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EZH2: Art, Function & Clinical significance

Enhancer of zeste homolog 2 (EZH2) is a histone-lysine N-methyltransferase enzyme (EC 2.1.1.43) encoded by EZH2 gene, that participates in histone methylation and, ultimately, transcriptional repression. EZH2 catalyzes the addition of methyl groups to histone H3 at lysine 27, by using the cofactor S-adenosyl-L-methionine. Methylation activity of EZH2…

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EZH2 topic overview

The analysis highlights Art, Function and Clinical significance as prominent areas in the source structure around EZH2.

Related topics
110
Source areas
5
Connected nodes
115
Extracted relationships
292
Concept neighborhoods
32
Bridge connections
115

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Clinical significance · 33 topics
Function · 31 topics
Overview · 28 topics
Enzymatic activity · 16 topics
Taxonomic distribution · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

2.1.1.356
Aliases
EZH2, ENX-1, ENX1, EZH1, EZH2b, KMT6, KMT6A, WVS, WVS2, enhancer of zeste 2 polycomb repressive complex 2 subunit
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4MI0, 4MI5, 5HYN, 5IJ8, 5IJ7
Band
7q36.1 · 6 B2.3|6 22.92 cM
Bgee
ganglionic eminence · ventricular zone · buccal mucosa cell · left testis · right testis
BioGPS
More reference expression data

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Enzymatic activity

Clinical significance

Taxonomic distribution

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How EZH2 connects Entity context

The extracted context around EZH2 shows recurring relationship patterns in the source. For example, EZH2 → cardiac muscle hypertrophy in response to stress, cellular response to hydrogen peroxide, cellular response to trichostatin A, cerebellar cortex development, chromatin binding, chromatin DNA binding, chromatin organization, cytoplasm, DNA binding, DNA methylation, DNA-binding transcription factor activity, RNA polymerase II-specific, ESC/E(Z) complex, G1 to G0 transition, hepatocyte homeostasis, hippocampus development, histone H3-K27 methylation, histone H3-K27 trimethylation, histone methylation, histone methyltransferase activity, histone methyltransferase activity (H3-K27 specific) Another extracted example is EZH2 → A677, B-cell, Developing, DNA, DZNep, DZNep DZNep, EI1, Epizyme, EPZ-6438, EPZ005687, EZH1, EZH1/EZH2, FDA, GlaxoSmithKline, GSK-2816126, GSK126, Hodgkin's, However, In, It. Use these groups to spot repeated connection types before inspecting the individual relationships.

EZH2

Top relations

Gene ontology · 71
EZH2 → cardiac muscle hypertrophy in response to stress, cellular response to hydrogen peroxide, cellular response to trichostatin A, cerebellar cortex development, chromatin binding, chromatin DNA binding, chromatin organization, cytoplasm, DNA binding, DNA methylation, DNA-binding transcription factor activity, RNA polymerase II-specific, ESC/E(Z) complex, G1 to G0 transition, hepatocyte homeostasis, hippocampus development, histone H3-K27 methylation, histone H3-K27 trimethylation, histone methylation, histone methyltransferase activity, histone methyltransferase activity (H3-K27 specific)
related to Inhibitors · 40
EZH2 → A677, B-cell, Developing, DNA, DZNep, DZNep DZNep, EI1, Epizyme, EPZ-6438, EPZ005687, EZH1, EZH1/EZH2, FDA, GlaxoSmithKline, GSK-2816126, GSK126, Hodgkin's, However, In, It
Bgee · 18
EZH2 → buccal mucosa cell, ganglionic eminence, genital tubercle, gingival epithelium, left testis, medial ganglionic eminence, mucosa of transverse colon, primary oocyte, primitive streak, right testis, secondary oocyte, skin of abdomen, sperm, tail of embryo, testicle, thymus, ventricular zone, zygote
RNA expression pattern · 18
EZH2 → buccal mucosa cell, ganglionic eminence, genital tubercle, gingival epithelium, left testis, medial ganglionic eminence, mucosa of transverse colon, primary oocyte, primitive streak, right testis, secondary oocyte, skin of abdomen, sperm, tail of embryo, testicle, thymus, ventricular zone, zygote
related to Cancer · 16
EZH2 → Another, B-cell, Because, D1, E2F, However, If, Importantly, In, Inhibition, It, One, PRC2, SET, This, Wnt
related to Enzymatic activity · 15
EZH2 → Additional, Both, EED, EZH2α, EZH2β, Furthermore, In, Most, PRC2, PRC2/EZH2α, PRC2/EZH2β, Recently, SET, SUZ12, WD40-repeat
related to Regulation of EZH2 activity · 13
EZH2 → H3K27, H3K27ac, H3K36, H3K36me, In, Phosphorylation, PRC2, PRC2/EZH2-EED, S21, Specifically, T350, T492, The
related to Function · 12
EZH2 → As, EED, EZH2's, H3K27, H3K27me, HMTase, Lys-27, Polycomb Repressive Complex, PRC2, S-adenosyl-L-methionine, SAM, SUZ12
related to Transcription repression · 11
EZH2 → DNA, EZH2-mediated, H3K27, H3K27me3, Heterochromatin, Polycomb, PRC1, PRC2, PRC2/EZH2-EED-mediated H3K27, The, This
related to Development and cell differentiation · 10
EZH2 → B-cells, During X-inactivation, EZH2-mediated, Further, H3K27, H3K27me3, In, T-cells, X-chromosome, X-inactivation

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

methylation activity gene prc2 histone lysine also genes development cancer function complex cell cofactor inhibitor differentiation heterochromatin methyl transcription involved

EZH2 relationships Subject–Predicate–Object triples

TTTA extracted 292 structured relationships around EZH2. Examples in this analysis include EZH2 → 2.1.1.356 → ↗ and EZH2 → Aliases → EZH2, ENX-1, ENX1, EZH1, EZH2b, KMT6, KMT6A, WVS, WVS2, enhancer of zeste 2 polycomb repressive complex 2 subunit. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
EZH22.1.1.3561.00infobox
EZH2AliasesEZH2, ENX-1, ENX1, EZH1, EZH2b, KMT6, KMT6A, WVS, WVS2, enhancer of zeste 2 polycomb repressive complex 2 subunit1.00infobox
EZH2Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4MI0, 4MI5, 5HYN, 5IJ8, 5IJ71.00infobox
EZH2Band7q36.11.00infobox
EZH2Band6 B2.3|6 22.92 cM1.00infobox
EZH2Bgeeganglionic eminence1.00infobox
EZH2Bgeeventricular zone1.00infobox
EZH2Bgeebuccal mucosa cell1.00infobox
EZH2Bgeeleft testis1.00infobox
EZH2Bgeeright testis1.00infobox
EZH2Bgeesperm1.00infobox
EZH2Bgeetesticle1.00infobox
EZH2Bgeegingival epithelium1.00infobox
EZH2Bgeemucosa of transverse colon1.00infobox
EZH2Bgeeskin of abdomen1.00infobox
EZH2Bgeetail of embryo1.00infobox
EZH2Bgeesecondary oocyte1.00infobox
EZH2Bgeegenital tubercle1.00infobox
EZH2Bgeezygote1.00infobox
EZH2Bgeeprimary oocyte1.00infobox
EZH2Bgeeprimitive streak1.00infobox
EZH2Bgeemedial ganglionic eminence1.00infobox
EZH2Bgeethymus1.00infobox
EZH2BioGPSMore reference expression data1.00infobox
EZH2Chr.Chromosome 7 (human)1.00infobox
EZH2Chr.Chromosome 6 (mouse)1.00infobox
EZH2DatabasesNCBI: entry; OMA: entry1.00infobox
EZH2End148,884,321 bp1.00infobox
EZH2End47,595,341 bp1.00infobox
EZH2EnsemblENSG000001064621.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around EZH2 bring nearby vocabulary together. In this analysis, examples include Activity, Cancer and Inhibitor. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • EZH2
    • Activity
    • Cancer
    • Inhibitor
    • Development
    • Gene
    • Also
    • Function
    • Prc2
    • Methylation
    • Histone
    • Genes
    • Tumor
  • ezh2
    • Activity
    • Cancer
    • Inhibitor
    • Development
    • Gene
    • Also
    • Function
    • Prc2
    • Methylation
    • Histone
    • Genes
    • Tumor
  • gene
    • Bp
    • Chr
    • Methylation
    • Human
    • Repression
    • Transcription
    • Involved
    • Cell
    • Function
    • Histone
    • Also
    • Epigenetic
  • histone methylation
    • Methylation
    • Lysine
    • Complex
    • Activity
    • Prc2
    • Function
    • Also
    • Transcription
    • Epigenetic
    • Repression
    • Formation
    • Proteins
  • histone h3
    • Methylation
    • Lysine
    • Function
    • Epigenetic
    • Prc2
    • Transcription
    • Cofactor
    • Involved
    • Complex
    • Methyl
    • Development
    • Genes
  • lysine
    • Substrate
    • Methylation
    • Methyl
    • Site
    • Function
    • Sam
    • May
    • Active
    • Complex
    • Also
    • Activity
    • Bp
  • embryonic development
    • Differentiation
    • Epigenetic
    • Ezh2
    • Bp
    • Chr
    • Human
    • Transcription
    • Involved
    • Active
    • Function
    • Histone
    • Gene
  • methylation
    • Lysine
    • Complex
    • Activity
    • Prc2
    • Function
    • Also
    • Transcription
    • Epigenetic
    • Repression
    • Formation
    • Proteins
    • May

Connections between topic areas Semantic bridges

For EZH2, one of the stronger structural bridges in this analysis connects EZH2 with Clinical significance. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
EZH2Clinical significance · splits 82 ⟂ 34
EZH2Function · splits 84 ⟂ 32
EZH2Overview · splits 87 ⟂ 29
EZH2Enzymatic activity · splits 99 ⟂ 17
EZH2Taxonomic distribution · splits 113 ⟂ 3

Map overview Semantic statistics

EZH2

Nodes116
Edges115
Triples292
Avg. degree1.98
Density0.017241
Components1

Source & methodology

TTTA analyzes the structure around EZH2 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Art, Function & Clinical significance, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — EZH2 · EN edition · Analysis: TopicsToTalkAbout

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