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Γ-Hydroxybutyric acid

γ-Hydroxybutyric acid (GHB), also known as 4-hydroxybutanoic acid, is a naturally occurring neurotransmitter and a depressant drug. It is a precursor to GABA, glutamate, and glycine in certain brain areas. It acts on the GHB receptor and is a weak agonist at the GABAB receptor. GHB has been used in medicine as a general anesthetic and as treatment for…

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3D model (JSmol)
Interactive image
Addiction liability
High
ATC code
N01AX11 (WHO) N07XX04 (WHO)
Bioavailability
25% (oral)
CAS Number
591-81-1 Y
ChEBI
CHEBI:30830 Y

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Overview

Medical uses

Adverse effects

Overdose

Endogenous production

Pharmacology

History

Society and culture

Advanced semantic analysis

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Map overview Semantic statistics

Γ-Hydroxybutyric acid

Nodes151
Edges150
Triples64
Avg. degree1.99
Density0.013245
Components1

How this topic connects Entity context

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Γ-Hydroxybutyric acid

Top relations

related to Endogenous production · 11
Γ-Hydroxybutyric acid → Cells, Conversely, GHB, GHB-activated, It, Other, People, SSR, The, These, This
Legal status · 10
Γ-Hydroxybutyric acid → AU: S9 (Prohibited substance) / S8 as sodium oxybate, BR: Class B1 (Psychoactive drugs), CA: Schedule I, DE: Prescription only (Anlage III for higher doses), EU: List I (Netherlands), NZ: Class B, SE: Förteckning II, UK: Class B, UN: Psychotropic Schedule II, US: Schedule I / Schedule III
3D model (JSmol) · 1
Γ-Hydroxybutyric acid → Interactive image
Addiction liability · 1
Γ-Hydroxybutyric acid → High
ATC code · 1
Γ-Hydroxybutyric acid → N01AX11 (WHO) N07XX04 (WHO)
Bioavailability · 1
Γ-Hydroxybutyric acid → 25% (oral)
CAS Number · 1
Γ-Hydroxybutyric acid → 591-81-1 Y
ChEBI · 1
Γ-Hydroxybutyric acid → CHEBI:30830 Y
ChEMBL · 1
Γ-Hydroxybutyric acid → ChEMBL1342 Y
ChemSpider · 1
Γ-Hydroxybutyric acid → 9984 Y

Important terminology Word statistics

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Important terminology

ghb also drug use may alcohol gabab sodium used receptor oxybate effects found however brain gaba drugs blood doses overdose

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Γ-Hydroxybutyric acid3D model (JSmol)Interactive image1.00infobox
Γ-Hydroxybutyric acidAddiction liabilityHigh1.00infobox
Γ-Hydroxybutyric acidATC codeN01AX11 (WHO) N07XX04 (WHO)1.00infobox
Γ-Hydroxybutyric acidBioavailability25% (oral)1.00infobox
Γ-Hydroxybutyric acidCAS Number591-81-1 Y1.00infobox
Γ-Hydroxybutyric acidChEBICHEBI:30830 Y1.00infobox
Γ-Hydroxybutyric acidChEMBLChEMBL1342 Y1.00infobox
Γ-Hydroxybutyric acidChemSpider9984 Y1.00infobox
Γ-Hydroxybutyric acidCompTox Dashboard (EPA)DTXSID20747401.00infobox
Γ-Hydroxybutyric acidDrug classGHB receptor agonist; GABAB receptor agonist; Depressant; Hypnotic; Sedative1.00infobox
Γ-Hydroxybutyric acidDrugBankDB01440 Y1.00infobox
Γ-Hydroxybutyric acidECHA InfoCard100.218.5191.00infobox
Γ-Hydroxybutyric acidElimination half-life30–60 minutes1.00infobox
Γ-Hydroxybutyric acidExcretion1–5%, kidney1.00infobox
Γ-Hydroxybutyric acidFormulaC4H8O31.00infobox
Γ-Hydroxybutyric acidIUPHAR/BPS47111.00infobox
Γ-Hydroxybutyric acidKEGGC00989 Y1.00infobox
Γ-Hydroxybutyric acidLegal statusAU: S9 (Prohibited substance) / S8 as sodium oxybate1.00infobox
Γ-Hydroxybutyric acidLegal statusBR: Class B1 (Psychoactive drugs)1.00infobox
Γ-Hydroxybutyric acidLegal statusCA: Schedule I1.00infobox
Γ-Hydroxybutyric acidLegal statusDE: Prescription only (Anlage III for higher doses)1.00infobox
Γ-Hydroxybutyric acidLegal statusNZ: Class B1.00infobox
Γ-Hydroxybutyric acidLegal statusUK: Class B1.00infobox
Γ-Hydroxybutyric acidLegal statusUS: Schedule I / Schedule III1.00infobox
Γ-Hydroxybutyric acidLegal statusUN: Psychotropic Schedule II1.00infobox
Γ-Hydroxybutyric acidLegal statusEU: List I (Netherlands)1.00infobox
Γ-Hydroxybutyric acidLegal statusSE: Förteckning II1.00infobox
Γ-Hydroxybutyric acidMetabolism95–98%, mainly liver, also in blood and tissues1.00infobox
Γ-Hydroxybutyric acidMetabolitesSuccinic semialdehyde, Succinic acid1.00infobox
Γ-Hydroxybutyric acidMolar mass104.105 g·mol−11.00infobox

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