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NEDD8

NEDD8 is a protein that in humans is encoded by the NEDD8 gene. (in Saccharomyces cerevisiae this protein is known as Rub1) This ubiquitin-like (UBL) protein becomes covalently conjugated to a limited number of cellular proteins, in a process called NEDDylation similar to ubiquitination. Human NEDD8 shares 60% amino acid sequence identity to ubiquitin.…

Research, In cancer chemotherapy & Substrates for NEDD8

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Aliases
NEDD8, NEDD-8, neural precursor cell expressed, developmentally down-regulated 8, NEDD8 ubiquitin like modifier
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1NDD, 1R4M, 1R4N, 1XT9, 2BKR, 2KO3, 2NVU, 3DBH, 3DBL, 3DBR, 3DQV, 3GZN, 4F8C, 4FBJ, 4HCP, 4P5O
Band
14q12 · 14 C3|14 28.19 cM
Bgee
prefrontal cortex · superior frontal gyrus · right frontal lobe · anterior cingulate cortex · dorsolateral prefrontal cortex
BioGPS
More reference expression data
Chr.
Chromosome 14 (human) · Chromosome 14 (mouse)

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Overview

Activation and conjugation

Substrates for NEDD8

Role in DNA repair

In cancer chemotherapy

In preclinical studies

Interactions

Advanced semantic analysis

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Map overview Semantic statistics

NEDD8

Nodes47
Edges46
Triples166
Avg. degree1.96
Density0.042553
Components1

How this topic connects Entity context

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NEDD8

Top relations

Gene ontology · 21
NEDD8 → anatomical structure morphogenesis, cellular iron ion homeostasis, cytoplasm, cytosol, extracellular exosome, modification-dependent protein catabolic process, nucleoplasm, nucleus, post-translational protein modification, protein binding, protein deubiquitination, protein localization, protein neddylation, protein tag, protein ubiquitination, proteolysis, regulation of proteolysis, response to organic cyclic compound, transforming growth factor beta receptor signaling pathway, ubiquitin protein ligase binding
Bgee · 19
NEDD8 → anterior cingulate cortex, apex of heart, blastocyst, caudate nucleus, dentate gyrus of hippocampal formation granule cell, dorsolateral prefrontal cortex, embryo, epiblast, hypothalamus, maxillary prominence, morula, neural layer of retina, nucleus accumbens, prefrontal cortex, primary visual cortex, right frontal lobe, somite, superior frontal gyrus, ventricular zone
RNA expression pattern · 19
NEDD8 → anterior cingulate cortex, apex of heart, blastocyst, caudate nucleus, dentate gyrus of hippocampal formation granule cell, dorsolateral prefrontal cortex, embryo, epiblast, hypothalamus, maxillary prominence, morula, neural layer of retina, nucleus accumbens, prefrontal cortex, primary visual cortex, right frontal lobe, somite, superior frontal gyrus, ventricular zone
related to Role in DNA repair · 19
NEDD8 → As, Brown, But, Cul4A, DDB2, DNA, DNA-damage, GGR, GGR-NER, In GGR, Ku, Ku70/Ku80, Neddylation, NER, NHEJ, Non-homologous, The, The Ku, UV
related to Activation and conjugation · 13
NEDD8 → APPBP1, As, ATP-dependent, C-terminal, E1, E3, SUMO, The, The APPBP1/UBA3, The NEDD8, The UBA3, UBA3, UbcH12 E2
related to In cancer chemotherapy · 12
NEDD8 → As, DNA, Epigenetically, Frequency, Gene, If, Jin, Loss, NER, NHEJ, Roberston, The
related to Removal · 11
NEDD8 → COP9, CUL1, DEN1, NEDP1, Proteases, SCF, SENP8, There, UCHL1, UCHL3, USP21
related to Substrates for NEDD8 · 9
NEDD8 → As, Brown, CRL, CRLs, CUL1, Cullin, Neddylation, PARC, RING
related to NF-κB and NEDD8 · 8
NEDD8 → Degradation, IκB, IκBα, IκBβ, MLN4924, NF-κB, Pevonedistat, The
related to Interactions · 4
NEDD8 → Aryl, NUB1, UBE1C, UBE2M

Important terminology Word statistics

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Important terminology

ubiquitin neddylation dna repair human pevonedistat bp gene protein cancer chr band cell activation nhej chromosome 14 ubiquitination substrates process

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
NEDD8AliasesNEDD8, NEDD-8, neural precursor cell expressed, developmentally down-regulated 8, NEDD8 ubiquitin like modifier1.00infobox
NEDD8Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1NDD, 1R4M, 1R4N, 1XT9, 2BKR, 2KO3, 2NVU, 3DBH, 3DBL, 3DBR, 3DQV, 3GZN, 4F8C, 4FBJ, 4HCP, 4P5O1.00infobox
NEDD8Band14q121.00infobox
NEDD8Band14 C3|14 28.19 cM1.00infobox
NEDD8Bgeeprefrontal cortex1.00infobox
NEDD8Bgeesuperior frontal gyrus1.00infobox
NEDD8Bgeeright frontal lobe1.00infobox
NEDD8Bgeeanterior cingulate cortex1.00infobox
NEDD8Bgeedorsolateral prefrontal cortex1.00infobox
NEDD8Bgeenucleus accumbens1.00infobox
NEDD8Bgeeprimary visual cortex1.00infobox
NEDD8Bgeeapex of heart1.00infobox
NEDD8Bgeehypothalamus1.00infobox
NEDD8Bgeecaudate nucleus1.00infobox
NEDD8Bgeedentate gyrus of hippocampal formation granule cell1.00infobox
NEDD8Bgeeventricular zone1.00infobox
NEDD8Bgeesomite1.00infobox
NEDD8Bgeeneural layer of retina1.00infobox
NEDD8Bgeeblastocyst1.00infobox
NEDD8Bgeemorula1.00infobox
NEDD8Bgeeembryo1.00infobox
NEDD8Bgeemaxillary prominence1.00infobox
NEDD8Bgeeepiblast1.00infobox
NEDD8BioGPSMore reference expression data1.00infobox
NEDD8Chr.Chromosome 14 (human)1.00infobox
NEDD8Chr.Chromosome 14 (mouse)1.00infobox
NEDD8DatabasesNCBI: entry; OMA: entry1.00infobox
NEDD8End24,232,367 bp1.00infobox
NEDD8End55,909,581 bp1.00infobox
NEDD8EnsemblENSG00000129559 ENSG000002852461.00infobox

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