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CD38 (cluster of differentiation 38), also known as cyclic ADP ribose hydrolase, is a glycoprotein found on the surface of many immune cells (white blood cells), including CD4+, CD8+, B lymphocytes and natural killer cells. CD38 also functions in cell adhesion, signal transduction and calcium signaling.
The analysis highlights History, Applications and Research as prominent areas in the source structure around CD38.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
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The extracted context around CD38 shows recurring relationship patterns in the source. For example, CD38 → apoptotic signaling pathway, artery smooth muscle contraction, B cell receptor signaling pathway, basolateral plasma membrane, cell surface, extracellular exosome, female pregnancy, hydrolase activity, hydrolase activity, acting on glycosyl bonds, identical protein binding, integral component of membrane, intracellular membrane-bounded organelle, long-term depression, membrane, NAD metabolic process, NAD(P)+ nucleosidase activity, NAD+ nucleosidase activity, NAD+ nucleotidase, cyclic ADP-ribose generating, negative regulation of apoptotic process, negative regulation of bone resorption Another extracted example is CD38 → appendix, bone marrow cell, bronchial epithelial cell, duodenum, gonad, granulocyte, jejunum, left colon, left lung lobe, lumbar subsegment of spinal cord, lymph node, mesenteric lymph nodes, muscle of thigh, Paneth cell, seminal vesicula, spleen, stroma of bone marrow, thymus. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
nad cell cells chromosome also bp surface human gene chr band expression cyclic macrophages function cadpr receptor location enzyme marker
TTTA extracted 130 structured relationships around CD38. Examples in this analysis include CD38 → 2.4.99.20 → ↗ and CD38 → Aliases → CD38, ADPRC1, ADPRC 1, CD38 molecule. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| CD38 | 2.4.99.20 | ↗ | 1.00 | infobox |
| CD38 | 3.2.2.6 | ↗ | 1.00 | infobox |
| CD38 | Aliases | CD38, ADPRC1, ADPRC 1, CD38 molecule | 1.00 | infobox |
| CD38 | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4TMF, 1YH3, 1ZVM, 2EF1, 2HCT, 2I65, 2I66, 2I67, 2O3Q, 2O3R, 2O3S, 2O3T, 2O3U, 2PGJ, 2PGL, 3DZF, 3DZG, 3DZH,… | 1.00 | infobox |
| CD38 | Band | 4p15.32 | 1.00 | infobox |
| CD38 | Band | 5 B3|5 23.85 cM | 1.00 | infobox |
| CD38 | Bgee | seminal vesicula | 1.00 | infobox |
| CD38 | Bgee | bone marrow cell | 1.00 | infobox |
| CD38 | Bgee | lymph node | 1.00 | infobox |
| CD38 | Bgee | thymus | 1.00 | infobox |
| CD38 | Bgee | appendix | 1.00 | infobox |
| CD38 | Bgee | spleen | 1.00 | infobox |
| CD38 | Bgee | bronchial epithelial cell | 1.00 | infobox |
| CD38 | Bgee | gonad | 1.00 | infobox |
| CD38 | Bgee | granulocyte | 1.00 | infobox |
| CD38 | Bgee | muscle of thigh | 1.00 | infobox |
| CD38 | Bgee | stroma of bone marrow | 1.00 | infobox |
| CD38 | Bgee | left colon | 1.00 | infobox |
| CD38 | Bgee | mesenteric lymph nodes | 1.00 | infobox |
| CD38 | Bgee | Paneth cell | 1.00 | infobox |
| CD38 | Bgee | jejunum | 1.00 | infobox |
| CD38 | Bgee | lumbar subsegment of spinal cord | 1.00 | infobox |
| CD38 | Bgee | left lung lobe | 1.00 | infobox |
| CD38 | Bgee | duodenum | 1.00 | infobox |
| CD38 | BioGPS | More reference expression data | 1.00 | infobox |
| CD38 | Chr. | Chromosome 4 (human) | 1.00 | infobox |
| CD38 | Chr. | Chromosome 5 (mouse) | 1.00 | infobox |
| CD38 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| CD38 | End | 15,853,232 bp | 1.00 | infobox |
| CD38 | End | 44,069,717 bp | 1.00 | infobox |
The concept neighborhoods around CD38 bring nearby vocabulary together. In this analysis, examples include Nad, Cell and Cells. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For CD38, one of the stronger structural bridges in this analysis connects CD38 with Clinical significance. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around CD38 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Applications & Research, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — CD38 · EN edition · Analysis: TopicsToTalkAbout
