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EIF2AK3

Eukaryotic translation initiation factor 2-alpha kinase 3, also known as protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK), is an enzyme that in humans is encoded by the EIF2AK3 gene.

Function, Interactions & Clinical significance

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Function

4 related topics

Interactions

4 related topics

Clinical significance

1 related topics

Inhibitors

1 related topics

Key facts & relationships

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2.7.10.2
2.7.11.1
Aliases
EIF2AK3, PEK, PERK, WRS, eukaryotic translation initiation factor 2 alpha kinase 3
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4G31, 4G34, 4M7I, 4X7H, 4X7J, 4X7K, 4X7L, 4X7N, 4X7O, 4YZS
Band
2p11.2 · 6|6 C1
Bgee
body of pancreas · mucosa of paranasal sinus · Achilles tendon · pylorus · parotid gland

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Overview

Function

Clinical significance

Interactions

Inhibitors

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Map overview Semantic statistics

EIF2AK3

Nodes18
Edges17
Triples127
Avg. degree1.89
Density0.111111
Components1

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EIF2AK3

Top relations

Gene ontology · 59
EIF2AK3 → activation of cysteine-type endopeptidase activity involved in apoptotic process, angiogenesis, ATP binding, bone mineralization, calcium-mediated signaling, cellular response to amino acid starvation, cellular response to cold, cellular response to glucose starvation, chondrocyte development, cytoplasm, cytosolic ribosome, eiF2alpha phosphorylation in response to endoplasmic reticulum stress, endocrine pancreas development, endoplasmic reticulum, endoplasmic reticulum membrane, endoplasmic reticulum organization, endoplasmic reticulum unfolded protein response, enzyme binding, ER overload response, eukaryotic translation initiation factor 2alpha kinase activity
Bgee · 19
EIF2AK3 → Achilles tendon, body of pancreas, calvaria, decidua, epithelium of nasopharynx, epithelium of stomach, granulocyte, islet of Langerhans, lacrimal gland, lumbar spinal ganglion, mucosa of paranasal sinus, mucosa of sigmoid colon, nasal epithelium, parotid gland, pylorus, seminal vesicula, submandibular gland, tibia, trachea
RNA expression pattern · 19
EIF2AK3 → Achilles tendon, body of pancreas, calvaria, decidua, epithelium of nasopharynx, epithelium of stomach, granulocyte, islet of Langerhans, lacrimal gland, lumbar spinal ganglion, mucosa of paranasal sinus, mucosa of sigmoid colon, nasal epithelium, parotid gland, pylorus, seminal vesicula, submandibular gland, tibia, trachea
related to Interactions · 4
EIF2AK3 → BiP, DNAJC3, Hsp70, NFE2L2
Band · 2
EIF2AK3 → 2p11.2, 6|6 C1
Chr. · 2
EIF2AK3 → Chromosome 2 (human), Chromosome 6 (mouse)
End · 2
EIF2AK3 → 70,882,229 bp, 88,691,518 bp
2.7.10.2 · 1
EIF2AK3 → ↗
2.7.11.1 · 1
EIF2AK3 → ↗
Aliases · 1
EIF2AK3 → EIF2AK3, PEK, PERK, WRS, eukaryotic translation initiation factor 2 alpha kinase 3

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Important terminology

bp gene chr human band eukaryotic initiation factor chromosome protein endoplasmic reticulum enzyme translation kinase location alpha mouse perk function

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
EIF2AK32.7.10.21.00infobox
EIF2AK32.7.11.11.00infobox
EIF2AK3AliasesEIF2AK3, PEK, PERK, WRS, eukaryotic translation initiation factor 2 alpha kinase 31.00infobox
EIF2AK3Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4G31, 4G34, 4M7I, 4X7H, 4X7J, 4X7K, 4X7L, 4X7N, 4X7O, 4YZS1.00infobox
EIF2AK3Band2p11.21.00infobox
EIF2AK3Band6|6 C11.00infobox
EIF2AK3Bgeebody of pancreas1.00infobox
EIF2AK3Bgeemucosa of paranasal sinus1.00infobox
EIF2AK3BgeeAchilles tendon1.00infobox
EIF2AK3Bgeepylorus1.00infobox
EIF2AK3Bgeeparotid gland1.00infobox
EIF2AK3Bgeenasal epithelium1.00infobox
EIF2AK3Bgeemucosa of sigmoid colon1.00infobox
EIF2AK3Bgeetibia1.00infobox
EIF2AK3Bgeeepithelium of nasopharynx1.00infobox
EIF2AK3Bgeetrachea1.00infobox
EIF2AK3Bgeesubmandibular gland1.00infobox
EIF2AK3Bgeelacrimal gland1.00infobox
EIF2AK3Bgeegranulocyte1.00infobox
EIF2AK3Bgeeseminal vesicula1.00infobox
EIF2AK3Bgeecalvaria1.00infobox
EIF2AK3Bgeeislet of Langerhans1.00infobox
EIF2AK3Bgeelumbar spinal ganglion1.00infobox
EIF2AK3Bgeeepithelium of stomach1.00infobox
EIF2AK3Bgeedecidua1.00infobox
EIF2AK3BioGPSMore reference expression data1.00infobox
EIF2AK3Chr.Chromosome 2 (human)1.00infobox
EIF2AK3Chr.Chromosome 6 (mouse)1.00infobox
EIF2AK3DatabasesNCBI: entry; OMA: entry1.00infobox
EIF2AK3End88,691,518 bp1.00infobox

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