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Factor VIII

Coagulation factor VIII (factor VIII, FVIII, also known as antihemophilic factor A (AHF)) is an essential blood clotting protein. In humans, it is encoded by F8 gene. Defects in this gene result in hemophilia A, an X-linked bleeding disorder.

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Aliases
F8, AHF, DXS1253E, F8B, F8C, FVIII, HEMA, coagulation factor VIII, THPH13
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1CFG, 1D7P, 1IQD, 2R7E, 3CDZ, 3HNB, 3HNY, 3HOB, 4BDV, 1FAC, 3J2Q, 3J2S, 4KI5, 4PT6, 4XZU
Band
Xq28 · X A7.3|X 38.17 cM
Bgee
myocardium of left ventricle · right ventricle · right auricle of heart · cardiac muscle tissue of right atrium · tibialis anterior muscle
BioGPS
More reference expression data
Chr.
X chromosome (human) · X chromosome (mouse)

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Overview

Genetics

Structure

Physiology

Medical use

Immunostain target

Contamination scandal

History

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Map overview Semantic statistics

Factor VIII

Nodes60
Edges59
Triples125
Avg. degree1.97
Density0.033333
Components1

How this topic connects Entity context

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Factor VIII

Top relations

Gene ontology · 20
Factor VIII → acute-phase response, blood coagulation, blood coagulation, intrinsic pathway, COPII vesicle coating, COPII-coated ER to Golgi transport vesicle, copper ion binding, endoplasmic reticulum lumen, endoplasmic reticulum to Golgi vesicle-mediated transport, endoplasmic reticulum-Golgi intermediate compartment membrane, extracellular region, extracellular space, Golgi membrane, hemostasis, metal ion binding, oxidoreductase activity, plasma membrane, platelet activation, platelet alpha granule lumen, platelet degranulation, protein binding
Bgee · 19
Factor VIII → abdominal fat, apex of heart, cardiac muscle tissue of right atrium, embryo, Epithelium of choroid plexus, genital tubercle, left lobe of liver, liver, lower lobe of lung, mesenteric lymph nodes, myocardium of left ventricle, olfactory epithelium, pericardium, proximal tubule, right auricle of heart, right kidney, right ventricle, tail of embryo, tibialis anterior muscle
RNA expression pattern · 19
Factor VIII → abdominal fat, apex of heart, cardiac muscle tissue of right atrium, embryo, Epithelium of choroid plexus, genital tubercle, left lobe of liver, liver, lower lobe of lung, mesenteric lymph nodes, myocardium of left ventricle, olfactory epithelium, pericardium, proximal tubule, right auricle of heart, right kidney, right ventricle, tail of embryo, tibialis anterior muscle
related to Contamination scandal · 14
Factor VIII → Asian, Baxter International, Bayer, Drug Administration, European, FDA, Food, HIV, In, Latin American, The, Under FDA, US, VIII
related to External links · 12
Factor VIII → GeneReviews/NCBI/NIH/UW, Hemophilia AFactor, Human Factor VIII, Medicine Medical Subject Headings, MeSH, National Library, Overview, P00451, PDB, PDBe-KB, UniProt, VIII
related to Genetics · 5
Factor VIII → F8A1, Genentech, The, VIII, Xq28
related to Medical use · 5
Factor VIII → Antibody, Bypassing, FVIIa, FVIII, VIII
related to Structure · 3
Factor VIII → A1-A2-B-A3-C1-C2, C2, The
Band · 2
Factor VIII → X A7.3|X 38.17 cM, Xq28
Chr. · 2
Factor VIII → X chromosome (human), X chromosome (mouse)

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Important terminology

factor viii protein blood gene coagulation liver bp human complex von willebrand chr band chromosome form fviii plasma binding domain

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Factor VIIIAliasesF8, AHF, DXS1253E, F8B, F8C, FVIII, HEMA, coagulation factor VIII, THPH131.00infobox
Factor VIIIAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1CFG, 1D7P, 1IQD, 2R7E, 3CDZ, 3HNB, 3HNY, 3HOB, 4BDV, 1FAC, 3J2Q, 3J2S, 4KI5, 4PT6, 4XZU1.00infobox
Factor VIIIBandXq281.00infobox
Factor VIIIBandX A7.3|X 38.17 cM1.00infobox
Factor VIIIBgeemyocardium of left ventricle1.00infobox
Factor VIIIBgeeright ventricle1.00infobox
Factor VIIIBgeeright auricle of heart1.00infobox
Factor VIIIBgeecardiac muscle tissue of right atrium1.00infobox
Factor VIIIBgeetibialis anterior muscle1.00infobox
Factor VIIIBgeeapex of heart1.00infobox
Factor VIIIBgeepericardium1.00infobox
Factor VIIIBgeeabdominal fat1.00infobox
Factor VIIIBgeelower lobe of lung1.00infobox
Factor VIIIBgeeEpithelium of choroid plexus1.00infobox
Factor VIIIBgeemesenteric lymph nodes1.00infobox
Factor VIIIBgeeolfactory epithelium1.00infobox
Factor VIIIBgeeliver1.00infobox
Factor VIIIBgeeembryo1.00infobox
Factor VIIIBgeeright kidney1.00infobox
Factor VIIIBgeeleft lobe of liver1.00infobox
Factor VIIIBgeegenital tubercle1.00infobox
Factor VIIIBgeeproximal tubule1.00infobox
Factor VIIIBgeetail of embryo1.00infobox
Factor VIIIBioGPSMore reference expression data1.00infobox
Factor VIIIChr.X chromosome (human)1.00infobox
Factor VIIIChr.X chromosome (mouse)1.00infobox
Factor VIIIDatabasesNCBI: entry; OMA: entry1.00infobox
Factor VIIIEnd155,026,940 bp1.00infobox
Factor VIIIEnd74,426,221 bp1.00infobox
Factor VIIIEnsemblENSG000001850101.00infobox

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