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Cortactin

Cortactin (from "cortical actin binding protein") is a monomeric protein located in the cytoplasm of cells that can be activated by external stimuli to promote polymerization and rearrangement of the actin cytoskeleton, especially the actin cortex around the cellular periphery. It is present in all cell types. When activated, it will recruit Arp2/3…

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Activation and binding

PhosphorylationTyrosine kinasesSerine/threonine kinasesGrowth factorsAdhesion sites
13 related topics

Location and function in the cell

TreadmillingReceptor tyrosine kinaseCell membraneMacrophagesPathogens
9 related topics

Interactions

InteractACTR3ARPC2CTNND1FER
9 related topics

Structure

MonomerSH3 domain
2 related topics

Key facts & relationships

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Aliases
CTTN, EMS1, cortactin
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1X69, 2D1X
Band
11q13.3 · 7|7 F5
Bgee
stromal cell of endometrium · body of uterus · left ovary · right ovary · right adrenal cortex
BioGPS
More reference expression data
Chr.
Chromosome 11 (human) · Chromosome 7 (mouse)

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Overview

Gene

Structure

Activation and binding

Location and function in the cell

Clinical significance

Interactions

Advanced semantic analysis

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Map overview Semantic statistics

Cortactin

Nodes55
Edges54
Triples143
Avg. degree1.96
Density0.036364
Components1

How this topic connects Entity context

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Cortactin

Top relations

Gene ontology · 43
Cortactin → actin cytoskeleton reorganization, actin filament, actin filament polymerization, cadherin binding, cell cortex, cell junction, cell motility, cell projection, clathrin-coated pit, cortical cytoskeleton, cytoplasm, cytoskeleton, cytosol, dendrite, dendritic spine, dendritic spine maintenance, endocytosis, extracellular exosome, focal adhesion, focal adhesion assembly
Bgee · 20
Cortactin → body of uterus, calvaria, canal of the cervix, cumulus cell, endothelial cell of lymphatic vessel, epithelium of stomach, gastric mucosa, gastrula, left adrenal cortex, left ovary, medullary collecting duct, myometrium, Paneth cell, renal corpuscle, right adrenal cortex, right ovary, right uterine tube, stromal cell of endometrium, tail of embryo, transitional epithelium of urinary bladder
RNA expression pattern · 20
Cortactin → body of uterus, calvaria, canal of the cervix, cumulus cell, endothelial cell of lymphatic vessel, epithelium of stomach, gastric mucosa, gastrula, left adrenal cortex, left ovary, medullary collecting duct, myometrium, Paneth cell, renal corpuscle, right adrenal cortex, right ovary, right uterine tube, stromal cell of endometrium, tail of embryo, transitional epithelium of urinary bladder
related to Activation and binding · 13
Cortactin → Arp2/3, As, DDW, F-actin, It, NPFs, NTA, Once, Src, The SH3, Tyr421, Tyr466, Tyr482
related to Interactions · 6
Cortactin → ACTR3ARPC2, CTNND1, FER, KCNA2, SHANK2, WASL
related to Location and function in the cell · 6
Cortactin → Arp2/3, Branches, Cortactin-assisted Arp2/3-nucleated, F-actin, Inactive, Thus
related to Clinical significance · 4
Cortactin → Amplification, EMS1, Overexpression, These
related to External links · 3
Cortactin → Medicine Medical Subject Headings, MeSH, National Library
related to Structure · 3
Cortactin → NTA, SH3, This
Band · 2
Cortactin → 11q13.3, 7|7 F5

Important terminology Word statistics

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Important terminology

actin cell arp2 bp complex activated polymerization chr gene human band endocytosis chromosome 11 protein binding location kinases cortex nucleation

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
CortactinAliasesCTTN, EMS1, cortactin1.00infobox
CortactinAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1X69, 2D1X1.00infobox
CortactinBand11q13.31.00infobox
CortactinBand7|7 F51.00infobox
CortactinBgeestromal cell of endometrium1.00infobox
CortactinBgeebody of uterus1.00infobox
CortactinBgeeleft ovary1.00infobox
CortactinBgeeright ovary1.00infobox
CortactinBgeeright adrenal cortex1.00infobox
CortactinBgeemyometrium1.00infobox
CortactinBgeegastric mucosa1.00infobox
CortactinBgeeright uterine tube1.00infobox
CortactinBgeecanal of the cervix1.00infobox
CortactinBgeeleft adrenal cortex1.00infobox
CortactinBgeemedullary collecting duct1.00infobox
CortactinBgeetransitional epithelium of urinary bladder1.00infobox
CortactinBgeegastrula1.00infobox
CortactinBgeeendothelial cell of lymphatic vessel1.00infobox
CortactinBgeecumulus cell1.00infobox
CortactinBgeecalvaria1.00infobox
CortactinBgeePaneth cell1.00infobox
CortactinBgeeepithelium of stomach1.00infobox
CortactinBgeerenal corpuscle1.00infobox
CortactinBgeetail of embryo1.00infobox
CortactinBioGPSMore reference expression data1.00infobox
CortactinChr.Chromosome 11 (human)1.00infobox
CortactinChr.Chromosome 7 (mouse)1.00infobox
CortactinDatabasesNCBI: entry; OMA: entry1.00infobox
CortactinEnd70,436,584 bp1.00infobox
CortactinEnd144,024,746 bp1.00infobox

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