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Persulfidation (referred to in older literature as sulfhydration) is a type of post-translational modification of proteins involving addition of a sulfur molecule onto a reactive thiol (-SH) group of a cysteine residue, forming a species known as a hydropersulfide (-SSH). Persulfidation occurs in plants, animals, and throughout all kingdoms. It is a…
The analysis highlights Overview, Related Topics and Entities as prominent areas in the source structure around Persulfidation.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
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disulfides proteins protein persulfides persulfide thiol cysteine modification addition sulfur species mechanism biological h2s major chemistry react alkylating agents may
TTTA extracted 5 structured relationships around Persulfidation. Examples in this analysis include iodoacetamide derivatives → instance of → alkylating agents and sulfinate → instance of → while disulfides and higher oxidation states. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| iodoacetamide derivatives | instance of | alkylating agents | 0.80 | text |
| N-ethylmaleimide have traditionally been used to trap persulfides as disulfides for analysis | instance of | alkylating agents | 0.80 | text |
| sulfinate | instance of | while disulfides and higher oxidation states | 0.80 | text |
| sulfonate are not modified | instance of | while disulfides and higher oxidation states | 0.80 | text |
| dithiothreitol | instance of | the tag on the trapped persulfide.This modification can be reversed back into a thiol by exogenous chemical reducing agents | 0.80 | text |
The concept neighborhoods around Persulfidation bring nearby vocabulary together. In this analysis, examples include Addition, Chemistry and Major. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
Bridges highlight paths between different parts of the Persulfidation map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around Persulfidation to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Overview, Related Topics & Entities, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — Persulfidation · EN edition · Analysis: TopicsToTalkAbout