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Pitolisant: History, Community, Culture & Applications

Pitolisant, sold under the brand name Wakix among others, is a medication used for the treatment of excessive daytime sleepiness in adults with narcolepsy. It is an inverse agonist of the histamine H3 receptor. It is the first commercially available medication in its class; the U.S. Food and Drug Administration (FDA) designated it a first-in-class…

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Pitolisant topic overview

The analysis highlights History, Community, Culture and Applications as prominent areas in the source structure around Pitolisant.

Related topics
43
Source areas
6
Connected nodes
49
Extracted relationships
64
Concept neighborhoods
18
Bridge connections
49

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Side effects · 15 topics
Overview · 10 topics
Pharmacology · 9 topics
History · 4 topics
Medical uses · 3 topics
Society and culture · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
N07XX11 (WHO)
Bioavailability
90 %
CAS Number
362665-56-3 N · HCl: 903576-44-3 N
ChEBI
CHEBI:134709 Y

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Medical uses

Side effects

Pharmacology

History

Society and culture

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Pitolisant connects Entity context

The extracted context around Pitolisant shows recurring relationship patterns in the source. For example, Pitolisant → An, Bioprojet Pharma, Drug Administration, EMA, Europe, European Medicines Agency, European Union, FDA, Food, It, March, NCT01067222, NCT01638403, NCT01800045, South America, The, Trial Another extracted example is Pitolisant → By, CNS, Eugeroics, H3, The H3. Use these groups to spot repeated connection types before inspecting the individual relationships.

Pitolisant

Top relations

related to history · 17
Pitolisant → An, Bioprojet Pharma, Drug Administration, EMA, Europe, European Medicines Agency, European Union, FDA, Food, It, March, NCT01067222, NCT01638403, NCT01800045, South America, The, Trial
related to Pharmacology · 5
Pitolisant → By, CNS, Eugeroics, H3, The H3
related to Legal status · 4
Pitolisant → European Union, Still, United States, US
Legal status · 3
Pitolisant → CA: ℞-only, EU: Rx-only, US: ℞-only
CAS Number · 2
Pitolisant → 362665-56-3 N, HCl: 903576-44-3 N
ChemSpider · 2
Pitolisant → 8123714 Y, HCl: 9726467
DrugBank · 2
Pitolisant → DB11642, HCl: DBSALT002888
KEGG · 2
Pitolisant → D10749 N, HCl: D11490 N
UNII · 2
Pitolisant → 4BC83L4PIY, HCl: YV33CH63HI Y
is a · 2
Pitolisant → drug that belongs to the class of central nervous system, first eugeroic drug that acts by blocking the histamine H3 autoreceptor

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

narcolepsy daytime sleepiness drug excessive effects participants histamine side h3 treatment approved medication activity fda inverse receptor administration trial adults

Pitolisant relationships Subject–Predicate–Object triples

TTTA extracted 64 structured relationships around Pitolisant. Examples in this analysis include Pitolisant → 3D model (JSmol) → Interactive image and Pitolisant → AHFS/Drugs.com → Monograph. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Pitolisant3D model (JSmol)Interactive image1.00infobox
PitolisantAHFS/Drugs.comMonograph1.00infobox
PitolisantATC codeN07XX11 (WHO)1.00infobox
PitolisantBioavailability90 %1.00infobox
PitolisantCAS Number362665-56-3 N1.00infobox
PitolisantCAS NumberHCl: 903576-44-3 N1.00infobox
PitolisantChEBICHEBI:134709 Y1.00infobox
PitolisantChEMBLChEMBL462605 Y1.00infobox
PitolisantChemSpider8123714 Y1.00infobox
PitolisantChemSpiderHCl: 97264671.00infobox
PitolisantCompTox Dashboard (EPA)DTXSID309576541.00infobox
PitolisantDrug classHistamine H3 receptor inverse agonist1.00infobox
PitolisantDrugBankDB116421.00infobox
PitolisantDrugBankHCl: DBSALT0028881.00infobox
PitolisantElimination half-life10–12 hours1.00infobox
PitolisantFormulaC17H26ClNO1.00infobox
PitolisantKEGGD10749 N1.00infobox
PitolisantKEGGHCl: D11490 N1.00infobox
PitolisantLegal statusCA: ℞-only1.00infobox
PitolisantLegal statusUS: ℞-only1.00infobox
PitolisantLegal statusEU: Rx-only1.00infobox
PitolisantLicense dataUS DailyMed: Pitolisant1.00infobox
PitolisantMedlinePlusa6190551.00infobox
PitolisantMetabolismCYP2D6, CYP3A41.00infobox
PitolisantMolar mass295.85 g·mol−11.00infobox
PitolisantOther namesTiprolisant; Ciproxidine; BF2.6491.00infobox
PitolisantPronunciation/pɪˈtɒlɪsənt/ pi-TOL-i-sənt1.00infobox
PitolisantProtein binding91-96 %1.00infobox
PitolisantPubChem CID99481021.00infobox
PitolisantRoutes of administrationBy mouth1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Pitolisant bring nearby vocabulary together. In this analysis, examples include Narcolepsy, Drug and Participants. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Pitolisant
    • Narcolepsy
    • Drug
    • Participants
    • Activity
    • Approved
    • H3
    • Histamine
    • Sleepiness
    • Daytime
    • Also
    • Brain
    • Hours
  • pitolisant
    • Narcolepsy
    • Drug
    • Participants
    • Activity
    • Approved
    • H3
    • Histamine
    • Sleepiness
    • Daytime
    • Also
    • Brain
    • Hours
  • narcolepsy
    • Sleepiness
    • Treatment
    • Drug
    • Approved
    • Pitolisant
    • Cataplexy
    • Trial
    • Effects
    • Participants
    • Wakix
    • Used
    • Administration
  • histamine h3 receptor
    • H3
    • Histamine
    • Inverse
    • Binding
    • Receptor
    • Activity
    • Brain
    • Histaminergic
    • Status
    • Wakix
    • Drug
    • Hours
  • food and drug administration
    • Hours
    • Drug
    • Fda
    • Narcolepsy
    • Approved
    • Legal
    • Pitolisant
    • Status
    • Name
    • Wakix
    • Agonist
    • Also
  • orphan drug
    • Narcolepsy
    • Approved
    • Pitolisant
    • Fda
    • H3
    • Histamine
    • Treatment
    • Excessive
    • Participants
    • Sleepiness
    • Legal
    • Status
  • excessive daytime sleepiness
    • Sleepiness
    • Daytime
    • Excessive
    • Narcolepsy
    • Adults
    • Treatment
    • Trial
    • Cataplexy
    • Fda
    • Used
    • Approved
    • Sleep
  • inverse agonist
    • Inverse
    • Receptor
    • H3
    • Histamine
    • Binding
    • Legal
    • Status
    • Name
    • Wakix
    • Also
    • Class
    • Hours

Connections between topic areas Semantic bridges

For Pitolisant, one of the stronger structural bridges in this analysis connects Pitolisant with Side effects. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Pitolisant — Side effects · splits 34 ⟂ 16
Pitolisant — Overview · splits 39 ⟂ 11
Pitolisant — Pharmacology · splits 40 ⟂ 10
Pitolisant — History · splits 45 ⟂ 5
Pitolisant — Medical uses · splits 46 ⟂ 4
Pitolisant — Society and culture · splits 47 ⟂ 3

Map overview Semantic statistics

Pitolisant

Nodes50
Edges49
Triples64
Avg. degree1.96
Density0.04
Components1

Source & methodology

TTTA analyzes the structure around Pitolisant to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Community, Culture & Applications, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Pitolisant · EN edition · Analysis: TopicsToTalkAbout

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