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Proteostasis

Proteostasis is the dynamic regulation of a balanced, functional proteome. The proteostasis network includes competing and integrated biological pathways within cells that control the biogenesis, folding, trafficking, and degradation of proteins present within and outside the cell. Loss of proteostasis is central to understanding the cause of diseases…

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Overview

Mechanisms of proteostasis

Signaling events in proteostasis

Diseases of proteostasis

Advanced semantic analysis

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Map overview Semantic statistics

Proteostasis

Nodes65
Edges64
Triples68
Avg. degree1.97
Density0.030769
Components1

How this topic connects Entity context

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Proteostasis

Top relations

related to Pharmacologic intervention in proteostasis · 9
Proteostasis → Amicus, CFTR, Fabry, G-protein, Pfizer, Previously, The, There, Vertex Pharmaceuticals
related to Proteostasis and diseases of protein folding · 9
Proteostasis → Alzheimer's, Disease, Dysfunction, Examples, However, Huntington's, If, The, These
related to Systemic stress signaling · 8
Proteostasis → Cell, HSR, Similarly ER, Stress, The, These, UPR, Work
related to Proteostasis and aging · 7
Proteostasis → Expression, Functional, IGF-1R, Over, The, These, This
related to Proteostasis and cancer · 7
Proteostasis → Cancer, Furthermore, Hsp90, Inhibitors, Proteasome, The, This
related to The roles of the ribosome in proteostasis · 7
Proteostasis → At, Characteristics, For, Its, One, The, This
related to Cytosolic heat shock response · 6
Proteostasis → DNA, HSF, Hsp90, HSR, The, Upon
related to Regulating proteostasis by protein degradation · 4
Proteostasis → Multiple, Protein, The, These
related to Proteostasis and obesity · 3
Proteostasis → For, Metabolic, This
related to Cell-autonomous stress responses · 2
Proteostasis → Cellular, The

Important terminology Word statistics

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Important terminology

protein proteins degradation cellular folding stress chaperones cells response ribosome peptide unfolded mechanisms chaperone chaperonins chain network cell also misfolded

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Proteostasisis adynamic regulation of a balanced0.90text
virusesinstance ofand to minimize homeostatic perturbations from pathogens0.80text
muscleinstance ofStress induced in the neurons of the worm can in the long run protect other tissues0.80text
intestinal cells from chronic proteotoxicityinstance ofStress induced in the neurons of the worm can in the long run protect other tissues0.80text
Proteostasisrelated to Cell-autonomous stress responsesCellular0.60section
Proteostasisrelated to Cell-autonomous stress responsesThe0.60section
Proteostasisrelated to Cytosolic heat shock responseThe0.60section
Proteostasisrelated to Cytosolic heat shock responseHSR0.60section
Proteostasisrelated to Cytosolic heat shock responseHSF0.60section
Proteostasisrelated to Cytosolic heat shock responseHsp900.60section
Proteostasisrelated to Cytosolic heat shock responseUpon0.60section
Proteostasisrelated to Cytosolic heat shock responseDNA0.60section

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