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GCLM: Measurement & Overview

Glutamate-cysteine ligase regulatory subunit is an enzyme that in humans is encoded by the GCLM gene.

Language: English [EN]
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GCLM topic overview

The analysis highlights Measurement and Overview as prominent areas in the source structure around GCLM.

Related topics
7
Source areas
1
Connected nodes
8
Extracted relationships
88
Concept neighborhoods
8
Bridge connections
8

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 7 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
GCLM, GLCLR, glutamate-cysteine ligase modifier subunit
Band
1p22.1 · 3 G1|3 52.94 cM
Bgee
bronchial epithelial cell · islet of Langerhans · jejunal mucosa · hair follicle · secondary oocyte
BioGPS
More reference expression data
Chr.
Chromosome 1 (human) · Chromosome 3 (mouse)
Databases
NCBI: entry; OMA: entry

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How GCLM connects Entity context

The extracted context around GCLM shows recurring relationship patterns in the source. For example, GCLM → ageing, apoptotic mitochondrial changes, cellular response to fibroblast growth factor stimulus, cellular response to follicle-stimulating hormone stimulus, cellular response to glucose stimulus, cellular response to hepatocyte growth factor stimulus, cellular response to leukemia inhibitory factor, cellular response to thyroxine stimulus, cysteine metabolic process, cytosol, enzyme regulator activity, glutamate metabolic process, glutamate-cysteine ligase activity, glutamate-cysteine ligase catalytic subunit binding, glutamate-cysteine ligase complex, glutathione biosynthetic process, glutathione metabolic process, hepatic stellate cell activation, negative regulation of extrinsic apoptotic signaling pathway, negative regulation of neuron apoptotic process Another extracted example is GCLM → blood, bronchial epithelial cell, cartilage tissue, duodenum, epithelium of nasopharynx, facial motor nucleus, fetal liver hematopoietic progenitor cell, hair follicle, human kidney, islet of Langerhans, jejunal mucosa, lacrimal gland, left lobe of liver, pyloric antrum, right kidney, secondary oocyte, Skeletal muscle tissue of rectus abdominis, stroma of bone marrow, tibiofemoral joint, trabecular bone. Use these groups to spot repeated connection types before inspecting the individual relationships.

GCLM

Top relations

Gene ontology · 28
GCLM → ageing, apoptotic mitochondrial changes, cellular response to fibroblast growth factor stimulus, cellular response to follicle-stimulating hormone stimulus, cellular response to glucose stimulus, cellular response to hepatocyte growth factor stimulus, cellular response to leukemia inhibitory factor, cellular response to thyroxine stimulus, cysteine metabolic process, cytosol, enzyme regulator activity, glutamate metabolic process, glutamate-cysteine ligase activity, glutamate-cysteine ligase catalytic subunit binding, glutamate-cysteine ligase complex, glutathione biosynthetic process, glutathione metabolic process, hepatic stellate cell activation, negative regulation of extrinsic apoptotic signaling pathway, negative regulation of neuron apoptotic process
Bgee · 20
GCLM → blood, bronchial epithelial cell, cartilage tissue, duodenum, epithelium of nasopharynx, facial motor nucleus, fetal liver hematopoietic progenitor cell, hair follicle, human kidney, islet of Langerhans, jejunal mucosa, lacrimal gland, left lobe of liver, pyloric antrum, right kidney, secondary oocyte, Skeletal muscle tissue of rectus abdominis, stroma of bone marrow, tibiofemoral joint, trabecular bone
RNA expression pattern · 20
GCLM → blood, bronchial epithelial cell, cartilage tissue, duodenum, epithelium of nasopharynx, facial motor nucleus, fetal liver hematopoietic progenitor cell, hair follicle, human kidney, islet of Langerhans, jejunal mucosa, lacrimal gland, left lobe of liver, pyloric antrum, right kidney, secondary oocyte, Skeletal muscle tissue of rectus abdominis, stroma of bone marrow, tibiofemoral joint, trabecular bone
Band · 2
GCLM → 1p22.1, 3 G1|3 52.94 cM
Chr. · 2
GCLM → Chromosome 1 (human), Chromosome 3 (mouse)
End · 2
GCLM → 122,064,381 bp, 93,909,456 bp
Aliases · 1
GCLM → GCLM, GLCLR, glutamate-cysteine ligase modifier subunit
BioGPS · 1
GCLM → More reference expression data
Databases · 1
GCLM → NCBI: entry; OMA: entry
Ensembl · 1
GCLM → ENSG00000023909

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

bp enzyme chr human band glutamate-cysteine ligase subunit gene chromosome synthetase location regulatory glutathione mouse catalytic 909 456 end 93

GCLM relationships Subject–Predicate–Object triples

TTTA extracted 88 structured relationships around GCLM. Examples in this analysis include GCLM → Aliases → GCLM, GLCLR, glutamate-cysteine ligase modifier subunit and GCLM → Band → 1p22.1. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
GCLMAliasesGCLM, GLCLR, glutamate-cysteine ligase modifier subunit1.00infobox
GCLMBand1p22.11.00infobox
GCLMBand3 G1|3 52.94 cM1.00infobox
GCLMBgeebronchial epithelial cell1.00infobox
GCLMBgeeislet of Langerhans1.00infobox
GCLMBgeejejunal mucosa1.00infobox
GCLMBgeehair follicle1.00infobox
GCLMBgeesecondary oocyte1.00infobox
GCLMBgeecartilage tissue1.00infobox
GCLMBgeeSkeletal muscle tissue of rectus abdominis1.00infobox
GCLMBgeeepithelium of nasopharynx1.00infobox
GCLMBgeeduodenum1.00infobox
GCLMBgeetrabecular bone1.00infobox
GCLMBgeeright kidney1.00infobox
GCLMBgeestroma of bone marrow1.00infobox
GCLMBgeeblood1.00infobox
GCLMBgeefetal liver hematopoietic progenitor cell1.00infobox
GCLMBgeeleft lobe of liver1.00infobox
GCLMBgeehuman kidney1.00infobox
GCLMBgeetibiofemoral joint1.00infobox
GCLMBgeepyloric antrum1.00infobox
GCLMBgeelacrimal gland1.00infobox
GCLMBgeefacial motor nucleus1.00infobox
GCLMBioGPSMore reference expression data1.00infobox
GCLMChr.Chromosome 1 (human)1.00infobox
GCLMChr.Chromosome 3 (mouse)1.00infobox
GCLMDatabasesNCBI: entry; OMA: entry1.00infobox
GCLMEnd93,909,456 bp1.00infobox
GCLMEnd122,064,381 bp1.00infobox
GCLMEnsemblENSG000000239091.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around GCLM bring nearby vocabulary together. In this analysis, examples include Gene, Glutamate-cysteine and Ligase. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • enzyme
    • Glutamate-cysteine
    • Ligase
    • Subunit
    • Catalytic
    • Glutathione
    • Regulatory
    • Gclm
    • Gene
    • Also
    • Consists
    • Encoded
    • First
  • glutamate-cysteine ligase
    • Ligase
    • Gclm
    • Enzyme
    • Gene
    • Subunit
    • Glutathione
    • Location
    • Chromosome
    • Human
    • Bp
    • Chr
    • Also
  • catalytic subunit
    • Consists
    • Enzyme
    • Heavy
    • Light
    • Subunit
    • Subunits
    • Two
    • Location
    • Chromosome
    • End
    • G1
    • Glutathione
  • GCLM
    • Gene
    • Glutamate-cysteine
    • Ligase
    • Subunit
    • Location
    • Chromosome
    • Human
    • Bp
    • Chr
    • Humans
    • Catalytic
    • End
  • gclm
    • Gene
    • Glutamate-cysteine
    • Ligase
    • Subunit
    • Location
    • Chromosome
    • Human
    • Bp
    • Chr
    • Humans
    • Catalytic
    • End
  • glutathione
    • Known
    • Ligase
    • Limiting
    • Rate
    • Synthesis
    • Catalytic
    • End
    • G1
    • Mouse
    • Synthetase
    • Location
    • Band
  • gene
    • Location
    • Chromosome
    • Glutamate-cysteine
    • Human
    • Ligase
    • Subunit
    • Bp
    • Chr
    • End
    • G1
    • Mouse
    • Band
  • synthetase
    • Also
    • First
    • Gamma-glutamylcysteine
    • Known
    • Limiting
    • Rate
    • Synthesis
    • Glutathione
    • Enzyme
    • Glutamate-cysteine
    • Ligase

Connections between topic areas Semantic bridges

Bridges highlight paths between different parts of the GCLM map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

Map overview Semantic statistics

GCLM

Nodes9
Edges8
Triples88
Avg. degree1.78
Density0.222222
Components1

Source & methodology

TTTA analyzes the structure around GCLM to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Measurement & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — GCLM · EN edition · Analysis: TopicsToTalkAbout

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