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Explore the main themes, entities and connections around CD38. Start with the topic map, then use the sections below for research and deeper semantic analysis.
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Clinical significance
Endothelial cellsEndotheliumLeukocytesPassage of leukocytes through blood vessel wallsInterferon gamma
15 related topics
Inhibitors
15 related topics
Function
14 related topics
Aging studies
14 related topics
Key facts & relationships
High-confidence facts extracted from structured source data. Use them as anchors for further research.
- 2.4.99.20
- ↗
- 3.2.2.6
- ↗
- Aliases
- CD38, ADPRC1, ADPRC 1, CD38 molecule
- Available structures
- Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4TMF, 1YH3, 1ZVM, 2EF1, 2HCT, 2I65, 2I66, 2I67, 2O3Q, 2O3R, 2O3S, 2O3T, 2O3U, 2PGJ, 2PGL, 3DZF, 3DZG, 3DZH,…
- Band
- 4p15.32 · 5 B3|5 23.85 cM
- Bgee
- seminal vesicula · bone marrow cell · lymph node · thymus · appendix
Topics to explore
A structured outline of related entities, concepts and subtopics. Open any item to build a new map centered on it.Browse the full topic structure. Each item opens a new analysis centered on that subject.
Overview
- Cluster of differentiation
- Glycoprotein
- White blood cells White blood cell
- CD4
- CD8
- B lymphocytes B lymphocyte
- Natural killer cells Natural killer cell
- Cell adhesion
- Signal transduction
- Calcium signaling
- Gene
- Chromosome 4 Chromosome 4 (human)
- Paralog
- CD157 BST1
History
- Thymus cell T cell
- Lymphocytes Lymphocyte
- B cells B cell
- Monocytes Monocyte
- Second messengers Second messenger system
- Cyclic ADP-ribose
- Nicotinic acid adenine dinucleotide phosphate
Tissue distribution
- Plasma B cells Plasma cell
Function
- CD31
- Cytokines Cytokine
- Enzyme
- ADP ribose Adenosine diphosphate ribose
- NAD+ Nicotinamide adenine dinucleotide
- NADase NAD+ glycohydrolase
- Nicotinic acid
- Nicotinamide adenine dinucleotide phosphate
- Cytosol
- Neurotransmitter
- Neuropeptide
- Oxytocin
- Catalyze Catalysis
- SARM1
Clinical significance
- Endothelial cells Endothelial cell
- Endothelium
- Leukocytes Leukocyte
- Passage of leukocytes through blood vessel walls Leukocyte extravasation
- Interferon gamma
- Gram negative
- Lipopolysaccharide
- Macrophages Macrophage
- Tumor necrosis factor
- Smooth muscle
- Asthmatic Asthma
- HIV
- Leukemias Leukemia
- Myelomas Myeloma
- Type II diabetes mellitus
Clinical application
Inhibitors
- Cassic acid
- CD38-IN-78c
- Chrysanthemin
- Isatuximab
- Felzartamab Felzartamab?action=edit&redlink=1
- Mezagitamab Mezagitamab?action=edit&redlink=1
- Erzotabart Erzotabart?action=edit&redlink=1
- Lumrotatug Lumrotatug?action=edit&redlink=1
- Sanritatug Sanritatug?action=edit&redlink=1
- Modakafusp Alfa Modakafusp Alfa?action=edit&redlink=1
- TAK-573 TAK-573?action=edit&redlink=1
- Apigenin
- Luteolinidin
- MK-0159 MK-0159?action=edit&redlink=1
- TNB-738 TNB-738?action=edit&redlink=1
Aging studies
- NAD+
- Knockout mice Knockout mouse
- Overexpressing Gene expression
- Mitochondrial dysfunction Mitochondrial disease
- Senescent cells Cellular senescence
- Visceral fat
- Inflammation
- Transcription factor
- NF-κB
- Secretions Senescence-associated secretory phenotype
- Astrocytes Astrocyte
- Microglia
- Neuroinflammation
- Neurodegeneration
Advanced semantic analysis
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
Map overview Semantic statistics
Number of nodes, edges, triples, density and central hubs. Use it to gauge the size and connectivity of the map.CD38
Nodes94
Edges93
Triples150
Avg. degree1.98
Density0.021277
Components1
How this topic connects Entity context
Quick relationship hints grouped by predicate. Useful for spotting recurring semantic connections around the current entity.See the strongest relationship patterns around the current topic before diving into the raw triples.
CD38
Top relations
Gene ontology · 43
CD38 → apoptotic signaling pathway, artery smooth muscle contraction, B cell receptor signaling pathway, basolateral plasma membrane, cell surface, extracellular exosome, female pregnancy, hydrolase activity, hydrolase activity, acting on glycosyl bonds, identical protein binding, integral component of membrane, intracellular membrane-bounded organelle, long-term depression, membrane, NAD metabolic process, NAD(P)+ nucleosidase activity, NAD+ nucleosidase activity, NAD+ nucleotidase, cyclic ADP-ribose generating, negative regulation of apoptotic process, negative regulation of bone resorption
Bgee · 18
CD38 → appendix, bone marrow cell, bronchial epithelial cell, duodenum, gonad, granulocyte, jejunum, left colon, left lung lobe, lumbar subsegment of spinal cord, lymph node, mesenteric lymph nodes, muscle of thigh, Paneth cell, seminal vesicula, spleen, stroma of bone marrow, thymus
RNA expression pattern · 18
CD38 → appendix, bone marrow cell, bronchial epithelial cell, duodenum, gonad, granulocyte, jejunum, left colon, left lung lobe, lumbar subsegment of spinal cord, lymph node, mesenteric lymph nodes, muscle of thigh, Paneth cell, seminal vesicula, spleen, stroma of bone marrow, thymus
related to External links · 13
CD38 → ADP-ribose, ADP-ribosyl, Antigens, GeneCard CD38Overview, Human CD38, Medicine Medical Subject Headings, MeSH, National Library, P28907, PDB, PDBe-KB, UCSC Genome Browser, UniProt
related to Aging studies · 8
CD38 → Cellular, Macrophages, NAD, NF-κB, On, Secretions, The, Treatment
related to Function · 7
CD38 → As, B-cell, BCR, CD19, CD31, It, TRPM2
related to Inhibitors · 6
CD38 → Cassic, CD38-IN-78cChrysanthemin, Kuromanin, MezagitamabErzotabartLumrotatugSanritatugModakafusp Alfa/TAK-573apigeninLuteolinidinMK-0159TNB-738, MOR202, Rhein
related to history · 5
CD38 → About, ADP-ribose, In, NAADP, NK
Band · 2
CD38 → 4p15.32, 5 B3|5 23.85 cM
Chr. · 2
CD38 → Chromosome 4 (human), Chromosome 5 (mouse)
Important terminology Word statistics
Frequent words and multi-word phrases across the lead, headings, infobox and body. Useful for terminology coverage.Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
Important terminology
nad cell cells chromosome also bp surface human gene chr band expression cyclic macrophages function cadpr receptor location enzyme marker
Entity relationships Subject–Predicate–Object triples
Extracted RDF-like relationships with confidence and source. The table includes structured facts and lower-confidence contextual relations.| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| CD38 | 2.4.99.20 | ↗ | 1.00 | infobox |
| CD38 | 3.2.2.6 | ↗ | 1.00 | infobox |
| CD38 | Aliases | CD38, ADPRC1, ADPRC 1, CD38 molecule | 1.00 | infobox |
| CD38 | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4TMF, 1YH3, 1ZVM, 2EF1, 2HCT, 2I65, 2I66, 2I67, 2O3Q, 2O3R, 2O3S, 2O3T, 2O3U, 2PGJ, 2PGL, 3DZF, 3DZG, 3DZH,… | 1.00 | infobox |
| CD38 | Band | 4p15.32 | 1.00 | infobox |
| CD38 | Band | 5 B3|5 23.85 cM | 1.00 | infobox |
| CD38 | Bgee | seminal vesicula | 1.00 | infobox |
| CD38 | Bgee | bone marrow cell | 1.00 | infobox |
| CD38 | Bgee | lymph node | 1.00 | infobox |
| CD38 | Bgee | thymus | 1.00 | infobox |
| CD38 | Bgee | appendix | 1.00 | infobox |
| CD38 | Bgee | spleen | 1.00 | infobox |
| CD38 | Bgee | bronchial epithelial cell | 1.00 | infobox |
| CD38 | Bgee | gonad | 1.00 | infobox |
| CD38 | Bgee | granulocyte | 1.00 | infobox |
| CD38 | Bgee | muscle of thigh | 1.00 | infobox |
| CD38 | Bgee | stroma of bone marrow | 1.00 | infobox |
| CD38 | Bgee | left colon | 1.00 | infobox |
| CD38 | Bgee | mesenteric lymph nodes | 1.00 | infobox |
| CD38 | Bgee | Paneth cell | 1.00 | infobox |
| CD38 | Bgee | jejunum | 1.00 | infobox |
| CD38 | Bgee | lumbar subsegment of spinal cord | 1.00 | infobox |
| CD38 | Bgee | left lung lobe | 1.00 | infobox |
| CD38 | Bgee | duodenum | 1.00 | infobox |
| CD38 | BioGPS | More reference expression data | 1.00 | infobox |
| CD38 | Chr. | Chromosome 4 (human) | 1.00 | infobox |
| CD38 | Chr. | Chromosome 5 (mouse) | 1.00 | infobox |
| CD38 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| CD38 | End | 15,853,232 bp | 1.00 | infobox |
| CD38 | End | 44,069,717 bp | 1.00 | infobox |
No triples extracted yet.
Related concept clusters Concept neighborhoods
Clusters of nearby vocabulary surrounding the topic. Scan them for adjacent concepts and language you may have missed.These clusters group vocabulary that occurs around closely connected concepts in the source material.
Connections between topic areas Semantic bridges
Bridge nodes connect otherwise separate parts of the map. Expand a row to inspect the topic groups on each side.Bridges can reveal useful research angles that are easy to miss in a flat list of related terms.
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