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APEX1

DNA-(apurinic or apyrimidinic site) lyase is an enzyme that in humans is encoded by the APEX1 gene.

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3.1.11.2
Aliases
APEX1, APE, APE1, APEN, APEX, APX, HAP1, REF1, apurinic/apyrimidinic endodeoxyribonuclease 1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1BIX, 1CQH, 4LND, 4QH9, 5DFF, 4QHD, 1E9N, 3U8U, 5DFI, 1HD7, 5DG0, 5DFJ, 4QHE, 5DFH, 1DE9, 4IEM, 2ISI, 1DE8,…
Band
14q11.2 · 14 C1|14 26.3 cM
Bgee
ganglionic eminence · ventricular zone · islet of Langerhans · right adrenal gland · right adrenal cortex
BioGPS
More reference expression data

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Map overview Semantic statistics

APEX1

Nodes18
Edges17
Triples140
Avg. degree1.89
Density0.111111
Components1

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APEX1

Top relations

Gene ontology · 66
APEX1 → 3'-5' exonuclease activity, ageing, base-excision repair, cell redox homeostasis, cellular response to cAMP, cellular response to DNA damage stimulus, cellular response to hydrogen peroxide, cellular response to organonitrogen compound, cellular response to peptide hormone stimulus, centrosome, chromatin DNA binding, class I DNA-(apurinic or apyrimidinic site) endonuclease activity, class III/IV DNA-(apurinic or apyrimidinic site) endonuclease activity, cytoplasm, damaged DNA binding, DNA binding, DNA demethylation, DNA recombination, DNA repair, DNA-(apurinic or apyrimidinic site) endonuclease activity
Bgee · 20
APEX1 → abdominal wall, condyle, embryo, epiblast, external carotid artery, gallbladder, ganglionic eminence, internal carotid artery, islet of Langerhans, left adrenal cortex, left ovary, mandibular prominence, maxillary prominence, medial ganglionic eminence, primitive streak, rectum, right adrenal cortex, right adrenal gland, right ovary, ventricular zone
RNA expression pattern · 20
APEX1 → abdominal wall, condyle, embryo, epiblast, external carotid artery, gallbladder, ganglionic eminence, internal carotid artery, islet of Langerhans, left adrenal cortex, left ovary, mandibular prominence, maxillary prominence, medial ganglionic eminence, primitive streak, rectum, right adrenal cortex, right adrenal gland, right ovary, ventricular zone
related to Aging · 3
APEX1 → Deficiency, DNA, This
related to Interactions · 3
APEX1 → Flap, MUTYH, XRCC1
Band · 2
APEX1 → 14 C1|14 26.3 cM, 14q11.2
Chr. · 2
APEX1 → Chromosome 14 (human), Chromosome 14 (mouse)
End · 2
APEX1 → 20,457,772 bp, 51,164,596 bp
related to External links · 2
APEX1 → Human APEX1, UCSC Genome Browser
3.1.11.2 · 1
APEX1 → ↗

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Important terminology

gene human bp ap dna chr band apurinic apyrimidinic chromosome 14 sites location site repair external endonuclease aging humans cells

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
APEX13.1.11.21.00infobox
APEX1AliasesAPEX1, APE, APE1, APEN, APEX, APX, HAP1, REF1, apurinic/apyrimidinic endodeoxyribonuclease 11.00infobox
APEX1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1BIX, 1CQH, 4LND, 4QH9, 5DFF, 4QHD, 1E9N, 3U8U, 5DFI, 1HD7, 5DG0, 5DFJ, 4QHE, 5DFH, 1DE9, 4IEM, 2ISI, 1DE8,…1.00infobox
APEX1Band14q11.21.00infobox
APEX1Band14 C1|14 26.3 cM1.00infobox
APEX1Bgeeganglionic eminence1.00infobox
APEX1Bgeeventricular zone1.00infobox
APEX1Bgeeislet of Langerhans1.00infobox
APEX1Bgeeright adrenal gland1.00infobox
APEX1Bgeeright adrenal cortex1.00infobox
APEX1Bgeeleft ovary1.00infobox
APEX1Bgeeright ovary1.00infobox
APEX1Bgeeleft adrenal cortex1.00infobox
APEX1Bgeegallbladder1.00infobox
APEX1Bgeerectum1.00infobox
APEX1Bgeeprimitive streak1.00infobox
APEX1Bgeeinternal carotid artery1.00infobox
APEX1Bgeeexternal carotid artery1.00infobox
APEX1Bgeeabdominal wall1.00infobox
APEX1Bgeeepiblast1.00infobox
APEX1Bgeecondyle1.00infobox
APEX1Bgeemaxillary prominence1.00infobox
APEX1Bgeemandibular prominence1.00infobox
APEX1Bgeemedial ganglionic eminence1.00infobox
APEX1Bgeeembryo1.00infobox
APEX1BioGPSMore reference expression data1.00infobox
APEX1Chr.Chromosome 14 (human)1.00infobox
APEX1Chr.Chromosome 14 (mouse)1.00infobox
APEX1DatabasesNCBI: entry; OMA: entry1.00infobox
APEX1End20,457,772 bp1.00infobox

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