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Prothrombin complex concentrate: History & Applications

Prothrombin complex concentrate (PCC), also known as factor IX complex, sold under the brand name Kcentra among others, is a combination medication made up of blood clotting factors II, IX, and X(3-factor PCC) or, when also containing factor VII as does Kcentra, 4-factor PCC. It is used to treat and prevent bleeding in hemophilia B if pure factor IX is…

Language: English [EN]
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Prothrombin complex concentrate topic overview

The analysis highlights History and Applications as prominent areas in the source structure around Prothrombin complex concentrate.

Related topics
30
Source areas
5
Connected nodes
35
Extracted relationships
39
Related term clusters
17
Bridge connections
35

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 18 topics
Medical uses · 6 topics
Contraindications · 3 topics
Chemistry · 2 topics
History · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

AHFS/Drugs.com
Monograph Monograph
ATC code
B02BD01 (WHO) B02BD04 (WHO)
CAS Number
37224-63-8 Y
DrugBank
DB11330 · DB13152
Factor II
Blood clotting factor
Factor IX
Blood clotting factor

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Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Medical uses

Contraindications

Chemistry

History

For the semantics nerds

You can skip this section if you’re here for content ideas and keyword inspiration.

Advanced semantic analysis

How Prothrombin complex concentrate connects Entity context

The extracted context around Prothrombin complex concentrate shows recurring relationship patterns in the source. For example, Prothrombin complex concentrate → AUD, Authority, IU, Prothrombinex, The Australian National Blood, United States, US Another extracted example is Prothrombin complex concentrate → Heparin, II, IX, Prothrombin, Typically, VII. Use these groups to spot repeated connection types before inspecting the individual relationships.

Prothrombin complex concentrate

Top relations

related to Economics · 7
Prothrombin complex concentrate → AUD, Authority, IU, Prothrombinex, The Australian National Blood, United States, US
related to Chemistry · 6
Prothrombin complex concentrate → Heparin, II, IX, Prothrombin, Typically, VII
Legal status · 5
Prothrombin complex concentrate → CA: ℞-only, EU: Rx-only, In general: ℞ (Prescription only), UK: POM (Prescription only), US: ℞-only
related to Medical uses · 5
Prothrombin complex concentrate → American College, Chest Physicians, INR, Prothrombin, Several
DrugBank · 2
Prothrombin complex concentrate → DB11330, DB13152
related to Contraindications · 2
Prothrombin complex concentrate → As PCC, PCC
AHFS/Drugs.com · 1
Prothrombin complex concentrate → Monograph Monograph
ATC code · 1
Prothrombin complex concentrate → B02BD01 (WHO) B02BD04 (WHO)
CAS Number · 1
Prothrombin complex concentrate → 37224-63-8 Y
Factor II · 1
Prothrombin complex concentrate → Blood clotting factor

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

prothrombin complex concentrate factor ix may also used blood clotting factors hemophilia bleeding available effects include warfarin ii vii pcc

Prothrombin complex concentrate relationships Subject–Predicate–Object triples

TTTA extracted 39 structured relationships around Prothrombin complex concentrate. Examples in this analysis include Prothrombin complex concentrate → AHFS/Drugs.com → Monograph Monograph and Prothrombin complex concentrate → ATC code → B02BD01 (WHO) B02BD04 (WHO). The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Prothrombin complex concentrateAHFS/Drugs.comMonograph Monograph1.00infobox
Prothrombin complex concentrateATC codeB02BD01 (WHO) B02BD04 (WHO)1.00infobox
Prothrombin complex concentrateCAS Number37224-63-8 Y1.00infobox
Prothrombin complex concentrateDrugBankDB113301.00infobox
Prothrombin complex concentrateDrugBankDB131521.00infobox
Prothrombin complex concentrateFactor IIBlood clotting factor1.00infobox
Prothrombin complex concentrateFactor IXBlood clotting factor1.00infobox
Prothrombin complex concentrateFactor VIIBlood clotting factor1.00infobox
Prothrombin complex concentrateFactor XBlood clotting factor1.00infobox
Prothrombin complex concentrateLegal statusCA: ℞-only1.00infobox
Prothrombin complex concentrateLegal statusUK: POM (Prescription only)1.00infobox
Prothrombin complex concentrateLegal statusUS: ℞-only1.00infobox
Prothrombin complex concentrateLegal statusEU: Rx-only1.00infobox
Prothrombin complex concentrateLegal statusIn general: ℞ (Prescription only)1.00infobox
Prothrombin complex concentrateLicense dataUS DailyMed: Kcentra1.00infobox
Prothrombin complex concentrateOther namesfactor IX complex1.00infobox
Prothrombin complex concentrateRoutes of administrationIntravenous1.00infobox
Prothrombin complex concentrateTrade namesKcentra, others1.00infobox
Prothrombin complex concentrateUNIIRZ22DI43TP1.00infobox

Related concept clusters Related term clusters

The concept neighborhoods around Prothrombin complex concentrate bring nearby vocabulary together. In this analysis, examples include Concentrate, Prothrombin and Clotting. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Prothrombin complex concentrate
    • Concentrate
    • Prothrombin
    • Clotting
    • Bleeding
    • Blood
    • Factors
    • Brand
    • Kcentra
    • Medical
    • Others
    • Factor
    • Administration
  • prothrombin complex concentrate
    • Concentrate
    • Prothrombin
    • Clotting
    • Bleeding
    • Blood
    • Factors
    • Brand
    • Kcentra
    • Medical
    • Others
    • Factor
    • Administration
  • blood clotting factors
    • Factors
    • Clotting
    • Brand
    • Complex
    • Concentrate
    • Kcentra
    • Others
    • Prothrombin
    • Uses
    • Effects
    • Ii
    • Number
  • ix
    • Ii
    • Brand
    • Kcentra
    • Others
    • Available
    • Vii
    • Bleeding
    • Blood
    • Clotting
    • Used
    • Names
    • Made
  • factor vii
    • Ix
    • Ii
    • Vii
    • Used
    • Brand
    • Kcentra
    • Others
    • Available
    • Hemophilia
    • Pcc
    • Prothrombin
    • Bleeding
  • warfarin
    • Reversal
    • Bleeding
    • Names
    • Used
    • Brand
    • Kcentra
    • Medical
    • Others
    • Serious
    • Status
    • Uses
    • Administration
  • blood clots
    • Clotting
    • Brand
    • Kcentra
    • Others
    • Effects
    • Ii
    • Number
    • Vii
    • Complex
    • Concentrate
    • Prothrombin
    • Factors
  • food and drug administration
    • Us
    • Bleeding
    • Names
    • Brand
    • Kcentra
    • Medical
    • Others
    • Plasma
    • Status
    • Uses
    • Complex
    • Concentrate

Connections between topic areas Semantic bridges

For Prothrombin complex concentrate, one of the stronger structural bridges in this analysis connects Prothrombin complex concentrate with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Prothrombin complex concentrate — Overview · splits 17 ⟂ 19
Prothrombin complex concentrate — Medical uses · splits 29 ⟂ 7
Prothrombin complex concentrate — Contraindications · splits 32 ⟂ 4
Prothrombin complex concentrate — Chemistry · splits 33 ⟂ 3

Map overview Semantic statistics

Prothrombin complex concentrate

Nodes36
Edges35
Triples39
Avg. degree1.94
Density0.055556
Components1

Source & methodology

TTTA analyzes the structure around Prothrombin complex concentrate to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History & Applications, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Prothrombin complex concentrate · EN edition · Analysis: TopicsToTalkAbout

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