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LRP2

Low density lipoprotein receptor-related protein 2 also known as LRP-2 or megalin is a protein which in humans is encoded by the LRP2 gene.

Function, Interactions & Clinical significance

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Aliases
LRP2, DBS, GP330, LDL receptor related protein 2, LRP-2
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2M0P
Band
2q31.1 · 2 C2|2 40.74 cM
Bgee
corpus callosum · human kidney · buccal mucosa cell · kidney tubule · inferior ganglion of vagus nerve
BioGPS
More reference expression data
Chr.
Chromosome 2 (human) · Chromosome 2 (mouse)

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Overview

Function

Clinical significance

Interactions

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Map overview Semantic statistics

LRP2

Nodes59
Edges58
Triples148
Avg. degree1.97
Density0.033898
Components1

How this topic connects Entity context

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LRP2

Top relations

Gene ontology · 59
LRP2 → aorta development, apical part of cell, apical plasma membrane, axon, brush border, brush border membrane, calcium ion binding, cell population proliferation, cell projection, chaperone binding, clathrin-coated pit, clathrin-coated vesicle membrane, coronary artery morphogenesis, coronary vasculature development, dendrite, development of the heart, endocytic vesicle, endocytosis, endoplasmic reticulum, endosome
Bgee · 19
LRP2 → buccal mucosa cell, corpus callosum, efferent ductule, epiblast, germinal epithelium, glomerulus, human kidney, inferior ganglion of vagus nerve, kidney tubule, left lobe of thyroid gland, olfactory epithelium, retinal pigment epithelium, right kidney, right lobe of thyroid gland, stria vascularis, thyroid gland, vestibular membrane of cochlear duct, vestibular sensory epithelium, yolk sac
RNA expression pattern · 19
LRP2 → buccal mucosa cell, corpus callosum, efferent ductule, epiblast, germinal epithelium, glomerulus, human kidney, inferior ganglion of vagus nerve, kidney tubule, left lobe of thyroid gland, olfactory epithelium, retinal pigment epithelium, right kidney, right lobe of thyroid gland, stria vascularis, thyroid gland, vestibular membrane of cochlear duct, vestibular sensory epithelium, yolk sac
related to Function · 12
LRP2 → At, Dab2, Heyman, Heymann, It, LDLR, LRP2/megalin, NPXY, S1, S2, S3, Tg
related to Interactions · 11
LRP2 → CUBAM, DAB2, DLG4, GIPC1, ITGB1BP1, LDL-receptor-related, LDLRAP1, MAGI1, MAPK8IP1, MAPK8IP2, NOS1AP
related to Clinical significance · 4
LRP2 → Disfunction, Donnai-Barrow, LRP2-mediated, Mutations
Band · 2
LRP2 → 2 C2|2 40.74 cM, 2q31.1
Chr. · 2
LRP2 → Chromosome 2 (human), Chromosome 2 (mouse)
End · 2
LRP2 → 169,362,534 bp, 69,416,409 bp
Aliases · 1
LRP2 → LRP2, DBS, GP330, LDL receptor related protein 2, LRP-2

Important terminology Word statistics

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Important terminology

cells tubule protein proximal receptor bp gene megalin cubam apical chr human band kidney endocytic ligands also chromosome endocytosis expressed

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
LRP2AliasesLRP2, DBS, GP330, LDL receptor related protein 2, LRP-21.00infobox
LRP2Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2M0P1.00infobox
LRP2Band2q31.11.00infobox
LRP2Band2 C2|2 40.74 cM1.00infobox
LRP2Bgeecorpus callosum1.00infobox
LRP2Bgeehuman kidney1.00infobox
LRP2Bgeebuccal mucosa cell1.00infobox
LRP2Bgeekidney tubule1.00infobox
LRP2Bgeeinferior ganglion of vagus nerve1.00infobox
LRP2Bgeethyroid gland1.00infobox
LRP2Bgeeretinal pigment epithelium1.00infobox
LRP2Bgeegerminal epithelium1.00infobox
LRP2Bgeeleft lobe of thyroid gland1.00infobox
LRP2Bgeeright lobe of thyroid gland1.00infobox
LRP2Bgeevestibular membrane of cochlear duct1.00infobox
LRP2Bgeestria vascularis1.00infobox
LRP2Bgeeright kidney1.00infobox
LRP2Bgeeyolk sac1.00infobox
LRP2Bgeeefferent ductule1.00infobox
LRP2Bgeeolfactory epithelium1.00infobox
LRP2Bgeevestibular sensory epithelium1.00infobox
LRP2Bgeeepiblast1.00infobox
LRP2Bgeeglomerulus1.00infobox
LRP2BioGPSMore reference expression data1.00infobox
LRP2Chr.Chromosome 2 (human)1.00infobox
LRP2Chr.Chromosome 2 (mouse)1.00infobox
LRP2DatabasesNCBI: entry; OMA: entry1.00infobox
LRP2End169,362,534 bp1.00infobox
LRP2End69,416,409 bp1.00infobox
LRP2EnsemblENSG000000814791.00infobox

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