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SET domain: Art & Regions

The SET domain is a protein domain that typically has methyltransferase activity. It was originally identified as part of a larger conserved region present in the Drosophila Trithorax protein and was subsequently identified in the Drosophila Su(var)3-9 and 'Enhancer of zeste' proteins, from which the acronym SET is derived [Su(var)3-9, Enhancer-of-zeste…

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SET domain topic overview

The analysis highlights Art and Regions as prominent areas in the source structure around SET domain.

Related topics
85
Source areas
5
Connected nodes
90
Extracted relationships
77
Related term clusters
31
Bridge connections
90

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Examples · 27 topics
Structure · 25 topics
Function · 19 topics
Associated domains · 9 topics
Overview · 5 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

AlphaFold
IPR001214 · PF00856
Available protein structures:
IPR001214 · PF00856
InterPro
IPR001214
PDB
IPR001214 PF00856 (ECOD; PDBsum)
Pfam
PF00856
SCOP2
1ml9 / SCOPe / SUPFAM

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Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure

Function

Associated domains

Examples

For the semantics nerds

You can skip this section if you’re here for content ideas and keyword inspiration.

Advanced semantic analysis

How SET domain connects Entity context

The extracted context around SET domain shows recurring relationship patterns in the source. For example, SET domain → ASH1L, AWS, BAT8, EHMT1, EHMT2, EZH1, EZH2MLL, FP13812, Human, KMT5B, MLL2, MLL3, MLL5NSD1, NSD2, NSD3PRDM1, PRDM2, PRDM5SETD1A, SET, SETD2, SETD3 Another extracted example is SET domain → DIM-5, H3, HKMTs, Neurospora, Rubisco, Rubisco LSMT, SET7, SET9, SETD7, Su, The SET. Use these groups to spot repeated connection types before inspecting the individual relationships.

SET domain

Top relations

related to Examples · 36
SET domain → ASH1L, AWS, BAT8, EHMT1, EHMT2, EZH1, EZH2MLL, FP13812, Human, KMT5B, MLL2, MLL3, MLL5NSD1, NSD2, NSD3PRDM1, PRDM2, PRDM5SETD1A, SET, SETD2, SETD3
related to Structure · 11
SET domain → DIM-5, H3, HKMTs, Neurospora, Rubisco, Rubisco LSMT, SET7, SET9, SETD7, Su, The SET
related to Associated domains · 10
SET domain → C-terminal, HMTase, InterPro, IPR003616, IPR007728, S-adenosyl-L-methionine-binding, SET, SUV39 SET, The C-terminal, The N-terminal
related to Function · 9
SET domain → Drosophila, Fruit, Histone, HMTase, HMTases, SET, SET7/9, Structural, The SET
AlphaFold · 2
SET domain → IPR001214, PF00856
Available protein structures: · 2
SET domain → IPR001214, PF00856
InterPro · 1
SET domain → IPR001214
PDB · 1
SET domain → IPR001214 PF00856 (ECOD; PDBsum)
Pfam · 1
SET domain → PF00856
SCOP2 · 1
SET domain → 1ml9 / SCOPe / SUPFAM

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

set domain protein structure histone substrate lysine proteins three residues methyltransferase conserved region function interpro part human enzyme adomet cofactor

SET domain relationships Subject–Predicate–Object triples

TTTA extracted 77 structured relationships around SET domain. Examples in this analysis include SET domain → AlphaFold → IPR001214 and SET domain → AlphaFold → PF00856. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
SET domainAlphaFoldIPR0012141.00infobox
SET domainAlphaFoldPF008561.00infobox
SET domainAvailable protein structures:IPR0012141.00infobox
SET domainAvailable protein structures:PF008561.00infobox
SET domainInterProIPR0012141.00infobox
SET domainPDBIPR001214 PF00856 (ECOD; PDBsum)1.00infobox
SET domainPfamPF008561.00infobox
SET domainSCOP21ml9 / SCOPe / SUPFAM1.00infobox
SET domainSMARTSM04681.00infobox
SET domainSymbolSET1.00infobox
SET domainis aprotein domain that typically has methyltransferase activity0.90text
SET domainrelated to Associated domainsThe N-terminal0.60section

Related concept clusters Related term clusters

The concept neighborhoods around SET domain bring nearby vocabulary together. In this analysis, examples include Set, Structure and Methyltransferase. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • SET domain
    • Set
    • Structure
    • Methyltransferase
    • Family
    • Human
    • Proteins
    • Three
    • Associated
    • C-terminal
    • Post-set
    • Setd7
    • Su
  • set domain
    • Set
    • Structure
    • Family
    • Human
    • Interpro
    • Methyltransferase
    • Proteins
    • Three
    • Associated
    • Setd7
    • Adomet
    • C-terminal
  • protein domain
    • Set
    • Structure
    • Drosophila
    • Larger
    • Rubisco
    • Su
    • Var
    • Enzyme
    • Methyltransferase
    • Part
    • Function
    • Proteins
  • methyltransferase
    • Protein
    • Structures
    • Three
    • Activity
    • Associated
    • Larger
    • Rubisco
    • Setd7
    • Su
    • Var
    • Set
    • Adomet
  • conserved region
    • C-terminal
    • Cysteine
    • Interpro
    • Post-set
    • Tail
    • Two
    • Residues
    • Histone
    • Three
    • Set
    • Drosophila
    • Larger
  • histone lysine methyltransferases
    • Tail
    • Lysine
    • Substrate
    • Methyl
    • One
    • Part
    • C-terminal
    • Interpro
    • Post-set
    • Two
    • Region
    • Structures
  • histone
    • Tail
    • Lysine
    • C-terminal
    • Interpro
    • One
    • Part
    • Post-set
    • Two
    • Region
    • Substrate
    • Three
    • Structures
  • lysine
    • Substrate
    • Methyl
    • One
    • Part
    • Structures
    • Three
    • Gene
    • Rubisco
    • Setd7
    • Su
    • Var
    • Adomet

Connections between topic areas Semantic bridges

For SET domain, one of the stronger structural bridges in this analysis connects SET domain with Examples. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
SET domain — Examples · splits 63 ⟂ 28
SET domain — Structure · splits 65 ⟂ 26
SET domain — Function · splits 71 ⟂ 20
SET domain — Associated domains · splits 81 ⟂ 10
SET domain — Overview · splits 85 ⟂ 6

Map overview Semantic statistics

SET domain

Nodes91
Edges90
Triples77
Avg. degree1.98
Density0.021978
Components1

Source & methodology

TTTA analyzes the structure around SET domain to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Art & Regions, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — SET domain · EN edition · Analysis: TopicsToTalkAbout

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