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Rossmann fold: History, Structure & Overview

The Rossmann fold is a tertiary fold found in proteins that bind nucleotides, such as enzyme cofactors FAD, NAD+, and NADP+. This fold is composed of alternating beta strands and alpha helical segments where the beta strands are hydrogen bonded to each other forming an extended beta sheet and the alpha helices surround both faces of the sheet to produce…

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Rossmann fold topic overview

The analysis highlights History, Structure and Overview as prominent areas in the source structure around Rossmann fold.

Related topics
26
Source areas
5
Connected nodes
31
Extracted relationships
68
Concept neighborhoods
16
Bridge connections
31

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 13 topics
Structure · 5 topics
Evolution · 3 topics
Function · 3 topics
History · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

ECOD
2003.1
Pfam clan
CL0063
Symbol
NADP_Rossmann

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

History

Structure

Function

Evolution

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Rossmann fold connects Entity context

The extracted context around Rossmann fold shows recurring relationship patterns in the source. For example, Rossmann fold → C-terminal, It, MAR, MARs, Metabolic, NAD, Rossmann, Rossmannoid-fold, The, This, UDP-glucose, UDP-glucuronic, UgdG Another extracted example is Rossmann fold → Dr, He, In, Israel Hanukoglu, It, Michael Rossmann, NAD, NADP, Rossmann, Science, The Rossmann, This, Weizmann Institute. Use these groups to spot repeated connection types before inspecting the individual relationships.

Rossmann fold

Top relations

related to Function · 13
Rossmann fold → C-terminal, It, MAR, MARs, Metabolic, NAD, Rossmann, Rossmannoid-fold, The, This, UDP-glucose, UDP-glucuronic, UgdG
related to history · 13
Rossmann fold → Dr, He, In, Israel Hanukoglu, It, Michael Rossmann, NAD, NADP, Rossmann, Science, The Rossmann, This, Weizmann Institute
related to Structure · 12
Rossmann fold → C-terminal, Five, N-terminal, NADH-binding, One, Overall, Rossmann, Rossmann-like, The, The Rossmann, This, Through
related to Rossman and Rossmannoids · 11
Rossmann fold → ECOD, H-groups, However, It, PDB, Rossmann, Rossmann-like, Rossmannoids, The, These, X-groups
related to Conventional Rossman group · 10
Rossmann fold → FAD, Hanukoglu, In, NAD, NAD-binding, NADP, Phylogenetic, Rossmann, These, Yet
related to External links · 2
Rossmann fold → Proteopedia, Rossmann
ECOD · 1
Rossmann fold → 2003.1
Pfam clan · 1
Rossmann fold → CL0063
Symbol · 1
Rossmann fold → NADP_Rossmann
is a · 1
Rossmann fold → tertiary fold found in proteins that bind nucleotides

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

rossmann fold binding proteins nad strands folds enzymes nadp conserved first found beta structure function fad motif structural nucleotide enzyme

Rossmann fold relationships Subject–Predicate–Object triples

TTTA extracted 68 structured relationships around Rossmann fold. Examples in this analysis include Rossmann fold → ECOD → 2003.1 and Rossmann fold → Pfam clan → CL0063. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Rossmann foldECOD2003.11.00infobox
Rossmann foldPfam clanCL00631.00infobox
Rossmann foldSymbolNADP_Rossmann1.00infobox
Rossmann foldis atertiary fold found in proteins that bind nucleotides0.90text
FADinstance ofSince this segment is in contact with the ADP portion of dinucleotides0.80text
NADinstance ofSince this segment is in contact with the ADP portion of dinucleotides0.80text
NADP it is also called as aninstance ofSince this segment is in contact with the ADP portion of dinucleotides0.80text
Rossmann foldrelated to Conventional Rossman groupPhylogenetic0.60section
Rossmann foldrelated to Conventional Rossman groupNADP0.60section
Rossmann foldrelated to Conventional Rossman groupFAD0.60section
Rossmann foldrelated to Conventional Rossman groupNAD-binding0.60section
Rossmann foldrelated to Conventional Rossman groupIn0.60section

Related concept clusters Concept neighborhoods

The concept neighborhoods around Rossmann fold bring nearby vocabulary together. In this analysis, examples include Rossmann, Folds and First. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Rossmann fold
    • Rossmann
    • Folds
    • First
    • Beta
    • Binding
    • Nadp
    • Nucleotide
    • Structure
    • Conserved
    • Composed
    • Extended
    • Function
  • rossmann fold
    • Rossmann
    • Folds
    • First
    • Beta
    • Binding
    • Nadp
    • Nucleotide
    • Structure
    • Conserved
    • Strands
    • Composed
    • Contain
  • michael rossmann
    • Folds
    • First
    • Binding
    • Nucleotide
    • Structure
    • Conserved
    • Function
    • Motif
    • Structural
    • Rossmannoid
    • Common
    • Contain
  • structure
    • First
    • Fold
    • Rossmann
    • Called
    • Composed
    • Extended
    • Sheet
    • Ecod
    • Enzyme
    • Fad
    • Helices
    • Beta
  • nad+
    • Nadp
    • Binding
    • Function
    • Motif
    • Rossmann
    • Conserved
    • Enzymes
    • Called
    • Contain
    • Hanukoglu
    • Metabolic
    • Segment
  • proteins
    • Metabolic
    • Enzyme
    • Cofactors
    • Extremely
    • Rossmannoid
    • Binding
    • Common
    • Rossmann
    • Fad
    • Function
    • Motif
    • Nucleotide
  • fad
    • Nadp
    • Nad
    • Conserved
    • Analysis
    • Binding
    • Called
    • Segment
    • Sequence
    • Motif
    • Proteins
    • Found
    • Structure
  • nadp+
    • Motif
    • Sequence
    • Conserved
    • Binding
    • Rossmann
    • Analysis
    • Called
    • Contain
    • Hanukoglu
    • Segment
    • Ecod
    • Function

Connections between topic areas Semantic bridges

For Rossmann fold, one of the stronger structural bridges in this analysis connects Rossmann fold with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Rossmann fold — Overview · splits 18 ⟂ 14
Rossmann fold — Structure · splits 26 ⟂ 6
Rossmann fold — Function · splits 28 ⟂ 4
Rossmann fold — Evolution · splits 28 ⟂ 4
Rossmann fold — History · splits 29 ⟂ 3

Map overview Semantic statistics

Rossmann fold

Nodes32
Edges31
Triples68
Avg. degree1.94
Density0.0625
Components1

Source & methodology

TTTA analyzes the structure around Rossmann fold to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Structure & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Rossmann fold · EN edition · Analysis: TopicsToTalkAbout

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