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Persulfidation

Persulfidation (referred to in older literature as sulfhydration) is a type of post-translational modification of proteins involving addition of a sulfur molecule onto a reactive thiol (-SH) group of a cysteine residue, forming a species known as a hydropersulfide (-SSH). Persulfidation occurs in plants, animals, and throughout all kingdoms. It is a…

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Persulfidation

Nodes20
Edges19
Triples5
Avg. degree1.9
Density0.1
Components1

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Important terminology

disulfides proteins protein persulfides persulfide thiol cysteine modification addition sulfur species mechanism biological h2s major chemistry react alkylating agents may

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
iodoacetamide derivativesinstance ofalkylating agents0.80text
N-ethylmaleimide have traditionally been used to trap persulfides as disulfides for analysisinstance ofalkylating agents0.80text
sulfinateinstance ofwhile disulfides and higher oxidation states0.80text
sulfonate are not modifiedinstance ofwhile disulfides and higher oxidation states0.80text
dithiothreitolinstance ofthe tag on the trapped persulfide.This modification can be reversed back into a thiol by exogenous chemical reducing agents0.80text

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