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MT-ND6: Measurement, Structure & Function

MT-ND6 is a gene of the mitochondrial genome coding for the NADH-ubiquinone oxidoreductase chain 6 protein (ND6). The ND6 protein is a subunit of NADH dehydrogenase (ubiquinone), which is located in the mitochondrial inner membrane and is the largest of the five complexes of the electron transport chain. Variations in the human MT-ND6 gene are associated…

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MT-ND6 topic overview

The analysis highlights Measurement, Structure and Function as prominent areas in the source structure around MT-ND6.

Related topics
35
Source areas
5
Connected nodes
40
Extracted relationships
132
Concept neighborhoods
15
Bridge connections
40

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Structure · 10 topics
Overview · 9 topics
Function · 7 topics
Clinical significance · 6 topics
Interactions · 3 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

7.1.1.2
Aliases
ND6, MTMT-NADH dehydrogenase, subunit 6 (complex I), NADH dehydrogenase subunit 6
Band
n/a
Bgee
gastric mucosa · left uterine tube · right uterine tube · right auricle of heart · granulocyte
BioGPS
n/a
Chr.
Mitochondrial DNA (human) · Mitochondrial DNA (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure

Function

Clinical significance

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How MT-ND6 connects Entity context

The extracted context around MT-ND6 shows recurring relationship patterns in the source. For example, MT-ND6 → adrenal gland, amygdala, bone marrow, caudate nucleus, cerebellar cortex, fundus, gastric mucosa, granulocyte, hippocampus proper, human kidney, hypothalamus, left uterine tube, neural layer of retina, nucleus accumbens, primary visual cortex, putamen, right auricle of heart, right uterine tube, striatum of neuraxis, superior frontal gyrus Another extracted example is MT-ND6 → Additional, Affected, ATP, Complex, French Canadian, Heart, It, Leber, Leber's, Leigh, Leigh's, LHON, NADH, NADH-ubiquinone, Researchers, ROS, The T14484C, These, This, This MT-ND6 G14459A. Use these groups to spot repeated connection types before inspecting the individual relationships.

MT-ND6

Top relations

Bgee · 20
MT-ND6 → adrenal gland, amygdala, bone marrow, caudate nucleus, cerebellar cortex, fundus, gastric mucosa, granulocyte, hippocampus proper, human kidney, hypothalamus, left uterine tube, neural layer of retina, nucleus accumbens, primary visual cortex, putamen, right auricle of heart, right uterine tube, striatum of neuraxis, superior frontal gyrus
RNA expression pattern · 20
MT-ND6 → adrenal gland, amygdala, bone marrow, caudate nucleus, cerebellar cortex, fundus, gastric mucosa, granulocyte, hippocampus proper, human kidney, hypothalamus, left uterine tube, neural layer of retina, nucleus accumbens, primary visual cortex, putamen, right auricle of heart, right uterine tube, striatum of neuraxis, superior frontal gyrus
related to Clinical significance · 20
MT-ND6 → Additional, Affected, ATP, Complex, French Canadian, Heart, It, Leber, Leber's, Leigh, Leigh's, LHON, NADH, NADH-ubiquinone, Researchers, ROS, The T14484C, These, This, This MT-ND6 G14459A
related to Structure · 14
MT-ND6 → Also, Complex, DNA, L-shaped, L-strand, MT-ND1, MT-ND2, MT-ND3, MT-ND4, MT-ND4L, MT-ND5, NADH, The, The MT-ND6
Gene ontology · 13
MT-ND6 → integral component of membrane, membrane, mitochondrial electron transport, NADH to ubiquinone, mitochondrial inner membrane, mitochondrial membranes, mitochondrial respiratory chain complex I assembly, mitochondrion, NADH dehydrogenase (ubiquinone) activity, oxidoreductase activity, respirasome, response to cocaine, response to hydrogen peroxide, response to nicotine
related to Function · 11
MT-ND6 → Complex, CoQ, CoQH2, Fe-S, FMN, FMNH2, Initially, NADH, Q10, The, The MT-ND6
related to External links · 7
MT-ND6 → COPaKB, GeneReviews/NCBI/NIH/UW, Mass, Medicine, Mitochondrial DNA-Associated Leigh Syndrome, NARP This, United States National Library
related to Interactions · 4
MT-ND6 → ATP-dependent, NADH, NDUFS3, YME1L1
Chr. · 2
MT-ND6 → Mitochondrial DNA (human), Mitochondrial DNA (mouse)
End · 2
MT-ND6 → 14,070 bp, 14,673 bp

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

gene mitochondrial nadh human protein complex ubiquinone bp chain mutation dehydrogenase chr band people dna also optic lhon nd6 syndrome

MT-ND6 relationships Subject–Predicate–Object triples

TTTA extracted 132 structured relationships around MT-ND6. Examples in this analysis include MT-ND6 → 7.1.1.2 → ↗ and MT-ND6 → Aliases → ND6, MTMT-NADH dehydrogenase, subunit 6 (complex I), NADH dehydrogenase subunit 6. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
MT-ND67.1.1.21.00infobox
MT-ND6AliasesND6, MTMT-NADH dehydrogenase, subunit 6 (complex I), NADH dehydrogenase subunit 61.00infobox
MT-ND6Bandn/a1.00infobox
MT-ND6Bgeegastric mucosa1.00infobox
MT-ND6Bgeeleft uterine tube1.00infobox
MT-ND6Bgeeright uterine tube1.00infobox
MT-ND6Bgeeright auricle of heart1.00infobox
MT-ND6Bgeegranulocyte1.00infobox
MT-ND6Bgeenucleus accumbens1.00infobox
MT-ND6Bgeeputamen1.00infobox
MT-ND6Bgeecaudate nucleus1.00infobox
MT-ND6Bgeeamygdala1.00infobox
MT-ND6Bgeefundus1.00infobox
MT-ND6Bgeeneural layer of retina1.00infobox
MT-ND6Bgeeadrenal gland1.00infobox
MT-ND6Bgeehypothalamus1.00infobox
MT-ND6Bgeestriatum of neuraxis1.00infobox
MT-ND6Bgeebone marrow1.00infobox
MT-ND6Bgeehippocampus proper1.00infobox
MT-ND6Bgeesuperior frontal gyrus1.00infobox
MT-ND6Bgeehuman kidney1.00infobox
MT-ND6Bgeecerebellar cortex1.00infobox
MT-ND6Bgeeprimary visual cortex1.00infobox
MT-ND6BioGPSn/a1.00infobox
MT-ND6Chr.Mitochondrial DNA (human)1.00infobox
MT-ND6Chr.Mitochondrial DNA (mouse)1.00infobox
MT-ND6DatabasesNCBI: entry; OMA: entry1.00infobox
MT-ND6End14,673 bp1.00infobox
MT-ND6End14,070 bp1.00infobox
MT-ND6EnsemblENSG000001986951.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around MT-ND6 bring nearby vocabulary together. In this analysis, examples include Syndrome, Lhon and Chain. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • MT-ND6
    • Syndrome
    • Lhon
    • Chain
    • Ubiquinone
    • Mutation
    • Protein
    • Leber's
    • Nadh
    • Oxidoreductase
    • Hereditary
    • Neuropathy
    • Optic
  • mt-nd6
    • Syndrome
    • Lhon
    • Chain
    • Ubiquinone
    • Mutation
    • Protein
    • Leber's
    • Nadh
    • Oxidoreductase
    • Hereditary
    • Neuropathy
    • Optic
  • gene
    • Mt-nd6
    • Human
    • Leber's
    • Location
    • Dna
    • Hereditary
    • Neuropathy
    • Syndrome
    • Mitochondrial
    • Bp
    • Chr
    • Lhon
  • mitochondrial genome
    • Dna
    • Bp
    • Chr
    • Chain
    • Dehydrogenase
    • Human
    • Location
    • Nd6
    • Protein
    • Band
    • Nadh
    • Ubiquinone
  • nadh dehydrogenase (ubiquinone)
    • Dehydrogenase
    • Nadh
    • Ubiquinone
    • Protein
    • Mitochondrial
    • Electron
    • Membrane
    • Subunit
    • Complex
    • Activity
    • Enzyme
    • Located
  • mitochondrial inner membrane
    • Electron
    • Dna
    • Bp
    • Chr
    • Chain
    • Dehydrogenase
    • Human
    • Location
    • Mouse
    • Nd6
    • Ubiquinone
    • Protein
  • electron transport chain
    • Membrane
    • Protein
    • Electron
    • Located
    • Oxidoreductase
    • Subunit
    • Ubiquinone
    • Mitochondrial
    • Nadh
    • Nd6
    • Mouse
    • Mt-nd6
  • complex i
    • Activity
    • Nadh
    • Ubiquinone
    • Electron
    • Enzyme
    • Location
    • Subunit
    • Dna
    • Bp
    • Chr
    • Also
    • Dehydrogenase

Connections between topic areas Semantic bridges

For MT-ND6, one of the stronger structural bridges in this analysis connects MT-ND6 with Structure. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
MT-ND6Structure · splits 30 ⟂ 11
MT-ND6Overview · splits 31 ⟂ 10
MT-ND6Function · splits 33 ⟂ 8
MT-ND6Clinical significance · splits 34 ⟂ 7
MT-ND6Interactions · splits 37 ⟂ 4

Map overview Semantic statistics

MT-ND6

Nodes41
Edges40
Triples132
Avg. degree1.95
Density0.04878
Components1

Source & methodology

TTTA analyzes the structure around MT-ND6 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Measurement, Structure & Function, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — MT-ND6 · EN edition · Analysis: TopicsToTalkAbout

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