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Protriptyline

Protriptyline, sold under the brand name Vivactil among others, is a tricyclic antidepressant (TCA), specifically a secondary amine. Uniquely among most of the TCAs, protriptyline tends to be energizing instead of sedating, and is sometimes used for narcolepsy to achieve a wakefulness-promoting effect.

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3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
N06AA11 (WHO)
Bioavailability
77–93%
CAS Number
438-60-8 Y 1225-55-4 (hydrochloride)
ChEBI
CHEBI:8597 Y

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Overview

Medical uses

Contraindications

Side effects

Overdose

Interactions

Pharmacology

Chemistry

History

Society and culture

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Map overview Semantic statistics

Protriptyline

Nodes153
Edges152
Triples115
Avg. degree1.99
Density0.013072
Components1

How this topic connects Entity context

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Protriptyline

Top relations

related to Generic names · 15
Protriptyline → BANMTooltip British Approved Name, BANTooltip British Approved Name, DCFTooltip Dénomination Commune Française, DCITTooltip Denominazione Comune Italiana, English, French, German, INNTooltip International Nonproprietary Name, Italian, Its, Latin, Name, Spanish, USANTooltip United States Adopted, USPTooltip United States Pharmacopeia
has effect · 9
Protriptyline → Dry, In, Men, Other, Patients, Some, Symptoms, TCAs, The
related to Pharmacodynamics · 9
Protriptyline → However, HT, It, Its, Maximum, NET, TCA, TCAs, The
related to Chemistry · 8
Protriptyline → C19H21N1, N-methylated, N-methylpropan-1-amine, Other, TCA, TCAs, The, The CAS Registry Number
related to Pharmacokinetics · 8
Protriptyline → Cumulative, It, Metabolic, Preliminary, Relatively, Studies, The, Urinary
related to Availability · 6
Protriptyline → Australia, Ireland, It, The, United Kingdom, United States
related to Brand names · 5
Protriptyline → Anelun, Concordin, Maximed, Triptil, Vivactil
related to Contraindications · 5
Protriptyline → In, It, Likewise, Paranoid, When
related to Interactions · 4
Protriptyline → It, SNRIs, SSRIs, The
related to Medical uses · 4
Protriptyline → Doses, It, Like, Some

Important terminology Word statistics

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Important terminology

may tcas drug used side also overdose urinary effects tca depression patients mg especially name antidepressants retention include amine including

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Protriptyline3D model (JSmol)Interactive image1.00infobox
ProtriptylineAHFS/Drugs.comMonograph1.00infobox
ProtriptylineATC codeN06AA11 (WHO)1.00infobox
ProtriptylineBioavailability77–93%1.00infobox
ProtriptylineCAS Number438-60-8 Y 1225-55-4 (hydrochloride)1.00infobox
ProtriptylineChEBICHEBI:8597 Y1.00infobox
ProtriptylineChEMBLChEMBL668 Y1.00infobox
ProtriptylineChemSpider4805 Y1.00infobox
ProtriptylineCompTox Dashboard (EPA)DTXSID00235351.00infobox
ProtriptylineDrugBankDB00344 Y1.00infobox
ProtriptylineECHA InfoCard100.006.4741.00infobox
ProtriptylineElimination half-life54–92 hours1.00infobox
ProtriptylineExcretionUrine: 50% Feces: minor1.00infobox
ProtriptylineFormulaC19H21N1.00infobox
ProtriptylineIUPHAR/BPS72851.00infobox
ProtriptylineKEGGD084471.00infobox
ProtriptylineLegal statusBR: Class C1 (Other controlled substances)1.00infobox
ProtriptylineLegal statusIn general: ℞ (Prescription only)1.00infobox
ProtriptylineMedlinePlusa6040251.00infobox
ProtriptylineMetabolismHepatic1.00infobox
ProtriptylineMolar mass263.384 g·mol−11.00infobox
ProtriptylineOther namesAmimethyline; Protriptyline hydrochloride; MK-2401.00infobox
ProtriptylineProtein binding92%1.00infobox
ProtriptylinePubChem CID49761.00infobox
ProtriptylineRoutes of administrationOral1.00infobox
ProtriptylineTrade namesVivactyl, others1.00infobox
ProtriptylineUNII4NDU154T121.00infobox
Protriptylineis aright antidepressant for them0.90text
Protriptylineis aTCA0.90text
Protriptylineis asecondary amine TCA0.90text

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