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Flap structure-specific endonuclease 1

Flap endonuclease 1 is an enzyme that in humans is encoded by the FEN1 gene.

Interactions, Therapeutic target for human cancer & Over expression of FEN1 in cancers

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Aliases
FEN1, Flap endonuclease 1, flap structure-specific endonuclease 1, FEN-1, MF1, RAD2
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1U7B, 1UL1, 3Q8K, 3Q8L, 3Q8M, 3UVU, 5E0V
Band
11q12.2 · 19|19 A
Bgee
oocyte · amniotic fluid · paraflocculus of cerebellum · gingival epithelium · secondary oocyte
BioGPS
More reference expression data
Chr.
Chromosome 11 (human) · Chromosome 19 (mouse)

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Overview

Function

Interactions

Over expression of FEN1 in cancers

Therapeutic target for human cancer

Advanced semantic analysis

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Map overview Semantic statistics

Flap structure-specific endonuclease 1

Nodes32
Edges31
Triples109
Avg. degree1.94
Density0.0625
Components1

How this topic connects Entity context

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Flap structure-specific endonuclease 1

Top relations

Gene ontology · 39
Flap structure-specific endonuclease 1 → 5'-3' exonuclease activity, 5'-flap endonuclease activity, apoptotic DNA fragmentation, base-excision repair, catalytic activity, cellular response to DNA damage stimulus, damaged DNA binding, DNA binding, DNA repair, DNA replication, DNA replication, removal of RNA primer, double-strand break repair, double-strand break repair via homologous recombination, double-stranded DNA binding, double-stranded DNA exodeoxyribonuclease activity, endonuclease activity, exonuclease activity, flap endonuclease activity, hydrolase activity, hydrolase activity, acting on ester bonds
Bgee · 20
Flap structure-specific endonuclease 1 → amniotic fluid, bone marrow, ciliary body, cumulus cell, embryo, endothelial cell of lymphatic vessel, fetal liver hematopoietic progenitor cell, gingival epithelium, gonad, iris, maxillary prominence, motor neuron, oocyte, Paneth cell, paraflocculus of cerebellum, primitive streak, retinal pigment epithelium, secondary oocyte, tendon of biceps brachii, trabecular bone
RNA expression pattern · 20
Flap structure-specific endonuclease 1 → amniotic fluid, bone marrow, ciliary body, cumulus cell, embryo, endothelial cell of lymphatic vessel, fetal liver hematopoietic progenitor cell, gingival epithelium, gonad, iris, maxillary prominence, motor neuron, oocyte, Paneth cell, paraflocculus of cerebellum, primitive streak, retinal pigment epithelium, secondary oocyte, tendon of biceps brachii, trabecular bone
related to Interactions · 7
Flap structure-specific endonuclease 1 → APEX1, BLMCDK2, CCNA2, EP300, Flap, HNRNPA1, PCNA
Band · 2
Flap structure-specific endonuclease 1 → 11q12.2, 19|19 A
Chr. · 2
Flap structure-specific endonuclease 1 → Chromosome 11 (human), Chromosome 19 (mouse)
End · 2
Flap structure-specific endonuclease 1 → 10,181,533 bp, 61,797,238 bp
Aliases · 1
Flap structure-specific endonuclease 1 → FEN1, Flap endonuclease 1, flap structure-specific endonuclease 1, FEN-1, MF1, RAD2
Available structures · 1
Flap structure-specific endonuclease 1 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1U7B, 1UL1, 3Q8K, 3Q8L, 3Q8M, 3UVU, 5E0V
BioGPS · 1
Flap structure-specific endonuclease 1 → More reference expression data

Important terminology Word statistics

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Important terminology

fen1 repair dna gene human bp cancer protein endonuclease cancers chr band expression pathway end flap mmej chromosome 11 enzyme

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Flap structure-specific endonuclease 1AliasesFEN1, Flap endonuclease 1, flap structure-specific endonuclease 1, FEN-1, MF1, RAD21.00infobox
Flap structure-specific endonuclease 1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1U7B, 1UL1, 3Q8K, 3Q8L, 3Q8M, 3UVU, 5E0V1.00infobox
Flap structure-specific endonuclease 1Band11q12.21.00infobox
Flap structure-specific endonuclease 1Band19|19 A1.00infobox
Flap structure-specific endonuclease 1Bgeeoocyte1.00infobox
Flap structure-specific endonuclease 1Bgeeamniotic fluid1.00infobox
Flap structure-specific endonuclease 1Bgeeparaflocculus of cerebellum1.00infobox
Flap structure-specific endonuclease 1Bgeegingival epithelium1.00infobox
Flap structure-specific endonuclease 1Bgeesecondary oocyte1.00infobox
Flap structure-specific endonuclease 1Bgeetendon of biceps brachii1.00infobox
Flap structure-specific endonuclease 1Bgeegonad1.00infobox
Flap structure-specific endonuclease 1Bgeetrabecular bone1.00infobox
Flap structure-specific endonuclease 1Bgeebone marrow1.00infobox
Flap structure-specific endonuclease 1Bgeeembryo1.00infobox
Flap structure-specific endonuclease 1BgeePaneth cell1.00infobox
Flap structure-specific endonuclease 1Bgeeciliary body1.00infobox
Flap structure-specific endonuclease 1Bgeeprimitive streak1.00infobox
Flap structure-specific endonuclease 1Bgeeretinal pigment epithelium1.00infobox
Flap structure-specific endonuclease 1Bgeefetal liver hematopoietic progenitor cell1.00infobox
Flap structure-specific endonuclease 1Bgeeiris1.00infobox
Flap structure-specific endonuclease 1Bgeecumulus cell1.00infobox
Flap structure-specific endonuclease 1Bgeeendothelial cell of lymphatic vessel1.00infobox
Flap structure-specific endonuclease 1Bgeemaxillary prominence1.00infobox
Flap structure-specific endonuclease 1Bgeemotor neuron1.00infobox
Flap structure-specific endonuclease 1BioGPSMore reference expression data1.00infobox
Flap structure-specific endonuclease 1Chr.Chromosome 11 (human)1.00infobox
Flap structure-specific endonuclease 1Chr.Chromosome 19 (mouse)1.00infobox
Flap structure-specific endonuclease 1DatabasesNCBI: entry; OMA: entry1.00infobox
Flap structure-specific endonuclease 1End61,797,238 bp1.00infobox
Flap structure-specific endonuclease 1End10,181,533 bp1.00infobox

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