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Coagulation factor VIII (factor VIII, FVIII, also known as antihemophilic factor A (AHF)) is an essential blood clotting protein. In humans, it is encoded by F8 gene. Defects in this gene result in hemophilia A, an X-linked bleeding disorder.
The analysis highlights History, Applications and Standards as prominent areas in the source structure around Factor VIII.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around Factor VIII shows recurring relationship patterns in the source. For example, Factor VIII → acute-phase response, blood coagulation, blood coagulation, intrinsic pathway, COPII vesicle coating, COPII-coated ER to Golgi transport vesicle, copper ion binding, endoplasmic reticulum lumen, endoplasmic reticulum to Golgi vesicle-mediated transport, endoplasmic reticulum-Golgi intermediate compartment membrane, extracellular region, extracellular space, Golgi membrane, hemostasis, metal ion binding, oxidoreductase activity, plasma membrane, platelet activation, platelet alpha granule lumen, platelet degranulation, protein binding Another extracted example is Factor VIII → abdominal fat, apex of heart, cardiac muscle tissue of right atrium, embryo, Epithelium of choroid plexus, genital tubercle, left lobe of liver, liver, lower lobe of lung, mesenteric lymph nodes, myocardium of left ventricle, olfactory epithelium, pericardium, proximal tubule, right auricle of heart, right kidney, right ventricle, tail of embryo, tibialis anterior muscle. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
factor viii protein blood gene coagulation liver bp human complex von willebrand chr band chromosome form fviii plasma binding domain
TTTA extracted 125 structured relationships around Factor VIII. Examples in this analysis include Factor VIII → Aliases → F8, AHF, DXS1253E, F8B, F8C, FVIII, HEMA, coagulation factor VIII, THPH13 and Factor VIII → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1CFG, 1D7P, 1IQD, 2R7E, 3CDZ, 3HNB, 3HNY, 3HOB, 4BDV, 1FAC, 3J2Q, 3J2S, 4KI5, 4PT6, 4XZU. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| Factor VIII | Aliases | F8, AHF, DXS1253E, F8B, F8C, FVIII, HEMA, coagulation factor VIII, THPH13 | 1.00 | infobox |
| Factor VIII | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1CFG, 1D7P, 1IQD, 2R7E, 3CDZ, 3HNB, 3HNY, 3HOB, 4BDV, 1FAC, 3J2Q, 3J2S, 4KI5, 4PT6, 4XZU | 1.00 | infobox |
| Factor VIII | Band | Xq28 | 1.00 | infobox |
| Factor VIII | Band | X A7.3|X 38.17 cM | 1.00 | infobox |
| Factor VIII | Bgee | myocardium of left ventricle | 1.00 | infobox |
| Factor VIII | Bgee | right ventricle | 1.00 | infobox |
| Factor VIII | Bgee | right auricle of heart | 1.00 | infobox |
| Factor VIII | Bgee | cardiac muscle tissue of right atrium | 1.00 | infobox |
| Factor VIII | Bgee | tibialis anterior muscle | 1.00 | infobox |
| Factor VIII | Bgee | apex of heart | 1.00 | infobox |
| Factor VIII | Bgee | pericardium | 1.00 | infobox |
| Factor VIII | Bgee | abdominal fat | 1.00 | infobox |
| Factor VIII | Bgee | lower lobe of lung | 1.00 | infobox |
| Factor VIII | Bgee | Epithelium of choroid plexus | 1.00 | infobox |
| Factor VIII | Bgee | mesenteric lymph nodes | 1.00 | infobox |
| Factor VIII | Bgee | olfactory epithelium | 1.00 | infobox |
| Factor VIII | Bgee | liver | 1.00 | infobox |
| Factor VIII | Bgee | embryo | 1.00 | infobox |
| Factor VIII | Bgee | right kidney | 1.00 | infobox |
| Factor VIII | Bgee | left lobe of liver | 1.00 | infobox |
| Factor VIII | Bgee | genital tubercle | 1.00 | infobox |
| Factor VIII | Bgee | proximal tubule | 1.00 | infobox |
| Factor VIII | Bgee | tail of embryo | 1.00 | infobox |
| Factor VIII | BioGPS | More reference expression data | 1.00 | infobox |
| Factor VIII | Chr. | X chromosome (human) | 1.00 | infobox |
| Factor VIII | Chr. | X chromosome (mouse) | 1.00 | infobox |
| Factor VIII | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| Factor VIII | End | 155,026,940 bp | 1.00 | infobox |
| Factor VIII | End | 74,426,221 bp | 1.00 | infobox |
| Factor VIII | Ensembl | ENSG00000185010 | 1.00 | infobox |
The concept neighborhoods around Factor VIII bring nearby vocabulary together. In this analysis, examples include Viii, Protein and Von. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For Factor VIII, one of the stronger structural bridges in this analysis connects Factor VIII with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around Factor VIII to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Applications & Standards, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — Factor VIII · EN edition · Analysis: TopicsToTalkAbout