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NEDD8: Research, In cancer chemotherapy & Substrates for NEDD8

NEDD8 is a protein that in humans is encoded by the NEDD8 gene. (in Saccharomyces cerevisiae this protein is known as Rub1) This ubiquitin-like (UBL) protein becomes covalently conjugated to a limited number of cellular proteins, in a process called NEDDylation similar to ubiquitination. Human NEDD8 shares 60% amino acid sequence identity to ubiquitin.…

Language: English [EN]
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NEDD8 topic overview

The analysis highlights Research, In cancer chemotherapy and Substrates for NEDD8 as prominent areas in the source structure around NEDD8. 1 topic appears in more than one source area, which can help identify connections that are less obvious in a linear reading.

Related topics
38
Source areas
7
Connected nodes
46
Extracted relationships
166
Concept neighborhoods
21
Bridge connections
46

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

In cancer chemotherapy · 8 topics
Overview · 7 topics
Substrates for NEDD8 · 7 topics
Interactions · 6 topics
In preclinical studies · 5 topics
Role in DNA repair · 4 topics
Activation and conjugation · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
NEDD8, NEDD-8, neural precursor cell expressed, developmentally down-regulated 8, NEDD8 ubiquitin like modifier
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1NDD, 1R4M, 1R4N, 1XT9, 2BKR, 2KO3, 2NVU, 3DBH, 3DBL, 3DBR, 3DQV, 3GZN, 4F8C, 4FBJ, 4HCP, 4P5O
Band
14q12 · 14 C3|14 28.19 cM
Bgee
prefrontal cortex · superior frontal gyrus · right frontal lobe · anterior cingulate cortex · dorsolateral prefrontal cortex
BioGPS
More reference expression data
Chr.
Chromosome 14 (human) · Chromosome 14 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Activation and conjugation

Substrates for NEDD8

Role in DNA repair

In cancer chemotherapy

In preclinical studies

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How NEDD8 connects Entity context

The extracted context around NEDD8 shows recurring relationship patterns in the source. For example, NEDD8 → anatomical structure morphogenesis, cellular iron ion homeostasis, cytoplasm, cytosol, extracellular exosome, modification-dependent protein catabolic process, nucleoplasm, nucleus, post-translational protein modification, protein binding, protein deubiquitination, protein localization, protein neddylation, protein tag, protein ubiquitination, proteolysis, regulation of proteolysis, response to organic cyclic compound, transforming growth factor beta receptor signaling pathway, ubiquitin protein ligase binding Another extracted example is NEDD8 → anterior cingulate cortex, apex of heart, blastocyst, caudate nucleus, dentate gyrus of hippocampal formation granule cell, dorsolateral prefrontal cortex, embryo, epiblast, hypothalamus, maxillary prominence, morula, neural layer of retina, nucleus accumbens, prefrontal cortex, primary visual cortex, right frontal lobe, somite, superior frontal gyrus, ventricular zone. Use these groups to spot repeated connection types before inspecting the individual relationships.

NEDD8

Top relations

Gene ontology · 21
NEDD8 → anatomical structure morphogenesis, cellular iron ion homeostasis, cytoplasm, cytosol, extracellular exosome, modification-dependent protein catabolic process, nucleoplasm, nucleus, post-translational protein modification, protein binding, protein deubiquitination, protein localization, protein neddylation, protein tag, protein ubiquitination, proteolysis, regulation of proteolysis, response to organic cyclic compound, transforming growth factor beta receptor signaling pathway, ubiquitin protein ligase binding
Bgee · 19
NEDD8 → anterior cingulate cortex, apex of heart, blastocyst, caudate nucleus, dentate gyrus of hippocampal formation granule cell, dorsolateral prefrontal cortex, embryo, epiblast, hypothalamus, maxillary prominence, morula, neural layer of retina, nucleus accumbens, prefrontal cortex, primary visual cortex, right frontal lobe, somite, superior frontal gyrus, ventricular zone
RNA expression pattern · 19
NEDD8 → anterior cingulate cortex, apex of heart, blastocyst, caudate nucleus, dentate gyrus of hippocampal formation granule cell, dorsolateral prefrontal cortex, embryo, epiblast, hypothalamus, maxillary prominence, morula, neural layer of retina, nucleus accumbens, prefrontal cortex, primary visual cortex, right frontal lobe, somite, superior frontal gyrus, ventricular zone
related to Role in DNA repair · 19
NEDD8 → As, Brown, But, Cul4A, DDB2, DNA, DNA-damage, GGR, GGR-NER, In GGR, Ku, Ku70/Ku80, Neddylation, NER, NHEJ, Non-homologous, The, The Ku, UV
related to Activation and conjugation · 13
NEDD8 → APPBP1, As, ATP-dependent, C-terminal, E1, E3, SUMO, The, The APPBP1/UBA3, The NEDD8, The UBA3, UBA3, UbcH12 E2
related to In cancer chemotherapy · 12
NEDD8 → As, DNA, Epigenetically, Frequency, Gene, If, Jin, Loss, NER, NHEJ, Roberston, The
related to Removal · 11
NEDD8 → COP9, CUL1, DEN1, NEDP1, Proteases, SCF, SENP8, There, UCHL1, UCHL3, USP21
related to Substrates for NEDD8 · 9
NEDD8 → As, Brown, CRL, CRLs, CUL1, Cullin, Neddylation, PARC, RING
related to NF-κB and NEDD8 · 8
NEDD8 → Degradation, IκB, IκBα, IκBβ, MLN4924, NF-κB, Pevonedistat, The
related to Interactions · 4
NEDD8 → Aryl, NUB1, UBE1C, UBE2M

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

ubiquitin neddylation dna repair human pevonedistat bp gene protein cancer chr band cell activation nhej chromosome 14 ubiquitination substrates process

NEDD8 relationships Subject–Predicate–Object triples

TTTA extracted 166 structured relationships around NEDD8. Examples in this analysis include NEDD8 → Aliases → NEDD8, NEDD-8, neural precursor cell expressed, developmentally down-regulated 8, NEDD8 ubiquitin like modifier and NEDD8 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1NDD, 1R4M, 1R4N, 1XT9, 2BKR, 2KO3, 2NVU, 3DBH, 3DBL, 3DBR, 3DQV, 3GZN, 4F8C, 4FBJ, 4HCP, 4P5O. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
NEDD8AliasesNEDD8, NEDD-8, neural precursor cell expressed, developmentally down-regulated 8, NEDD8 ubiquitin like modifier1.00infobox
NEDD8Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1NDD, 1R4M, 1R4N, 1XT9, 2BKR, 2KO3, 2NVU, 3DBH, 3DBL, 3DBR, 3DQV, 3GZN, 4F8C, 4FBJ, 4HCP, 4P5O1.00infobox
NEDD8Band14q121.00infobox
NEDD8Band14 C3|14 28.19 cM1.00infobox
NEDD8Bgeeprefrontal cortex1.00infobox
NEDD8Bgeesuperior frontal gyrus1.00infobox
NEDD8Bgeeright frontal lobe1.00infobox
NEDD8Bgeeanterior cingulate cortex1.00infobox
NEDD8Bgeedorsolateral prefrontal cortex1.00infobox
NEDD8Bgeenucleus accumbens1.00infobox
NEDD8Bgeeprimary visual cortex1.00infobox
NEDD8Bgeeapex of heart1.00infobox
NEDD8Bgeehypothalamus1.00infobox
NEDD8Bgeecaudate nucleus1.00infobox
NEDD8Bgeedentate gyrus of hippocampal formation granule cell1.00infobox
NEDD8Bgeeventricular zone1.00infobox
NEDD8Bgeesomite1.00infobox
NEDD8Bgeeneural layer of retina1.00infobox
NEDD8Bgeeblastocyst1.00infobox
NEDD8Bgeemorula1.00infobox
NEDD8Bgeeembryo1.00infobox
NEDD8Bgeemaxillary prominence1.00infobox
NEDD8Bgeeepiblast1.00infobox
NEDD8BioGPSMore reference expression data1.00infobox
NEDD8Chr.Chromosome 14 (human)1.00infobox
NEDD8Chr.Chromosome 14 (mouse)1.00infobox
NEDD8DatabasesNCBI: entry; OMA: entry1.00infobox
NEDD8End24,232,367 bp1.00infobox
NEDD8End55,909,581 bp1.00infobox
NEDD8EnsemblENSG00000129559 ENSG000002852461.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around NEDD8 bring nearby vocabulary together. In this analysis, examples include Ubiquitin, Activation and Neddylation. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • NEDD8
    • Ubiquitin
    • Activation
    • Neddylation
    • Protein
    • Cell
    • Cancer
    • Pevonedistat
    • Conjugated
    • Cullin
    • Modification
    • Dna
    • Ligases
  • nedd8
    • Ubiquitin
    • Activation
    • Neddylation
    • Protein
    • Cell
    • Cancer
    • Pevonedistat
    • Conjugated
    • Cullin
    • Modification
    • Dna
    • Ligases
  • gene
    • Location
    • Chromosome
    • Bp
    • Chr
    • Cellular
    • Human
    • Mouse
    • Conjugated
    • End
    • Band
    • Neddylation
    • Process
  • neddylation
    • Conjugation
    • Protein
    • Proteins
    • Ubiquitination
    • Ubiquitin
    • Cullin
    • Location
    • Role
    • Chromosome
    • Process
    • Bp
    • Cell
  • ubiquitination
    • Cellular
    • Conjugated
    • Process
    • Protein
    • Proteins
    • Neddylation
    • Gene
    • Known
    • Mouse
    • End
    • Location
    • Modification
  • nedd8 activating e1 enzyme
    • Ubiquitin
    • Activation
    • Neddylation
    • Protein
    • Cell
    • Cancer
    • Pevonedistat
    • Conjugated
    • Cullin
    • Modification
    • Dna
    • Ligases
  • frequency of hypermethylation of dna repair genes in cancer
    • Repair
    • Cell
    • Dna
    • Ner
    • Nhej
    • Progression
    • Gene
    • Pevonedistat
    • Nedd8
    • Pathway
    • Role
    • Cells
  • activation and conjugation
    • Pevonedistat
    • Neddylation
    • Cancer
    • Nedd8
    • Nf-κb
    • Cell
    • Cullin
    • Location
    • Pparγ
    • Role
    • Ubiquitin
    • Chromosome

Connections between topic areas Semantic bridges

For NEDD8, one of the stronger structural bridges in this analysis connects NEDD8 with In cancer chemotherapy. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
NEDD8In cancer chemotherapy · splits 38 ⟂ 9
NEDD8Overview · splits 39 ⟂ 8
NEDD8Substrates for NEDD8 · splits 39 ⟂ 8
NEDD8Interactions · splits 40 ⟂ 7
NEDD8In preclinical studies · splits 41 ⟂ 6
NEDD8Role in DNA repair · splits 42 ⟂ 5
NEDD8Activation and conjugation · splits 44 ⟂ 3

Map overview Semantic statistics

NEDD8

Nodes47
Edges46
Triples166
Avg. degree1.96
Density0.042553
Components1

Source & methodology

TTTA analyzes the structure around NEDD8 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Research, In cancer chemotherapy & Substrates for NEDD8, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — NEDD8 · EN edition · Analysis: TopicsToTalkAbout

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