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TCF7L2: Art, Clinical significance & Function

Transcription factor 7-like 2 (T-cell specific, HMG-box), also known as TCF7L2 or TCF4, is a protein acting as a transcription factor that, in humans, is encoded by the TCF7L2 gene. The TCF7L2 gene is located on chromosome 10q25.2–q25.3, contains 19 exons. As a member of the TCF family, TCF7L2 can form a bipartite transcription factor and influence…

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TCF7L2 topic overview

The analysis highlights Art, Clinical significance and Function as prominent areas in the source structure around TCF7L2.

Related topics
63
Source areas
7
Connected nodes
70
Extracted relationships
200
Concept neighborhoods
22
Bridge connections
70

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Clinical significance · 34 topics
Overview · 11 topics
Function · 7 topics
Model organisms · 4 topics
Structure · 4 topics
Tissue distribution · 2 topics
Nomenclature · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
TCF7L2, TCF-4, TCF4, transcription factor 7 like 2
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2GL7, 1JDH, 1JPW
Band
10q25.2-q25.3 · 19 D2|19 51.59 cM
Bgee
lateral nuclear group of thalamus · endothelial cell · pancreatic ductal cell · hair follicle · decidua
BioGPS
More reference expression data
Chr.
Chromosome 10 (human) · Chromosome 19 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Structure

Tissue distribution

Clinical significance

Model organisms

Nomenclature

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How TCF7L2 connects Entity context

The extracted context around TCF7L2 shows recurring relationship patterns in the source. For example, TCF7L2 → armadillo repeat domain binding, beta-catenin binding, beta-catenin-TCF complex assembly, beta-catenin-TCF7L2 complex, blood vessel development, canonical Wnt signaling pathway, canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition, cell population proliferation, chromatin binding, DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, fat cell differentiation, gamma-catenin binding, glucose homeostasis, maintenance of DNA repeat elements, myoblast fate commitment, negative regulation of canonical Wnt signaling pathway, negative regulation of DNA-binding transcription factor activity, negative regulation of extrinsic apoptotic signaling pathway Another extracted example is TCF7L2 → aortic valve, ascending aorta, decidua, endothelial cell, epithelium of lactiferous gland, external carotid artery, genital tubercle, germinal epithelium, habenula, hair follicle, inferior colliculi, internal carotid artery, lactiferous duct, lateral geniculate nucleus, lateral nuclear group of thalamus, medial dorsal nucleus, medial geniculate nucleus, pancreatic ductal cell, tibia, visceral pleura. Use these groups to spot repeated connection types before inspecting the individual relationships.

TCF7L2

Top relations

Gene ontology · 49
TCF7L2 → armadillo repeat domain binding, beta-catenin binding, beta-catenin-TCF complex assembly, beta-catenin-TCF7L2 complex, blood vessel development, canonical Wnt signaling pathway, canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition, cell population proliferation, chromatin binding, DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, fat cell differentiation, gamma-catenin binding, glucose homeostasis, maintenance of DNA repeat elements, myoblast fate commitment, negative regulation of canonical Wnt signaling pathway, negative regulation of DNA-binding transcription factor activity, negative regulation of extrinsic apoptotic signaling pathway
Bgee · 20
TCF7L2 → aortic valve, ascending aorta, decidua, endothelial cell, epithelium of lactiferous gland, external carotid artery, genital tubercle, germinal epithelium, habenula, hair follicle, inferior colliculi, internal carotid artery, lactiferous duct, lateral geniculate nucleus, lateral nuclear group of thalamus, medial dorsal nucleus, medial geniculate nucleus, pancreatic ductal cell, tibia, visceral pleura
RNA expression pattern · 20
TCF7L2 → aortic valve, ascending aorta, decidua, endothelial cell, epithelium of lactiferous gland, external carotid artery, genital tubercle, germinal epithelium, habenula, hair follicle, inferior colliculi, internal carotid artery, lactiferous duct, lateral geniculate nucleus, lateral nuclear group of thalamus, medial dorsal nucleus, medial geniculate nucleus, pancreatic ductal cell, tibia, visceral pleura
related to Function · 18
TCF7L2 → BCL9, Bipartite, Chinese Han, GDM, HBP1, HMG-box, However, It, Stimulation, T2DM, TCF, TCF7L2's, That, The, The TCF7L2, Therefore, Type, Wnt
related to Neurodevelopmental disorders · 13
TCF7L2 → Arab, Chinese Han, Danio, European, In, It, Single, SNP, SNPs, TCF7L2's, The, This, Wnt
related to Type 2 Diabetes · 13
TCF7L2 → Chromosome, DeCODE, GLP-1, Mexican Americans This, Michael Stern, Ravindranath Duggirala, San Antonio, Several, Struan Grant, Studies, Texas Health Science Center, The, The University
related to External links · 11
TCF7L2 → PDB, PDBe-KB, PubMedPubMed GeneRIFs, Q9NQB0, TCF4, TCF7L2Overview, TCFsStructure, Transcription, UniProt, Weizmann Institute GeneCard, Wnt
related to Model organisms · 10
TCF7L2 → Additional, EUCOMM, In-depth, Male, Model, Tcf7l2tm1a, Therefore, Variations, Wellcome Trust Sanger Institute, Wtsi
related to Structure · 5
TCF7L2 → Da, Of, TCF7L2's, The, The TCF7L2
related to Cancer · 4
TCF7L2 → KM12, PI3K/Akt, The, Variants

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

gene transcription wnt type factor diabetes thalamus chromosome pathway polymorphisms bp genes multiple chr human band 19 risk 10 protein

TCF7L2 relationships Subject–Predicate–Object triples

TTTA extracted 200 structured relationships around TCF7L2. Examples in this analysis include TCF7L2 → Aliases → TCF7L2, TCF-4, TCF4, transcription factor 7 like 2 and TCF7L2 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2GL7, 1JDH, 1JPW. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
TCF7L2AliasesTCF7L2, TCF-4, TCF4, transcription factor 7 like 21.00infobox
TCF7L2Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2GL7, 1JDH, 1JPW1.00infobox
TCF7L2Band10q25.2-q25.31.00infobox
TCF7L2Band19 D2|19 51.59 cM1.00infobox
TCF7L2Bgeelateral nuclear group of thalamus1.00infobox
TCF7L2Bgeeendothelial cell1.00infobox
TCF7L2Bgeepancreatic ductal cell1.00infobox
TCF7L2Bgeehair follicle1.00infobox
TCF7L2Bgeedecidua1.00infobox
TCF7L2Bgeeepithelium of lactiferous gland1.00infobox
TCF7L2Bgeelactiferous duct1.00infobox
TCF7L2Bgeetibia1.00infobox
TCF7L2Bgeevisceral pleura1.00infobox
TCF7L2Bgeegerminal epithelium1.00infobox
TCF7L2Bgeemedial dorsal nucleus1.00infobox
TCF7L2Bgeemedial geniculate nucleus1.00infobox
TCF7L2Bgeehabenula1.00infobox
TCF7L2Bgeelateral geniculate nucleus1.00infobox
TCF7L2Bgeeinferior colliculi1.00infobox
TCF7L2Bgeeascending aorta1.00infobox
TCF7L2Bgeeaortic valve1.00infobox
TCF7L2Bgeeinternal carotid artery1.00infobox
TCF7L2Bgeeexternal carotid artery1.00infobox
TCF7L2Bgeegenital tubercle1.00infobox
TCF7L2BioGPSMore reference expression data1.00infobox
TCF7L2Chr.Chromosome 10 (human)1.00infobox
TCF7L2Chr.Chromosome 19 (mouse)1.00infobox
TCF7L2DatabasesNCBI: entry; OMA: entry1.00infobox
TCF7L2End113,167,678 bp1.00infobox
TCF7L2End55,922,086 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around TCF7L2 bring nearby vocabulary together. In this analysis, examples include Gene, Transcription and Wnt. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • TCF7L2
    • Gene
    • Transcription
    • Wnt
    • Diabetes
    • Type
    • Pathway
    • Thalamus
    • Polymorphisms
    • Function
    • Shown
    • Susceptibility
    • Cancer
  • tcf7l2
    • Gene
    • Transcription
    • Wnt
    • Diabetes
    • Type
    • Pathway
    • Thalamus
    • Polymorphisms
    • Function
    • Shown
    • Susceptibility
    • Cancer
  • transcription factor
    • Transcription
    • Gene
    • Pathway
    • Multiple
    • Wnt
    • Also
    • Human
    • Bp
    • Chr
    • Function
    • Protein
    • Signalling
  • gene
    • Chromosome
    • Type
    • Polymorphisms
    • Tcf7l2
    • Diabetes
    • Protein
    • Risk
    • Transcription
    • Human
    • Bp
    • Chr
    • Multiple
  • hugo gene nomenclature committee
    • Chromosome
    • Type
    • Polymorphisms
    • Tcf7l2
    • Diabetes
    • Protein
    • Risk
    • Transcription
    • Human
    • Bp
    • Chr
    • Multiple
  • chromosome 10
    • Human
    • Bp
    • Chr
    • Band
    • Gene
    • Type
    • Mouse
    • Function
    • Protein
    • Factor
    • Diabetes
    • Transcription
  • wnt signalling pathway
    • Wnt
    • Pathway
    • Signalling
    • Β-catenin
    • Involved
    • Transcription
    • Genes
    • Tcf7l2
    • Band
    • Human
    • Mouse
    • Pathways
  • type 2 diabetes
    • Type
    • Polymorphisms
    • Susceptibility
    • Multiple
    • Gene
    • Disorders
    • Gdm
    • Including
    • Neurodevelopmental
    • Significant
    • Tcf7l2
    • Risk

Connections between topic areas Semantic bridges

For TCF7L2, one of the stronger structural bridges in this analysis connects TCF7L2 with Clinical significance. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
TCF7L2Clinical significance · splits 36 ⟂ 35
TCF7L2Overview · splits 59 ⟂ 12
TCF7L2Function · splits 63 ⟂ 8
TCF7L2Structure · splits 66 ⟂ 5
TCF7L2Model organisms · splits 66 ⟂ 5
TCF7L2Tissue distribution · splits 68 ⟂ 3

Map overview Semantic statistics

TCF7L2

Nodes71
Edges70
Triples200
Avg. degree1.97
Density0.028169
Components1

Source & methodology

TTTA analyzes the structure around TCF7L2 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Art, Clinical significance & Function, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — TCF7L2 · EN edition · Analysis: TopicsToTalkAbout

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