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Coenzyme A

Coenzyme A (CoA, SHCoA, CoASH) is a coenzyme, notable for its role in the synthesis and oxidation of fatty acids, and the oxidation of pyruvate in the citric acid cycle. Every genome sequenced to date encodes enzymes that use coenzyme A as a substrate, and around 4% of cellular enzymes use it (or a thioester) as a substrate. In humans, CoA biosynthesis…

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Overview

Discovery of structure

Biosynthesis

Function

Use in biological research

Non-exhaustive list of coenzyme A-activated acyl groups

Bibliography

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Coenzyme A

Nodes96
Edges95
Triples91
Avg. degree1.98
Density0.020833
Components1

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Coenzyme A

Top relations

related to Antioxidant function and regulation · 19
Coenzyme A → A-mediated, CoAlated, CoAlation, Different, Discovery, GAPDH, LC-MS/MS, Mammalian, NME1, Protein-S-SCoA, S-glutathionylation, The, Thioredoxin, Thioredoxin-like, This, To, Upon, Using, YtpP
related to Discovery of structure · 17
Coenzyme A → Beverly Guirard, Coenzyme, Fritz Lipmann, Harvard Medical School, He, In, Its, Lipmann, Lister Institute, London, Massachusetts General Hospital, Medicine, Nathan Kaplan, Nobel Prize, Physiology, The, Work
related to Fatty acid synthesis · 8
Coenzyme A → CoA, CoASH, Coenzyme, HSCoA, It, Since, This, When
related to Regulation · 7
Coenzyme A → CoA, During, Here, In, Insulin, This, When
related to Use in biological research · 7
Coenzyme A → Aqueous, CoA, CoA-S, Coenzyme, Free CoA, S-glutathione, The
related to Biosynthesis · 6
Coenzyme A → ATP, B5, Coenzyme, Escherichia, In, These
related to Commercial production · 3
Coenzyme A → CoA, Coenzyme, Various
related to Energy production · 3
Coenzyme A → Coenzyme, Its, This
is a · 1
Coenzyme A → highly versatile molecule

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Important terminology

coenzyme coa acid fatty synthesis pantothenate acyl acids cysteine biosynthesis acetyl-coa enzyme proteins protein atp form oxidation process regulation pyruvate

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Coenzyme Ais ahighly versatile molecule0.90text
meatinstance ofwhich is found in food0.80text
vegetablesinstance ofwhich is found in food0.80text
cereal grainsinstance ofwhich is found in food0.80text
legumesinstance ofwhich is found in food0.80text
eggsinstance ofwhich is found in food0.80text
and milkinstance ofwhich is found in food0.80text
acyl carrier proteininstance ofwhich are essential in cell membrane structure.Coenzyme A is also the source of the phosphopantetheine group that is added as a prosthetic group to proteins0.80text
formyltetrahydrofolate dehydrogenase.Energy productionCoenzyme A is one of five crucial coenzymes that are necessary in the reaction mechanism of the citric acid cycleinstance ofwhich are essential in cell membrane structure.Coenzyme A is also the source of the phosphopantetheine group that is added as a prosthetic group to proteins0.80text
carbohydratesinstance ofThis process is the body's primary catabolic pathway and is essential in breaking down the building blocks of the cell0.80text
amino acidsinstance ofThis process is the body's primary catabolic pathway and is essential in breaking down the building blocks of the cell0.80text
and lipids.RegulationWhen there is excess glucoseinstance ofThis process is the body's primary catabolic pathway and is essential in breaking down the building blocks of the cell0.80text

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