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DNA-(apurinic or apyrimidinic site) lyase is an enzyme that in humans is encoded by the APEX1 gene.
The analysis highlights Interactions, Aging and Overview as prominent areas in the source structure around APEX1.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around APEX1 shows recurring relationship patterns in the source. For example, APEX1 → 3'-5' exonuclease activity, ageing, base-excision repair, cell redox homeostasis, cellular response to cAMP, cellular response to DNA damage stimulus, cellular response to hydrogen peroxide, cellular response to organonitrogen compound, cellular response to peptide hormone stimulus, centrosome, chromatin DNA binding, class I DNA-(apurinic or apyrimidinic site) endonuclease activity, class III/IV DNA-(apurinic or apyrimidinic site) endonuclease activity, cytoplasm, damaged DNA binding, DNA binding, DNA demethylation, DNA recombination, DNA repair, DNA-(apurinic or apyrimidinic site) endonuclease activity Another extracted example is APEX1 → abdominal wall, condyle, embryo, epiblast, external carotid artery, gallbladder, ganglionic eminence, internal carotid artery, islet of Langerhans, left adrenal cortex, left ovary, mandibular prominence, maxillary prominence, medial ganglionic eminence, primitive streak, rectum, right adrenal cortex, right adrenal gland, right ovary, ventricular zone. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
gene human bp ap dna chr band apurinic apyrimidinic chromosome 14 sites location site repair external endonuclease aging humans cells
TTTA extracted 140 structured relationships around APEX1. Examples in this analysis include APEX1 → 3.1.11.2 → ↗ and APEX1 → Aliases → APEX1, APE, APE1, APEN, APEX, APX, HAP1, REF1, apurinic/apyrimidinic endodeoxyribonuclease 1. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| APEX1 | 3.1.11.2 | ↗ | 1.00 | infobox |
| APEX1 | Aliases | APEX1, APE, APE1, APEN, APEX, APX, HAP1, REF1, apurinic/apyrimidinic endodeoxyribonuclease 1 | 1.00 | infobox |
| APEX1 | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1BIX, 1CQH, 4LND, 4QH9, 5DFF, 4QHD, 1E9N, 3U8U, 5DFI, 1HD7, 5DG0, 5DFJ, 4QHE, 5DFH, 1DE9, 4IEM, 2ISI, 1DE8,… | 1.00 | infobox |
| APEX1 | Band | 14q11.2 | 1.00 | infobox |
| APEX1 | Band | 14 C1|14 26.3 cM | 1.00 | infobox |
| APEX1 | Bgee | ganglionic eminence | 1.00 | infobox |
| APEX1 | Bgee | ventricular zone | 1.00 | infobox |
| APEX1 | Bgee | islet of Langerhans | 1.00 | infobox |
| APEX1 | Bgee | right adrenal gland | 1.00 | infobox |
| APEX1 | Bgee | right adrenal cortex | 1.00 | infobox |
| APEX1 | Bgee | left ovary | 1.00 | infobox |
| APEX1 | Bgee | right ovary | 1.00 | infobox |
| APEX1 | Bgee | left adrenal cortex | 1.00 | infobox |
| APEX1 | Bgee | gallbladder | 1.00 | infobox |
| APEX1 | Bgee | rectum | 1.00 | infobox |
| APEX1 | Bgee | primitive streak | 1.00 | infobox |
| APEX1 | Bgee | internal carotid artery | 1.00 | infobox |
| APEX1 | Bgee | external carotid artery | 1.00 | infobox |
| APEX1 | Bgee | abdominal wall | 1.00 | infobox |
| APEX1 | Bgee | epiblast | 1.00 | infobox |
| APEX1 | Bgee | condyle | 1.00 | infobox |
| APEX1 | Bgee | maxillary prominence | 1.00 | infobox |
| APEX1 | Bgee | mandibular prominence | 1.00 | infobox |
| APEX1 | Bgee | medial ganglionic eminence | 1.00 | infobox |
| APEX1 | Bgee | embryo | 1.00 | infobox |
| APEX1 | BioGPS | More reference expression data | 1.00 | infobox |
| APEX1 | Chr. | Chromosome 14 (human) | 1.00 | infobox |
| APEX1 | Chr. | Chromosome 14 (mouse) | 1.00 | infobox |
| APEX1 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| APEX1 | End | 20,457,772 bp | 1.00 | infobox |
The concept neighborhoods around APEX1 bring nearby vocabulary together. In this analysis, examples include Gene, Human and Apurinic. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For APEX1, one of the stronger structural bridges in this analysis connects APEX1 with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around APEX1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Interactions, Aging & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — APEX1 · EN edition · Analysis: TopicsToTalkAbout