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Imatinib, sold under the brand names Gleevec and Glivec (both marketed worldwide by Novartis) among others, is an oral targeted therapy medication used to treat cancer. Imatinib is a small molecule inhibitor targeting multiple tyrosine kinases such as CSF1R, ABL, c-KIT, FLT3, and PDGFR-β. Specifically, it is used for chronic myelogenous leukemia (CML)…
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Explore the main themes, entities and connections around Imatinib. Start with the topic map, then use the sections below for research and deeper semantic analysis.
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High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the full topic structure. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
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novartis patent drug tyrosine gleevec treatment may use kinase also c-kit effects patients application bcr-abl mesylate growth used cyp3a4 chronic
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| Imatinib | 3D model (JSmol) | Interactive image | 1.00 | infobox |
| Imatinib | AHFS/Drugs.com | Monograph | 1.00 | infobox |
| Imatinib | ATC code | L01EA01 (WHO) | 1.00 | infobox |
| Imatinib | Bioavailability | 98% | 1.00 | infobox |
| Imatinib | CAS Number | 152459-95-5 Y 220127-57-1 (mesilate) | 1.00 | infobox |
| Imatinib | ChEBI | CHEBI:45783 Y | 1.00 | infobox |
| Imatinib | ChEMBL | ChEMBL941 Y | 1.00 | infobox |
| Imatinib | ChemSpider | 5101 Y | 1.00 | infobox |
| Imatinib | CompTox Dashboard (EPA) | DTXSID3037125 | 1.00 | infobox |
| Imatinib | Drug class | Tyrosine kinase inhibitor | 1.00 | infobox |
| Imatinib | DrugBank | DB00619 Y | 1.00 | infobox |
| Imatinib | ECHA InfoCard | 100.122.739 | 1.00 | infobox |
| Imatinib | Elimination half-life | 18 h (imatinib) 40 h (active metabolite) | 1.00 | infobox |
| Imatinib | Excretion | Fecal (68%) and kidney (13%) | 1.00 | infobox |
| Imatinib | Formula | C29H31N7O | 1.00 | infobox |
| Imatinib | IUPHAR/BPS | 5687 | 1.00 | infobox |
| Imatinib | KEGG | D08066 Y | 1.00 | infobox |
| Imatinib | Legal status | AU: S4 (Prescription only) | 1.00 | infobox |
| Imatinib | Legal status | CA: ℞-only | 1.00 | infobox |
| Imatinib | Legal status | UK: POM (Prescription only) | 1.00 | infobox |
| Imatinib | Legal status | US: ℞-only | 1.00 | infobox |
| Imatinib | Legal status | EU: Rx-only | 1.00 | infobox |
| Imatinib | License data | US DailyMed: Imatinib | 1.00 | infobox |
| Imatinib | MedlinePlus | a606018 | 1.00 | infobox |
| Imatinib | Metabolism | Liver (mainly CYP3A4-mediated) | 1.00 | infobox |
| Imatinib | Molar mass | 493.615 g·mol−1 | 1.00 | infobox |
| Imatinib | Other names | STI-571 | 1.00 | infobox |
| Imatinib | PDB ligand | STI (PDBe, RCSB PDB) | 1.00 | infobox |
| Imatinib | Pregnancy category | AU: D | 1.00 | infobox |
| Imatinib | Pronunciation | ih-MAT-ih-nib | 1.00 | infobox |
These clusters group vocabulary that occurs around closely connected concepts in the source material.
Bridges can reveal useful research angles that are easy to miss in a flat list of related terms.