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LRP2: Function, Interactions & Clinical significance

Low density lipoprotein receptor-related protein 2 also known as LRP-2 or megalin is a protein which in humans is encoded by the LRP2 gene.

Language: English [EN]
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LRP2 topic overview

The analysis highlights Function, Interactions and Clinical significance as prominent areas in the source structure around LRP2.

Related topics
54
Source areas
4
Connected nodes
58
Extracted relationships
148
Concept neighborhoods
19
Bridge connections
58

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Interactions · 24 topics
Function · 22 topics
Clinical significance · 6 topics
Overview · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
LRP2, DBS, GP330, LDL receptor related protein 2, LRP-2
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2M0P
Band
2q31.1 · 2 C2|2 40.74 cM
Bgee
corpus callosum · human kidney · buccal mucosa cell · kidney tubule · inferior ganglion of vagus nerve
BioGPS
More reference expression data
Chr.
Chromosome 2 (human) · Chromosome 2 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Clinical significance

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How LRP2 connects Entity context

The extracted context around LRP2 shows recurring relationship patterns in the source. For example, LRP2 → aorta development, apical part of cell, apical plasma membrane, axon, brush border, brush border membrane, calcium ion binding, cell population proliferation, cell projection, chaperone binding, clathrin-coated pit, clathrin-coated vesicle membrane, coronary artery morphogenesis, coronary vasculature development, dendrite, development of the heart, endocytic vesicle, endocytosis, endoplasmic reticulum, endosome Another extracted example is LRP2 → buccal mucosa cell, corpus callosum, efferent ductule, epiblast, germinal epithelium, glomerulus, human kidney, inferior ganglion of vagus nerve, kidney tubule, left lobe of thyroid gland, olfactory epithelium, retinal pigment epithelium, right kidney, right lobe of thyroid gland, stria vascularis, thyroid gland, vestibular membrane of cochlear duct, vestibular sensory epithelium, yolk sac. Use these groups to spot repeated connection types before inspecting the individual relationships.

LRP2

Top relations

Gene ontology · 59
LRP2 → aorta development, apical part of cell, apical plasma membrane, axon, brush border, brush border membrane, calcium ion binding, cell population proliferation, cell projection, chaperone binding, clathrin-coated pit, clathrin-coated vesicle membrane, coronary artery morphogenesis, coronary vasculature development, dendrite, development of the heart, endocytic vesicle, endocytosis, endoplasmic reticulum, endosome
Bgee · 19
LRP2 → buccal mucosa cell, corpus callosum, efferent ductule, epiblast, germinal epithelium, glomerulus, human kidney, inferior ganglion of vagus nerve, kidney tubule, left lobe of thyroid gland, olfactory epithelium, retinal pigment epithelium, right kidney, right lobe of thyroid gland, stria vascularis, thyroid gland, vestibular membrane of cochlear duct, vestibular sensory epithelium, yolk sac
RNA expression pattern · 19
LRP2 → buccal mucosa cell, corpus callosum, efferent ductule, epiblast, germinal epithelium, glomerulus, human kidney, inferior ganglion of vagus nerve, kidney tubule, left lobe of thyroid gland, olfactory epithelium, retinal pigment epithelium, right kidney, right lobe of thyroid gland, stria vascularis, thyroid gland, vestibular membrane of cochlear duct, vestibular sensory epithelium, yolk sac
related to Function · 12
LRP2 → At, Dab2, Heyman, Heymann, It, LDLR, LRP2/megalin, NPXY, S1, S2, S3, Tg
related to Interactions · 11
LRP2 → CUBAM, DAB2, DLG4, GIPC1, ITGB1BP1, LDL-receptor-related, LDLRAP1, MAGI1, MAPK8IP1, MAPK8IP2, NOS1AP
related to Clinical significance · 4
LRP2 → Disfunction, Donnai-Barrow, LRP2-mediated, Mutations
Band · 2
LRP2 → 2 C2|2 40.74 cM, 2q31.1
Chr. · 2
LRP2 → Chromosome 2 (human), Chromosome 2 (mouse)
End · 2
LRP2 → 169,362,534 bp, 69,416,409 bp
Aliases · 1
LRP2 → LRP2, DBS, GP330, LDL receptor related protein 2, LRP-2

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

cells tubule protein proximal receptor bp gene megalin cubam apical chr human band kidney endocytic ligands also chromosome endocytosis expressed

LRP2 relationships Subject–Predicate–Object triples

TTTA extracted 148 structured relationships around LRP2. Examples in this analysis include LRP2 → Aliases → LRP2, DBS, GP330, LDL receptor related protein 2, LRP-2 and LRP2 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2M0P. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
LRP2AliasesLRP2, DBS, GP330, LDL receptor related protein 2, LRP-21.00infobox
LRP2Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2M0P1.00infobox
LRP2Band2q31.11.00infobox
LRP2Band2 C2|2 40.74 cM1.00infobox
LRP2Bgeecorpus callosum1.00infobox
LRP2Bgeehuman kidney1.00infobox
LRP2Bgeebuccal mucosa cell1.00infobox
LRP2Bgeekidney tubule1.00infobox
LRP2Bgeeinferior ganglion of vagus nerve1.00infobox
LRP2Bgeethyroid gland1.00infobox
LRP2Bgeeretinal pigment epithelium1.00infobox
LRP2Bgeegerminal epithelium1.00infobox
LRP2Bgeeleft lobe of thyroid gland1.00infobox
LRP2Bgeeright lobe of thyroid gland1.00infobox
LRP2Bgeevestibular membrane of cochlear duct1.00infobox
LRP2Bgeestria vascularis1.00infobox
LRP2Bgeeright kidney1.00infobox
LRP2Bgeeyolk sac1.00infobox
LRP2Bgeeefferent ductule1.00infobox
LRP2Bgeeolfactory epithelium1.00infobox
LRP2Bgeevestibular sensory epithelium1.00infobox
LRP2Bgeeepiblast1.00infobox
LRP2Bgeeglomerulus1.00infobox
LRP2BioGPSMore reference expression data1.00infobox
LRP2Chr.Chromosome 2 (human)1.00infobox
LRP2Chr.Chromosome 2 (mouse)1.00infobox
LRP2DatabasesNCBI: entry; OMA: entry1.00infobox
LRP2End169,362,534 bp1.00infobox
LRP2End69,416,409 bp1.00infobox
LRP2EnsemblENSG000000814791.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around LRP2 bring nearby vocabulary together. In this analysis, examples include Protein, Cells and Tubule. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • LRP2
    • Protein
    • Cells
    • Tubule
    • Megalin
    • Receptor
    • Proximal
    • Cubam
    • Kidney
    • Apical
    • Dab2
    • Endocytosis
    • Membrane
  • lrp2
    • Protein
    • Cells
    • Tubule
    • Megalin
    • Receptor
    • Proximal
    • Cubam
    • Kidney
    • Apical
    • Dab2
    • Endocytosis
    • Membrane
  • gene
    • Location
    • Chromosome
    • Human
    • Protein
    • Bp
    • Chr
    • Lrp-2
    • Mouse
    • Megalin
    • Receptor
    • Function
    • Lipoprotein
  • proximal tubule
    • Proximal
    • Tubule
    • Endocytic
    • Capacity
    • Cells
    • Apical
    • Surface
    • Lrp2
    • Expressed
    • Kidney
    • Megalin
    • Protein
  • function
    • Location
    • Chromosome
    • Human
    • Bp
    • Chr
    • Endocytic
    • Gene
    • Lrp-2
    • Mouse
    • Receptor
    • Protein
    • Expression
  • protein
    • Receptor
    • Proteins
    • Cells
    • Membrane
    • Plasma
    • Tubule
    • Expressed
    • Endocytic
    • Apical
    • Proximal
    • Mouse
    • Expression
  • ldl-receptor-related protein associated protein
    • Receptor
    • Proteins
    • Cells
    • Membrane
    • Plasma
    • Tubule
    • Expressed
    • Endocytic
    • Apical
    • Proximal
    • Mouse
    • Expression
  • vitamin d-binding protein
    • Receptor
    • Proteins
    • Cells
    • Membrane
    • Plasma
    • Tubule
    • Expressed
    • Endocytic
    • Apical
    • Proximal
    • Mouse
    • Expression

Connections between topic areas Semantic bridges

For LRP2, one of the stronger structural bridges in this analysis connects LRP2 with Interactions. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
LRP2Interactions · splits 34 ⟂ 25
LRP2Function · splits 36 ⟂ 23
LRP2Clinical significance · splits 52 ⟂ 7
LRP2Overview · splits 56 ⟂ 3

Map overview Semantic statistics

LRP2

Nodes59
Edges58
Triples148
Avg. degree1.97
Density0.033898
Components1

Source & methodology

TTTA analyzes the structure around LRP2 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Interactions & Clinical significance, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — LRP2 · EN edition · Analysis: TopicsToTalkAbout

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