131.00infobox
NDUFA2Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1S3A1.00infobox
NDUFA2Band5q31.31.00infobox
NDUFA2Band18|18 B21.00infobox
NDUFA2Bgeebiceps brachii1.00infobox
NDUFA2Bgeeright ventricle1.00infobox
NDUFA2BgeeSkeletal muscle tissue of biceps brachii1.00infobox
NDUFA2Bgeeapex of heart1.00infobox
NDUFA2Bgeetriceps brachii muscle1.00infobox
NDUFA2Bgeemucosa of transverse colon1.00infobox
NDUFA2Bgeevastus lateralis muscle1.00infobox
NDUFA2Bgeethoracic diaphragm1.00infobox
NDUFA2Bgeeleft ventricle1.00infobox
NDUFA2Bgeebody of tongue1.00infobox
NDUFA2Bgeeaortic valve1.00infobox
NDUFA2Bgeefossa1.00infobox
NDUFA2Bgeefacial motor nucleus1.00infobox
NDUFA2Bgeeascending aorta1.00infobox
NDUFA2Bgeemedullary collecting duct1.00infobox
NDUFA2Bgeecondyle1.00infobox
NDUFA2Bgeerenal corpuscle1.00infobox
NDUFA2Bgeeintercostal muscle1.00infobox
NDUFA2Bgeeright kidney1.00infobox
NDUFA2BgeePaneth cell1.00infobox
NDUFA2BioGPSMore reference expression data1.00infobox
NDUFA2Chr.Chromosome 5 (human)1.00infobox
NDUFA2Chr.Chromosome 18 (mouse)1.00infobox
NDUFA2DatabasesNCBI: entry; OMA: entry1.00infobox
NDUFA2End140,647,771 bp1.00infobox
NDUFA2End36,877,610 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around NDUFA2 bring nearby vocabulary together. In this analysis, examples include Ubiquinone, Subunit and Protein. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • NDUFA2
    • Ubiquinone
    • Subunit
    • Protein
    • Complex
    • Respiratory
    • Chain
    • Human
    • Associated
    • Complexes
    • Electron
    • Largest
    • Leigh's
  • ndufa2
    • Ubiquinone
    • Subunit
    • Protein
    • Complex
    • Respiratory
    • Chain
    • Human
    • Associated
    • Complexes
    • Electron
    • Largest
    • Leigh's
  • protein
    • Mitochondrial
    • Ubiquinone
    • Chain
    • Inner
    • Membrane
    • Ndufa2
    • Electron
    • Located
    • Subcomplex
    • Transport
    • Function
    • Complex
  • gene
    • Ndufa2
    • Human
    • Location
    • Chromosome
    • Ubiquinone
    • Bp
    • Chr
    • Nadh
    • Subunit
    • Leigh's
    • Mouse
    • Mutations
  • nadh dehydrogenase (ubiquinone)
    • Nadh
    • Ubiquinone
    • Dehydrogenase
    • Subunit
    • Ndufa2
    • Protein
    • Complexes
    • Electron
    • Largest
    • Located
    • Subcomplex
    • Transport
  • mitochondrial inner membrane
    • Membrane
    • Inner
    • Mitochondrial
    • Chain
    • Electron
    • Located
    • Protein
    • Transport
    • Domain
    • Function
    • Hydrophobic
    • Ubiquinone
  • electron transport chain
    • Located
    • Transport
    • Chain
    • Electron
    • Inner
    • Membrane
    • Mitochondrial
    • Respiratory
    • Protein
    • Electrons
    • Largest
    • Mouse
  • chromosome 5
    • Bp
    • Human
    • Location
    • Band
    • Mouse
    • Function
    • Gene
    • Electron
    • Located
    • Transport
    • Ubiquinone
    • Activity

Connections between topic areas Semantic bridges

For NDUFA2, one of the stronger structural bridges in this analysis connects NDUFA2 with Structure. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
NDUFA2Structure · splits 19 ⟂ 12
NDUFA2Function · splits 22 ⟂ 9
NDUFA2Overview · splits 24 ⟂ 7

Map overview Semantic statistics

NDUFA2

Nodes31
Edges30
Triples102
Avg. degree1.94
Density0.064516
Components1

Source & methodology

TTTA analyzes the structure around NDUFA2 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Measurement, Structure & Function, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — NDUFA2 · EN edition · Analysis: TopicsToTalkAbout

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