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Transcription factor 7-like 2 (T-cell specific, HMG-box), also known as TCF7L2 or TCF4, is a protein acting as a transcription factor that, in humans, is encoded by the TCF7L2 gene. The TCF7L2 gene is located on chromosome 10q25.2–q25.3, contains 19 exons. As a member of the TCF family, TCF7L2 can form a bipartite transcription factor and influence…
The analysis highlights Art, Clinical significance and Function as prominent areas in the source structure around TCF7L2.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around TCF7L2 shows recurring relationship patterns in the source. For example, TCF7L2 → armadillo repeat domain binding, beta-catenin binding, beta-catenin-TCF complex assembly, beta-catenin-TCF7L2 complex, blood vessel development, canonical Wnt signaling pathway, canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition, cell population proliferation, chromatin binding, DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, fat cell differentiation, gamma-catenin binding, glucose homeostasis, maintenance of DNA repeat elements, myoblast fate commitment, negative regulation of canonical Wnt signaling pathway, negative regulation of DNA-binding transcription factor activity, negative regulation of extrinsic apoptotic signaling pathway Another extracted example is TCF7L2 → aortic valve, ascending aorta, decidua, endothelial cell, epithelium of lactiferous gland, external carotid artery, genital tubercle, germinal epithelium, habenula, hair follicle, inferior colliculi, internal carotid artery, lactiferous duct, lateral geniculate nucleus, lateral nuclear group of thalamus, medial dorsal nucleus, medial geniculate nucleus, pancreatic ductal cell, tibia, visceral pleura. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
gene transcription wnt type factor diabetes thalamus chromosome pathway polymorphisms bp genes multiple chr human band 19 risk 10 protein
TTTA extracted 200 structured relationships around TCF7L2. Examples in this analysis include TCF7L2 → Aliases → TCF7L2, TCF-4, TCF4, transcription factor 7 like 2 and TCF7L2 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2GL7, 1JDH, 1JPW. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| TCF7L2 | Aliases | TCF7L2, TCF-4, TCF4, transcription factor 7 like 2 | 1.00 | infobox |
| TCF7L2 | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2GL7, 1JDH, 1JPW | 1.00 | infobox |
| TCF7L2 | Band | 10q25.2-q25.3 | 1.00 | infobox |
| TCF7L2 | Band | 19 D2|19 51.59 cM | 1.00 | infobox |
| TCF7L2 | Bgee | lateral nuclear group of thalamus | 1.00 | infobox |
| TCF7L2 | Bgee | endothelial cell | 1.00 | infobox |
| TCF7L2 | Bgee | pancreatic ductal cell | 1.00 | infobox |
| TCF7L2 | Bgee | hair follicle | 1.00 | infobox |
| TCF7L2 | Bgee | decidua | 1.00 | infobox |
| TCF7L2 | Bgee | epithelium of lactiferous gland | 1.00 | infobox |
| TCF7L2 | Bgee | lactiferous duct | 1.00 | infobox |
| TCF7L2 | Bgee | tibia | 1.00 | infobox |
| TCF7L2 | Bgee | visceral pleura | 1.00 | infobox |
| TCF7L2 | Bgee | germinal epithelium | 1.00 | infobox |
| TCF7L2 | Bgee | medial dorsal nucleus | 1.00 | infobox |
| TCF7L2 | Bgee | medial geniculate nucleus | 1.00 | infobox |
| TCF7L2 | Bgee | habenula | 1.00 | infobox |
| TCF7L2 | Bgee | lateral geniculate nucleus | 1.00 | infobox |
| TCF7L2 | Bgee | inferior colliculi | 1.00 | infobox |
| TCF7L2 | Bgee | ascending aorta | 1.00 | infobox |
| TCF7L2 | Bgee | aortic valve | 1.00 | infobox |
| TCF7L2 | Bgee | internal carotid artery | 1.00 | infobox |
| TCF7L2 | Bgee | external carotid artery | 1.00 | infobox |
| TCF7L2 | Bgee | genital tubercle | 1.00 | infobox |
| TCF7L2 | BioGPS | More reference expression data | 1.00 | infobox |
| TCF7L2 | Chr. | Chromosome 10 (human) | 1.00 | infobox |
| TCF7L2 | Chr. | Chromosome 19 (mouse) | 1.00 | infobox |
| TCF7L2 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| TCF7L2 | End | 113,167,678 bp | 1.00 | infobox |
| TCF7L2 | End | 55,922,086 bp | 1.00 | infobox |
The concept neighborhoods around TCF7L2 bring nearby vocabulary together. In this analysis, examples include Gene, Transcription and Wnt. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For TCF7L2, one of the stronger structural bridges in this analysis connects TCF7L2 with Clinical significance. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around TCF7L2 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Art, Clinical significance & Function, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — TCF7L2 · EN edition · Analysis: TopicsToTalkAbout