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TCF7L2

Transcription factor 7-like 2 (T-cell specific, HMG-box), also known as TCF7L2 or TCF4, is a protein acting as a transcription factor that, in humans, is encoded by the TCF7L2 gene. The TCF7L2 gene is located on chromosome 10q25.2–q25.3, contains 19 exons. As a member of the TCF family, TCF7L2 can form a bipartite transcription factor and influence…

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Aliases
TCF7L2, TCF-4, TCF4, transcription factor 7 like 2
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2GL7, 1JDH, 1JPW
Band
10q25.2-q25.3 · 19 D2|19 51.59 cM
Bgee
lateral nuclear group of thalamus · endothelial cell · pancreatic ductal cell · hair follicle · decidua
BioGPS
More reference expression data
Chr.
Chromosome 10 (human) · Chromosome 19 (mouse)

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Map overview Semantic statistics

TCF7L2

Nodes71
Edges70
Triples200
Avg. degree1.97
Density0.028169
Components1

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TCF7L2

Top relations

Gene ontology · 49
TCF7L2 → armadillo repeat domain binding, beta-catenin binding, beta-catenin-TCF complex assembly, beta-catenin-TCF7L2 complex, blood vessel development, canonical Wnt signaling pathway, canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition, cell population proliferation, chromatin binding, DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, fat cell differentiation, gamma-catenin binding, glucose homeostasis, maintenance of DNA repeat elements, myoblast fate commitment, negative regulation of canonical Wnt signaling pathway, negative regulation of DNA-binding transcription factor activity, negative regulation of extrinsic apoptotic signaling pathway
Bgee · 20
TCF7L2 → aortic valve, ascending aorta, decidua, endothelial cell, epithelium of lactiferous gland, external carotid artery, genital tubercle, germinal epithelium, habenula, hair follicle, inferior colliculi, internal carotid artery, lactiferous duct, lateral geniculate nucleus, lateral nuclear group of thalamus, medial dorsal nucleus, medial geniculate nucleus, pancreatic ductal cell, tibia, visceral pleura
RNA expression pattern · 20
TCF7L2 → aortic valve, ascending aorta, decidua, endothelial cell, epithelium of lactiferous gland, external carotid artery, genital tubercle, germinal epithelium, habenula, hair follicle, inferior colliculi, internal carotid artery, lactiferous duct, lateral geniculate nucleus, lateral nuclear group of thalamus, medial dorsal nucleus, medial geniculate nucleus, pancreatic ductal cell, tibia, visceral pleura
related to Function · 18
TCF7L2 → BCL9, Bipartite, Chinese Han, GDM, HBP1, HMG-box, However, It, Stimulation, T2DM, TCF, TCF7L2's, That, The, The TCF7L2, Therefore, Type, Wnt
related to Neurodevelopmental disorders · 13
TCF7L2 → Arab, Chinese Han, Danio, European, In, It, Single, SNP, SNPs, TCF7L2's, The, This, Wnt
related to Type 2 Diabetes · 13
TCF7L2 → Chromosome, DeCODE, GLP-1, Mexican Americans This, Michael Stern, Ravindranath Duggirala, San Antonio, Several, Struan Grant, Studies, Texas Health Science Center, The, The University
related to External links · 11
TCF7L2 → PDB, PDBe-KB, PubMedPubMed GeneRIFs, Q9NQB0, TCF4, TCF7L2Overview, TCFsStructure, Transcription, UniProt, Weizmann Institute GeneCard, Wnt
related to Model organisms · 10
TCF7L2 → Additional, EUCOMM, In-depth, Male, Model, Tcf7l2tm1a, Therefore, Variations, Wellcome Trust Sanger Institute, Wtsi
related to Structure · 5
TCF7L2 → Da, Of, TCF7L2's, The, The TCF7L2
related to Cancer · 4
TCF7L2 → KM12, PI3K/Akt, The, Variants

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Important terminology

gene transcription wnt type factor diabetes thalamus chromosome pathway polymorphisms bp genes multiple chr human band 19 risk 10 protein

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
TCF7L2AliasesTCF7L2, TCF-4, TCF4, transcription factor 7 like 21.00infobox
TCF7L2Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2GL7, 1JDH, 1JPW1.00infobox
TCF7L2Band10q25.2-q25.31.00infobox
TCF7L2Band19 D2|19 51.59 cM1.00infobox
TCF7L2Bgeelateral nuclear group of thalamus1.00infobox
TCF7L2Bgeeendothelial cell1.00infobox
TCF7L2Bgeepancreatic ductal cell1.00infobox
TCF7L2Bgeehair follicle1.00infobox
TCF7L2Bgeedecidua1.00infobox
TCF7L2Bgeeepithelium of lactiferous gland1.00infobox
TCF7L2Bgeelactiferous duct1.00infobox
TCF7L2Bgeetibia1.00infobox
TCF7L2Bgeevisceral pleura1.00infobox
TCF7L2Bgeegerminal epithelium1.00infobox
TCF7L2Bgeemedial dorsal nucleus1.00infobox
TCF7L2Bgeemedial geniculate nucleus1.00infobox
TCF7L2Bgeehabenula1.00infobox
TCF7L2Bgeelateral geniculate nucleus1.00infobox
TCF7L2Bgeeinferior colliculi1.00infobox
TCF7L2Bgeeascending aorta1.00infobox
TCF7L2Bgeeaortic valve1.00infobox
TCF7L2Bgeeinternal carotid artery1.00infobox
TCF7L2Bgeeexternal carotid artery1.00infobox
TCF7L2Bgeegenital tubercle1.00infobox
TCF7L2BioGPSMore reference expression data1.00infobox
TCF7L2Chr.Chromosome 10 (human)1.00infobox
TCF7L2Chr.Chromosome 19 (mouse)1.00infobox
TCF7L2DatabasesNCBI: entry; OMA: entry1.00infobox
TCF7L2End113,167,678 bp1.00infobox
TCF7L2End55,922,086 bp1.00infobox

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