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Pitolisant

Pitolisant, sold under the brand name Wakix among others, is a medication used for the treatment of excessive daytime sleepiness in adults with narcolepsy. It is an inverse agonist of the histamine H3 receptor. It is the first commercially available medication in its class; the U.S. Food and Drug Administration (FDA) designated it a first-in-class…

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3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
N07XX11 (WHO)
Bioavailability
90 %
CAS Number
362665-56-3 N · HCl: 903576-44-3 N
ChEBI
CHEBI:134709 Y

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Overview

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Side effects

Pharmacology

History

Society and culture

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Map overview Semantic statistics

Pitolisant

Nodes50
Edges49
Triples64
Avg. degree1.96
Density0.04
Components1

How this topic connects Entity context

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Pitolisant

Top relations

related to history · 17
Pitolisant → An, Bioprojet Pharma, Drug Administration, EMA, Europe, European Medicines Agency, European Union, FDA, Food, It, March, NCT01067222, NCT01638403, NCT01800045, South America, The, Trial
related to Pharmacology · 5
Pitolisant → By, CNS, Eugeroics, H3, The H3
related to Legal status · 4
Pitolisant → European Union, Still, United States, US
Legal status · 3
Pitolisant → CA: ℞-only, EU: Rx-only, US: ℞-only
CAS Number · 2
Pitolisant → 362665-56-3 N, HCl: 903576-44-3 N
ChemSpider · 2
Pitolisant → 8123714 Y, HCl: 9726467
DrugBank · 2
Pitolisant → DB11642, HCl: DBSALT002888
KEGG · 2
Pitolisant → D10749 N, HCl: D11490 N
UNII · 2
Pitolisant → 4BC83L4PIY, HCl: YV33CH63HI Y
is a · 2
Pitolisant → drug that belongs to the class of central nervous system, first eugeroic drug that acts by blocking the histamine H3 autoreceptor

Important terminology Word statistics

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Important terminology

narcolepsy daytime sleepiness drug excessive effects participants histamine side h3 treatment approved medication activity fda inverse receptor administration trial adults

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Pitolisant3D model (JSmol)Interactive image1.00infobox
PitolisantAHFS/Drugs.comMonograph1.00infobox
PitolisantATC codeN07XX11 (WHO)1.00infobox
PitolisantBioavailability90 %1.00infobox
PitolisantCAS Number362665-56-3 N1.00infobox
PitolisantCAS NumberHCl: 903576-44-3 N1.00infobox
PitolisantChEBICHEBI:134709 Y1.00infobox
PitolisantChEMBLChEMBL462605 Y1.00infobox
PitolisantChemSpider8123714 Y1.00infobox
PitolisantChemSpiderHCl: 97264671.00infobox
PitolisantCompTox Dashboard (EPA)DTXSID309576541.00infobox
PitolisantDrug classHistamine H3 receptor inverse agonist1.00infobox
PitolisantDrugBankDB116421.00infobox
PitolisantDrugBankHCl: DBSALT0028881.00infobox
PitolisantElimination half-life10–12 hours1.00infobox
PitolisantFormulaC17H26ClNO1.00infobox
PitolisantKEGGD10749 N1.00infobox
PitolisantKEGGHCl: D11490 N1.00infobox
PitolisantLegal statusCA: ℞-only1.00infobox
PitolisantLegal statusUS: ℞-only1.00infobox
PitolisantLegal statusEU: Rx-only1.00infobox
PitolisantLicense dataUS DailyMed: Pitolisant1.00infobox
PitolisantMedlinePlusa6190551.00infobox
PitolisantMetabolismCYP2D6, CYP3A41.00infobox
PitolisantMolar mass295.85 g·mol−11.00infobox
PitolisantOther namesTiprolisant; Ciproxidine; BF2.6491.00infobox
PitolisantPronunciation/pɪˈtɒlɪsənt/ pi-TOL-i-sənt1.00infobox
PitolisantProtein binding91-96 %1.00infobox
PitolisantPubChem CID99481021.00infobox
PitolisantRoutes of administrationBy mouth1.00infobox

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