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NEDD8 is a protein that in humans is encoded by the NEDD8 gene. (in Saccharomyces cerevisiae this protein is known as Rub1) This ubiquitin-like (UBL) protein becomes covalently conjugated to a limited number of cellular proteins, in a process called NEDDylation similar to ubiquitination. Human NEDD8 shares 60% amino acid sequence identity to ubiquitin.…
The analysis highlights Research, In cancer chemotherapy and Substrates for NEDD8 as prominent areas in the source structure around NEDD8. 1 topic appears in more than one source area, which can help identify connections that are less obvious in a linear reading.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around NEDD8 shows recurring relationship patterns in the source. For example, NEDD8 → anatomical structure morphogenesis, cellular iron ion homeostasis, cytoplasm, cytosol, extracellular exosome, modification-dependent protein catabolic process, nucleoplasm, nucleus, post-translational protein modification, protein binding, protein deubiquitination, protein localization, protein neddylation, protein tag, protein ubiquitination, proteolysis, regulation of proteolysis, response to organic cyclic compound, transforming growth factor beta receptor signaling pathway, ubiquitin protein ligase binding Another extracted example is NEDD8 → anterior cingulate cortex, apex of heart, blastocyst, caudate nucleus, dentate gyrus of hippocampal formation granule cell, dorsolateral prefrontal cortex, embryo, epiblast, hypothalamus, maxillary prominence, morula, neural layer of retina, nucleus accumbens, prefrontal cortex, primary visual cortex, right frontal lobe, somite, superior frontal gyrus, ventricular zone. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
ubiquitin neddylation dna repair human pevonedistat bp gene protein cancer chr band cell activation nhej chromosome 14 ubiquitination substrates process
TTTA extracted 166 structured relationships around NEDD8. Examples in this analysis include NEDD8 → Aliases → NEDD8, NEDD-8, neural precursor cell expressed, developmentally down-regulated 8, NEDD8 ubiquitin like modifier and NEDD8 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1NDD, 1R4M, 1R4N, 1XT9, 2BKR, 2KO3, 2NVU, 3DBH, 3DBL, 3DBR, 3DQV, 3GZN, 4F8C, 4FBJ, 4HCP, 4P5O. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| NEDD8 | Aliases | NEDD8, NEDD-8, neural precursor cell expressed, developmentally down-regulated 8, NEDD8 ubiquitin like modifier | 1.00 | infobox |
| NEDD8 | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1NDD, 1R4M, 1R4N, 1XT9, 2BKR, 2KO3, 2NVU, 3DBH, 3DBL, 3DBR, 3DQV, 3GZN, 4F8C, 4FBJ, 4HCP, 4P5O | 1.00 | infobox |
| NEDD8 | Band | 14q12 | 1.00 | infobox |
| NEDD8 | Band | 14 C3|14 28.19 cM | 1.00 | infobox |
| NEDD8 | Bgee | prefrontal cortex | 1.00 | infobox |
| NEDD8 | Bgee | superior frontal gyrus | 1.00 | infobox |
| NEDD8 | Bgee | right frontal lobe | 1.00 | infobox |
| NEDD8 | Bgee | anterior cingulate cortex | 1.00 | infobox |
| NEDD8 | Bgee | dorsolateral prefrontal cortex | 1.00 | infobox |
| NEDD8 | Bgee | nucleus accumbens | 1.00 | infobox |
| NEDD8 | Bgee | primary visual cortex | 1.00 | infobox |
| NEDD8 | Bgee | apex of heart | 1.00 | infobox |
| NEDD8 | Bgee | hypothalamus | 1.00 | infobox |
| NEDD8 | Bgee | caudate nucleus | 1.00 | infobox |
| NEDD8 | Bgee | dentate gyrus of hippocampal formation granule cell | 1.00 | infobox |
| NEDD8 | Bgee | ventricular zone | 1.00 | infobox |
| NEDD8 | Bgee | somite | 1.00 | infobox |
| NEDD8 | Bgee | neural layer of retina | 1.00 | infobox |
| NEDD8 | Bgee | blastocyst | 1.00 | infobox |
| NEDD8 | Bgee | morula | 1.00 | infobox |
| NEDD8 | Bgee | embryo | 1.00 | infobox |
| NEDD8 | Bgee | maxillary prominence | 1.00 | infobox |
| NEDD8 | Bgee | epiblast | 1.00 | infobox |
| NEDD8 | BioGPS | More reference expression data | 1.00 | infobox |
| NEDD8 | Chr. | Chromosome 14 (human) | 1.00 | infobox |
| NEDD8 | Chr. | Chromosome 14 (mouse) | 1.00 | infobox |
| NEDD8 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| NEDD8 | End | 24,232,367 bp | 1.00 | infobox |
| NEDD8 | End | 55,909,581 bp | 1.00 | infobox |
| NEDD8 | Ensembl | ENSG00000129559 ENSG00000285246 | 1.00 | infobox |
The concept neighborhoods around NEDD8 bring nearby vocabulary together. In this analysis, examples include Ubiquitin, Activation and Neddylation. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For NEDD8, one of the stronger structural bridges in this analysis connects NEDD8 with In cancer chemotherapy. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around NEDD8 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Research, In cancer chemotherapy & Substrates for NEDD8, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — NEDD8 · EN edition · Analysis: TopicsToTalkAbout