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Dimethyl fumarate: History, Applications, Research & Products

Dimethyl fumarate (DMF) is the methyl ester of fumaric acid. Dimethyl fumarate combined with three other fumaric acid esters (FAEs) is solely licensed in Germany as an oral therapy for psoriasis (brand name Fumaderm). Since 2013, it has been approved by the U.S. Food and Drug Administration (FDA) as a treatment option for adults with relapsing multiple…

Language: English [EN]
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Dimethyl fumarate topic overview

The analysis highlights History, Applications, Research and Products as prominent areas in the source structure around Dimethyl fumarate.

Related topics
38
Source areas
8
Connected nodes
46
Extracted relationships
83
Concept neighborhoods
20
Bridge connections
46

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 11 topics
Pharmacology · 7 topics
Consumer products · 5 topics
Adverse effects · 4 topics
History · 4 topics
Chemistry · 3 topics
Medical uses · 2 topics
Research · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image
ATC code
L04AX07 (WHO)
Boiling point
193 °C (379 °F)
CAS Number
624-49-7 Y
ChEBI
CHEBI:76004 Y
ChEMBL
ChEMBL2107333

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Medical uses

Adverse effects

Pharmacology

Chemistry

History

Consumer products

Research

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Dimethyl fumarate connects Entity context

The extracted context around Dimethyl fumarate shows recurring relationship patterns in the source. For example, Dimethyl fumarate → Argos, BBC Watchdog, British Journal, Chinese, Concentrations, Dermatology, Dimethyl, Finland, In, In Finland, July, Land, Leather, Linkwise, Tapio Rantanen, The, There, United Kingdom, Walmsley, Walmsley Furnishing Another extracted example is Dimethyl fumarate → Almirall, Based, EMA, European Medicines Agency, Fumaderm, Fumapharm, German, Germany, June, Skilarence, The, The Swiss, This, Walter Schweckendiek. Use these groups to spot repeated connection types before inspecting the individual relationships.

Dimethyl fumarate

Top relations

related to Consumer products · 20
Dimethyl fumarate → Argos, BBC Watchdog, British Journal, Chinese, Concentrations, Dermatology, Dimethyl, Finland, In, In Finland, July, Land, Leather, Linkwise, Tapio Rantanen, The, There, United Kingdom, Walmsley, Walmsley Furnishing
related to history · 14
Dimethyl fumarate → Almirall, Based, EMA, European Medicines Agency, Fumaderm, Fumapharm, German, Germany, June, Skilarence, The, The Swiss, This, Walter Schweckendiek
related to Medical uses · 9
Dimethyl fumarate → Cochrane, Fumaderm, In Germany, It, MS, Skilarence, Tecfidera, UK, US
related to COVID-19 · 5
Dimethyl fumarate → COVID-19, In, RECOVERY Trial, The, UK
related to Pharmacology · 5
Dimethyl fumarate → Dimethyl, FDA, MMF, October, Other
Legal status · 3
Dimethyl fumarate → EU: Rx-only, UK: POM (Prescription only), US: ℞-only
related to Synthesis and reactions · 3
Dimethyl fumarate → Dimethyl, Fischer, Several
is a · 2
Dimethyl fumarate → old compound used in industrial chemistry and can be purchased by the ton, precursor of monomethyl fumarate
3D model (JSmol) · 1
Dimethyl fumarate → Interactive image
ATC code · 1
Dimethyl fumarate → L04AX07 (WHO)

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

dimethyl fumarate oral psoriasis treatment products name formulation acid monomethyl multiple sclerosis approved biogen consumer european brand drug relapsing tecfidera

Dimethyl fumarate relationships Subject–Predicate–Object triples

TTTA extracted 83 structured relationships around Dimethyl fumarate. Examples in this analysis include Dimethyl fumarate → 3D model (JSmol) → Interactive image and Dimethyl fumarate → ATC code → L04AX07 (WHO). The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Dimethyl fumarate3D model (JSmol)Interactive image1.00infobox
Dimethyl fumarateATC codeL04AX07 (WHO)1.00infobox
Dimethyl fumarateBoiling point193 °C (379 °F)1.00infobox
Dimethyl fumarateCAS Number624-49-7 Y1.00infobox
Dimethyl fumarateChEBICHEBI:76004 Y1.00infobox
Dimethyl fumarateChEMBLChEMBL21073331.00infobox
Dimethyl fumarateChemSpider553171 Y1.00infobox
Dimethyl fumarateCompTox Dashboard (EPA)DTXSID40607871.00infobox
Dimethyl fumarateDensity1.37 g/cm3 g/cm31.00infobox
Dimethyl fumarateDrug classImmunomodulator1.00infobox
Dimethyl fumarateDrugBankDB08908 Y1.00infobox
Dimethyl fumarateECHA InfoCard100.009.8631.00infobox
Dimethyl fumarateFormulaC6H8O41.00infobox
Dimethyl fumarateIUPHAR/BPS70451.00infobox
Dimethyl fumarateKEGGD038461.00infobox
Dimethyl fumarateLegal statusUK: POM (Prescription only)1.00infobox
Dimethyl fumarateLegal statusUS: ℞-only1.00infobox
Dimethyl fumarateLegal statusEU: Rx-only1.00infobox
Dimethyl fumarateLicense dataEU EMA: by INN1.00infobox
Dimethyl fumarateMelting point103.5 °C (218.3 °F)1.00infobox
Dimethyl fumarateMolar mass144.126 g·mol−11.00infobox
Dimethyl fumarateOther namesDHF; trans-1,2-Ethylenedicarboxylic acid dimethyl ester; (E)-2-Butenedioic acid dimethyl ester1.00infobox
Dimethyl fumaratePubChem CID6375681.00infobox
Dimethyl fumarateRoutes of administrationOral1.00infobox
Dimethyl fumarateUNIIFO2303MNI21.00infobox
Dimethyl fumarateis aprecursor of monomethyl fumarate0.90text
Dimethyl fumarateis aold compound used in industrial chemistry and can be purchased by the ton0.90text

Related concept clusters Concept neighborhoods

The concept neighborhoods around Dimethyl fumarate bring nearby vocabulary together. In this analysis, examples include Fumarate, Products and Oral. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Dimethyl fumarate
    • Fumarate
    • Products
    • Oral
    • Consumer
    • Monomethyl
    • Treatment
    • Acid
    • Formulation
    • Psoriasis
    • Union
    • Containing
    • European
  • dimethyl fumarate
    • Fumarate
    • Monomethyl
    • Products
    • Oral
    • Consumer
    • Psoriasis
    • Treatment
    • Acid
    • Formulation
    • Union
    • Containing
    • European
  • monomethyl fumarate
    • Monomethyl
    • Products
    • Oral
    • Multiple
    • Sclerosis
    • Psoriasis
    • Treatment
    • Consumer
    • Formulation
    • Containing
    • Name
    • Immunomodulatory
  • diroximel fumarate
    • Monomethyl
    • Products
    • Oral
    • Psoriasis
    • Treatment
    • Consumer
    • Formulation
    • Containing
    • Name
    • Covid-19
    • Immunomodulatory
    • Also
  • dimethyl maleate
    • Fumarate
    • Products
    • Oral
    • Consumer
    • Monomethyl
    • Treatment
    • Acid
    • Formulation
    • Psoriasis
    • Union
    • Containing
    • European
  • food and drug administration
    • Uk
    • Relapsing
    • Biogen
    • Name
    • Multiple
    • Sclerosis
    • Treatment
    • Covid-19
    • Medical
    • Reactions
    • Adults
    • Adverse
  • fumaric acid
    • Fumaric
    • Medical
    • Psoriasis
    • Name
    • Formulation
    • Oral
    • Use
    • Dimethyl
    • Fumarate
    • Covid-19
    • Reactions
    • Uk
  • nicotinic acid
    • Fumaric
    • Medical
    • Psoriasis
    • Name
    • Formulation
    • Oral
    • Dimethyl
    • Fumarate
    • Covid-19
    • Reactions
    • Uk
    • Adverse

Connections between topic areas Semantic bridges

For Dimethyl fumarate, one of the stronger structural bridges in this analysis connects Dimethyl fumarate with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Dimethyl fumarate — Overview · splits 35 ⟂ 12
Dimethyl fumarate — Pharmacology · splits 39 ⟂ 8
Dimethyl fumarate — Consumer products · splits 41 ⟂ 6
Dimethyl fumarate — Adverse effects · splits 42 ⟂ 5
Dimethyl fumarate — History · splits 42 ⟂ 5
Dimethyl fumarate — Chemistry · splits 43 ⟂ 4
Dimethyl fumarate — Medical uses · splits 44 ⟂ 3
Dimethyl fumarate — Research · splits 44 ⟂ 3

Map overview Semantic statistics

Dimethyl fumarate

Nodes47
Edges46
Triples83
Avg. degree1.96
Density0.042553
Components1

Source & methodology

TTTA analyzes the structure around Dimethyl fumarate to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Applications, Research & Products, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Dimethyl fumarate · EN edition · Analysis: TopicsToTalkAbout

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