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Enhancer of zeste homolog 2 (EZH2) is a histone-lysine N-methyltransferase enzyme (EC 2.1.1.43) encoded by EZH2 gene, that participates in histone methylation and, ultimately, transcriptional repression. EZH2 catalyzes the addition of methyl groups to histone H3 at lysine 27, by using the cofactor S-adenosyl-L-methionine. Methylation activity of EZH2…
The analysis highlights Art, Function and Clinical significance as prominent areas in the source structure around EZH2.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around EZH2 shows recurring relationship patterns in the source. For example, EZH2 → cardiac muscle hypertrophy in response to stress, cellular response to hydrogen peroxide, cellular response to trichostatin A, cerebellar cortex development, chromatin binding, chromatin DNA binding, chromatin organization, cytoplasm, DNA binding, DNA methylation, DNA-binding transcription factor activity, RNA polymerase II-specific, ESC/E(Z) complex, G1 to G0 transition, hepatocyte homeostasis, hippocampus development, histone H3-K27 methylation, histone H3-K27 trimethylation, histone methylation, histone methyltransferase activity, histone methyltransferase activity (H3-K27 specific) Another extracted example is EZH2 → A677, B-cell, Developing, DNA, DZNep, DZNep DZNep, EI1, Epizyme, EPZ-6438, EPZ005687, EZH1, EZH1/EZH2, FDA, GlaxoSmithKline, GSK-2816126, GSK126, Hodgkin's, However, In, It. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
methylation activity gene prc2 histone lysine also genes development cancer function complex cell cofactor inhibitor differentiation heterochromatin methyl transcription involved
TTTA extracted 292 structured relationships around EZH2. Examples in this analysis include EZH2 → 2.1.1.356 → ↗ and EZH2 → Aliases → EZH2, ENX-1, ENX1, EZH1, EZH2b, KMT6, KMT6A, WVS, WVS2, enhancer of zeste 2 polycomb repressive complex 2 subunit. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| EZH2 | 2.1.1.356 | ↗ | 1.00 | infobox |
| EZH2 | Aliases | EZH2, ENX-1, ENX1, EZH1, EZH2b, KMT6, KMT6A, WVS, WVS2, enhancer of zeste 2 polycomb repressive complex 2 subunit | 1.00 | infobox |
| EZH2 | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4MI0, 4MI5, 5HYN, 5IJ8, 5IJ7 | 1.00 | infobox |
| EZH2 | Band | 7q36.1 | 1.00 | infobox |
| EZH2 | Band | 6 B2.3|6 22.92 cM | 1.00 | infobox |
| EZH2 | Bgee | ganglionic eminence | 1.00 | infobox |
| EZH2 | Bgee | ventricular zone | 1.00 | infobox |
| EZH2 | Bgee | buccal mucosa cell | 1.00 | infobox |
| EZH2 | Bgee | left testis | 1.00 | infobox |
| EZH2 | Bgee | right testis | 1.00 | infobox |
| EZH2 | Bgee | sperm | 1.00 | infobox |
| EZH2 | Bgee | testicle | 1.00 | infobox |
| EZH2 | Bgee | gingival epithelium | 1.00 | infobox |
| EZH2 | Bgee | mucosa of transverse colon | 1.00 | infobox |
| EZH2 | Bgee | skin of abdomen | 1.00 | infobox |
| EZH2 | Bgee | tail of embryo | 1.00 | infobox |
| EZH2 | Bgee | secondary oocyte | 1.00 | infobox |
| EZH2 | Bgee | genital tubercle | 1.00 | infobox |
| EZH2 | Bgee | zygote | 1.00 | infobox |
| EZH2 | Bgee | primary oocyte | 1.00 | infobox |
| EZH2 | Bgee | primitive streak | 1.00 | infobox |
| EZH2 | Bgee | medial ganglionic eminence | 1.00 | infobox |
| EZH2 | Bgee | thymus | 1.00 | infobox |
| EZH2 | BioGPS | More reference expression data | 1.00 | infobox |
| EZH2 | Chr. | Chromosome 7 (human) | 1.00 | infobox |
| EZH2 | Chr. | Chromosome 6 (mouse) | 1.00 | infobox |
| EZH2 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| EZH2 | End | 148,884,321 bp | 1.00 | infobox |
| EZH2 | End | 47,595,341 bp | 1.00 | infobox |
| EZH2 | Ensembl | ENSG00000106462 | 1.00 | infobox |
The concept neighborhoods around EZH2 bring nearby vocabulary together. In this analysis, examples include Activity, Cancer and Inhibitor. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For EZH2, one of the stronger structural bridges in this analysis connects EZH2 with Clinical significance. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around EZH2 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Art, Function & Clinical significance, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — EZH2 · EN edition · Analysis: TopicsToTalkAbout