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Deamidation

Deamidation is a chemical reaction in which an amide functional group in the side chain of the amino acids asparagine or glutamine is removed or converted to another functional group. Typically, asparagine is converted to aspartic acid or isoaspartic acid. Glutamine is converted to glutamic acid or pyroglutamic acid (5-oxoproline). In a protein or…

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Overview

AmideFunctional groupSide chainAmino acidsAsparagine
15 related topics

Kinetics of deamidation

GlycineStericPeptidePHTemperature
5 related topics

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Overview

Kinetics of deamidation

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Deamidation

Nodes23
Edges22
Triples36
Avg. degree1.91
Density0.086957
Components1

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Deamidation

Top relations

related to References · 27
Deamidation → Althouse Press, Asparaginyl, Asparaginyl Peptides, Aspartyl, Biological Chemistry, Cave Junction, Clarke, Glutaminyl Residues, International Journal, Model, Molecular Clocks, OCLC, Ore, Peptide, Peptides, PMID, Propensity, Protein Research, Proteins, RC
related to Analytical method · 7
Deamidation → ERLIC-MS/MS, Mass, Protein, Recently, RPLC, The, This
is a · 1
Deamidation → chemical reaction in which an amide functional group in the side chain of the amino acids asparagine or glutamine is removed or converted to another functional group

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Important terminology

acid asparagine peptide glutamine ph group proteins amino aspartic conditions residue protein succinimide converted intermediate formation side amide artifacts reactions

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Deamidationis achemical reaction in which an amide functional group in the side chain of the amino acids asparagine or glutamine is removed or converted to another functional group0.90text
glycine whose low steric hindrance leaves the peptide group open for attackinstance offlexible residue0.80text
Deamidationrelated to Analytical methodProtein0.60section
Deamidationrelated to Analytical methodRPLC0.60section
Deamidationrelated to Analytical methodRecently0.60section
Deamidationrelated to Analytical methodERLIC-MS/MS0.60section
Deamidationrelated to Analytical methodMass0.60section
Deamidationrelated to Analytical methodThe0.60section
Deamidationrelated to Analytical methodThis0.60section
Deamidationrelated to ReferencesClarke0.60section
Deamidationrelated to ReferencesPropensity0.60section
Deamidationrelated to ReferencesInternational Journal0.60section

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