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MT-ND1: Measurement, Structure & Clinical significance

MT-ND1 is a gene of the mitochondrial genome coding for the NADH-ubiquinone oxidoreductase chain 1 (ND1) protein. The ND1 protein is a subunit of NADH dehydrogenase, which is located in the mitochondrial inner membrane and is the largest of the five complexes of the electron transport chain. Variants of the human MT-ND1 gene are associated with…

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MT-ND1 topic overview

The analysis highlights Measurement, Structure and Clinical significance as prominent areas in the source structure around MT-ND1.

Related topics
36
Source areas
4
Connected nodes
40
Extracted relationships
128
Concept neighborhoods
20
Bridge connections
40

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Structure · 11 topics
Clinical significance · 9 topics
Overview · 9 topics
Function · 7 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

7.1.1.2
Aliases
ND1, MTMT-NADH dehydrogenase, subunit 1 (complex I), NADH dehydrogenase subunit 1
Band
n/a
Bgee
subcutaneous adipose tissue · right hemisphere of cerebellum · right testis · right frontal lobe · left testis
BioGPS
n/a
Chr.
Mitochondrial DNA (human) · Mitochondrial DNA (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure

Function

Clinical significance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How MT-ND1 connects Entity context

The extracted context around MT-ND1 shows recurring relationship patterns in the source. For example, MT-ND1 → A/MT-ND1, Abnormalities, BMI, Leber's, Leigh, Leigh-like, LHON, MELAS, Mitochondrial, MT-ATP6, MT-CO3, MT-ND2, MT-ND3, MT-ND4, MT-ND4L, MT-ND5, MT-ND6, MT-TK, MT-TL1, MT-TV Another extracted example is MT-ND1 → aerobic dissimilation, cellular respiration, dendrite, integral component of membrane, membrane, mitochondrial electron transport, NADH to ubiquinone, mitochondrial inner membrane, mitochondrial membranes, mitochondrial respiratory chain complex I, mitochondrial respiratory chain complex I assembly, mitochondrion, NADH dehydrogenase (ubiquinone) activity, NADH dehydrogenase activity, oxidoreductase activity, protein binding, respirasome, response to hydroperoxide, response to organic cyclic compound, soma. Use these groups to spot repeated connection types before inspecting the individual relationships.

MT-ND1

Top relations

related to Clinical significance · 25
MT-ND1 → A/MT-ND1, Abnormalities, BMI, Leber's, Leigh, Leigh-like, LHON, MELAS, Mitochondrial, MT-ATP6, MT-CO3, MT-ND2, MT-ND3, MT-ND4, MT-ND4L, MT-ND5, MT-ND6, MT-TK, MT-TL1, MT-TV
Gene ontology · 19
MT-ND1 → aerobic dissimilation, cellular respiration, dendrite, integral component of membrane, membrane, mitochondrial electron transport, NADH to ubiquinone, mitochondrial inner membrane, mitochondrial membranes, mitochondrial respiratory chain complex I, mitochondrial respiratory chain complex I assembly, mitochondrion, NADH dehydrogenase (ubiquinone) activity, NADH dehydrogenase activity, oxidoreductase activity, protein binding, respirasome, response to hydroperoxide, response to organic cyclic compound, soma
Bgee · 18
MT-ND1 → cerebellum, gastrocnemius muscle, genital tubercle, hypothalamus, left testis, olfactory bulb, olfactory zone of nasal mucosa, prefrontal cortex, primary visual cortex, right frontal lobe, right hemisphere of cerebellum, right kidney, right testis, striatum of neuraxis, subcutaneous adipose tissue, superior frontal gyrus, tail of embryo, yolk sac
RNA expression pattern · 18
MT-ND1 → cerebellum, gastrocnemius muscle, genital tubercle, hypothalamus, left testis, olfactory bulb, olfactory zone of nasal mucosa, prefrontal cortex, primary visual cortex, right frontal lobe, right hemisphere of cerebellum, right kidney, right testis, striatum of neuraxis, subcutaneous adipose tissue, superior frontal gyrus, tail of embryo, yolk sac
related to Structure · 13
MT-ND1 → Also, Complex, DNA, L-shaped, MT-ND2, MT-ND3, MT-ND4, MT-ND4L, MT-ND5, MT-ND6, NADH, The, The MT-ND1
related to Function · 11
MT-ND1 → Complex, CoQ, CoQH2, Fe-S, FMN, FMNH2, Initially, MT-ND1-encoded NADH-ubiquinone, NADH, Q10, The
Chr. · 2
MT-ND1 → Mitochondrial DNA (human), Mitochondrial DNA (mouse)
End · 2
MT-ND1 → 3,707 bp, 4,262 bp
related to External links · 2
MT-ND1 → COPaKB, Mass
7.1.1.2 · 1
MT-ND1 → ↗

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

mitochondrial gene nadh human bp protein complex chain chr band dna syndrome dehydrogenase nd1 respiratory oxidoreductase subunit electron location ubiquinone

MT-ND1 relationships Subject–Predicate–Object triples

TTTA extracted 128 structured relationships around MT-ND1. Examples in this analysis include MT-ND1 → 7.1.1.2 → ↗ and MT-ND1 → Aliases → ND1, MTMT-NADH dehydrogenase, subunit 1 (complex I), NADH dehydrogenase subunit 1. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
MT-ND17.1.1.21.00infobox
MT-ND1AliasesND1, MTMT-NADH dehydrogenase, subunit 1 (complex I), NADH dehydrogenase subunit 11.00infobox
MT-ND1Bandn/a1.00infobox
MT-ND1Bgeesubcutaneous adipose tissue1.00infobox
MT-ND1Bgeeright hemisphere of cerebellum1.00infobox
MT-ND1Bgeeright testis1.00infobox
MT-ND1Bgeeright frontal lobe1.00infobox
MT-ND1Bgeeleft testis1.00infobox
MT-ND1Bgeegastrocnemius muscle1.00infobox
MT-ND1Bgeesuperior frontal gyrus1.00infobox
MT-ND1Bgeeprimary visual cortex1.00infobox
MT-ND1Bgeeolfactory zone of nasal mucosa1.00infobox
MT-ND1Bgeeprefrontal cortex1.00infobox
MT-ND1Bgeetail of embryo1.00infobox
MT-ND1Bgeestriatum of neuraxis1.00infobox
MT-ND1Bgeeolfactory bulb1.00infobox
MT-ND1Bgeeyolk sac1.00infobox
MT-ND1Bgeecerebellum1.00infobox
MT-ND1Bgeehypothalamus1.00infobox
MT-ND1Bgeegenital tubercle1.00infobox
MT-ND1Bgeeright kidney1.00infobox
MT-ND1BioGPSn/a1.00infobox
MT-ND1Chr.Mitochondrial DNA (human)1.00infobox
MT-ND1Chr.Mitochondrial DNA (mouse)1.00infobox
MT-ND1DatabasesNCBI: entry; OMA: entry1.00infobox
MT-ND1End4,262 bp1.00infobox
MT-ND1End3,707 bp1.00infobox
MT-ND1EnsemblENSG000001988881.00infobox
MT-ND1Entrez45351.00infobox
MT-ND1Enzyme activityEnzyme activityEC #BRENDAExPASyKEGGMetaCyc7.1.1.2↗↗↗↗1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around MT-ND1 bring nearby vocabulary together. In this analysis, examples include Mt-nd2, Variants and Protein. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • MT-ND1
    • Mt-nd2
    • Variants
    • Protein
    • Syndrome
    • Genes
    • Oxidoreductase
    • Resulting
    • Ubiquinone
    • Dehydrogenase
    • Leigh
    • Chain
    • Human
  • mt-nd1
    • Mt-nd2
    • Variants
    • Protein
    • Syndrome
    • Genes
    • Oxidoreductase
    • Resulting
    • Ubiquinone
    • Dehydrogenase
    • Leigh
    • Chain
    • Human
  • gene
    • Human
    • Location
    • Mitochondrial
    • Mt-nd1
    • Dna
    • Bp
    • Chr
    • Protein
    • Function
    • Mouse
    • Nd1
    • Oxidoreductase
  • mitochondrial genome
    • Mt-nd1
    • Human
    • Syndrome
    • Dehydrogenase
    • Dna
    • Leigh
    • Bp
    • Chain
    • Chr
    • Protein
    • Nadh
    • Genes
  • nadh dehydrogenase
    • Dehydrogenase
    • Nadh
    • Function
    • Inner
    • Membrane
    • Transport
    • Electron
    • Subunit
    • Ubiquinone
    • Complex
    • Enzyme
    • Location
  • mitochondrial inner membrane
    • Membrane
    • Transport
    • Electron
    • Protein
    • Mt-nd1
    • Human
    • Syndrome
    • Function
    • Mouse
    • Dehydrogenase
    • Dna
    • Leigh
  • electron transport chain
    • Inner
    • Membrane
    • Protein
    • Transport
    • Electron
    • Oxidoreductase
    • Subunit
    • Ubiquinone
    • Nadh
    • Respiratory
    • Nd1
    • Dehydrogenase
  • mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes
    • Mt-nd1
    • Human
    • Syndrome
    • Dehydrogenase
    • Dna
    • Leigh
    • Bp
    • Chain
    • Chr
    • Protein
    • Nadh
    • Genes

Connections between topic areas Semantic bridges

For MT-ND1, one of the stronger structural bridges in this analysis connects MT-ND1 with Structure. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
MT-ND1Structure · splits 29 ⟂ 12
MT-ND1Overview · splits 31 ⟂ 10
MT-ND1Clinical significance · splits 31 ⟂ 10
MT-ND1Function · splits 33 ⟂ 8

Map overview Semantic statistics

MT-ND1

Nodes41
Edges40
Triples128
Avg. degree1.95
Density0.04878
Components1

Source & methodology

TTTA analyzes the structure around MT-ND1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Measurement, Structure & Clinical significance, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — MT-ND1 · EN edition · Analysis: TopicsToTalkAbout

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