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EZH2

Enhancer of zeste homolog 2 (EZH2) is a histone-lysine N-methyltransferase enzyme (EC 2.1.1.43) encoded by EZH2 gene, that participates in histone methylation and, ultimately, transcriptional repression. EZH2 catalyzes the addition of methyl groups to histone H3 at lysine 27, by using the cofactor S-adenosyl-L-methionine. Methylation activity of EZH2…

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2.1.1.356
Aliases
EZH2, ENX-1, ENX1, EZH1, EZH2b, KMT6, KMT6A, WVS, WVS2, enhancer of zeste 2 polycomb repressive complex 2 subunit
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4MI0, 4MI5, 5HYN, 5IJ8, 5IJ7
Band
7q36.1 · 6 B2.3|6 22.92 cM
Bgee
ganglionic eminence · ventricular zone · buccal mucosa cell · left testis · right testis
BioGPS
More reference expression data

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Enzymatic activity

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EZH2

Nodes116
Edges115
Triples292
Avg. degree1.98
Density0.017241
Components1

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EZH2

Top relations

Gene ontology · 71
EZH2 → cardiac muscle hypertrophy in response to stress, cellular response to hydrogen peroxide, cellular response to trichostatin A, cerebellar cortex development, chromatin binding, chromatin DNA binding, chromatin organization, cytoplasm, DNA binding, DNA methylation, DNA-binding transcription factor activity, RNA polymerase II-specific, ESC/E(Z) complex, G1 to G0 transition, hepatocyte homeostasis, hippocampus development, histone H3-K27 methylation, histone H3-K27 trimethylation, histone methylation, histone methyltransferase activity, histone methyltransferase activity (H3-K27 specific)
related to Inhibitors · 40
EZH2 → A677, B-cell, Developing, DNA, DZNep, DZNep DZNep, EI1, Epizyme, EPZ-6438, EPZ005687, EZH1, EZH1/EZH2, FDA, GlaxoSmithKline, GSK-2816126, GSK126, Hodgkin's, However, In, It
Bgee · 18
EZH2 → buccal mucosa cell, ganglionic eminence, genital tubercle, gingival epithelium, left testis, medial ganglionic eminence, mucosa of transverse colon, primary oocyte, primitive streak, right testis, secondary oocyte, skin of abdomen, sperm, tail of embryo, testicle, thymus, ventricular zone, zygote
RNA expression pattern · 18
EZH2 → buccal mucosa cell, ganglionic eminence, genital tubercle, gingival epithelium, left testis, medial ganglionic eminence, mucosa of transverse colon, primary oocyte, primitive streak, right testis, secondary oocyte, skin of abdomen, sperm, tail of embryo, testicle, thymus, ventricular zone, zygote
related to Cancer · 16
EZH2 → Another, B-cell, Because, D1, E2F, However, If, Importantly, In, Inhibition, It, One, PRC2, SET, This, Wnt
related to Enzymatic activity · 15
EZH2 → Additional, Both, EED, EZH2α, EZH2β, Furthermore, In, Most, PRC2, PRC2/EZH2α, PRC2/EZH2β, Recently, SET, SUZ12, WD40-repeat
related to Regulation of EZH2 activity · 13
EZH2 → H3K27, H3K27ac, H3K36, H3K36me, In, Phosphorylation, PRC2, PRC2/EZH2-EED, S21, Specifically, T350, T492, The
related to Function · 12
EZH2 → As, EED, EZH2's, H3K27, H3K27me, HMTase, Lys-27, Polycomb Repressive Complex, PRC2, S-adenosyl-L-methionine, SAM, SUZ12
related to Transcription repression · 11
EZH2 → DNA, EZH2-mediated, H3K27, H3K27me3, Heterochromatin, Polycomb, PRC1, PRC2, PRC2/EZH2-EED-mediated H3K27, The, This
related to Development and cell differentiation · 10
EZH2 → B-cells, During X-inactivation, EZH2-mediated, Further, H3K27, H3K27me3, In, T-cells, X-chromosome, X-inactivation

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Important terminology

methylation activity gene prc2 histone lysine also genes development cancer function complex cell cofactor inhibitor differentiation heterochromatin methyl transcription involved

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
EZH22.1.1.3561.00infobox
EZH2AliasesEZH2, ENX-1, ENX1, EZH1, EZH2b, KMT6, KMT6A, WVS, WVS2, enhancer of zeste 2 polycomb repressive complex 2 subunit1.00infobox
EZH2Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4MI0, 4MI5, 5HYN, 5IJ8, 5IJ71.00infobox
EZH2Band7q36.11.00infobox
EZH2Band6 B2.3|6 22.92 cM1.00infobox
EZH2Bgeeganglionic eminence1.00infobox
EZH2Bgeeventricular zone1.00infobox
EZH2Bgeebuccal mucosa cell1.00infobox
EZH2Bgeeleft testis1.00infobox
EZH2Bgeeright testis1.00infobox
EZH2Bgeesperm1.00infobox
EZH2Bgeetesticle1.00infobox
EZH2Bgeegingival epithelium1.00infobox
EZH2Bgeemucosa of transverse colon1.00infobox
EZH2Bgeeskin of abdomen1.00infobox
EZH2Bgeetail of embryo1.00infobox
EZH2Bgeesecondary oocyte1.00infobox
EZH2Bgeegenital tubercle1.00infobox
EZH2Bgeezygote1.00infobox
EZH2Bgeeprimary oocyte1.00infobox
EZH2Bgeeprimitive streak1.00infobox
EZH2Bgeemedial ganglionic eminence1.00infobox
EZH2Bgeethymus1.00infobox
EZH2BioGPSMore reference expression data1.00infobox
EZH2Chr.Chromosome 7 (human)1.00infobox
EZH2Chr.Chromosome 6 (mouse)1.00infobox
EZH2DatabasesNCBI: entry; OMA: entry1.00infobox
EZH2End148,884,321 bp1.00infobox
EZH2End47,595,341 bp1.00infobox
EZH2EnsemblENSG000001064621.00infobox

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