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RAD51C: Function, Mutation, splicing, and epigenetic deficiency in cancer & Clinical significance

RAD51 homolog C (S. cerevisiae), also known as RAD51C, is a protein which in humans is encoded by the RAD51C gene.

Language: English [EN]
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RAD51C topic overview

The analysis highlights Function, Mutation, splicing, and epigenetic deficiency in cancer and Clinical significance as prominent areas in the source structure around RAD51C.

Related topics
31
Source areas
5
Connected nodes
36
Extracted relationships
119
Concept neighborhoods
20
Bridge connections
36

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 14 topics
Mutation, splicing, and epigenetic deficiency in cancer · 10 topics
Clinical significance · 4 topics
Overview · 2 topics
Interactions · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
RAD51C, BROVCA3, FANCO, R51H3, RAD51L2, RAD51 paralog C
Band
17q22 · 11 C|11 52.08 cM
Bgee
gonad · right testis · left testis · testicle · right frontal lobe
BioGPS
More reference expression data
Chr.
Chromosome 17 (human) · Chromosome 11 (mouse)
Databases
NCBI: entry; OMA: entry

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Clinical significance

Mutation, splicing, and epigenetic deficiency in cancer

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How RAD51C connects Entity context

The extracted context around RAD51C shows recurring relationship patterns in the source. For example, RAD51C → ATP binding, ATP-dependent activity, acting on DNA, blood coagulation, cell junction, cellular response to DNA damage stimulus, crossover junction endodeoxyribonuclease activity, cytoplasm, cytosol, DNA binding, DNA recombination, DNA repair, DNA strand exchange activity, double-strand break repair via homologous recombination, double-stranded DNA binding, female meiosis sister chromatid cohesion, four-way junction DNA binding, Holliday junction resolvase complex, intracellular membrane-bounded organelle, male meiosis I, meiotic DNA recombinase assembly Another extracted example is RAD51C → atrioventricular valve, Brodmann area 9, endocardial cushion, gonad, left testis, neural layer of retina, oocyte, prefrontal cortex, primary oocyte, right auricle of heart, right frontal lobe, right testis, secondary oocyte, seminiferous tubule, spermatocyte, tail of embryo, testicle, ventricular zone, zygote. Use these groups to spot repeated connection types before inspecting the individual relationships.

RAD51C

Top relations

Gene ontology · 38
RAD51C → ATP binding, ATP-dependent activity, acting on DNA, blood coagulation, cell junction, cellular response to DNA damage stimulus, crossover junction endodeoxyribonuclease activity, cytoplasm, cytosol, DNA binding, DNA recombination, DNA repair, DNA strand exchange activity, double-strand break repair via homologous recombination, double-stranded DNA binding, female meiosis sister chromatid cohesion, four-way junction DNA binding, Holliday junction resolvase complex, intracellular membrane-bounded organelle, male meiosis I, meiotic DNA recombinase assembly
Bgee · 19
RAD51C → atrioventricular valve, Brodmann area 9, endocardial cushion, gonad, left testis, neural layer of retina, oocyte, prefrontal cortex, primary oocyte, right auricle of heart, right frontal lobe, right testis, secondary oocyte, seminiferous tubule, spermatocyte, tail of embryo, testicle, ventricular zone, zygote
RNA expression pattern · 19
RAD51C → atrioventricular valve, Brodmann area 9, endocardial cushion, gonad, left testis, neural layer of retina, oocyte, prefrontal cortex, primary oocyte, right auricle of heart, right frontal lobe, right testis, secondary oocyte, seminiferous tubule, spermatocyte, tail of embryo, testicle, ventricular zone, zygote
related to Function · 12
RAD51C → DNA, RAD51, RAD51B, RAD51D, RAD51L1, RAD51L2, RAD51L3, The RAD51, The RAD51C, They, XRCC2, XRCC3
related to Clinical significance · 4
RAD51C → ATXN7, MCF-7, One, Since
related to Mutation, splicing, and epigenetic deficiency in cancer · 4
RAD51C → Carriers, EZH2, In, These
Band · 2
RAD51C → 11 C|11 52.08 cM, 17q22
Chr. · 2
RAD51C → Chromosome 11 (mouse), Chromosome 17 (human)
End · 2
RAD51C → 58,735,611 bp, 87,295,780 bp
related to Interactions · 2
RAD51C → RAD51L1, RAD51L3

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

gene rad51 cancer bp protein human chromosome ezh2 chr band complex mrna paralogs cancers 17 expression repair methylation genes breast

RAD51C relationships Subject–Predicate–Object triples

TTTA extracted 119 structured relationships around RAD51C. Examples in this analysis include RAD51C → Aliases → RAD51C, BROVCA3, FANCO, R51H3, RAD51L2, RAD51 paralog C and RAD51C → Band → 17q22. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
RAD51CAliasesRAD51C, BROVCA3, FANCO, R51H3, RAD51L2, RAD51 paralog C1.00infobox
RAD51CBand17q221.00infobox
RAD51CBand11 C|11 52.08 cM1.00infobox
RAD51CBgeegonad1.00infobox
RAD51CBgeeright testis1.00infobox
RAD51CBgeeleft testis1.00infobox
RAD51CBgeetesticle1.00infobox
RAD51CBgeeright frontal lobe1.00infobox
RAD51CBgeeventricular zone1.00infobox
RAD51CBgeeBrodmann area 91.00infobox
RAD51CBgeeoocyte1.00infobox
RAD51CBgeeprefrontal cortex1.00infobox
RAD51CBgeeright auricle of heart1.00infobox
RAD51CBgeesecondary oocyte1.00infobox
RAD51CBgeezygote1.00infobox
RAD51CBgeeprimary oocyte1.00infobox
RAD51CBgeeseminiferous tubule1.00infobox
RAD51CBgeeendocardial cushion1.00infobox
RAD51CBgeespermatocyte1.00infobox
RAD51CBgeeneural layer of retina1.00infobox
RAD51CBgeetail of embryo1.00infobox
RAD51CBgeeatrioventricular valve1.00infobox
RAD51CBioGPSMore reference expression data1.00infobox
RAD51CChr.Chromosome 17 (human)1.00infobox
RAD51CChr.Chromosome 11 (mouse)1.00infobox
RAD51CDatabasesNCBI: entry; OMA: entry1.00infobox
RAD51CEnd58,735,611 bp1.00infobox
RAD51CEnd87,295,780 bp1.00infobox
RAD51CEnsemblENSG000001083841.00infobox
RAD51CEntrez58891.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around RAD51C bring nearby vocabulary together. In this analysis, examples include Mrna, Colorectal and Ovarian. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • RAD51C
    • Mrna
    • Colorectal
    • Ovarian
    • Risk
    • Expression
    • Cancers
    • One
    • Xrcc2
    • Xrcc3
    • Variant
    • Breast
    • Paralogs
  • rad51c
    • Mrna
    • Colorectal
    • Ovarian
    • Risk
    • Expression
    • Cancers
    • One
    • Xrcc2
    • Xrcc3
    • Variant
    • Breast
    • Paralogs
  • protein
    • Ezh2
    • Mrna
    • Xrcc2
    • Xrcc3
    • Rad51
    • Expression
    • Paralogs
    • Cancers
    • Chromosome
    • Rad51c
    • Function
    • Mouse
  • gene
    • Rad51c
    • Human
    • Chromosome
    • Location
    • One
    • Mutation
    • Bp
    • Breast
    • Chr
    • Genes
    • Cancer
    • Complex
  • rad51 nucleoprotein filament
    • Paralogs
    • Complex
    • Damage
    • Homologous
    • Expression
    • Repair
    • Protein
    • Function
    • Bcdx2
    • Location
    • Xrcc2
    • Xrcc3
  • xrcc3
    • Xrcc2
    • Expression
    • Paralogs
    • Mrna
    • Protein
    • Function
    • Mouse
    • End
    • Location
    • One
    • Rad51
    • Also
  • gene conversion
    • Rad51c
    • Human
    • Chromosome
    • Location
    • One
    • Mutation
    • Bp
    • Breast
    • Chr
    • Genes
    • Cancer
    • Complex
  • gene fusion
    • Rad51c
    • Human
    • Chromosome
    • Location
    • One
    • Mutation
    • Bp
    • Breast
    • Chr
    • Genes
    • Cancer
    • Complex

Connections between topic areas Semantic bridges

For RAD51C, one of the stronger structural bridges in this analysis connects RAD51C with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
RAD51CFunction · splits 22 ⟂ 15
RAD51CMutation, splicing, and epigenetic deficiency in cancer · splits 26 ⟂ 11
RAD51CClinical significance · splits 32 ⟂ 5
RAD51COverview · splits 34 ⟂ 3

Map overview Semantic statistics

RAD51C

Nodes37
Edges36
Triples119
Avg. degree1.95
Density0.054054
Components1

Source & methodology

TTTA analyzes the structure around RAD51C to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Mutation, splicing, and epigenetic deficiency in cancer & Clinical significance, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — RAD51C · EN edition · Analysis: TopicsToTalkAbout

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