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Gamma-secretase-activating protein

Gamma-secretase-activating protein, also known as Protein pigeon homolog (PION) is a protein that in humans is encoded by the GSAP gene.

Gene, Therapeutic target for Alzheimer's disease & Protein

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Aliases
GSAP, PION, Protein pigeon homolog, gamma-secretase activating protein
Band
7q11.23 · 5|5 A3
Bgee
granulocyte · right uterine tube · monocyte · spleen · right lung
BioGPS
n/a
Chr.
Chromosome 7 (human) · Chromosome 5 (mouse)
Databases
NCBI: entry; OMA: entry

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Overview

Gene

Protein

Function

Therapeutic target for Alzheimer's disease

Discovery

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Map overview Semantic statistics

Gamma-secretase-activating protein

Nodes27
Edges26
Triples62
Avg. degree1.93
Density0.074074
Components1

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Gamma-secretase-activating protein

Top relations

Bgee · 18
Gamma-secretase-activating protein → epithelium of nasopharynx, granulocyte, left lobe of liver, lumbar spinal ganglion, monocyte, proximal tubule, right kidney, right lobe of thyroid gland, right lung, right lung lobe, right uterine tube, Rostral migratory stream, secondary oocyte, spermatid, spleen, tibiofemoral joint, upper lobe of left lung, visceral pleura
RNA expression pattern · 18
Gamma-secretase-activating protein → epithelium of nasopharynx, granulocyte, left lobe of liver, lumbar spinal ganglion, monocyte, proximal tubule, right kidney, right lobe of thyroid gland, right lung, right lung lobe, right uterine tube, Rostral migratory stream, secondary oocyte, spermatid, spleen, tibiofemoral joint, upper lobe of left lung, visceral pleura
Gene ontology · 6
Gamma-secretase-activating protein → amyloid-beta binding, Golgi apparatus, positive regulation of amyloid-beta formation, protein binding, regulation of proteolysis, trans-Golgi network
Band · 2
Gamma-secretase-activating protein → 5|5 A3, 7q11.23
Chr. · 2
Gamma-secretase-activating protein → Chromosome 5 (mouse), Chromosome 7 (human)
End · 2
Gamma-secretase-activating protein → 21,520,130 bp, 77,416,349 bp
Aliases · 1
Gamma-secretase-activating protein → GSAP, PION, Protein pigeon homolog, gamma-secretase activating protein
BioGPS · 1
Gamma-secretase-activating protein → n/a
Databases · 1
Gamma-secretase-activating protein → NCBI: entry; OMA: entry
Ensembl · 1
Gamma-secretase-activating protein → ENSG00000186088

Important terminology Word statistics

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Important terminology

gene gsap γ-secretase human protein bp pion band chr function chromosome imatinib pigeon β-amyloid activating homolog location orthologs ad also

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Gamma-secretase-activating proteinAliasesGSAP, PION, Protein pigeon homolog, gamma-secretase activating protein1.00infobox
Gamma-secretase-activating proteinBand7q11.231.00infobox
Gamma-secretase-activating proteinBand5|5 A31.00infobox
Gamma-secretase-activating proteinBgeegranulocyte1.00infobox
Gamma-secretase-activating proteinBgeeright uterine tube1.00infobox
Gamma-secretase-activating proteinBgeemonocyte1.00infobox
Gamma-secretase-activating proteinBgeespleen1.00infobox
Gamma-secretase-activating proteinBgeeright lung1.00infobox
Gamma-secretase-activating proteinBgeeepithelium of nasopharynx1.00infobox
Gamma-secretase-activating proteinBgeevisceral pleura1.00infobox
Gamma-secretase-activating proteinBgeeright lobe of thyroid gland1.00infobox
Gamma-secretase-activating proteinBgeesecondary oocyte1.00infobox
Gamma-secretase-activating proteinBgeeupper lobe of left lung1.00infobox
Gamma-secretase-activating proteinBgeelumbar spinal ganglion1.00infobox
Gamma-secretase-activating proteinBgeespermatid1.00infobox
Gamma-secretase-activating proteinBgeeright lung lobe1.00infobox
Gamma-secretase-activating proteinBgeeright kidney1.00infobox
Gamma-secretase-activating proteinBgeeRostral migratory stream1.00infobox
Gamma-secretase-activating proteinBgeeleft lobe of liver1.00infobox
Gamma-secretase-activating proteinBgeetibiofemoral joint1.00infobox
Gamma-secretase-activating proteinBgeeproximal tubule1.00infobox
Gamma-secretase-activating proteinBioGPSn/a1.00infobox
Gamma-secretase-activating proteinChr.Chromosome 7 (human)1.00infobox
Gamma-secretase-activating proteinChr.Chromosome 5 (mouse)1.00infobox
Gamma-secretase-activating proteinDatabasesNCBI: entry; OMA: entry1.00infobox
Gamma-secretase-activating proteinEnd77,416,349 bp1.00infobox
Gamma-secretase-activating proteinEnd21,520,130 bp1.00infobox
Gamma-secretase-activating proteinEnsemblENSG000001860881.00infobox
Gamma-secretase-activating proteinEntrez541031.00infobox
Gamma-secretase-activating proteinExternal IDsOMIM: 613552; MGI: 2442259; GeneCards: GSAP1.00infobox

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