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Simvastatin

Simvastatin, sold under the brand name Zocor among others, is a statin, a type of lipid-lowering medication. It is used along with exercise, diet, and weight loss to decrease elevated lipid levels. It is also used to decrease the risk of heart problems in those at high risk. It is taken by mouth.

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3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
C10AA01 (WHO)
Bioavailability
5%
CAS Number
79902-63-9 Y
ChEBI
CHEBI:9150 Y

Topics to explore

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Overview

Medical uses

Contraindications

Adverse effects

Interactions

Pharmacology

History

Society and culture

Advanced semantic analysis

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Map overview Semantic statistics

Simvastatin

Nodes79
Edges78
Triples137
Avg. degree1.97
Density0.025316
Components1

How this topic connects Entity context

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Simvastatin

Top relations

related to Brand names · 38
Simvastatin → Australia, Austria, Berlin Pharmaceutical Industry Co, Bestatin, Brand, Co, Denan, France, Germany, India, Israel, Italy, Japan, Lipex, Liponorm, Lipovas, Lodales, Ltd, Merck, New Zealand
related to history · 19
Simvastatin → Akira Endo, Aspergillus, Biochemist Jesse Huff, By, Carl Hoffman, Daiichi Sankyo, HMG-CoA, Hoffman, Huff, In, Japan, Karl Folkers, Max Planck Institute, Merck, MK-733, Penicillium, The, This, While
related to Economics · 12
Simvastatin → Affordable Care Act, Co, Merck, Patient Protection, PPACA, Prior, Task Force, Under, United States, United States Preventive Services, US, USPSTF
related to Pharmacodynamics · 9
Simvastatin → All, HMG, HMG-CoA, However, LDL, LDL-cholesterol, PPAR-alpha, Statins, This
has effect · 8
Simvastatin → Cholestatic, Clinical Pharmacogenetics Implementation Consortium, Common, DNA, In, Serious, SNP, There
related to Medical uses · 5
Simvastatin → In, It, LDL, MI, The
Legal status · 4
Simvastatin → AU: S4 (Prescription only), EU: Rx-only, UK: POM (Prescription only), US: ℞-only
related to Contraindications · 3
Simvastatin → High, Patients, Pregnancy
related to Interactions · 3
Simvastatin → Consuming, The FDA, These
related to Pharmacokinetics · 3
Simvastatin → CYP3A4, HMG-CoA, The

Important terminology Word statistics

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Important terminology

cholesterol effects risk used statin heart people levels liver cardiovascular statins drug also muscle needed side drugs merck patients taking

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Simvastatin3D model (JSmol)Interactive image1.00infobox
SimvastatinAHFS/Drugs.comMonograph1.00infobox
SimvastatinATC codeC10AA01 (WHO)1.00infobox
SimvastatinBioavailability5%1.00infobox
SimvastatinCAS Number79902-63-9 Y1.00infobox
SimvastatinChEBICHEBI:9150 Y1.00infobox
SimvastatinChEMBLChEMBL1064 Y1.00infobox
SimvastatinChemSpider49179 Y1.00infobox
SimvastatinCompTox Dashboard (EPA)DTXSID00235811.00infobox
SimvastatinDrugBankDB00641 Y1.00infobox
SimvastatinECHA InfoCard100.115.7491.00infobox
SimvastatinElimination half-life2 hours for simvastatin and 1.9 hours for simvastatin acid1.00infobox
SimvastatinExcretionKidney 13%, faecal 60%1.00infobox
SimvastatinFormulaC25H38O51.00infobox
SimvastatinIUPHAR/BPS29551.00infobox
SimvastatinKEGGD00434 Y1.00infobox
SimvastatinLegal statusAU: S4 (Prescription only)1.00infobox
SimvastatinLegal statusUK: POM (Prescription only)1.00infobox
SimvastatinLegal statusUS: ℞-only1.00infobox
SimvastatinLegal statusEU: Rx-only1.00infobox
SimvastatinLicense dataUS DailyMed: Simvastatin1.00infobox
SimvastatinMedlinePlusa6920301.00infobox
SimvastatinMetabolismLiver (CYP3A4)1.00infobox
SimvastatinMolar mass418.574 g·mol−11.00infobox
SimvastatinPregnancy categoryAU: D1.00infobox
SimvastatinPronunciation/ˈsɪmvəstætɪn/ ⓘ1.00infobox
SimvastatinProtein binding95%1.00infobox
SimvastatinPubChem CID544541.00infobox
SimvastatinRoutes of administrationBy mouth1.00infobox
SimvastatinTrade namesZocor, other1.00infobox

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