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Dynorphin

Dynorphins (Dyn) are a class of opioid peptides that arise from the precursor protein prodynorphin. When prodynorphin is cleaved during processing by proprotein convertase 2 (PC2), multiple active peptides are released: dynorphin A, dynorphin B, and α/β-neoendorphin. Depolarization of a neuron containing prodynorphin stimulates PC2 processing, which…

Analgesia, Addiction & Stress and depression

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Key facts & relationships

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Domains
InterPro
HGNC
8820
Locus
Chr. 20 pter-p12.2
NCBI gene
5173
OMIM
131340
RefSeq
NM_024411

Topics to explore

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Overview

Production

Analgesia

Addiction

Stress and depression

Appetite and circadian rhythms

Temperature regulation

Advanced semantic analysis

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Map overview Semantic statistics

Dynorphin

Nodes129
Edges128
Triples83
Avg. degree1.98
Density0.015504
Components1

How this topic connects Entity context

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Dynorphin

Top relations

related to Temperature regulation · 19
Dynorphin → A1-17, Alm, Ansonoff, BNI, Further, Hypothermia, In, K1, K2, KOR, MOR, NOS, Opioid, PAG, Sharma, The, They, Thus, Xin
related to Stress and depression · 10
Dynorphin → CRF, CRF2, In, KOR, Land, Place, The, They, Together, While
related to Addiction · 9
Dynorphin → According, Although, Carlezon, Cocaine, CREB, Dynorphins, KORs, One, PKA
related to Analgesia · 9
Dynorphin → A1-13, Analgesia, Han, However, ICV, In, Ren, The, Xie
related to Appetite and circadian rhythms · 9
Dynorphin → Deprivation, Dynorphins, In, Inui, NI, Opioid, Przewlocki, These, This
related to Cocaine · 9
Dynorphin → Blocking KORs, BNI, Carlezon, CREB, However, Northern, They, This, Thus
related to External links · 4
Dynorphin → Dynorphins, Medicine Medical Subject Headings, MeSH, National Library
related to Production · 2
Dynorphin → Allen Brain Atlases, Gene
Domains · 1
Dynorphin → InterPro
HGNC · 1
Dynorphin → 8820

Important terminology Word statistics

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Important terminology

dynorphins et al found kor opioid levels effects cocaine receptor peptides prodynorphin stress peptide creb mice release antagonist hypothalamus authors

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
DynorphinDomainsInterPro1.00infobox
DynorphinHGNC88201.00infobox
DynorphinLocusChr. 20 pter-p12.21.00infobox
DynorphinNCBI gene51731.00infobox
DynorphinOMIM1313401.00infobox
DynorphinRefSeqNM_0244111.00infobox
DynorphinSearch forSearch forStructuresSwiss-modelDomainsInterPro1.00infobox
DynorphinStructuresSwiss-model1.00infobox
DynorphinSymbolPDYN1.00infobox
DynorphinUniProtP012131.00infobox
KORinstance ofThe N-terminal tyrosine of dynorphin A is necessary to activate opioid receptors0.80text
but is unnecessary in binding to bradykinin receptorsinstance ofThe N-terminal tyrosine of dynorphin A is necessary to activate opioid receptors0.80text

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    Min side: 3
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