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Factor V: History, Structure & Physiology

Coagulation factor V (Factor V), also less commonly known as proaccelerin or labile factor, is a protein involved in coagulation, encoded, in humans, by F5 gene. In contrast to most other coagulation factors, it is not enzymatically active but functions as a cofactor. Factor V deficiency leads to predisposition for hemorrhage, while some mutations (most…

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Factor V topic overview

The analysis highlights History, Structure and Physiology as prominent areas in the source structure around Factor V.

Related topics
50
Source areas
7
Connected nodes
57
Extracted relationships
133
Concept neighborhoods
23
Bridge connections
57

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

History · 14 topics
Structure · 9 topics
Physiology · 8 topics
Role in disease · 8 topics
Overview · 7 topics
Genetics · 3 topics
Interactions · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
F5, FVL, PCCF, RPRGL1, THPH2, coagulation factor V
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3S9C, 1CZS, 1CZV, 3P6Z, 3P70
Band
1q24.2 · 1 H2.2|1 71.46 cM
Bgee
right lobe of liver · Epithelium of choroid plexus · pancreatic ductal cell · placenta · optic nerve
BioGPS
More reference expression data
Chr.
Chromosome 1 (human) · Chromosome 1 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Genetics

Structure

Physiology

Role in disease

History

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Factor V connects Entity context

The extracted context around Factor V shows recurring relationship patterns in the source. For example, Factor V → blood circulation, blood coagulation, COPII vesicle coating, COPII-coated ER to Golgi transport vesicle, copper ion binding, endoplasmic reticulum, endoplasmic reticulum lumen, endoplasmic reticulum to Golgi vesicle-mediated transport, endoplasmic reticulum-Golgi intermediate compartment membrane, extracellular region, extracellular space, extracellular vesicle, Golgi apparatus, Golgi membrane, hemostasis, membrane, metal ion binding, plasma membrane, platelet alpha granule, platelet alpha granule lumen Another extracted example is Factor V → However, II, III, IV, Mary, Morawitz, Most, Norway, Norwegian, Owren, Paul Morawitz, Paul Owren, Second World War, She, The, The Lancet, They, Until, Using Mary's. Use these groups to spot repeated connection types before inspecting the individual relationships.

Factor V

Top relations

Gene ontology · 24
Factor V → blood circulation, blood coagulation, COPII vesicle coating, COPII-coated ER to Golgi transport vesicle, copper ion binding, endoplasmic reticulum, endoplasmic reticulum lumen, endoplasmic reticulum to Golgi vesicle-mediated transport, endoplasmic reticulum-Golgi intermediate compartment membrane, extracellular region, extracellular space, extracellular vesicle, Golgi apparatus, Golgi membrane, hemostasis, membrane, metal ion binding, plasma membrane, platelet alpha granule, platelet alpha granule lumen
related to history · 19
Factor V → However, II, III, IV, Mary, Morawitz, Most, Norway, Norwegian, Owren, Paul Morawitz, Paul Owren, Second World War, She, The, The Lancet, They, Until, Using Mary's
Bgee · 17
Factor V → blood, choroid plexus of fourth ventricle, ciliary body, Epithelium of choroid plexus, gallbladder, granulocyte, iris, lacrimal gland, left lobe of liver, monocyte, olfactory zone of nasal mucosa, optic nerve, pancreatic ductal cell, parotid gland, placenta, right lobe of liver, tibiofemoral joint
RNA expression pattern · 17
Factor V → blood, choroid plexus of fourth ventricle, ciliary body, Epithelium of choroid plexus, gallbladder, granulocyte, iris, lacrimal gland, left lobe of liver, monocyte, olfactory zone of nasal mucosa, optic nerve, pancreatic ductal cell, parotid gland, placenta, right lobe of liver, tibiofemoral joint
related to Role in disease · 11
Factor V → Amsterdam, Deficiency, FV, It, Karen, Owren, Texas, There, This, Various, Zimowski
related to External links · 7
Factor V → Coagulation, P12259, PDB, PDBe-KB, ProteinOverview, The Coagulation Factor, UniProt
related to Physiology · 5
Factor V → Factor, FVa, FXa, On, The
related to Structure · 5
Factor V → A1-A2-B-A3-C1-C2, A1-A3, A3, Factor, The
related to Genetics · 3
Factor V → It, The, VIII
Band · 2
Factor V → 1 H2.2|1 71.46 cM, 1q24.2

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

factor protein coagulation gene bp thrombin chr human band chromosome prothrombin activated f5 form owren leiden cofactor mutations thrombosis plasma

Factor V relationships Subject–Predicate–Object triples

TTTA extracted 133 structured relationships around Factor V. Examples in this analysis include Factor V → Aliases → F5, FVL, PCCF, RPRGL1, THPH2, coagulation factor V and Factor V → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3S9C, 1CZS, 1CZV, 3P6Z, 3P70. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Factor VAliasesF5, FVL, PCCF, RPRGL1, THPH2, coagulation factor V1.00infobox
Factor VAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3S9C, 1CZS, 1CZV, 3P6Z, 3P701.00infobox
Factor VBand1q24.21.00infobox
Factor VBand1 H2.2|1 71.46 cM1.00infobox
Factor VBgeeright lobe of liver1.00infobox
Factor VBgeeEpithelium of choroid plexus1.00infobox
Factor VBgeepancreatic ductal cell1.00infobox
Factor VBgeeplacenta1.00infobox
Factor VBgeeoptic nerve1.00infobox
Factor VBgeemonocyte1.00infobox
Factor VBgeeolfactory zone of nasal mucosa1.00infobox
Factor VBgeeblood1.00infobox
Factor VBgeegallbladder1.00infobox
Factor VBgeegranulocyte1.00infobox
Factor VBgeechoroid plexus of fourth ventricle1.00infobox
Factor VBgeeleft lobe of liver1.00infobox
Factor VBgeeciliary body1.00infobox
Factor VBgeelacrimal gland1.00infobox
Factor VBgeeiris1.00infobox
Factor VBgeetibiofemoral joint1.00infobox
Factor VBgeeparotid gland1.00infobox
Factor VBioGPSMore reference expression data1.00infobox
Factor VChr.Chromosome 1 (human)1.00infobox
Factor VChr.Chromosome 1 (mouse)1.00infobox
Factor VDatabasesNCBI: entry; OMA: entry1.00infobox
Factor VEnd169,586,588 bp1.00infobox
Factor VEnd164,047,846 bp1.00infobox
Factor VEnsemblENSG000001987341.00infobox
Factor VEntrez21531.00infobox
Factor VExternal IDsOMIM: 612309; MGI: 88382; GeneCards: F51.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Factor V bring nearby vocabulary together. In this analysis, examples include Protein, Activated and Leiden. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Factor V
    • Protein
    • Activated
    • Leiden
    • Thrombin
    • Calcium
    • F5
    • Mutations
    • Thrombosis
    • Va
    • Gene
    • Prothrombin
    • P12259
  • factor v
    • Protein
    • Activated
    • Leiden
    • Thrombin
    • Calcium
    • F5
    • Mutations
    • Thrombosis
    • Va
    • Gene
    • Prothrombin
    • P12259
  • coagulation
    • F5
    • Factor
    • Gene
    • P12259
    • Pdb
    • Uniprot
    • Location
    • Protein
    • Chromosome
    • Human
    • Bp
    • Chr
  • factor v leiden
    • Common
    • Mutations
    • Thrombosis
    • Protein
    • Activated
    • Leiden
    • Thrombin
    • Calcium
    • F5
    • Va
    • Gene
    • Prothrombin
  • coagulation factor viii
    • F5
    • Factor
    • Gene
    • Protein
    • Activated
    • P12259
    • Pdb
    • Uniprot
    • Location
    • Chromosome
    • Human
    • Bp
  • factor x
    • Protein
    • Activated
    • Leiden
    • Thrombin
    • Calcium
    • F5
    • Mutations
    • Thrombosis
    • Va
    • Gene
    • Prothrombin
    • P12259
  • blood clots
    • Mouse
    • P12259
    • Uniprot
    • Common
    • Deficiency
    • F5
    • Location
    • Membrane
    • Molecular
    • Chromosome
    • Human
    • Plasma
  • first chromosome
    • Human
    • Bp
    • Location
    • Band
    • Gene
    • Mouse
    • F5
    • External
    • P12259
    • Pdb
    • Uniprot
    • Coagulation

Connections between topic areas Semantic bridges

For Factor V, one of the stronger structural bridges in this analysis connects Factor V with History. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Factor VHistory · splits 43 ⟂ 15
Factor VStructure · splits 48 ⟂ 10
Factor VPhysiology · splits 49 ⟂ 9
Factor VRole in disease · splits 49 ⟂ 9
Factor VOverview · splits 50 ⟂ 8
Factor VGenetics · splits 54 ⟂ 4

Map overview Semantic statistics

Factor V

Nodes58
Edges57
Triples133
Avg. degree1.97
Density0.034483
Components1

Source & methodology

TTTA analyzes the structure around Factor V to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Structure & Physiology, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Factor V · EN edition · Analysis: TopicsToTalkAbout

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