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CD38: History, Applications & Research

CD38 (cluster of differentiation 38), also known as cyclic ADP ribose hydrolase, is a glycoprotein found on the surface of many immune cells (white blood cells), including CD4+, CD8+, B lymphocytes and natural killer cells. CD38 also functions in cell adhesion, signal transduction and calcium signaling.

Language: English [EN]
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CD38 topic overview

The analysis highlights History, Applications and Research as prominent areas in the source structure around CD38.

Related topics
85
Source areas
8
Connected nodes
93
Extracted relationships
150
Concept neighborhoods
27
Bridge connections
93

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Clinical significance · 15 topics
Inhibitors · 15 topics
Aging studies · 14 topics
Function · 14 topics
Overview · 14 topics
History · 7 topics
Clinical application · 5 topics
Tissue distribution · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

2.4.99.20
3.2.2.6
Aliases
CD38, ADPRC1, ADPRC 1, CD38 molecule
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4TMF, 1YH3, 1ZVM, 2EF1, 2HCT, 2I65, 2I66, 2I67, 2O3Q, 2O3R, 2O3S, 2O3T, 2O3U, 2PGJ, 2PGL, 3DZF, 3DZG, 3DZH,…
Band
4p15.32 · 5 B3|5 23.85 cM
Bgee
seminal vesicula · bone marrow cell · lymph node · thymus · appendix

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

History

Tissue distribution

Function

Clinical significance

Clinical application

Inhibitors

Aging studies

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How CD38 connects Entity context

The extracted context around CD38 shows recurring relationship patterns in the source. For example, CD38 → apoptotic signaling pathway, artery smooth muscle contraction, B cell receptor signaling pathway, basolateral plasma membrane, cell surface, extracellular exosome, female pregnancy, hydrolase activity, hydrolase activity, acting on glycosyl bonds, identical protein binding, integral component of membrane, intracellular membrane-bounded organelle, long-term depression, membrane, NAD metabolic process, NAD(P)+ nucleosidase activity, NAD+ nucleosidase activity, NAD+ nucleotidase, cyclic ADP-ribose generating, negative regulation of apoptotic process, negative regulation of bone resorption Another extracted example is CD38 → appendix, bone marrow cell, bronchial epithelial cell, duodenum, gonad, granulocyte, jejunum, left colon, left lung lobe, lumbar subsegment of spinal cord, lymph node, mesenteric lymph nodes, muscle of thigh, Paneth cell, seminal vesicula, spleen, stroma of bone marrow, thymus. Use these groups to spot repeated connection types before inspecting the individual relationships.

CD38

Top relations

Gene ontology · 43
CD38 → apoptotic signaling pathway, artery smooth muscle contraction, B cell receptor signaling pathway, basolateral plasma membrane, cell surface, extracellular exosome, female pregnancy, hydrolase activity, hydrolase activity, acting on glycosyl bonds, identical protein binding, integral component of membrane, intracellular membrane-bounded organelle, long-term depression, membrane, NAD metabolic process, NAD(P)+ nucleosidase activity, NAD+ nucleosidase activity, NAD+ nucleotidase, cyclic ADP-ribose generating, negative regulation of apoptotic process, negative regulation of bone resorption
Bgee · 18
CD38 → appendix, bone marrow cell, bronchial epithelial cell, duodenum, gonad, granulocyte, jejunum, left colon, left lung lobe, lumbar subsegment of spinal cord, lymph node, mesenteric lymph nodes, muscle of thigh, Paneth cell, seminal vesicula, spleen, stroma of bone marrow, thymus
RNA expression pattern · 18
CD38 → appendix, bone marrow cell, bronchial epithelial cell, duodenum, gonad, granulocyte, jejunum, left colon, left lung lobe, lumbar subsegment of spinal cord, lymph node, mesenteric lymph nodes, muscle of thigh, Paneth cell, seminal vesicula, spleen, stroma of bone marrow, thymus
related to External links · 13
CD38 → ADP-ribose, ADP-ribosyl, Antigens, GeneCard CD38Overview, Human CD38, Medicine Medical Subject Headings, MeSH, National Library, P28907, PDB, PDBe-KB, UCSC Genome Browser, UniProt
related to Aging studies · 8
CD38 → Cellular, Macrophages, NAD, NF-κB, On, Secretions, The, Treatment
related to Function · 7
CD38 → As, B-cell, BCR, CD19, CD31, It, TRPM2
related to Inhibitors · 6
CD38 → Cassic, CD38-IN-78cChrysanthemin, Kuromanin, MezagitamabErzotabartLumrotatugSanritatugModakafusp Alfa/TAK-573apigeninLuteolinidinMK-0159TNB-738, MOR202, Rhein
related to history · 5
CD38 → About, ADP-ribose, In, NAADP, NK
Band · 2
CD38 → 4p15.32, 5 B3|5 23.85 cM
Chr. · 2
CD38 → Chromosome 4 (human), Chromosome 5 (mouse)

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

nad cell cells chromosome also bp surface human gene chr band expression cyclic macrophages function cadpr receptor location enzyme marker

CD38 relationships Subject–Predicate–Object triples

TTTA extracted 150 structured relationships around CD38. Examples in this analysis include CD38 → 2.4.99.20 → ↗ and CD38 → Aliases → CD38, ADPRC1, ADPRC 1, CD38 molecule. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
CD382.4.99.201.00infobox
CD383.2.2.61.00infobox
CD38AliasesCD38, ADPRC1, ADPRC 1, CD38 molecule1.00infobox
CD38Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4TMF, 1YH3, 1ZVM, 2EF1, 2HCT, 2I65, 2I66, 2I67, 2O3Q, 2O3R, 2O3S, 2O3T, 2O3U, 2PGJ, 2PGL, 3DZF, 3DZG, 3DZH,…1.00infobox
CD38Band4p15.321.00infobox
CD38Band5 B3|5 23.85 cM1.00infobox
CD38Bgeeseminal vesicula1.00infobox
CD38Bgeebone marrow cell1.00infobox
CD38Bgeelymph node1.00infobox
CD38Bgeethymus1.00infobox
CD38Bgeeappendix1.00infobox
CD38Bgeespleen1.00infobox
CD38Bgeebronchial epithelial cell1.00infobox
CD38Bgeegonad1.00infobox
CD38Bgeegranulocyte1.00infobox
CD38Bgeemuscle of thigh1.00infobox
CD38Bgeestroma of bone marrow1.00infobox
CD38Bgeeleft colon1.00infobox
CD38Bgeemesenteric lymph nodes1.00infobox
CD38BgeePaneth cell1.00infobox
CD38Bgeejejunum1.00infobox
CD38Bgeelumbar subsegment of spinal cord1.00infobox
CD38Bgeeleft lung lobe1.00infobox
CD38Bgeeduodenum1.00infobox
CD38BioGPSMore reference expression data1.00infobox
CD38Chr.Chromosome 4 (human)1.00infobox
CD38Chr.Chromosome 5 (mouse)1.00infobox
CD38DatabasesNCBI: entry; OMA: entry1.00infobox
CD38End15,853,232 bp1.00infobox
CD38End44,069,717 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around CD38 bring nearby vocabulary together. In this analysis, examples include Nad, Cell and Cells. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • CD38
    • Nad
    • Cell
    • Cells
    • Cadpr
    • Expression
    • Cyclic
    • Decline
    • Function
    • Surface
    • Acid
    • Activity
    • Adp-ribose
  • cd38
    • Nad
    • Cell
    • Cells
    • Cadpr
    • Expression
    • Cyclic
    • Decline
    • Function
    • Surface
    • Acid
    • Activity
    • Adp-ribose
  • cell adhesion
    • Marker
    • Protein
    • Signaling
    • Expression
    • Surface
    • Cells
    • Hydrolase
    • Acid
    • Activity
    • Adp-ribose
    • Band
    • Killer
  • thymus cell
    • Marker
    • Protein
    • Signaling
    • Expression
    • Surface
    • Cells
    • Hydrolase
    • Acid
    • Activity
    • Adp-ribose
    • Band
    • Killer
  • cyclic adp-ribose
    • Adp-ribose
    • Cyclic
    • Hydrolase
    • Acid
    • Ribose
    • Activity
    • Cadpr
    • Surface
    • Protein
    • Signaling
    • Band
    • Enzyme
  • nicotinic acid adenine dinucleotide phosphate
    • Activity
    • Adp-ribose
    • Cyclic
    • Daratumumab
    • Hydrolase
    • Protein
    • Signaling
    • Age
    • Band
    • Location
    • Muscle
    • Nad
  • nicotinic acid
    • Activity
    • Adp-ribose
    • Cyclic
    • Daratumumab
    • Hydrolase
    • Protein
    • Signaling
    • Age
    • Band
    • Location
    • Muscle
    • Nad
  • cassic acid
    • Activity
    • Adp-ribose
    • Cyclic
    • Daratumumab
    • Hydrolase
    • Protein
    • Signaling
    • Age
    • Band
    • Location
    • Muscle
    • Nad

Connections between topic areas Semantic bridges

For CD38, one of the stronger structural bridges in this analysis connects CD38 with Clinical significance. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
CD38Clinical significance · splits 78 ⟂ 16
CD38Inhibitors · splits 78 ⟂ 16
CD38Overview · splits 79 ⟂ 15
CD38Function · splits 79 ⟂ 15
CD38Aging studies · splits 79 ⟂ 15
CD38History · splits 86 ⟂ 8
CD38Clinical application · splits 88 ⟂ 6

Map overview Semantic statistics

CD38

Nodes94
Edges93
Triples150
Avg. degree1.98
Density0.021277
Components1

Source & methodology

TTTA analyzes the structure around CD38 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Applications & Research, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — CD38 · EN edition · Analysis: TopicsToTalkAbout

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