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GHB receptor: History, Ligands & Function

The γ-hydroxybutyrate (GHB) receptor (GHBR), originally identified as GPR172A, is an excitatory G protein-coupled receptor (GPCR) that binds the neurotransmitter and psychoactive drug γ-hydroxybutyric acid (GHB). As solute carrier family 52 member 2 (SLC52A2), it is also a transporter for riboflavin.

Language: English [EN]
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GHB receptor topic overview

The analysis highlights History, Ligands and Function as prominent areas in the source structure around GHB receptor.

Related topics
32
Source areas
4
Connected nodes
36
Extracted relationships
59
Related term clusters
14
Bridge connections
36

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Ligands · 20 topics
Overview · 6 topics
Function · 4 topics
History · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
SLC52A2, BVVLS2, D15Ertd747e, GPCR41, GPR172A, PAR1, RFT3, RFVT2, hRFT3, solute carrier family 52 member 2, GHB receptor, GHBh1
Band
8q24.3
Bgee
mucosa of transverse colon · stromal cell of endometrium · right hemisphere of cerebellum · granulocyte · apex of heart
BioGPS
n/a
Chr.
Chromosome 8 (human)
Databases
NCBI: entry; OMA: entry

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Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

History

Function

Ligands

For the semantics nerds

You can skip this section if you’re here for content ideas and keyword inspiration.

Advanced semantic analysis

How GHB receptor connects Entity context

The extracted context around GHB receptor shows recurring relationship patterns in the source. For example, GHB receptor → apex of heart, body of pancreas, body of stomach, gonad, granulocyte, left adrenal cortex, mucosa of transverse colon, right hemisphere of cerebellum, spleen, stromal cell of endometrium Another extracted example is GHB receptor → integral component of membrane, integral component of plasma membrane, membrane, plasma membrane, protein binding, riboflavin metabolic process, riboflavin transmembrane transporter activity, riboflavin transport, viral entry into host cell, virus receptor activity. Use these groups to spot repeated connection types before inspecting the individual relationships.

GHB receptor

Top relations

Bgee · 10
GHB receptor → apex of heart, body of pancreas, body of stomach, gonad, granulocyte, left adrenal cortex, mucosa of transverse colon, right hemisphere of cerebellum, spleen, stromal cell of endometrium
Gene ontology · 10
GHB receptor → integral component of membrane, integral component of plasma membrane, membrane, plasma membrane, protein binding, riboflavin metabolic process, riboflavin transmembrane transporter activity, riboflavin transport, viral entry into host cell, virus receptor activity
RNA expression pattern · 10
GHB receptor → apex of heart, body of pancreas, body of stomach, gonad, granulocyte, left adrenal cortex, mucosa of transverse colon, right hemisphere of cerebellum, spleen, stromal cell of endometrium
related to history · 9
GHB receptor → Due, Following, G-protein, GABAB, GCPR41, GHB, GPCR, GPR172A, SLC
related to Function · 4
GHB receptor → GABAB, GHB, GHB/GABAB, Na
Aliases · 1
GHB receptor → SLC52A2, BVVLS2, D15Ertd747e, GPCR41, GPR172A, PAR1, RFT3, RFVT2, hRFT3, solute carrier family 52 member 2, GHB receptor, GHBh1
Band · 1
GHB receptor → 8q24.3
BioGPS · 1
GHB receptor → n/a
Chr. · 1
GHB receptor → Chromosome 8 (human)
Databases · 1
GHB receptor → NCBI: entry; OMA: entry

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

receptor ghb human slc52a2 bp function identified riboflavin gpr172a family 52 transporter chr chromosome gpcr gene band protein solute carrier

GHB receptor relationships Subject–Predicate–Object triples

TTTA extracted 59 structured relationships around GHB receptor. Examples in this analysis include GHB receptor → Aliases → SLC52A2, BVVLS2, D15Ertd747e, GPCR41, GPR172A, PAR1, RFT3, RFVT2, hRFT3, solute carrier family 52 member 2, GHB receptor, GHBh1 and GHB receptor → Band → 8q24.3. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
GHB receptorAliasesSLC52A2, BVVLS2, D15Ertd747e, GPCR41, GPR172A, PAR1, RFT3, RFVT2, hRFT3, solute carrier family 52 member 2, GHB receptor, GHBh11.00infobox
GHB receptorBand8q24.31.00infobox
GHB receptorBgeemucosa of transverse colon1.00infobox
GHB receptorBgeestromal cell of endometrium1.00infobox
GHB receptorBgeeright hemisphere of cerebellum1.00infobox
GHB receptorBgeegranulocyte1.00infobox
GHB receptorBgeeapex of heart1.00infobox
GHB receptorBgeegonad1.00infobox
GHB receptorBgeebody of stomach1.00infobox
GHB receptorBgeebody of pancreas1.00infobox
GHB receptorBgeespleen1.00infobox
GHB receptorBgeeleft adrenal cortex1.00infobox
GHB receptorBioGPSn/a1.00infobox
GHB receptorChr.Chromosome 8 (human)1.00infobox
GHB receptorDatabasesNCBI: entry; OMA: entry1.00infobox
GHB receptorEnd144,361,286 bp1.00infobox
GHB receptorEnsemblENSG00000185803 ENSG000002851121.00infobox
GHB receptorEntrez795811.00infobox
GHB receptorExternal IDsOMIM: 607882; MGI: 1289288; GeneCards: SLC52A21.00infobox
GHB receptorGene location (Human)Gene location (Human)Chr.Chromosome 8 (human)Band8q24.3Start144,333,957 bpEnd144,361,286 bp1.00infobox
GHB receptorGene ontologyprotein binding1.00infobox
GHB receptorGene ontologyvirus receptor activity1.00infobox
GHB receptorGene ontologyriboflavin transmembrane transporter activity1.00infobox
GHB receptorGene ontologyintegral component of membrane1.00infobox
GHB receptorGene ontologymembrane1.00infobox
GHB receptorGene ontologyintegral component of plasma membrane1.00infobox
GHB receptorGene ontologyplasma membrane1.00infobox
GHB receptorGene ontologyviral entry into host cell1.00infobox
GHB receptorGene ontologyriboflavin transport1.00infobox
GHB receptorGene ontologyriboflavin metabolic process1.00infobox

Related concept clusters Related term clusters

The concept neighborhoods around GHB receptor bring nearby vocabulary together. In this analysis, examples include Receptor, Gabab and Gpr172a. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • GHB receptor
    • Receptor
    • Gabab
    • Gpr172a
    • Function
    • Human
    • Acid
    • Agonists
    • Existence
    • Location
    • Predicted
    • Γ-hydroxybutyric
    • Bp
  • ghb receptor
    • Receptor
    • Gabab
    • Gpr172a
    • Function
    • Human
    • Acid
    • Agonists
    • Existence
    • Location
    • Predicted
    • Γ-hydroxybutyric
    • Bp
  • g protein-coupled receptor
    • Gabab
    • Function
    • Human
    • Agonists
    • Existence
    • Location
    • Predicted
    • Bp
    • Chr
    • Chromosome
    • Found
    • Gene
  • gabab receptor
    • Gabab
    • Ghb
    • Receptor
    • Function
    • Human
    • Location
    • Predicted
    • Transmembrane
    • Agonists
    • Existence
    • Bp
    • Chr
  • function
    • Location
    • Bp
    • Chr
    • Chromosome
    • Gabab
    • Gene
    • Slc52a2
    • Ghb
    • Receptor
    • Human
    • Activity
    • Agonists
  • riboflavin
    • Transporter
    • Slc52a2
    • Activity
    • Band
    • Binding
    • Data
    • Existence
    • Location
    • Predicted
    • Solute
    • Transmembrane
    • Bp
  • solute carrier
    • Member
    • Solute
    • Family
    • Slc52a2
    • Agonists
    • Also
    • History
    • Location
    • Bp
    • Chr
    • Chromosome
    • Gene
  • history
    • Gene
    • Location
    • Member
    • Solute
    • Bp
    • Chr
    • Chromosome
    • Due
    • Slc52a2
    • Human
    • Receptor

Connections between topic areas Semantic bridges

For GHB receptor, one of the stronger structural bridges in this analysis connects GHB receptor with Ligands. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
GHB receptor — Ligands · splits 16 ⟂ 21
GHB receptor — Overview · splits 30 ⟂ 7
GHB receptor — Function · splits 32 ⟂ 5
GHB receptor — History · splits 34 ⟂ 3

Map overview Semantic statistics

GHB receptor

Nodes37
Edges36
Triples59
Avg. degree1.95
Density0.054054
Components1

Source & methodology

TTTA analyzes the structure around GHB receptor to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Ligands & Function, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — GHB receptor · EN edition · Analysis: TopicsToTalkAbout

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