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Imatinib

Imatinib, sold under the brand names Gleevec and Glivec (both marketed worldwide by Novartis) among others, is an oral targeted therapy medication used to treat cancer. Imatinib is a small molecule inhibitor targeting multiple tyrosine kinases such as CSF1R, ABL, c-KIT, FLT3, and PDGFR-β. Specifically, it is used for chronic myelogenous leukemia (CML)…

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3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
L01EA01 (WHO)
Bioavailability
98%
CAS Number
152459-95-5 Y 220127-57-1 (mesilate)
ChEBI
CHEBI:45783 Y

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Overview

Medical uses

Side effects

Interactions

Pharmacology

History

Society and culture

Research

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Map overview Semantic statistics

Imatinib

Nodes169
Edges168
Triples197
Avg. degree1.99
Density0.011834
Components1

How this topic connects Entity context

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Imatinib

Top relations

related to history · 34
Imatinib → After, Anthony, Biological Studies, Brian Druker, British, California, Carlo Gambacorti-Passerini, Center, Charles Sawyers, Ciba-Geigy, CML, Elisabeth Buchdunger, Hammersmith Hospital, Hunter, Italy, John Goldman, Jürg Zimmermann, La Jolla, London, Memorial Sloan Kettering Cancer
related to Pharmacokinetics · 17
Imatinib → Abelson, ABL, As, CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4, FIP1L1-PDGFRalpha, It, Kit, Metabolism, Most, N-demethylated, P450, PDGFR, The
related to Other · 13
Imatinib → ALL, CHIC2, D816V, FIP1L1-PDGFRα, For, Gleevec, January, KIT, On, Ph, Philadelphia, The FDA, There
related to Interactions · 12
Imatinib → An, As, Conversely, CYP2C9, CYP2D6, CYP3A4, Inactivated, Its, Likewise, Since, St John's Wort, The
related to Economics · 11
Imatinib → Blood, Brian Druker, Carlo Gambacorti-Passerini, Druker, In, John Goldman, Novartis, Other, Signatories, They, United States
related to Medical uses · 11
Imatinib → ALL, ASM, CCyR, CML, DFSP, FDA, GISTs, In, It, MDS/MPD, MMR
related to Chronic myelogenous leukemia · 9
Imatinib → By, CML, Drug Administration, Due, FDA, Food, Philadelphia, Starting, The
related to Cardiotoxicity · 7
Imatinib → ABL, ABL1, Cardiotoxic, Clinical, In, Patient, Studies
related to Gastrointestinal stromal tumors · 7
Imatinib → February, GIST, KIT-positive, KIT-positive GISTs, On, The, The FDA
related to Research · 7
Imatinib → D816V, Experience, However, It, KIT, One, These

Important terminology Word statistics

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Important terminology

novartis patent drug tyrosine gleevec treatment may use kinase also c-kit effects patients application bcr-abl mesylate growth used cyp3a4 chronic

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Imatinib3D model (JSmol)Interactive image1.00infobox
ImatinibAHFS/Drugs.comMonograph1.00infobox
ImatinibATC codeL01EA01 (WHO)1.00infobox
ImatinibBioavailability98%1.00infobox
ImatinibCAS Number152459-95-5 Y 220127-57-1 (mesilate)1.00infobox
ImatinibChEBICHEBI:45783 Y1.00infobox
ImatinibChEMBLChEMBL941 Y1.00infobox
ImatinibChemSpider5101 Y1.00infobox
ImatinibCompTox Dashboard (EPA)DTXSID30371251.00infobox
ImatinibDrug classTyrosine kinase inhibitor1.00infobox
ImatinibDrugBankDB00619 Y1.00infobox
ImatinibECHA InfoCard100.122.7391.00infobox
ImatinibElimination half-life18 h (imatinib) 40 h (active metabolite)1.00infobox
ImatinibExcretionFecal (68%) and kidney (13%)1.00infobox
ImatinibFormulaC29H31N7O1.00infobox
ImatinibIUPHAR/BPS56871.00infobox
ImatinibKEGGD08066 Y1.00infobox
ImatinibLegal statusAU: S4 (Prescription only)1.00infobox
ImatinibLegal statusCA: ℞-only1.00infobox
ImatinibLegal statusUK: POM (Prescription only)1.00infobox
ImatinibLegal statusUS: ℞-only1.00infobox
ImatinibLegal statusEU: Rx-only1.00infobox
ImatinibLicense dataUS DailyMed: Imatinib1.00infobox
ImatinibMedlinePlusa6060181.00infobox
ImatinibMetabolismLiver (mainly CYP3A4-mediated)1.00infobox
ImatinibMolar mass493.615 g·mol−11.00infobox
ImatinibOther namesSTI-5711.00infobox
ImatinibPDB ligandSTI (PDBe, RCSB PDB)1.00infobox
ImatinibPregnancy categoryAU: D1.00infobox
ImatinibPronunciationih-MAT-ih-nib1.00infobox

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