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Thrombin

Thrombin (factor IIa, EC 3.4.21.5) is a serine protease that converts fibrinogen into strands of insoluble fibrin, as well as catalyzing many other coagulation-related reactions.

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3.4.21.5
Aliases
F2, PT, RPRGL2, THPH1, coagulation factor II, thrombin
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1A2C, 1A3B, 1A3E, 1ABI, 1ABJ, 1AD8, 1AE8, 1AI8, 1AIX, 1AWF, 1AWH, 1AY6, 1B5G, 1B7X, 1BA8, 1BB0, 1BCU, 1BHX,…
Band
11p11.2 · 2 E1|2 50.63 cM
Bgee
right lobe of liver · testicle · oocyte · secondary oocyte · cerebellar hemisphere
BioGPS
More reference expression data

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Physiology

Structure

Gene

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Map overview Semantic statistics

Thrombin

Nodes90
Edges89
Triples238
Avg. degree1.98
Density0.022222
Components1

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Thrombin

Top relations

Gene ontology · 61
Thrombin → acute-phase response, antimicrobial humoral immune response mediated by antimicrobial peptide, blood coagulation, blood coagulation, fibrin clot formation, blood coagulation, intrinsic pathway, blood microparticle, calcium ion binding, cell surface receptor signaling pathway, collagen-containing extracellular matrix, endoplasmic reticulum lumen, endoplasmic reticulum to Golgi vesicle-mediated transport, enzyme activator activity, external side of plasma membrane, extracellular exosome, extracellular region, extracellular space, fibrinolysis, G protein-coupled receptor signaling pathway, Golgi lumen, growth factor activity
related to External links · 27
Thrombin → Adam MP, Anti-coagulation, Archived, Ardinger HH, February, GeneReviews, Human Thrombin, Month Archived, Mouse Thrombin, NBK1148, Pagon RA, PDB, PDBe-KB, PMID, Prothrombin Thrombophilia, RCSB PDB Molecule, S01, Seattle, Seattle WA, The MEROPS
Bgee · 19
Thrombin → cerebellar hemisphere, embryo, fetal liver hematopoietic progenitor cell, fundus, gallbladder, human fetus, left lobe of liver, morula, oocyte, popliteal artery, primary oocyte, right hemisphere of cerebellum, right lobe of liver, secondary oocyte, sexually immature organism, testicle, tibial arteries, yolk sac, zygote
RNA expression pattern · 19
Thrombin → cerebellar hemisphere, embryo, fetal liver hematopoietic progenitor cell, fundus, gallbladder, human fetus, left lobe of liver, morula, oocyte, popliteal artery, primary oocyte, right hemisphere of cerebellum, right lobe of liver, secondary oocyte, sexually immature organism, testicle, tibial arteries, yolk sac, zygote
related to Mechanism of action · 12
Thrombin → Aα, Bβ, Factor XIIIa, In, The, Va, VIII, VIIIa, XI, XIa, XIII, XIIIa
related to Gene · 10
Thrombin → Crohn's, Factor II, G20210A, Homozygous, II, Leiden, Other, Prothrombin G20210A, The, There
related to Structure · 10
Thrombin → C-terminal, Da, Factor Xa, Gla, Kringle, N-terminal Gla, PA, Prothrombin, Structurally, The
related to Synthesis · 10
Thrombin → Deficiency, Factor, Gla, In, K-dependent, Newborn, Prothrombin, The, Va, Xa
related to Medicine and surgery · 8
Thrombin → Heparin, Indications, K-dependent, Manipulation, Prothrombin, The, Warfarin, Xa
related to Food production · 7
Thrombin → According, Both, Fibrimex, General, Jan Bertoft, Swedish Consumers' Association, The

Important terminology Word statistics

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Important terminology

prothrombin factor coagulation human fibrin protein gene bp fibrinogen binding blood chr band serine activity enzyme also activation protease form

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Thrombin3.4.21.51.00infobox
ThrombinAliasesF2, PT, RPRGL2, THPH1, coagulation factor II, thrombin1.00infobox
ThrombinAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1A2C, 1A3B, 1A3E, 1ABI, 1ABJ, 1AD8, 1AE8, 1AI8, 1AIX, 1AWF, 1AWH, 1AY6, 1B5G, 1B7X, 1BA8, 1BB0, 1BCU, 1BHX,…1.00infobox
ThrombinBand11p11.21.00infobox
ThrombinBand2 E1|2 50.63 cM1.00infobox
ThrombinBgeeright lobe of liver1.00infobox
ThrombinBgeetesticle1.00infobox
ThrombinBgeeoocyte1.00infobox
ThrombinBgeesecondary oocyte1.00infobox
ThrombinBgeecerebellar hemisphere1.00infobox
ThrombinBgeeright hemisphere of cerebellum1.00infobox
ThrombinBgeepopliteal artery1.00infobox
ThrombinBgeetibial arteries1.00infobox
ThrombinBgeefundus1.00infobox
ThrombinBgeeembryo1.00infobox
ThrombinBgeeleft lobe of liver1.00infobox
ThrombinBgeefetal liver hematopoietic progenitor cell1.00infobox
ThrombinBgeegallbladder1.00infobox
ThrombinBgeeyolk sac1.00infobox
ThrombinBgeehuman fetus1.00infobox
ThrombinBgeesexually immature organism1.00infobox
ThrombinBgeemorula1.00infobox
ThrombinBgeeprimary oocyte1.00infobox
ThrombinBgeezygote1.00infobox
ThrombinBioGPSMore reference expression data1.00infobox
ThrombinChr.Chromosome 11 (human)1.00infobox
ThrombinChr.Chromosome 2 (mouse)1.00infobox
ThrombinDatabasesNCBI: entry; OMA: entry1.00infobox
ThrombinEnd46,739,506 bp1.00infobox
ThrombinEnd91,466,759 bp1.00infobox

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