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Gla domain

Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain is a protein domain that contains post-translational modifications of many glutamate residues by vitamin K-dependent carboxylation to form γ-carboxyglutamate (Gla). Proteins with this domain are known informally as Gla proteins. The Gla residues are responsible for the high-affinity…

Human proteins containing this domain, Functions & Subfamilies

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Human proteins containing this domain

ThrombinCoagulationFactor VIIFactor IXFactor X
24 related topics

Functions

PhosphatidylserinePhosphatidic acidCiona intestinalis
3 related topics

Subfamilies

Coagulation factorInterPro
2 related topics

Overview

Protein domainVitamin KCarboxylationΓ-carboxyglutamateCarboxylic acid
11 related topics

Key facts & relationships

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AlphaFold
IPR000294 · PF00594
Available protein structures:
IPR000294 · PF00594
InterPro
IPR000294
Membranome
342
OPM protein
1pfx
OPM superfamily
89

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Overview

Functions

Human proteins containing this domain

Subfamilies

Advanced semantic analysis

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Map overview Semantic statistics

Gla domain

Nodes45
Edges44
Triples27
Avg. degree1.96
Density0.044444
Components1

How this topic connects Entity context

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Gla domain

Top relations

related to In invertebrates · 7
Gla domain → Ciona, Despite, Gla, It, IX, Jagged1, PRGP1
related to Coagulation and anticoagulation proteins · 6
Gla domain → FVII, Gla, In, The, The Gla, There
AlphaFold · 2
Gla domain → IPR000294, PF00594
Available protein structures: · 2
Gla domain → IPR000294, PF00594
InterPro · 1
Gla domain → IPR000294
Membranome · 1
Gla domain → 342
OPM protein · 1
Gla domain → 1pfx
OPM superfamily · 1
Gla domain → 89
PDB · 1
Gla domain → IPR000294 PF00594 (ECOD; PDBsum)
Pfam · 1
Gla domain → PF00594

Important terminology Word statistics

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Important terminology

gla coagulation domain proteins protein residues factor blood cell calcium ions bone matrix domains membrane calcification ix form known necessary

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Gla domainAlphaFoldIPR0002941.00infobox
Gla domainAlphaFoldPF005941.00infobox
Gla domainAvailable protein structures:IPR0002941.00infobox
Gla domainAvailable protein structures:PF005941.00infobox
Gla domainInterProIPR0002941.00infobox
Gla domainMembranome3421.00infobox
Gla domainOPM protein1pfx1.00infobox
Gla domainOPM superfamily891.00infobox
Gla domainPDBIPR000294 PF00594 (ECOD; PDBsum)1.00infobox
Gla domainPfamPF005941.00infobox
Gla domainPROSITEPDOC000111.00infobox
Gla domainSCOP21cfi / SCOPe / SUPFAM1.00infobox
Gla domainSymbolGla1.00infobox
Gla domaincausesa binding affinity to phosphatidylserine0.90text

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