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SET domain

The SET domain is a protein domain that typically has methyltransferase activity. It was originally identified as part of a larger conserved region present in the Drosophila Trithorax protein and was subsequently identified in the Drosophila Su(var)3-9 and 'Enhancer of zeste' proteins, from which the acronym SET is derived [Su(var)3-9, Enhancer-of-zeste…

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Explore the main themes, entities and connections around SET domain. Start with the topic map, then use the sections below for research and deeper semantic analysis.

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Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

AlphaFold
IPR001214 · PF00856
Available protein structures:
IPR001214 · PF00856
InterPro
IPR001214
PDB
IPR001214 PF00856 (ECOD; PDBsum)
Pfam
PF00856
SCOP2
1ml9 / SCOPe / SUPFAM

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Overview

Structure

Function

Associated domains

Examples

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Map overview Semantic statistics

SET domain

Nodes98
Edges97
Triples81
Avg. degree1.98
Density0.020408
Components1

How this topic connects Entity context

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SET domain

Top relations

related to Examples · 36
SET domain → ASH1L, AWS, BAT8, EHMT1, EHMT2, EZH1, EZH2MLL, FP13812, Human, KMT5B, MLL2, MLL3, MLL5NSD1, NSD2, NSD3PRDM1, PRDM2, PRDM5SETD1A, SET, SETD2, SETD3
related to Associated domains · 12
SET domain → C-terminal, HMTase, InterPro, IPR003616, IPR007728, S-adenosyl-L-methionine-binding, SET, SUV39 SET, The, The C-terminal, The N-terminal, These
related to Function · 11
SET domain → Drosophila, Fruit, Histone, HMTase, HMTases, It, SET, SET7/9, Structural, The SET, With
related to Structure · 11
SET domain → DIM-5, H3, HKMTs, Neurospora, Rubisco, Rubisco LSMT, SET7, SET9, SETD7, Su, The SET
AlphaFold · 2
SET domain → IPR001214, PF00856
Available protein structures: · 2
SET domain → IPR001214, PF00856
InterPro · 1
SET domain → IPR001214
PDB · 1
SET domain → IPR001214 PF00856 (ECOD; PDBsum)
Pfam · 1
SET domain → PF00856
SCOP2 · 1
SET domain → 1ml9 / SCOPe / SUPFAM

Important terminology Word statistics

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Important terminology

set domain protein structure histone substrate lysine proteins three residues methyltransferase conserved region function interpro part human enzyme adomet cofactor

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
SET domainAlphaFoldIPR0012141.00infobox
SET domainAlphaFoldPF008561.00infobox
SET domainAvailable protein structures:IPR0012141.00infobox
SET domainAvailable protein structures:PF008561.00infobox
SET domainInterProIPR0012141.00infobox
SET domainPDBIPR001214 PF00856 (ECOD; PDBsum)1.00infobox
SET domainPfamPF008561.00infobox
SET domainSCOP21ml9 / SCOPe / SUPFAM1.00infobox
SET domainSMARTSM04681.00infobox
SET domainSymbolSET1.00infobox
SET domainis aprotein domain that typically has methyltransferase activity0.90text
SET domainrelated to Associated domainsThe N-terminal0.60section

Related concept clusters Concept neighborhoods

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    Connections between topic areas Semantic bridges

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    Min side: 3
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